Broad Institute

OCTOBER 23, 2023

By Makenzie Kohler October 23, 2023 People of South Asian ancestry around the world have more than double the risk of developing cardiometabolic diseases like diabetes, heart attack, and stroke compared to other populations.

Disease 145

Disease Research Hospitals DNA 145

SCIENMAG: Medicine & Health

AUGUST 29, 2023

Media Contacts: Credit: UMass Lowell Media Contacts: Emily Gowdey-Backus, director of media relations Nancy Cicco, assistant director of media relations More than a dozen medical studies from around the globe show women suffer worse outcomes when diagnosed with and treated for cardiac issues – the No.

Disease 89

Disease 89

Drug Target Review

AUGUST 28, 2024

What are the main challenges currently faced in the treatment of chronic liver diseases, and how does Resolution Therapeutics aim to address these challenges? Once a patient develops advanced cirrhosis/end-stage liver disease there are no specific therapies to significantly avoid major decompensations and death in the next few years.

Therapies 114

Therapies Disease Engineering Medical Schools 114

Chemical Biology and Drug Design

MAY 11, 2023

The figure depicts the neuroprotective role of crocin in Parkinson's disease. Abstract Parkinson's disease is among the most common forms of neurodegenerative illness, with present treatment being primarily symptomatic and frequently coming with substantial adverse effects.

Disease 100

Disease Research Clinical Trials Treatment 100

Chemical Biology and Drug Design

JANUARY 23, 2024

Abstract Nonalcoholic fatty liver disease (NAFLD) is a chronic liver disease associated with lipid deposition in liver cells and/or subsequent inflammation, excluding other known causes. At present, the pathogenesis of NAFLD remains unclear. At present, the pathogenesis of NAFLD remains unclear.

Production 100

Production Disease Regulations 100

Drug Target Review

JULY 3, 2023

There is a significant unmet need for effective treatments to alleviate suffering and prevent premature death across the spectrum of genetic diseases. Unfortunately, the majority of genetic diseases lack a cure, leaving limited therapeutic options available.

Disease 98

Disease Therapies DNA Treatment 98

Drug Target Review

AUGUST 31, 2023

In the pursuit of a remedy for Alzheimer’s disease, a frontier in medical science is illuminating a glimmer of hope. Chronic inflammation involving microglia has been linked to the disease, as the release of inflammatory molecules triggers an increase in β-amyloid production.

Therapies 105

Therapies Disease Research Treatment 105

Drug Target Review

AUGUST 22, 2023

This Q&A explores how pre-clinical research is being used to identify potential therapies for Huntington’s disease, a devastating condition that currently lacks disease- modifying treatments. What makes the potential therapeutic for Huntington’s disease unique compared to other treatments?

Therapies 98

Therapies Disease RNA Treatment 98

Drug Target Review

NOVEMBER 29, 2023

Our primary focus is to design and develop RNA therapies for liver diseases. Using humans as the model, we use an approach called deep phenotyping to explore the relationships between cells, genes, biological pathways and patterns of disease. At present, we test discarded human livers deemed not good enough for transplant.

Therapies 102

Therapies Disease RNA Engineering 102

Conversations in Drug Development Trends

JANUARY 24, 2024

Written By: Derek Ansel, MS, CCRA, Executive Director, Therapeutic Strategy Lead, Rare Disease Given that 80% of rare diseases have a genetic etiology, genetic implications should be addressed at the onset of a clinical program to support trial enrollment. One diagnostic example that I discussed in my presentation is autism.

Trials 75

Trials Disease Clinical Trials Clinical Research 75

Broad Institute

DECEMBER 7, 2023

When researchers detect two mutations within a particular gene in a patient’s genome, it can be difficult or expensive to determine if those two mutations are present in the same copy of the gene (“in cis ”) or different copies of the gene (“in trans ”). Tags: Medical and Population Genetics Program Rare Disease Clinical genomics

Disease 104

Disease Hospitals International Research 104

PLOS: DNA Science

JANUARY 25, 2024

We can learn about life, past and present, anywhere we find DNA and determine its sequence. The presence of DNA sequences from Treponema denticola , Streptococcus anginosus , and Slackia exigua indicate tooth decay, and from Streptococcus sobrinus and Parascardovia denticolens , periodontal disease.

Disease 98

Disease DNA Science Virus 98

Chemical Biology and Drug Design

FEBRUARY 2, 2024

Abstract Existing chemotherapy for neglected tropical diseases (NTDs) can often be toxic and ineffective, highlighting the necessity for new treatments. Their use in combination therapy decreases the concentration of the reference drug used. Terpenes are secondary metabolites with pharmacological potential.

Treatment 100

Treatment Disease Immune Response Therapies 100

Drug Target Review

JUNE 21, 2023

Most rare diseases are caused by a single gene defect, but severity can vary considerably among patients. Modifier genes can help explain that variability and can alter or even prevent disease onset and progression, making them appealing therapeutic targets. However, the identification of these genes is challenging.

Disease 111

Disease Clinical Trials Therapies Science 111

SCIENMAG: Medicine & Health

JUNE 27, 2023

18F-flurpiridaz […]

Disease 90

Disease Research 90

SCIENMAG: Medicine & Health

AUGUST 31, 2023

A new blood test called p-tau217 shows promise as an Alzheimer’s disease biomarker, and when used in a two-step workflow very high accuracy to either identify or exclude brain amyloidosis, the most important and earliest pathology.

Disease 87

Disease Research 87

Drug Target Review

JULY 7, 2023

Approximately three percent of the global population — 240 million people — experience autoantibody diseases, which occur when one’s own body attacks critical organs and tissues. This can create an abnormal immune response that attacks the cells of our bodies and contributes to the development of autoantibody diseases.

Disease 98

Disease Immune Response Therapies Treatment 98

SCIENMAG: Medicine & Health

DECEMBER 5, 2023

The protein TDP-43 is present in all cells of our body and important for their biochemical processes. However, this protein can aggregate into large clumps in the brain, which can cause degenerative diseases such as Alzheimer’s and other dementias.

Disease 85

Disease Research 85

Chemical Biology and Drug Design

SEPTEMBER 20, 2023

Ovarian cancer is the most lethal gynecologic cancer with recurrent or resistant disease observed in 70% of patients. Most patients experience recurrence and succumb eventually to resistant disease, underscoring the need for an alternative treatment option.

Treatment 190

Treatment Disease Research 190

Drugs.com

JANUARY 11, 2024

11, 2024 -- DNA locked in the bones and teeth of more than 5,000 humans who lived in Asia and Europe up to 34,000 years ago are providing vital clues to a myriad of present-day medical conditions.The descendants of these ancient. THURSDAY, Jan.

DNA 98

DNA Disease 98

ASPET

JANUARY 23, 2024

Patients with sickle cell disease (SCD) display priapism, a prolonged penile erection in the absence of sexual arousal. The current pharmacological treatments for SCD-associated priapism are limited and focused on acute interventions rather than prevention.

Disease 100

Disease Therapies Treatment Research 100

Chemical Biology and Drug Design

JULY 30, 2023

Abstract Parkinson's disease (PD) is a neurodegenerative disorder that affects 2%–3% of the population worldwide. Clinical presentation of PD includes motor and non-motor symptoms. SG restored striatal histopathological damage and dopamine concentration in rat striatum, and behavioural alterations in rats.

Disease 100

Disease Research 100

Chemical Biology and Drug Design

APRIL 19, 2023

Abstract Alzheimer's disease (AD) is a progressive neurodegenerative disorder caused due to the damage and loss of neurons in specific brain regions. The present work identifies and explains compounds with considerable Acetylcholinesterase (AChE) inhibitory activities. It is the most common form of dementia observed in older people.

Disease 100

Disease Therapies Research Drugs 100

SCIENMAG: Medicine & Health

JANUARY 17, 2024

and colleagues present these findings in the open-access journal PLOS ONE on January 17. A study of more than 25,000 U.S. dogs and 238 breeds has linked dog size to varying patterns of risk for health conditions over the course of a dog’s lifespan. Yunbi Nam of the University of Washington, U.S., On average, smaller […]

Disease 94

Disease 94

Broad Institute

AUGUST 17, 2023

Chao joined the NIH as a Post-Baccalaureate Intramural Research Training Award fellow, where she processed and analyzed genomic data in the context of rare disease. In that role, Chao continued to work in rare disease genomic analysis, identifying sections of duplicated or deleted genomic sequences called copy number variants.

Disease 98

Disease Production Science Research 98

Drug Target Review

JUNE 15, 2023

Interested in a more disease-focused training for his postdoc, he pursued work in the National Institutes of Health (NIH), particularly in the National Center for Advancing Translational Sciences (NCATS), US. The core of their platform aims to modulate disease-relevant mRNAs that have been previously thought to be undruggable.t.

RNA 96

RNA Small Molecule Disease Assay Development 96

SCIENMAG: Medicine & Health

MARCH 5, 2024

WHAT: A weekly injection of semaglutide was safe and reduced the amount of fat in the liver by 31% in people with HIV and metabolic dysfunction-associated steatotic liver disease (MASLD), according to a presentation today at the 2024 Conference on Retroviruses and Opportunistic Infections (CROI) in Denver.

Disease 68

Disease Clinical Trials Trials 68

Science Daily: Pharmacology News

SEPTEMBER 19, 2024

A new study provides a list of the wildlife species present at the market from which SARS-CoV-2, the virus responsible for the COVID-19 pandemic, most likely arose in late 2019. The study is based on a new analysis of metatranscriptomic data released by the Chinese Center for Disease Control and Prevention (CDC).

Marketing 135

Marketing Virus Disease 135

ASPET

JUNE 4, 2024

The goal of the present study was to determine the antiarthritic potential of the minor cannabinoid 8 -THC using the collagen-induced arthritis (CIA) mouse model. Adult male DBA/1J mice were immunized and boosted 21 days later with an emulsion of collagen and complete Freund's adjuvant.

Treatment 186

Treatment Disease Production 186

Science Daily: Pharmacology News

DECEMBER 14, 2023

New study demonstrates that diverse communities of resident bacteria can protect the human gut from disease-causing microorganisms. However, this protective effect is lost when only single species of gut bacteria are present.

Disease 127

Disease Research 127

Conversations in Drug Development Trends

OCTOBER 29, 2024

By: Juliane Mills, Senior Director, Therapeutic Strategy Lead, Rare Disease The rise of patient-led clinical research, particularly in rare disease, represents a significant shift in the clinical trial landscape. Why Is There an Increase in Patient-Led Rare Disease Research?

Clinical Research 72

Clinical Research Disease Research Clinical Trials 72

Conversations in Drug Development Trends

NOVEMBER 21, 2023

Since the advent of modern medicine, the scientific community has developed more than 3,000 drugs for thousands of diseases. Despite significant progress, there are more than 6,500 rare diseases without a single approved treatment. There are so many patients suffering from diseases that have no treatments.

Disease 78

Disease Treatment Clinical Trials Clinical Development 78

Drug Target Review

SEPTEMBER 9, 2024

functions to reset the immune system and potentially provide remission for allergic diseases? 1104 acts upstream in the inflammatory response, targeting one of the first key players: antigen-presenting cells (APCs). In allergic diseases, APCs identify and present unknown antigens to the immune system.

Disease 64

Disease Immune Response Clinical Trials Treatment 64

Drug Target Review

JANUARY 24, 2024

Scientists from Northwestern Medicine have demonstrated that RNA interference could have a crucial role in the onset and development of Alzheimer’s disease (AD). Alzheimer’s disease Alzheimer’s is the most common cause of dementia. The team found very short sequences present in some of these sRNAs. Alzheimer’s disease.

RNA 64

RNA Disease DNA Engineering 64

Drug Target Review

MAY 7, 2024

Why are biomarkers particularly critical in the context of rare diseases? Developing novel therapeutic approaches for rare diseases poses inherent challenges due to the limited populations available for testing. How do AI-enhanced approaches accelerate the drug development process for rare diseases?

Disease 59

Disease Clinical Trials Clinical Pharmacology Trials 59

Chemical Biology and Drug Design

DECEMBER 17, 2023

Abstract The cognitive dysfunction caused by prediabetes causes great difficulties in human life, and the terrible thing is that the means to prevent the occurrence of this disease are very limited at present, Berberine has shown the potential to treat diabetes and cognitive dysfunction, but it still needs to be further explored to clarify the mechanism (..)

Disease 189

Disease Research 189

Drug Target Review

JULY 11, 2023

In the quest to combat and eradicate diseases, scientists and researchers are increasingly turning to the immense potential of artificial intelligence (AI) as a tool. It was here that the Impact Medicine Fund was raised as a concept around wellness for those with disease, with the ambition of unlocking some of this vast potential.

Disease 75

Disease RNA Small Molecule Clinical Development 75