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Novel drug reduces neuronal death in neurodegenerative disease

Drug Discovery World

New research has shown that Ellorarxine, a novel drug compound developed by biotech Nevrargenics, provides a robust neuroprotective effect and reduces neuronal death in cell models of neurodegenerative disease. As expected, when the neurones were exposed to glutamate, they started to die.

Disease 290
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Researchers discover treatment for rare muscle disease

Drug Discovery World

Israeli researchers have developed a drug that is effective in treating a rare genetic muscle disease. The team demonstrated that the disease is caused by a mutation in the gene encoding HMG CoA reductase, inhibiting the enzyme’s activity. This is the first study to link muscle pain and weakness to statin use.

Disease 130
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Scottish partnership to boost kidney disease research

Drug Discovery World

A new partnership between NHS Scotland, AstraZeneca and the Universities of Dundee and Glasgow hopes to accelerate research into treating chronic kidney disease. As we navigate the complex issue of chronic kidney disease, our commitment to patient-centred research remains unwavering.

Disease 130
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UK researchers discover new treatment target for atheroschlerosis

Drug Discovery World

Scientists at the University of Bristol have uncovered a new disease driving mechanism which they are aiming to target to help treat the development of atherosclerotic plaques. This unique award will allow us to develop a therapeutic to target this novel non-coding RNA, and validate its use in patients with heart disease.”

Treatment 147
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LifeArc’s £40m research centres to boost research into rare diseases

Drug Discovery World

Four new LifeArc Translational Centres for Rare Diseases have been created to give people living with rare medical conditions access to improved tests and treatments. Globally, there are more than 300 million people living with rare diseases. However, rare disease research can be fragmented. The £9.4 ($11.7)

Research 130
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Researchers discover genetic cause of inflammatory bowel diseases

Drug Discovery World

Researchers have discovered a new biological pathway in inflammatory bowel disease (IBD) and related conditions that can be targeted using existing drugs. About 5% of the world’s population are currently affected by an autoimmune disease, such as IBD, the umbrella term for Crohn’s disease and ulcerative colitis.

Disease 147
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Potent drug candidate could transform liver disease treatment

Drug Discovery World

Scientists from Gwangju Institute of Science and Technology in Korea have discovered compound 11c, a potentially ground-breaking oral treatment for metabolic dysfunction-associated steatohepatitis. Their research signals a transformative leap in liver disease management, addressing both inflammation and fibrosis.

Disease 130