Drugs.com

APRIL 11, 2024

THURSDAY, April 11, 2024 -- The discovery of a gene variant that rids the brain of toxic plaques linked to Alzheimer's might lead to new treatments for the disease, researchers report.The variant arises naturally in people who don't seem to get.

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Science Daily: Pharmacology News

OCTOBER 5, 2023

Researchers have identified a 'guard mechanism' for a protein which attacks microbes in infected cells, opening the possibility of new treatments for Toxoplasma, Chlamydia, Tuberculosis and even cancer.

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Broad Institute

OCTOBER 30, 2024

Researchers map communities of single cells in metastatic breast cancers By Corie Lok October 30, 2024 Breadcrumb Home Researchers map communities of single cells in metastatic breast cancers The team compared different single-cell and spatial profiling methods to explore the diversity of cells in metastatic breast cancer biopsies.

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Science Daily: Pharmacology News

FEBRUARY 1, 2024

It's an achievement with important implications for scientists studying the brain and working on treatments for a broad range of neurological and neurodevelopmental disorders, such as Alzheimer's and Parkinson's disease.

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Drugs.com

DECEMBER 19, 2024

19, 2024 -- Parkinson's is a relentless disease for which few treatments, and no real cure, exists. Now, researchers say they are on the trail of a potential new therapy for the disabling neurological illness.It's early research. THURSDAY, Dec.

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Science Daily: Pharmacology News

AUGUST 29, 2024

Innovative study of DNA's hidden structures may open up new approaches for treatment and diagnosis of diseases, including cancer.

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Drugs.com

FEBRUARY 5, 2024

However, new research suggests that a less aggressive approach to treating the disease has helped an increasing. MONDAY, Feb. 5, 2024 -- Rectal cancer often involves surgeries that can lead to a debilitating loss of bowel function for patients.

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Science Daily: Pharmacology News

JULY 27, 2023

A gene encoding a protein linked to tau production -- tripartite motif protein 11 (TRIM11) -- was found to suppress deterioration in small animal models of neurodegenerative diseases similar to Alzheimer's disease (AD), while improving cognitive and motor abilities, according to new research.

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Drugs.com

JANUARY 23, 2024

23, 2024 -- Two new strategies using deep brain stimulation can improve symptoms of Parkinson’s disease, Duke University researchers have found.Doctors can efficiently improve symptoms of Parkinson’s by simultaneously targeting to. TUESDAY, Jan.

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Science Daily: Pharmacology News

SEPTEMBER 15, 2023

Researchers have achieved a significant breakthrough in identifying the primary cause and potential treatment for preeclampsia, a severe pregnancy complication. Upon testing this antibody in mice, the researchers found the all symptoms associated with preeclampsia were corrected.

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BioPharma Drive: Drug Pricing

JULY 24, 2023

The Swiss pharma company is the latest large drugmaker to invest big in an experimental heart treatment, after years of prioritizing medicines for cancer and immune diseases.

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BioPharma Drive: Drug Pricing

JULY 17, 2023

Scribe will receive $40 million upfront from Sanofi in a collaboration initially focused on developing an in vivo gene editing treatment for sickle cell disease.

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Chemical Biology and Drug Design

DECEMBER 15, 2023

The figure depicts the neuroprotective role of exendin-4 in Alzheimer's disease and Parkinson's disease. Exendin-4's diverse therapeutic targets suggest its potential therapeutic uses in neurodegenerative ailments like Alzheimer's disease and Parkinson's disease and have garnered an increasing amount of attention.

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FDA Law Blog: Drug Discovery

NOVEMBER 10, 2024

Food and Drug Administration (FDA) plays a pivotal role in fostering the development of treatments for rare diseases through its Orphan Products Grants Program. Each year, FDA selects a limited number of clinical trials to fund to help sponsors pursue development of medical products for rare diseases and advance their field.

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Science Daily: Pharmacology News

SEPTEMBER 25, 2024

Researchers have discovered that mutations affect protein stability following remarkably simple rules. The discovery has profound implications for accelerating the development of new treatments for diseases or the design of new proteins with industrial applications.

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Science Daily: Pharmacology News

DECEMBER 4, 2024

New research shows that the heart has a mini-brain -- its own nervous system that controls the heartbeat. A better understanding of this system, which is much more diverse and complex than previously thought, could lead to new treatments for heart diseases.

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Science Daily: Pharmacology News

OCTOBER 17, 2024

In two studies, researchers have now conducted a detailed study of the microbiome, i.e. the totality of all microorganisms, in humans and zoo animals. The aim was to identify starting points for strategies for the treatment and diagnosis of diseases.

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Drugs.com

SEPTEMBER 23, 2024

Researchers in Japan found a positive turnaround in markers of gum well-being after people with. MONDAY, Sept. 23, 2024 -- Diabetes can worsen the state of your gums, but a new study suggests that diabetes medications may undo some of that damage.

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Science Daily: Pharmacology News

JULY 15, 2024

Early exposure to antibiotics can trigger long term susceptibility to asthma, according to new research.

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Drug Target Review

OCTOBER 11, 2023

Almost every one of us will know someone with a neurodegenerative disease such as Alzheimer’s or Parkinson’s. It is less common to know someone with a rare genetic disease; but while individually rare, collectively they have an enormous impact. Most of these conditions are genetic in origin and the majority have no effective treatment.

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Science Daily: Pharmacology News

FEBRUARY 27, 2025

Using an animal model of multiple sclerosis (MS), researchers have created a four-dimensional brain map that reveals how lesions similar to those seen in human MS form. These findings provide a window into the early disease state and could help identify potential targets for MS treatments and brain tissue repair.

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Broad Institute

JUNE 27, 2024

Neurons were classified by software as either positive for prion protein expression (yellow) before treatment with CHARM (left panel), or negative (purple) after treatment (right panel). Previous research has shown that as little as 21 percent elimination of the protein can improve symptoms.

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Science Daily: Pharmacology News

JANUARY 14, 2024

New research for the first time reveals the function of a little-understood junction between cells in the brain that could have important treatment implications for conditions ranging from multiple sclerosis to Alzheimer's disease, to a type of brain cancer known as glioma.

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Science Daily: Pharmacology News

JULY 17, 2024

A new gene therapy treatment for Duchenne muscular dystrophy (DMD) shows promise of not only arresting the decline of the muscles of those affected by this inherited genetic disease, but perhaps, in the future, repairing those muscles.

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Drug Target Review

OCTOBER 30, 2024

Imagine being able to create an in vitro replica of a diseased organ to study the molecular mechanism underlying the illness. Now take a step further: envision testing drugs in these organoids to identify the ones that can treat disease safely and effectively without needing to run expensive clinical trials first.

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Drug Target Review

DECEMBER 20, 2024

Their work focuses on creating ‘digital twin generators’ – AI-driven models that predict how a patients disease may progress over time. AI-powered digital twins A key component of Unlearns work is its focus on digital twin technology, which uses AI to create personalised models of disease progression for individual patients.

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Drugs.com

MAY 20, 2024

MONDAY, May 20, 2024 -- Women treated for infertility were twice as likely as those who conceived naturally to be hospitalized with heart disease within a year of delivery, recent research shows.They are particularly likely to land in the hospital.

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Science Daily: Pharmacology News

JANUARY 15, 2025

It is the first time researchers use data from protein shapes and combine it with data from genomic sequences to improve the reliability of evolutionary trees, a critical resource used by the scientific community for understanding the history of life, monitor the spread of pathogens or create new treatments for disease.

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Broad Institute

SEPTEMBER 6, 2023

This collaboration has the potential not only to accelerate our understanding of the diseases, but also potentially enable scientific advancements in disease-modifying interventions — a true game changer in addressing cardiometabolic diseases.” The collaboration will focus on advancing three programs over the next three years.

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Broad Institute

NOVEMBER 4, 2024

By Lucy Mutz November 4, 2024 Credit: Juliana Sohn Kasper Lage is managing director of the Novo Nordisk Foundation Center for Genomic Mechanisms of Disease. The overall goal is to translate genetic findings into biological mechanisms underlying disease that could be targeted with new medicines.

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Nvidia Developer: Drug Discovery

OCTOBER 30, 2024

The integration of AI in drug discovery is revolutionizing the way researchers approach the development of new treatments for various diseases. The integration of AI in drug discovery is revolutionizing the way researchers approach the development of new treatments for various diseases. Traditional.

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Science Daily: Pharmacology News

FEBRUARY 12, 2025

Researchers have discovered a new type of neuron that plays a fundamental role in recognition memory -- how the brain registers the difference between new and familiar objects and forms long-term memories. The new cell type, called ovoid cells, are found in the hippocampus of mice, humans and other mammals.

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BioPharma Drive: Drug Pricing

OCTOBER 5, 2023

All told, the biotech said it will discontinue more than half of its research and technology projects, including a Parkinson’s disease treatment.

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Chemical Biology and Drug Design

MARCH 6, 2025

ABSTRACT Parkinson's disease (PD) is the second most common neurodegenerative disease but has limited medications. Targeting leucine-rich repeat kinase 2 (LRRK2) has been identified as a potential strategy for the treatment of PD.

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Drug Target Review

MARCH 3, 2025

The search for effective treatments for neurodegenerative diseases like Parkinson’s disease has long been hindered by the brain’s complexity and the absence of adequate models for drug discovery. Schwamborns research focuses on creating patient-specific brain organoids.

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Broad Institute

JANUARY 25, 2024

They found significant associations between the thinning of different retinal layers and increased risk of developing ocular, cardiac, pulmonary, metabolic, and neuropsychiatric diseases and identified genes that are associated with retinal layer thickness. Their findings are published in Science Translational Medicine. “We

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Drug Target Review

MARCH 17, 2025

Neuropsychiatric treatment is on the verge of a major transformation. Historically, treatment options have been limited, with patients relying on daily medications that have minimal efficacy and troublesome side effects. “Zelquistinel is a positive modulator of NMDA receptors,” Donello explains.

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