PLOS: DNA Science

FEBRUARY 1, 2024

Five people treated for pituitary dwarfism decades ago with human growth hormone (hGH) pooled from cadavers have shown cognitive decline reminiscent of early-onset Alzheimer’s disease. None had mutations that cause Alzheimer’s disease, ruling out genetics as a cause. More than 85 animal species develop prion diseases.

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Disease Treatment DNA Research 98

Nvidia Developer: Drug Discovery

OCTOBER 2, 2024

A groundbreaking drug-repurposing AI model could bring new hope to doctors and patients trying to treat diseases with limited or no existing treatment options. A groundbreaking drug-repurposing AI model could bring new hope to doctors and patients trying to treat diseases with limited or no existing treatment options.

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Disease Doctors Drugs Treatment 145

Drug Target Review

DECEMBER 29, 2023

Scientists in China have published their findings 1 regarding novel biomarkers, which they hope will benefit patients by identifying the disease at an earlier stage. Diabetic kidney disease DKD is a major microvascular complication of type 2 diabetes mellitus (T2DM). References Du S, Zhai L, Ye S, et al. Science China Life Sciences.

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Disease Science Hospitals Treatment 126

SCIENMAG: Medicine & Health

JANUARY 31, 2024

In the past year, three researchers at the University of Oklahoma College of Medicine at OU Health Sciences have earned more than $5 million in grant money to study causes and potential treatments for necrotizing enterocolitis, a deadly intestinal disease that primarily affects infants born prematurely.

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Disease Research Science Treatment 92

Science Daily: Pharmacology News

FEBRUARY 1, 2024

It's an achievement with important implications for scientists studying the brain and working on treatments for a broad range of neurological and neurodevelopmental disorders, such as Alzheimer's and Parkinson's disease.

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Research Treatment Disease 135

Broad Institute

SEPTEMBER 28, 2023

By Allessandra DiCorato September 28, 2023 Credit: Strittmatter Laboratory, Yale University Amyloid beta clusters (red) builds up among neurons (green) in a mouse model of Alzheimer’s disease. Neurons are thought to produce the plaque-forming protein called amyloid beta, and the researchers found evidence for this in their data.

Disease 144

Disease Medical Schools Research Hospitals 144

Broad Institute

OCTOBER 30, 2024

Researchers map communities of single cells in metastatic breast cancers By Corie Lok October 30, 2024 Breadcrumb Home Researchers map communities of single cells in metastatic breast cancers The team compared different single-cell and spatial profiling methods to explore the diversity of cells in metastatic breast cancer biopsies.

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Research RNA Medical Schools Treatment 127

Drug Target Review

OCTOBER 16, 2023

As we explore translatability, technological advancements and the integration of artificial intelligence (AI), we envision the potential role of PDOs throughout the entire medicine creation pipeline, from target identification to personalised clinical treatments, ultimately reducing costs and improving patient outcomes.

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Disease Immune Response Cell Biology Therapies 122

On Medicine

FEBRUARY 28, 2024

What is Perthes’ disease? Perthes’ Disease is a rare condition that affects the developing femoral head (the “ball” of the “ball and socket” hip joint) of a child due to poor blood supply. This in turn can cause significant pain for children with Perthes’ disease and limit their activity levels significantly.

Disease 109

Disease Doctors Treatment Trials 109

Drugs.com

APRIL 11, 2024

THURSDAY, April 11, 2024 -- The discovery of a gene variant that rids the brain of toxic plaques linked to Alzheimer's might lead to new treatments for the disease, researchers report.The variant arises naturally in people who don't seem to get.

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Treatment Disease Research 111

Drug Target Review

JANUARY 23, 2024

What innovative approaches and technologies are anticipated to reshape immuno-oncology treatments in 2024? Immuno-oncology, notably through checkpoint inhibitors, has significantly reshaped cancer treatment over the past decade.

Treatment 122

Treatment Immune Response Vaccine Therapies 122

Chemical Biology and Drug Design

FEBRUARY 13, 2024

Alzheimer's disease (AD) is a common age-related neurodegenerative brain disorder characterized by the impairment in memory and other cognitive functions. Although there is currently no successful pharmacotherapy for AD, and researchers are continuously exploring the various pathogenesis of AD to develop potential therapeutic drugs.

Disease 100

Disease Treatment Therapies Research 100

Broad Institute

NOVEMBER 21, 2024

Researchers identify source of a brain cancer’s deadly transformation By Corie Lok November 21, 2024 Breadcrumb Home Researchers identify source of a brain cancer’s deadly transformation Slow-growing glioma tumors become more aggressive when their cells shift identities and acquire new genetic mutations.

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Research Medical Schools DNA Hospitals 124

Broad Institute

FEBRUARY 19, 2024

Over the past decade, scientists have developed these risk scores for dozens of diseases, including heart disease, kidney disease, diabetes, and cancer, with the hope that patients could one day use this information to lower any heightened risk of disease.

Disease 124

Disease Clinical Research Research Treatment 124

Science Daily: Pharmacology News

OCTOBER 5, 2023

Researchers have identified a 'guard mechanism' for a protein which attacks microbes in infected cells, opening the possibility of new treatments for Toxoplasma, Chlamydia, Tuberculosis and even cancer.

Treatment 105

Treatment Disease Research 105

Drug Target Review

MARCH 12, 2024

The study’s findings offer new insights into the biochemical language microbes use to influence distant organ systems, which could revolutionise the way researchers approach disease. The diversity and range of functions of these secondary bile acids has been greatly underappreciated by researchers until now. Gut Microbes.

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Disease Biochemical Pharmacology FDA Approval Pharmacy 111

Drug Target Review

JANUARY 15, 2024

Cancer is a disease driven by variable genetic mutations. Research 1 has shown that neutrophil elastase selectively and potently kills cancer cells irrespective of their genetics and anatomical origin, mobilises adaptive immunity, and avoids resistance mechanisms. What aspects prompted this research direction?

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Treatment Immune Response Therapies Clinical Trials 105

Science Daily: Pharmacology News

AUGUST 29, 2024

Innovative study of DNA's hidden structures may open up new approaches for treatment and diagnosis of diseases, including cancer.

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DNA Research Treatment Disease 120

ProRelix Research

SEPTEMBER 7, 2023

Autoimmune disorders comprise several diseases in which the immune system mistakenly attacks and destroys the body’s own healthy cells instead of destroying bacteria and viruses to keep the body healthy. […] The post Autoimmune disorders and current developments of novel treatments under clinical trials appeared first on ProRelix Research.

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Clinical Trials Trials Treatment Virus 105

Drug Target Review

AUGUST 31, 2023

In the pursuit of a remedy for Alzheimer’s disease, a frontier in medical science is illuminating a glimmer of hope. Chronic inflammation involving microglia has been linked to the disease, as the release of inflammatory molecules triggers an increase in β-amyloid production.

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Therapies Disease Research Treatment 105

Chemical Biology and Drug Design

APRIL 3, 2024

The present review explores the intricate relationship between autophagy and proteostasis in the pathogenesis of neurodegenerative diseases along with the therapeutic interventions to mitigate the same. The common pathological features of these diseases are associated with the accumulation of misfolded or aggregation of proteins.

Disease 100

Disease Treatment Research 100

Broad Institute

FEBRUARY 7, 2024

However, researchers lack efficient ways to explore how these genetic variants are molecularly connected to cardiovascular disease, limiting efforts to develop therapeutics. In a study published in Nature , the researchers applied this technique to endothelial cells, which line blood vessels.

Disease 105

Disease Hospitals Medical Schools Therapies 105

Drug Target Review

APRIL 4, 2024

What are the key findings of the preclinical study regarding the neurophysiological brain state in a Parkinson’s disease psychosis (PDP) model? Treatment with mesdopetam counteracted both these features of the psychosis model, ie, restored normal levels of synchronisation and reduced HFOs. Visual hallucinations are common in PD.

Disease 105

Disease Treatment Licensing Licensing 105

ASPET

DECEMBER 22, 2023

This study provides a unique translational research opportunity to help both humans and dogs diagnosed with diseases that carry dismal prognoses in both species: histiocytic sarcoma (HS), hemangiosarcoma (HSA), and disseminated mastocytosis/mast cell tumor (MCT).

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Clinical Trials Disease Drugs Therapies 189

Broad Institute

OCTOBER 11, 2023

Manguso, who’d recently graduated from college and was conducting research at the University of Copenhagen as a Fulbright scholar, moved back to the Boston area to be with his mother as she underwent treatment. His mother had a presentation of the disease that suggested her immune system was already on the job.

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Research Immune Response Clinical Trials Therapies 137

Broad Institute

NOVEMBER 7, 2023

While RA therapies targeted to specific inflammatory pathways have emerged, only some patients’ symptoms improve with treatment, emphasizing the need for multiple treatment approaches tailored to different disease subtypes.

Treatment 96

Treatment RNA Hospitals Disease 96

FDA Law Blog: Drug Discovery

JULY 17, 2024

Importantly, the Hub is intended to establish a new model within FDA, which leverages cross-Agency expertise in providing guidance and conducting reviews for products for rare disease populations. Early Direction for the Rare Disease Innovation Hub The Hub, which will be co-chaired by Drs.

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FDA Disease Clinical Pharmacology Science 105

Drug Discovery Today

MAY 26, 2023

The new collaboration between Seqera Labs and Genomics England will enable whole genome analysis to be carried out at a larger scale with greater efficiency, helping more patients benefit from genomic healthcare and equipping researchers with extra data to find the causes of disease and develop new treatments.

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Research Government Science Treatment 113

Drug Target Review

DECEMBER 12, 2023

This has several advantages, including increased speed of development, cost-effectiveness and leveraging already established and extensively researched antibodies. Can you provide more details on ARC-02, Araris’ lead candidate, and what it is designed to treat?

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Treatment Engineering Pharmacokinetics Doctors 114

Drug Target Review

OCTOBER 11, 2023

In this unprecedented research effort, mutations in eleven genes associated with aggressive forms of prostate cancer have been pinpointed. This momentous discovery has the potential to reshape how we approach the diagnosis, treatment, and prevention of this deadly disease. The research unfolded in two distinct phases.

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Research Disease Treatment DNA 98

Drug Target Review

AUGUST 28, 2024

What are the main challenges currently faced in the treatment of chronic liver diseases, and how does Resolution Therapeutics aim to address these challenges? Once a patient develops advanced cirrhosis/end-stage liver disease there are no specific therapies to significantly avoid major decompensations and death in the next few years.

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Therapies Disease Engineering Medical Schools 114

Conversations in Drug Development Trends

OCTOBER 29, 2024

By: Juliane Mills, Senior Director, Therapeutic Strategy Lead, Rare Disease The rise of patient-led clinical research, particularly in rare disease, represents a significant shift in the clinical trial landscape. Why Is There an Increase in Patient-Led Rare Disease Research?

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Clinical Research Disease Research Clinical Trials 72

Drug Target Review

SEPTEMBER 22, 2023

Organoid technologies are becoming an invaluable solution for preclinical research, with the ability to augment the development of personalised medicine, drug discovery and gene therapies. The derived drug was given to both patients, to which researchers report the patients saw significant improvement.

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Clinical Research Research Drug Development Molecular Biology 116

PLOS: DNA Science

MARCH 28, 2024

A new drug has entered the arsenal against Duchenne muscular dystrophy (DMD), a genetic disease that affects boys and is challenging to treat. FDA classifies it as a “nonsteroidal treatment” – not a gene therapy, but it affects gene expression. In 2023, two gene-based treatments became available.

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FDA Approval Treatment FDA DNA 98

Broad Institute

MARCH 8, 2024

By Claire Hendershot March 8, 2024 Credit: National Institute of Allergy and Infectious Diseases, National Institutes of Health via U.S. Levine and Siddle say that these findings could improve the precision of diagnostics and treatments in areas with high numbers of NMFI cases.

Research 111

Research Disease Medical Schools RNA 111

Drugs.com

FEBRUARY 5, 2024

However, new research suggests that a less aggressive approach to treating the disease has helped an increasing. MONDAY, Feb. 5, 2024 -- Rectal cancer often involves surgeries that can lead to a debilitating loss of bowel function for patients.

Treatment 111

Treatment Disease Research 111

ASPET

JULY 2, 2024

People with sickle cell disease (SCD) often experience chronic pain as well as unpredictable episodes of acute pain, which significantly affect their quality of life and life expectancy. Current treatment strategies for SCD-associated pain primarily rely on opioid analgesics, which have limited efficacy and cause serious adverse effects.

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Disease Treatment Research 100