Drug Discovery World

NOVEMBER 22, 2022

Currently, no effective cure or treatment for Huntington’s disease exists. Download this new App Note from bit.bio to learn: How Charles River Laboratories characterised the phenotype of a human iPSC-derived Huntington’s disease model from bit.bio over 38 days in vitro with high-density microelectrode arrays from MaxWell Biosystems.

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Drug Discovery World

AUGUST 19, 2024

The discovery of a new regulator affecting immune cells could lead to new treatments to reduce inflammation in diseases including arthritis and severe Covid-19. A large research collaboration, led by the University of Exeter’s MRC Centre for Medical Mycology, has focused on how immune cells sense their environment.

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Drug Discovery World

AUGUST 28, 2024

Pfizer has expanded its strategic partnership with Flagship Pioneering, adding two new research programmes with Flagship-founded Quotient Therapeutics. “With our deep cardiometabolic heritage, we will continue to push the boundaries of research innovation to help address significant gaps in care that remain for these patients.”

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Drug Discovery World

AUGUST 11, 2023

Liverpool School of Tropical Medicine (LSTM) and LifeArc are partnering to launch a new Translational Development Fund to help tackle infectious diseases. million into the fund, which will support the progression of new technologies and treatments for emerging viral threats and neglected tropical diseases. LifeArc will invest £2.7 ($3.4)

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Drug Discovery World

MARCH 24, 2023

Israeli researchers have developed a drug that is effective in treating a rare genetic muscle disease. The team demonstrated that the disease is caused by a mutation in the gene encoding HMG CoA reductase, inhibiting the enzyme’s activity.

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Drug Discovery World

JANUARY 12, 2023

X-Chem and Sironax have agreed a research partnership, in which X-Chem will use its DEL platform to support Sironax’s drug discovery pipeline. . Through the collaboration, X-Chem will screen its DNA-encoded libraries (DEL) against difficult-to-drug targets implicated in neurodegenerative disease to discover hits.

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Drug Discovery World

AUGUST 7, 2023

Evox Therapeutics has agreed a research collaboration and option agreement with the Icahn School of Medicine at Mount Sinai (Icahn Mount Sinai) in New York, NY, US. The collaboration will work on developing exosome-encapsulated AAV (exoAAV) vectors as a novel gene delivery technology aimed at improving treatments for heart disease.

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Drug Discovery World

DECEMBER 13, 2022

PacBio, developer of sequencing solutions, has announced its HiFi sequencing technology will be used in a pilot project for the Children’s Rare Disease Cohorts Initiative (CRDC) at Boston Children’s Hospital. . As causative variants are identified by CRDC researchers, results are returned to participants.

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Drug Discovery World

SEPTEMBER 4, 2024

Cancer Research Horizons and AstraZeneca have signed a five-year renewal of the Functional Genomics Centre, a facility dedicated to advancing drug discovery with genome-altering technologies such as CRISPR. It helps us tap into previously unknown biology and advances our understanding of cancer resistance mechanisms.

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Drug Discovery World

JANUARY 23, 2024

Breast cancer was the most studied disease in 2023 for the third consecutive year, followed by solid tumours, stroke, Covid-19 and prostate cancer. The post Breast cancer most researched disease area for third year running appeared first on Drug Discovery World (DDW). Read the full report.

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Drug Discovery World

DECEMBER 9, 2022

The ‘Rare Disease Moonshot’, a new initiative to boost research and development into rare and paediatric diseases, has launched at the European Health Summit. . It aims to speed up research into more than 7000 identified rare diseases, of which a staggering 95% have no approved treatment or cure. .

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Drug Discovery World

JULY 5, 2024

The Division of Clinical Neuroscience at Oslo University Hospital (OUS) and the Swedish drug development company TikoMed have signed a research collaboration agreement focused on amyotrophic lateral sclerosis (ALS).

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Drug Discovery World

AUGUST 29, 2024

The US Parkinson’s Foundation has invested nearly $3 million for 33 grants to accelerate Parkinson’s disease (PD) research. The research grants will fund scientists conducting studies across various aspects of PD to bring forward new therapies, treatments, and ultimately a cure for the disease.

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Drug Discovery World

JULY 24, 2024

Fox Foundation for Parkinson’s Research (MJFF). calcium channel inhibition as a novel and disease-modifying approach for treatment of Parkinson’s disease. There is extensive literature linking calcium channels to pathology of the disease, and it has been demonstrated in preclinical experimental studies that the deletion of CaV2.3

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Fierce BioTech

AUGUST 20, 2024

Alzheimer’s disease research and drug development is evolving at a rapid pace. Decades of research has led to the approval of the first disease-modifying drugs and new pathological discoveries. |

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Drug Discovery World

SEPTEMBER 21, 2023

A research team from VIB-KU Leuven and the UK Dementia Research Institute has discovered how neurons die in Alzheimer’s disease, opening new pathways for potential future treatments. The research team was also able to prevent the death of neurons, rescuing them in the process.

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Drug Discovery World

MAY 24, 2024

Dr Paulien Baeten, postdoctoral researcher, commented: “The collaboration with etherna in this VLAIO-funded project is a great opportunity to contribute to the application of mRNA technologies in the fight against autoimmune disorders.

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Drug Discovery World

JULY 24, 2024

The drug research was originally carried out by the Children’s Hospital of Philadelphia (CHOP), the world’s leading centre for leukodystrophy research, under a sponsored research agreement. CHOP identified a candidate antisense oligonucleotide (ASO) as a potential therapy for H-ABC.

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Drug Discovery World

JUNE 5, 2024

million to fund a new two-year collaborative partnership with King’s College London (KCL) to validate a portfolio of human genetic driven therapeutic targets for motor neuron disease (MND). Historical pipeline data suggests that drug targets with human genetic disease association are twice as likely to lead to approved drugs.

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Drug Discovery World

JUNE 26, 2024

Scientists at the University of Bristol have uncovered a new disease driving mechanism which they are aiming to target to help treat the development of atherosclerotic plaques. This unique award will allow us to develop a therapeutic to target this novel non-coding RNA, and validate its use in patients with heart disease.”

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Drug Discovery World

JUNE 6, 2024

With the 2024 American Society of Clinical Oncology (ASCO) Annual Meeting , taking place from 30 May to 3 June, the drug discovery announcements have been coming thick and fast, with many new cancer therapies making significant strides forward in our ability to treat the disease.

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Drug Discovery World

FEBRUARY 2, 2024

Head of clinical trials at the University College London (UCL) Dementia Research Centre, Dr Cath Mummery, has been announced as the Director of a new network of dementia trial sites across the country. The post UK dementia research gets £49.9 The UK government has authorised £49.9 ($63.4)

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Drug Discovery World

SEPTEMBER 12, 2023

Twist Bioscience and Ono Pharmaceutical will combine their efforts to discover and develop novel antibodies for the treatment of autoimmune diseases. Under the terms of the agreement, Twist will use its ‘Library of Libraries’ to conduct research activities to discover novel antibodies against targets identified by Ono.

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Drug Discovery World

NOVEMBER 23, 2022

Scientists have found a new drug treatment that can slow the progression of neurodegenerative disease in mice. The breakthrough research may offer fresh hope in tackling currently untreatable conditions such as Alzheimer’s disease (AD). .

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Chemical Biology and Drug Design

DECEMBER 15, 2023

The figure depicts the neuroprotective role of exendin-4 in Alzheimer's disease and Parkinson's disease. Exendin-4's diverse therapeutic targets suggest its potential therapeutic uses in neurodegenerative ailments like Alzheimer's disease and Parkinson's disease and have garnered an increasing amount of attention.

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Broad Institute

JANUARY 25, 2024

They found significant associations between the thinning of different retinal layers and increased risk of developing ocular, cardiac, pulmonary, metabolic, and neuropsychiatric diseases and identified genes that are associated with retinal layer thickness. Their findings are published in Science Translational Medicine. “We

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Drug Discovery World

JULY 11, 2024

This platform has several advantages over existing drug discovery approaches, as the screen takes place inside a disease-relevant mammalian cell, with the targeted protein correctly decorated with post-translational modifications, and dynamic so that allosteric and cryptic pockets are exposed and available for inhibitor engagement.

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Drug Discovery World

NOVEMBER 28, 2023

An experimental drug has shown potential as a disease-modifying therapy for Parkinson’s disease, according to a new study published in Nature Communications. Parkinson’s disease is highly associated with mitochondrial dysfunction. By inhibiting USP30, MTX325 helps restore normal mitophagy and thus cellular health.

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Drug Discovery World

MAY 17, 2024

PlaqueTec and the Welch research group at the Babraham Institute have announced the completion of their collaboration to evaluate lead compounds predicted to bind a pro-inflammatory protein discovered by PlaqueTec. The post Partners explore precision medicine approach to heart disease appeared first on Drug Discovery World (DDW).

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Drug Discovery World

DECEMBER 28, 2023

Oxford Target Therapeutics, a company developing a promising therapy for triple negative breast cancer, is one of three UK life science companies awarded research prizes by the Rosalind Franklin Institute, based in Oxfordshire, UK. But it is instrumental for us, so the Franklin’s offer of funding and expertise will really fill a vital gap.”

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Drug Discovery World

MARCH 7, 2024

Research published in Cell Genomics has shown that prostate cancer includes two different subtypes of the disease, also known as evotypes. The researchers analysed the DNA of prostate cancer samples in 159 patients using whole genome sequencing and used an AI technique known as neural networks to compare the different samples.

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Drug Discovery World

MAY 13, 2024

The University of Texas MD Anderson Cancer Center has been awarded $20 million to strengthen neurodegeneration research. The consortium was established to gain a deeper understanding of neurodegenerative disease biology and translate those findings into effective therapeutic interventions. Yet, we still have more work to do.

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SCIENMAG: Medicine & Health

SEPTEMBER 6, 2023

PITTSBURGH – To reimagine existing preclinical trials for Alzheimer’s disease, University of Pittsburgh School of Medicine neuroscientists created the first non-human primate model of hereditary Alzheimer’s in marmoset monkeys, outlining their approach in Alzheimer’s & Dementia: Translational Research & Clinical Interventions.

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Drug Discovery World

MAY 14, 2024

I lead a translational and multidisciplinary project, PUMA, where we will uncover the elusive tumour immunology of this rare and hard-to treat disease. The neoadjuvant concept has become an ideal platform for both drug discovery and translational research. That it mandates close multidisciplinary team work makes it even more rewarding!

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Drug Discovery World

AUGUST 15, 2024

Scale Biosciences (Scale Bio) has launched the ‘100 Million Cell Challenge’, which hopes to push the boundaries of single-cell genomics research, in collaboration with Ultima Genomics and NVIDIA. Researchers interested in participating can submit their project proposals from 8 August to 15 October 2024.

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Broad Institute

OCTOBER 23, 2023

By Makenzie Kohler October 23, 2023 People of South Asian ancestry around the world have more than double the risk of developing cardiometabolic diseases like diabetes, heart attack, and stroke compared to other populations. They will also have the opportunity to inform the researchers on whether their health status changes over time.

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Drug Discovery World

APRIL 8, 2024

Their research signals a transformative leap in liver disease management, addressing both inflammation and fibrosis. Metabolic dysfunction-associated steatotic liver disease (MASLD) is a burgeoning global health concern, posing a significant threat to public health and escalating the burden on healthcare resources.

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