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Exendin?4: A potential therapeutic strategy for Alzheimer's disease and Parkinson's disease

Chemical Biology and Drug Design

The figure depicts the neuroprotective role of exendin-4 in Alzheimer's disease and Parkinson's disease. Due to the complex pathological processes underlying neurodegeneration, at present, there is no viable therapy available for neurodegenerative disorders.

Disease 189
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Alcohol raises heart disease risk, particularly among women

Science Daily: Pharmacology News

Young to middle-aged women who reported drinking eight or more alcoholic beverages per week--more than one per day, on average--were significantly more likely to develop coronary heart disease compared with those who drank less, finds a study presented at the American College of Cardiology's Annual Scientific Session.

Disease 140
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New biomarkers found for diabetic kidney disease

Drug Target Review

Scientists in China have published their findings 1 regarding novel biomarkers, which they hope will benefit patients by identifying the disease at an earlier stage. Diabetic kidney disease DKD is a major microvascular complication of type 2 diabetes mellitus (T2DM). References Du S, Zhai L, Ye S, et al. Science China Life Sciences.

Disease 126
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Scientists reveal cellular changes unique to early Alzheimer’s disease

Broad Institute

By Allessandra DiCorato September 28, 2023 Credit: Strittmatter Laboratory, Yale University Amyloid beta clusters (red) builds up among neurons (green) in a mouse model of Alzheimer’s disease. The scientists identified a suite of changes in cells unique to the early stages of Alzheimer’s, including some not seen before in animal studies.

Disease 144
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New data showcase promise, growing pains of CAR-T in autoimmune disease

BioPharma Drive: Drug Pricing

One expert described trial results presented at EULAR last week as “unprecedented.” ” But reports of relapses in some patients drew questions about the therapies’ ultimate potential.

Disease 139
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Role of autophagy and proteostasis in neurodegenerative diseases: Exploring the therapeutic interventions

Chemical Biology and Drug Design

The present review explores the intricate relationship between autophagy and proteostasis in the pathogenesis of neurodegenerative diseases along with the therapeutic interventions to mitigate the same. The common pathological features of these diseases are associated with the accumulation of misfolded or aggregation of proteins.

Disease 100
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Brain macrophage in Parkinson’s disease neuroinflammation

Drug Target Review

By employing a mouse model of Parkinson’s disease, the researchers have illuminated a surprising revelation: it’s the border-associated macrophages (BAMs), not the microglia, that steer the neuroinflammatory response within the brain. However, identifying the precise cells presenting the antigens remained elusive.

Disease 98