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First-in-human vaccine trial for deadly Marburg virus

Drug Discovery World

Scientists at the University of Oxford in the UK have launched a new clinical trial to test a vaccine to protect against “devastating” Marburg virus. This is the first-in-human trial of the ChAdOx1 Marburg vaccine, which has been developed and manufactured by researchers at the University of Oxford.

Virus 147
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Could a modified cold sore virus cure brain cancer?

Drug Discovery World

A team of scientists in the US and the UK are combining a genetically modified cold sore virus with a cancer vaccine to treat an aggressive type of brain cancer in children. The researchers will use a genetically engineered herpes simplex virus type 1 to eliminate cancer cells. million of funding for this research project.

Virus 147
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Research reveals therapeutic potential of mRNA in rare diseases

Drug Discovery World

Researchers have used messenger RNA (mRNA) to create an effective therapy for a rare liver disease in preclinical studies, demonstrating the technology’s potential therapeutic use in people. Patients affected by the disease are found to also experience an imbalance of glutathione regulation, which is important for liver detoxification.

Disease 147
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Novel antibodies target ‘dark side’ of influenza virus protein

Drug Discovery World

Researchers at the National Institutes of Health have identified antibodies targeting a hard-to-spot region of the influenza virus, shedding light on the relatively unexplored ‘dark side’ of the neuraminidase (NA) protein head.

Virus 147
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In-human trial begins for first potential Nipah virus vaccine

Drug Discovery World

Nipah virus is mostly found in South-East Asia that can be fatal in up to 75% of cases. Dr In-Kyu Yoon, Acting Executive Director of Vaccine Research & Development at CEPI, said: “Nipah has epidemic potential, with its fruit bat hosts found in areas home to over two billion people.

Virus 130
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Ancient viruses may hold key to gene therapy treatments

Drug Discovery World

Scientists have unlocked key insights into virus evolution, revealing new information that could help develop treatments for a wide variety of genetic diseases. . The research focuses on a group of small, ubiquitous viruses called ‘parvoviruses’ (from the Latin word ‘ parvus’ meaning ‘small’, ‘puny’ or ‘unimportant’).

Virus 130
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Swiss scientists identify a virus that kills dormant bacteria

Drug Discovery World

Researchers have found a virus that kills dormant bacteria, a discovery that could help to combat infections that can’t be treated with antibiotics. For the first time, ETH Zurich researchers in Switzerland have isolated a bacteriophage from rotting plant material that can attack and kill bacteria in a dormant state.

Virus 130