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Exendin?4: A potential therapeutic strategy for Alzheimer's disease and Parkinson's disease

Chemical Biology and Drug Design

The figure depicts the neuroprotective role of exendin-4 in Alzheimer's disease and Parkinson's disease. Exendin-4's diverse therapeutic targets suggest its potential therapeutic uses in neurodegenerative ailments like Alzheimer's disease and Parkinson's disease and have garnered an increasing amount of attention.

Disease 189
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Researchers roll out a more accurate way to estimate genetic risks of disease

Broad Institute

Researchers roll out a more accurate way to estimate genetic risks of disease By Claire Hendershot March 19, 2024 Breadcrumb Home Researchers roll out a more accurate way to estimate genetic risks of disease Two new approaches for generating polygenic scores demonstrate that compiled data improves score accuracy.

Disease 136
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With retinal images and genetic data, researchers predict cardiovascular, metabolic, and other disease risks

Broad Institute

They found significant associations between the thinning of different retinal layers and increased risk of developing ocular, cardiac, pulmonary, metabolic, and neuropsychiatric diseases and identified genes that are associated with retinal layer thickness. Their findings are published in Science Translational Medicine. “We

Disease 124
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New patient-partnered research project will study heart disease and diabetes risk in South Asian populations

Broad Institute

By Makenzie Kohler October 23, 2023 People of South Asian ancestry around the world have more than double the risk of developing cardiometabolic diseases like diabetes, heart attack, and stroke compared to other populations. They will also have the opportunity to inform the researchers on whether their health status changes over time.

Disease 145
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A therapy candidate for fatal prion diseases turns off disease-causing gene

Broad Institute

Science (2024) Related content New gene delivery vehicle shows promise for human brain gene therapy My Quest to Cure Prion Disease — Before It’s Too Late | Sonia Vallabh | TED Prion diseases lead to rapid neurodegeneration and death and are caused by misshapen versions of the prion protein in the brain.

Disease 142
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Scientists Map Genetics of Lyme Disease Bacteria, Aiding Research

Drugs.com

19, 2024 -- All 23 known species of the bacteria that cause Lyme disease have now been genetically mapped, providing an aid to better diagnosis and research."This This comprehensive, high-quality sequencing investigation of Lyme disease and. MONDAY, Aug.

Disease 104
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New research alliance with Novo Nordisk to identify therapeutic targets for type 2 diabetes and cardiometabolic diseases

Broad Institute

This collaboration has the potential not only to accelerate our understanding of the diseases, but also potentially enable scientific advancements in disease-modifying interventions — a true game changer in addressing cardiometabolic diseases.” The collaboration will focus on advancing three programs over the next three years.

Disease 136