Drug Target Review

JULY 4, 2023

1 Regulators invest significant consideration balancing quality-of-life measures with overall survival when assessing novel oncology treatments. In practice, some patients may be left managing a syndrome associated with the therapy along with the disease. 3D rendering of Antibody Drug Conjugate Molecules.

Small Molecule 145

Small Molecule Drugs Clinical Pharmacology Trials 145

Drug Hunter

AUGUST 21, 2023

Obtaining adequate drug exposure in the brain is key to treating CNS diseases effectively. The BBB is composed of specialized brain endothelial cells that regulate the distribution of molecules into and out of the brain from the blood. Recently, Dennis Koester gave us a crash course in CNS drug discovery in a Drug Hunter Flash Talk.

Drugs 206

Drugs Disease Targeted Protein Degradation Screening Hits 206

Broad Institute

NOVEMBER 17, 2023

He studies the genetics of numerous common diseases, particularly neuropsychiatric genetics especially schizophrenia, autism, and ADHD. His research focuses on the function of synapses and their disruption in animal models (especially non human primate models) of neurodevelopmental and psychiatric disease.

Engineering 52

Engineering Organic Chemistry Molecular Biology Disease 52