Drugs.com

NOVEMBER 12, 2024

12, 2024 -- A cutting-edge genetic test can rapidly detect and identify almost any kind of disease-causing microorganism in the human body, whether it’s a virus, bacteria, fungus or parasite, researchers say.Doctors have been using t. TUESDAY, Nov.

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Virus Disease Research 246

Broad Institute

JUNE 27, 2024

Science (2024) Related content New gene delivery vehicle shows promise for human brain gene therapy My Quest to Cure Prion Disease — Before It’s Too Late | Sonia Vallabh | TED Prion diseases lead to rapid neurodegeneration and death and are caused by misshapen versions of the prion protein in the brain.

Disease 142

Disease Therapies Engineering Clinical Trials 142

Drugs.com

SEPTEMBER 7, 2023

7, 2023 -- While it doesn't prevent infection altogether, new research shows the mpox vaccine does reduces the severity of disease in those who fall ill from the virus. THURSDAY, Sept. An international team of scientists found that those people who.

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Vaccine Virus International Disease 214

Broad Institute

JANUARY 8, 2024

Williams January 8, 2024 Credit: Susanna Hamilton, Broad Communications Researchers have developed virus-like particles that can deliver gene-editing cargo to cells, including those in the mouse brain. By Sarah C.P. They also delivered prime editors to the mouse brain, and did not detect any off-target editing.

Engineering 144

Engineering Research Virus DNA 144

addgene Blog

JUNE 22, 2023

Viruses have become a regular part of basic biological research as well as clinical therapy. Some of these viruses are completely inert, but others can cause diseases. These biological tools are useful because they ’ re derived from viruses that can infect people, cells, and animals. Nervous about handling viruses? That ’ s okay!

Virus 91

Virus Therapies Disease Research 91

Broad Institute

JUNE 18, 2024

Simple test for flu could improve diagnosis and surveillance By Allessandra DiCorato June 18, 2024 Breadcrumb Home Simple test for flu could improve diagnosis and surveillance A low-cost CRISPR-based paper strip test distinguishes between influenza types and can be reprogrammed to recognize different viruses including the H5N1 bird flu virus.

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Virus RNA Laboratories Medical Schools 144

SCIENMAG: Medicine & Health

JANUARY 5, 2024

When the body encounters bacteria, viruses or harmful substances, its innate immune cells, neutrophils, assemble at the site to combat the invader. Credit: UofL photo. When the body encounters bacteria, viruses or harmful substances, its innate immune cells, neutrophils, assemble at the site to combat the invader.

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Virus Disease Research 84

SCIENMAG: Medicine & Health

DECEMBER 21, 2023

Researchers have identified a previously unrecognized class of antibodies—immune system proteins that protect against disease—that appear capable of neutralizing multiple forms of flu virus.

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Virus Vaccine Disease Research 77

ASPET

APRIL 2, 2024

Bromine domain protein 2 (BRD2), a member of the Bromodomain and extraterminal domain (BET) protein family, is a crucial epigenetic regulator with significant function in various diseases and cellular processes. Notably, the potential role of BRD2 as a diagnostic marker and therapeutic target is discussed in the context of various diseases.

Disease 100

Disease Regulations Virus Research 100

Broad Institute

FEBRUARY 8, 2024

Researchers uncover genetic factors for severe Lassa fever By Allessandra DiCorato February 8, 2024 Breadcrumb Home Researchers uncover genetic factors for severe Lassa fever New findings from an international collaboration pave the way for studies of highly infectious diseases in Africa such as Ebola.

Research 81

Research Virus Hospitals Disease 81

Chemical Biology and Drug Design

APRIL 18, 2023

The severity of chagas disease remains a major concern in endemic areas and an emerging public health hazard in nonendemic countries. Abstract Twenty different infectious disorders induced by bacteria, viruses, and parasites are categorized as neglected tropical diseases (NTDs) by WHO.

Treatment 100

Treatment Disease Virus Therapies 100

Broad Institute

JUNE 25, 2024

If you only study a small, homogeneous population, you will probably miss something," said co-corresponding author Daniel (Dong) Wang, an assistant professor of medicine at Brigham and Women's Hospital and of nutrition at Harvard Chan School, and an associate member of Broad's Infectious Disease and Microbiome Program (IDMP).

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Virus Hospitals Disease Nurses 135

PLOS: DNA Science

JANUARY 25, 2024

A recent report in PLOS ONE analyzes DNA from an adenovirus and a herpes virus discovered in preserved feces – coprolites – from 5,500 to 7,000 years ago at an archaeological site in Japan. An international research team published their findings on the Mesolithic gum in Scientific Reports.

Disease 98

Disease DNA Science Virus 98

Drug Target Review

JULY 7, 2023

Approximately three percent of the global population — 240 million people — experience autoantibody diseases, which occur when one’s own body attacks critical organs and tissues. This can create an abnormal immune response that attacks the cells of our bodies and contributes to the development of autoantibody diseases.

Disease 98

Disease Immune Response Therapies Treatment 98

Broad Institute

APRIL 25, 2024

He started to imagine how the deadly and contagious disease, if confirmed, might spread to half the city’s population. Eight of the 20 patients died, but the spread of the disease in Nigeria stopped there. Partnering with researchers on the ground to reach communities where they are is absolutely critical to making that a reality.” “We

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Virus Hospitals Disease Government 132

Broad Institute

MAY 16, 2024

The enormous challenge of getting therapies past this barrier — a highly selective membrane separating the blood from the brain — has stymied the development of safer and more effective gene therapies for brain diseases for decades. It also reached a large fraction of important types of brain cells, including neurons and astrocytes.

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Therapies FDA Approval Engineering Disease 137

PLOS: DNA Science

JULY 27, 2023

That information led, thanks to vaccine shelved from the first SARS circa 2003, to the rapid development and deployment of mRNA vaccines against the new infectious disease. I tracked the numbers of sequenced SARS-CoV-2 genomes posted at GISAID every few days during the pandemic, contributed by researchers everywhere.

Disease 95

Disease DNA Virus RNA 95

Broad Institute

MAY 30, 2023

#WhyIScience Q&A: A process development lead returns to her research roots By Corie Lok May 30, 2023 Breadcrumb Home #WhyIScience Q&A: A process development lead returns to her research roots Isabella Teixeira-Soldano reflects on her time as a technician in Broad’s COVID-19 testing lab and how that led to a position doing single-cell research.

Research 89

Research Medical Schools Doctors Science 89

ProRelix Research

SEPTEMBER 7, 2023

Autoimmune disorders comprise several diseases in which the immune system mistakenly attacks and destroys the body’s own healthy cells instead of destroying bacteria and viruses to keep the body healthy. […] The post Autoimmune disorders and current developments of novel treatments under clinical trials appeared first on ProRelix Research.

Clinical Trials 105

Clinical Trials Trials Treatment Virus 105

Drug Target Review

SEPTEMBER 8, 2023

New researched published in the journal Immunity , T cells exhibit an unusual, yet vital behaviour in their battle against pathogens and cancer cells, involving a nuclear receptor. Remarkably, these findings propose that the presence of a cytoplasmic version of RARα is indispensable for T cells to initiate their defence against diseases.

Regulations 98

Regulations Research DNA Immune Response 98

Broad Institute

AUGUST 7, 2024

Machine learning approach helps researchers design better gene-delivery vehicles for gene therapy By Allessandra DiCorato August 7, 2024 Breadcrumb Home Machine learning approach helps researchers design better gene-delivery vehicles for gene therapy The method could accelerate the development of more effective adeno-associated viruses (AAVs).

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Therapies Research Engineering Packaging 84

The Pharma Data

MARCH 23, 2022

To treat Ebola virus infections, researchers are taking a close look at a key piece of the virus: polymerase. Polymerase is a viral protein that directs how Ebola virus replicates its genome as it infects new hosts. Drugs that target polymerase could potentially treat Ebola virus infections and save lives.

Virus 52

Virus Small Molecule Protein Production Research 52

Broad Institute

JUNE 10, 2024

The advance, from the lab of Broad core institute member David Liu , could one day help researchers develop a single gene therapy for diseases such as cystic fibrosis that are caused by one of hundreds or thousands of different mutations in a gene.

DNA 144

DNA Engineering Therapies Disease 144

Broad Institute

DECEMBER 13, 2023

By Leah Eisenstadt December 13, 2023 Two teams of Broad researchers produced detailed maps of the mouse nervous system. Related news Researchers map brain cell changes in Alzheimer’s disease Courtesy of the Chen and Macosko labs. Courtesy of the Chen and Macosko labs. Our results underscore the need to study them more deeply.”

DNA 140

DNA Virus Research Engineering 140

Drug Target Review

AUGUST 11, 2023

In a new development, a recent paper published in Biology Methods & Protocols by Oxford University Press has highlighted a promising avenue for enhancing vaccine efficacy against infectious pathogens like the COVID-19 virus. Since December 2019, SARS-CoV-2 (COVID-19) infection has become a worldwide urgent public health concern.

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Vaccine Immune Response Bioinformatics Virus 98

Codon

AUGUST 26, 2024

When COVID-19 emerged in 2019, by contrast, mRNA vaccines developed by Pfizer and Moderna took just 326 days from the initial sequencing of the virus to gaining approval for emergency use. The Coalition for Epidemic Preparedness Innovations (CEPI)—a nonprofit organization that funds vaccine research and development—thinks so.

RNA 97

RNA Virus DNA Vaccine 97

The Pharma Data

APRIL 8, 2022

Now, new research from the Wyss Institute at Harvard University has revealed that this constant pattern of stretching and relaxing does even more – it generates immune responses against invading viruses. a Wyss Technology Development Fellow at the Institute. ” The results are published today in Nature Communications.

Virus 52

Virus Immune Response Disease Clinical Trials 52

Broad Institute

DECEMBER 6, 2023

Cytokines are also targeted by drugs for many diseases such as rheumatoid arthritis, COVID-19, and cancer, but until now, scientists haven’t had a comprehensive view of how different immune cells respond to different cytokines because the immune system is so complex. For many immune-mediated diseases, there's no cure or treatment.

Immune Response 138

Immune Response RNA Disease Medical Schools 138

The Pharma Data

AUGUST 3, 2021

The drug, which has undergone several clinical trials for human conditions but has not yet received approval to treat humans, inhibited the replication of SARS-CoV-2, the virus that causes COVID-19, in human cell cultures and in a mouse model, leading to much lower viral loads. The research team, including scientists from the U.S.

Virus 52

Virus Clinical Trials Drugs Laboratories 52

The Pharma Data

SEPTEMBER 30, 2021

Using a virus that grows in black-eyed pea plants, nanoengineers at the University of California San Diego developed a replacement treatment that would keep metastatic cancers cornered from the lungs. The research was published Sept. It involves a bodily injection of a virus called the cowpea mosaic virus.

Virus 52

Virus Engineering Treatment Research 52

Broad Institute

JANUARY 30, 2024

More bottles on the medicine shelf would help, but Bhattacharyya, who’s now also a research scientist, realized that science might lead to better tools for diagnosing and treating such challenging cases. Every question that I've chosen to pursue in my lab today is deeply informed by what I’ve seen in the clinic,” he said. "I

Hospitals 137

Hospitals Virus Medical Schools Science 137

The Pharma Data

JUNE 26, 2021

Early in the COVID-19 pandemic, scientists identified how SARS-CoV-2, the virus that causes COVID-19, gets inside cells to cause infection. Now, researchers at Washington University School of Medicine in St. However, the discovery does show that the virus can change in unexpected ways and find new ways to cause infection.

Virus 52

Virus Cell Biology Vaccine Research 52

Broad Institute

AUGUST 31, 2023

Evolved prime editors are smaller and more efficient for therapeutic applications By Corie Lok August 31, 2023 Breadcrumb Home Evolved prime editors are smaller and more efficient for therapeutic applications Researchers have evolved the editing machine at the heart of the prime editing system, which can make a wide range of changes to the genome.

DNA 145

DNA RNA Engineering Laboratories 145

Drug Target Review

JULY 11, 2023

In the quest to combat and eradicate diseases, scientists and researchers are increasingly turning to the immense potential of artificial intelligence (AI) as a tool. It was here that the Impact Medicine Fund was raised as a concept around wellness for those with disease, with the ambition of unlocking some of this vast potential.

Disease 75

Disease RNA Small Molecule Clinical Development 75

The Pharma Data

MAY 5, 2022

In animal studies that mimic human exposures, an investigational COVID vaccine designed to be taken orally not only protects the host, but also decreases the airborne spread of the virus to other close contacts. The study, led by Duke researcher Stephanie N. Langel, Ph.D., The human vaccine is designed to be taken as a pill.

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Vaccine Disease Virus Science 52

Drug Target Review

MARCH 26, 2024

In my role as Chief Business Development Officer at Osivax, my main challenge is taking the deep scientific work of our research & development team and simplifying it for various audiences Could you share an example of a specific project or research that you have worked on and the impact it has had in your field?

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Vaccine Virus Immune Response Science 110

The Pharma Data

MARCH 13, 2022

People who gained immunity – either through vaccination or exposure – against the original strain of SARS-CoV-2, the virus that causes COVID-19, also are likely to have some protection against the pathogen’s omicron variant. The samples were stored after the researchers measured the T cell response.

Virus 52

Virus Immune Response Vaccine Research 52