Science Daily: Pharmacology News

DECEMBER 14, 2023

New study demonstrates that diverse communities of resident bacteria can protect the human gut from disease-causing microorganisms. However, this protective effect is lost when only single species of gut bacteria are present.

Disease 309

Disease Research 309

Broad Institute

SEPTEMBER 28, 2023

By Allessandra DiCorato September 28, 2023 Credit: Strittmatter Laboratory, Yale University Amyloid beta clusters (red) builds up among neurons (green) in a mouse model of Alzheimer’s disease. The scientists identified a suite of changes in cells unique to the early stages of Alzheimer’s, including some not seen before in animal studies.

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Disease Medical Schools Research Hospitals 144

Drug Target Review

DECEMBER 29, 2023

Scientists in China have published their findings 1 regarding novel biomarkers, which they hope will benefit patients by identifying the disease at an earlier stage. Diabetic kidney disease DKD is a major microvascular complication of type 2 diabetes mellitus (T2DM). References Du S, Zhai L, Ye S, et al. Science China Life Sciences.

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Disease Science Hospitals Treatment 126

Chemical Biology and Drug Design

JANUARY 21, 2025

ABSTRACT Infectious diseases, including bacterial, fungal, and viral, have once again gained urgency in the drug development pipeline after the recent COVID-19 pandemic. Tuberculosis (TB) is an old infectious disease for which eradication has not yet been successful. Compound 26 was identified as a promising antiproliferative hit.

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Drug Development Disease Drugs Research 100

BioPharma Drive: Drug Pricing

FEBRUARY 24, 2025

Detailed results presented at a medical congress help reinforce analyst expectations the drug, called duvakitug, will be competitive with other Crohn’s, colitis medicines in testing.

Disease 144

Disease Drugs 144

Chemical Biology and Drug Design

APRIL 3, 2024

The present review explores the intricate relationship between autophagy and proteostasis in the pathogenesis of neurodegenerative diseases along with the therapeutic interventions to mitigate the same. The common pathological features of these diseases are associated with the accumulation of misfolded or aggregation of proteins.

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Disease Treatment Research 100

Drug Target Review

SEPTEMBER 5, 2023

By employing a mouse model of Parkinson’s disease, the researchers have illuminated a surprising revelation: it’s the border-associated macrophages (BAMs), not the microglia, that steer the neuroinflammatory response within the brain. However, identifying the precise cells presenting the antigens remained elusive.

Disease 98

Disease Immune Response Research 98

Broad Institute

OCTOBER 23, 2023

By Makenzie Kohler October 23, 2023 People of South Asian ancestry around the world have more than double the risk of developing cardiometabolic diseases like diabetes, heart attack, and stroke compared to other populations.

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Disease Research Hospitals DNA 145

SCIENMAG: Medicine & Health

AUGUST 29, 2023

Media Contacts: Credit: UMass Lowell Media Contacts: Emily Gowdey-Backus, director of media relations Nancy Cicco, assistant director of media relations More than a dozen medical studies from around the globe show women suffer worse outcomes when diagnosed with and treated for cardiac issues – the No.

Disease 89

Disease 89

BioPharma Drive: Drug Pricing

DECEMBER 10, 2023

While new gene therapies for the blood disease grabbed headlines at ASH, Pfizer presented fresh data for an oral drug meant to build on its marketed therapy Oxbryta.

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Therapies Drugs Disease Marketing 190

Chemical Biology and Drug Design

MAY 11, 2023

The figure depicts the neuroprotective role of crocin in Parkinson's disease. Abstract Parkinson's disease is among the most common forms of neurodegenerative illness, with present treatment being primarily symptomatic and frequently coming with substantial adverse effects.

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Disease Research Clinical Trials Treatment 100

Drug Target Review

JULY 3, 2023

There is a significant unmet need for effective treatments to alleviate suffering and prevent premature death across the spectrum of genetic diseases. Unfortunately, the majority of genetic diseases lack a cure, leaving limited therapeutic options available.

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Disease Therapies DNA Treatment 98

Drug Target Review

AUGUST 31, 2023

In the pursuit of a remedy for Alzheimer’s disease, a frontier in medical science is illuminating a glimmer of hope. Chronic inflammation involving microglia has been linked to the disease, as the release of inflammatory molecules triggers an increase in β-amyloid production.

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Therapies Disease Treatment Research 105

Drug Target Review

AUGUST 22, 2023

This Q&A explores how pre-clinical research is being used to identify potential therapies for Huntington’s disease, a devastating condition that currently lacks disease- modifying treatments. What makes the potential therapeutic for Huntington’s disease unique compared to other treatments?

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Therapies Disease Treatment RNA 98

Covalent Modifiers

JULY 5, 2024

Overall, we present a potent NSD2 degrader for the exploration of NSD2 disease phenotypes and a new FBXO22-recruitment strategy for TPD. We further demonstrate that a previously reported alkyl amine-containing degrader targeting XIAP is similarly dependent on SCF FBXO22.

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Targeted Protein Degradation Disease Drugs 200

Drug Target Review

NOVEMBER 29, 2023

Our primary focus is to design and develop RNA therapies for liver diseases. Using humans as the model, we use an approach called deep phenotyping to explore the relationships between cells, genes, biological pathways and patterns of disease. At present, we test discarded human livers deemed not good enough for transplant.

Therapies 102

Therapies Disease RNA Engineering 102

Broad Institute

DECEMBER 7, 2023

When researchers detect two mutations within a particular gene in a patient’s genome, it can be difficult or expensive to determine if those two mutations are present in the same copy of the gene (“in cis ”) or different copies of the gene (“in trans ”). Tags: Medical and Population Genetics Program Rare Disease Clinical genomics

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Disease Hospitals International Research 104

BioPharma Drive: Drug Pricing

JULY 17, 2023

New data presented Monday at a research conference support the case for Lilly’s donanemab, which works in a similar way as the two Alzheimer’s medicines recently approved in the U.S.

Disease 130

Disease Drugs Research 130

Chemical Biology and Drug Design

JANUARY 23, 2024

Abstract Nonalcoholic fatty liver disease (NAFLD) is a chronic liver disease associated with lipid deposition in liver cells and/or subsequent inflammation, excluding other known causes. At present, the pathogenesis of NAFLD remains unclear. At present, the pathogenesis of NAFLD remains unclear.

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Production Disease Regulations 100

SCIENMAG: Medicine & Health

JUNE 27, 2023

18F-flurpiridaz […]

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Disease Research 90

Drug Target Review

JUNE 21, 2023

Most rare diseases are caused by a single gene defect, but severity can vary considerably among patients. Modifier genes can help explain that variability and can alter or even prevent disease onset and progression, making them appealing therapeutic targets. However, the identification of these genes is challenging.

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Disease Clinical Trials Therapies Science 111

SCIENMAG: Medicine & Health

AUGUST 31, 2023

A new blood test called p-tau217 shows promise as an Alzheimer’s disease biomarker, and when used in a two-step workflow very high accuracy to either identify or exclude brain amyloidosis, the most important and earliest pathology.

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Disease Research 87

SCIENMAG: Medicine & Health

DECEMBER 5, 2023

The protein TDP-43 is present in all cells of our body and important for their biochemical processes. However, this protein can aggregate into large clumps in the brain, which can cause degenerative diseases such as Alzheimer’s and other dementias.

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Disease Research 85

Drug Target Review

JULY 7, 2023

Approximately three percent of the global population — 240 million people — experience autoantibody diseases, which occur when one’s own body attacks critical organs and tissues. This can create an abnormal immune response that attacks the cells of our bodies and contributes to the development of autoantibody diseases.

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Disease Immune Response Therapies Treatment 98

Chemical Biology and Drug Design

SEPTEMBER 20, 2023

Ovarian cancer is the most lethal gynecologic cancer with recurrent or resistant disease observed in 70% of patients. Most patients experience recurrence and succumb eventually to resistant disease, underscoring the need for an alternative treatment option.

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Treatment Disease Research 190

PLOS: DNA Science

JANUARY 25, 2024

We can learn about life, past and present, anywhere we find DNA and determine its sequence. The presence of DNA sequences from Treponema denticola , Streptococcus anginosus , and Slackia exigua indicate tooth decay, and from Streptococcus sobrinus and Parascardovia denticolens , periodontal disease.

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Disease DNA Science Virus 98

Chemical Biology and Drug Design

FEBRUARY 2, 2024

Abstract Existing chemotherapy for neglected tropical diseases (NTDs) can often be toxic and ineffective, highlighting the necessity for new treatments. Their use in combination therapy decreases the concentration of the reference drug used. Terpenes are secondary metabolites with pharmacological potential.

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Treatment Disease Immune Response Therapies 100

Covalent Modifiers

JULY 25, 2024

We have integrated structural and quantitative proteomics with biochemical assays to decipher the mode of action of covalent USP30 inhibition by a small molecule containing a cyanopyrrolidine reactive group, USP30-I-1.

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Biochemical Assays Small Molecule Treatment Disease 182

Chemical Biology and Drug Design

JULY 30, 2023

Abstract Parkinson's disease (PD) is a neurodegenerative disorder that affects 2%–3% of the population worldwide. Clinical presentation of PD includes motor and non-motor symptoms. SG restored striatal histopathological damage and dopamine concentration in rat striatum, and behavioural alterations in rats.

Disease 100

Disease Research 100

Chemical Biology and Drug Design

APRIL 19, 2023

Abstract Alzheimer's disease (AD) is a progressive neurodegenerative disorder caused due to the damage and loss of neurons in specific brain regions. The present work identifies and explains compounds with considerable Acetylcholinesterase (AChE) inhibitory activities. It is the most common form of dementia observed in older people.

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Disease Therapies Research Drugs 100

FDA Law Blog: Drug Discovery

NOVEMBER 10, 2024

Food and Drug Administration (FDA) plays a pivotal role in fostering the development of treatments for rare diseases through its Orphan Products Grants Program. Each year, FDA selects a limited number of clinical trials to fund to help sponsors pursue development of medical products for rare diseases and advance their field.

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Clinical Development Production Clinical Trials Treatment 69

Broad Institute

AUGUST 17, 2023

Chao joined the NIH as a Post-Baccalaureate Intramural Research Training Award fellow, where she processed and analyzed genomic data in the context of rare disease. In that role, Chao continued to work in rare disease genomic analysis, identifying sections of duplicated or deleted genomic sequences called copy number variants.

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Disease Production Science Research 98

Drug Target Review

JUNE 15, 2023

Interested in a more disease-focused training for his postdoc, he pursued work in the National Institutes of Health (NIH), particularly in the National Center for Advancing Translational Sciences (NCATS), US. The core of their platform aims to modulate disease-relevant mRNAs that have been previously thought to be undruggable.t.

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RNA Small Molecule Disease Assay Development 96

Drugs.com

AUGUST 29, 2024

You’re probably doing your heart a world of good, a new study shows.Weekend “catch-up” sleep can lower a person’s risk of heart disease by up to 20%, according to findings to be presented T. THURSDAY, Aug. 29, 2024 -- Like to sleep in on the weekends?You’re

Disease 130

Disease 130

Elrig

MARCH 25, 2025

It will also cover recent advancements in broadening their application, including innovative approaches to ensure their safety and efficacy, the use of targeted delivery to reach disease-relevant tissues as well as success stories in bringing therapeutic oligonucleotides to the clinic.

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RNA Bioinformatics Science Pharmacokinetics 59

ASPET

JANUARY 23, 2024

Patients with sickle cell disease (SCD) display priapism, a prolonged penile erection in the absence of sexual arousal. The current pharmacological treatments for SCD-associated priapism are limited and focused on acute interventions rather than prevention.

Disease 100

Disease Therapies Treatment Research 100

ASPET

JUNE 4, 2024

The goal of the present study was to determine the antiarthritic potential of the minor cannabinoid 8 -THC using the collagen-induced arthritis (CIA) mouse model. Adult male DBA/1J mice were immunized and boosted 21 days later with an emulsion of collagen and complete Freund's adjuvant.

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Treatment Disease Production 186