Disease Research Targeted Protein Degradation 
Broad Institute
MARCH 14, 2024
Related groups Liu lab Choudhary lab Fischer lab Researchers studying the role of proteins in health and disease use experimental tools that inactivate proteins, destroy them, or prevent them from being made in cells. PACE allows researchers to rapidly evolve new proteins that have useful features.
Drug Target Review
JULY 6, 2023
TPD is a rapidly evolving therapeutic modality to degrade a disease-causing proteins, thereby eliminating their function specifically. 1 TPD is expected to challenge undruggable proteins, which are highly difficult to target by conventional small molecules. How does TPD work?
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SugarCone Biotech
OCTOBER 6, 2024
Thus, it is not enough for 2 proteins to each be expressed on the same cell surface, other features such as protein mobility in the cell membrane must play a role. I suspect this is an area of active research. These are in development for neurodegenerative diseases.
Drug Hunter
JUNE 25, 2023
This edition includes Maze’s glycogen synthase 1 (GYS1) inhibitors that were recently licensed to Sanofi, allosteric androgen receptor (AR) modulators that may be of interest to targeted protein degradation researchers, and brain-penetrant HER2 and ROCK2 inhibitors.
The Pharma Data
DECEMBER 16, 2020
Evotec and Bristol Myers Squibb (the successor in interest to Celgene ) initiated their long-term strategic drug discovery and development partnership in the field of targeted protein degradation in 2018 with the goal to identify novel drug targets.
Sygnature Discovery
SEPTEMBER 25, 2023
Sygnature Discovery identifies potent SHP2 degrader compounds using its proprietary targeted protein degrader platform, CHARMED, in collaboration with Japanese specialty chemical company, UBE Corporation. Its staff of over 1,000, which includes 900 scientists, partners with global pharma, biotech and NFP organisations.
Drug Target Review
JULY 23, 2024
Shortly after finishing my studies, I landed my first job in industry working on cell biology research for several disease indications. At the time, research and leadership roles in biotech/pharma industry were predominately held by men and there were not as many opportunities for career development and mentorship from women leaders.
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