Broad Institute

JANUARY 8, 2024

Williams January 8, 2024 Credit: Susanna Hamilton, Broad Communications Researchers have developed virus-like particles that can deliver gene-editing cargo to cells, including those in the mouse brain. By Sarah C.P. They also delivered prime editors to the mouse brain, and did not detect any off-target editing.

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Engineering Research Virus DNA 144

addgene Blog

JUNE 22, 2023

Viruses have become a regular part of basic biological research as well as clinical therapy. Some of these viruses are completely inert, but others can cause diseases. These biological tools are useful because they ’ re derived from viruses that can infect people, cells, and animals. Nervous about handling viruses? That ’ s okay!

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Virus Therapies Disease Research 97

Broad Institute

JUNE 18, 2024

Simple test for flu could improve diagnosis and surveillance By Allessandra DiCorato June 18, 2024 Breadcrumb Home Simple test for flu could improve diagnosis and surveillance A low-cost CRISPR-based paper strip test distinguishes between influenza types and can be reprogrammed to recognize different viruses including the H5N1 bird flu virus.

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Virus RNA Laboratories Medical Schools 144

SCIENMAG: Medicine & Health

JANUARY 5, 2024

When the body encounters bacteria, viruses or harmful substances, its innate immune cells, neutrophils, assemble at the site to combat the invader. Credit: UofL photo. When the body encounters bacteria, viruses or harmful substances, its innate immune cells, neutrophils, assemble at the site to combat the invader.

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Virus Disease Research 84

ASPET

APRIL 2, 2024

Bromine domain protein 2 (BRD2), a member of the Bromodomain and extraterminal domain (BET) protein family, is a crucial epigenetic regulator with significant function in various diseases and cellular processes. Notably, the potential role of BRD2 as a diagnostic marker and therapeutic target is discussed in the context of various diseases.

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Disease Regulations Virus Research 100

Chemical Biology and Drug Design

APRIL 18, 2023

The severity of chagas disease remains a major concern in endemic areas and an emerging public health hazard in nonendemic countries. Abstract Twenty different infectious disorders induced by bacteria, viruses, and parasites are categorized as neglected tropical diseases (NTDs) by WHO.

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Treatment Disease Virus Therapies 100

Broad Institute

JUNE 25, 2024

If you only study a small, homogeneous population, you will probably miss something," said co-corresponding author Daniel (Dong) Wang, an assistant professor of medicine at Brigham and Women's Hospital and of nutrition at Harvard Chan School, and an associate member of Broad's Infectious Disease and Microbiome Program (IDMP).

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Virus Hospitals Disease Nurses 135

PLOS: DNA Science

JANUARY 25, 2024

A recent report in PLOS ONE analyzes DNA from an adenovirus and a herpes virus discovered in preserved feces – coprolites – from 5,500 to 7,000 years ago at an archaeological site in Japan. An international research team published their findings on the Mesolithic gum in Scientific Reports.

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Disease DNA Science Virus 97

Broad Institute

MAY 16, 2024

The enormous challenge of getting therapies past this barrier — a highly selective membrane separating the blood from the brain — has stymied the development of safer and more effective gene therapies for brain diseases for decades. It also reached a large fraction of important types of brain cells, including neurons and astrocytes.

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Therapies FDA Approval Engineering Disease 137

Broad Institute

MAY 30, 2023

#WhyIScience Q&A: A process development lead returns to her research roots By Corie Lok May 30, 2023 Breadcrumb Home #WhyIScience Q&A: A process development lead returns to her research roots Isabella Teixeira-Soldano reflects on her time as a technician in Broad’s COVID-19 testing lab and how that led to a position doing single-cell research.

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Research Medical Schools Doctors Science 89

ProRelix Research

SEPTEMBER 7, 2023

Autoimmune disorders comprise several diseases in which the immune system mistakenly attacks and destroys the body’s own healthy cells instead of destroying bacteria and viruses to keep the body healthy. […] The post Autoimmune disorders and current developments of novel treatments under clinical trials appeared first on ProRelix Research.

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Clinical Trials Trials Treatment Virus 105

Drug Target Review

SEPTEMBER 8, 2023

New researched published in the journal Immunity , T cells exhibit an unusual, yet vital behaviour in their battle against pathogens and cancer cells, involving a nuclear receptor. Remarkably, these findings propose that the presence of a cytoplasmic version of RARα is indispensable for T cells to initiate their defence against diseases.

Regulations 98

Regulations Research DNA Immune Response 98

Broad Institute

AUGUST 7, 2024

Machine learning approach helps researchers design better gene-delivery vehicles for gene therapy By Allessandra DiCorato August 7, 2024 Breadcrumb Home Machine learning approach helps researchers design better gene-delivery vehicles for gene therapy The method could accelerate the development of more effective adeno-associated viruses (AAVs).

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Therapies Research Engineering Packaging 84

The Pharma Data

MARCH 23, 2022

To treat Ebola virus infections, researchers are taking a close look at a key piece of the virus: polymerase. Polymerase is a viral protein that directs how Ebola virus replicates its genome as it infects new hosts. Drugs that target polymerase could potentially treat Ebola virus infections and save lives.

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Virus Small Molecule Protein Production Research 52

Broad Institute

JUNE 10, 2024

The advance, from the lab of Broad core institute member David Liu , could one day help researchers develop a single gene therapy for diseases such as cystic fibrosis that are caused by one of hundreds or thousands of different mutations in a gene.

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DNA Engineering Therapies Disease 144

Broad Institute

DECEMBER 13, 2023

By Leah Eisenstadt December 13, 2023 Two teams of Broad researchers produced detailed maps of the mouse nervous system. Related news Researchers map brain cell changes in Alzheimer’s disease Courtesy of the Chen and Macosko labs. Courtesy of the Chen and Macosko labs. Our results underscore the need to study them more deeply.”

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DNA Virus Research Engineering 140

Drug Target Review

AUGUST 11, 2023

In a new development, a recent paper published in Biology Methods & Protocols by Oxford University Press has highlighted a promising avenue for enhancing vaccine efficacy against infectious pathogens like the COVID-19 virus. Since December 2019, SARS-CoV-2 (COVID-19) infection has become a worldwide urgent public health concern.

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Vaccine Immune Response Bioinformatics Virus 98

Broad Institute

AUGUST 31, 2023

Evolved prime editors are smaller and more efficient for therapeutic applications By Corie Lok August 31, 2023 Breadcrumb Home Evolved prime editors are smaller and more efficient for therapeutic applications Researchers have evolved the editing machine at the heart of the prime editing system, which can make a wide range of changes to the genome.

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DNA RNA Engineering Laboratories 145

The Pharma Data

MAY 5, 2022

In animal studies that mimic human exposures, an investigational COVID vaccine designed to be taken orally not only protects the host, but also decreases the airborne spread of the virus to other close contacts. The study, led by Duke researcher Stephanie N. Langel, Ph.D., The human vaccine is designed to be taken as a pill.

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Vaccine Disease Virus Science 52

Advarra

AUGUST 8, 2023

Gene therapy research is booming in the clinical setting. In this blog, we summarize the growth, risks, and regulatory requirements for gene therapy research. We also discuss how a centralized biosafety review process can benefit this type of research.

Therapies 52

Therapies Research Engineering Clinical Research 52

PLOS: DNA Science

FEBRUARY 8, 2024

Borrowed from Bacteria Researchers are using the gene editing tool CRISPR to improve upon naturally-evolved human microbiomes, to build a better probiotic. A recent paper in BioDesign Research , CRISPR-Cas-Based Engineering of Probiotics , from investigators at several Chinese research institutions, contributed to the report.

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Immune Response DNA Engineering Virus 97

SCIENMAG: Medicine & Health

AUGUST 20, 2023

Research at a Glance: A Murdoch Children’s Research Institute-led review has found COVID-19 vaccines are effective against severe cases of the disease in children and adolescents.

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Vaccine Virus Disease Research 75

Drug Target Review

SEPTEMBER 28, 2023

After that, I spent over a decade at a large instrument and genomics company working in, and then leading, research and development. Could you share an example of a specific project or research that you have worked on and the impact it has had in your field? These are synthetic, not the live virus, so do not pose a risk of infection.

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DNA Organic Chemistry Science Virus 116

The Pharma Data

SEPTEMBER 30, 2021

That’s how easy it’s for SARS-CoV-2, the virus that causes COVID-19, to enter your nose. As prior work with other respiratory pathogens like influenza has shown, sterilizing immunity to virus re-infection requires adaptive immune responses within the tract and therefore the lung. Breathe in, exhale.

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Vaccine Disease Immune Response Virus 52

The Pharma Data

JULY 6, 2021

If a virus is disease-causing, the right mutation can allow the virus to escape the immune response by changing the viral pieces the immune system uses to recognize the virus as a threat, pieces scientists call epitopes. ” You can think of a virus’s structure like the design of a house, explains Nathan. .

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Vaccine Virus Research Immune Response 52

Drug Target Review

SEPTEMBER 11, 2023

The solution devised by the Stanford research team involves creating a biomolecule that combines an enzyme-based “scissors” called mucinase (a type of protein-cutting enzyme known as a protease) with a cancer cell -targeting nanobody (a fragment of an antibody).

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Immune Response Research Engineering Virus 116

The Pharma Data

MARCH 9, 2022

Novartis today announced a license option agreement with Voyager Therapeutics, a gene therapy company focused on next-generation adeno-associated virus (AAV) technologies, for three capsids to use in potential gene therapies for neurological diseases, with options to access capsids for two other targets.

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Licensing Licensing Therapies Disease 52

DrugBank

MARCH 12, 2025

However, mRNA technology is not limited to infectious diseases. This unique mechanism has enabled scientists to rethink how they tackle diseases, paving the way for advancements in oncology, genetic disorders, and regenerative medicine. 

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Vaccine Treatment Clinical Trials Therapies 97

Drug Target Review

NOVEMBER 24, 2023

Researchers have explored systems that can deliver drugs directly to tumours in hope to reduce chemotherapy side effects. The use of nanoparticles, which are around the size of a virus particle, is a very promising delivery method for overcoming chemotherapy issues. Cancer Research. Eurekalert [Internet].

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Immune Response Pharmacy Treatment Virus 111

Chemical Biology and Drug Design

JULY 27, 2023

cells, which demonstrates its potential as a drug against virus related diseases. Through further analysis, we obtained five possible targets of PA, and verified that PA inhibited the expressions of IL-1β, HMOX1, PTGS2 and Abca1 as well as the activation of NF-κB pathway in poly (I:C)-induced RAW264.7

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RNA Virus Disease Drugs 100

Drug Target Review

OCTOBER 25, 2023

Previous studies by the same researchers showed that early in pregnancy, bone marrow cells, including immune cells, migrate to the uterus and the decidua. The researchers were intrigued by the mechanisms that recruit these cells to the pregnant uterus. This research was published in JCI Insight. Dovepress [Internet].

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Treatment Virus Research Science 106

Drug Target Review

AUGUST 25, 2023

The Michael J Fox Foundation and Fight MND have awarded substantial, long-term grants to evaluate RRx-001 (nibrozetone) in Parkinson’s Disease and ALS/MND, respectively. The virus carries a transforming growth factor- beta (TGF-β), which it expresses at high levels. Journal of Cancer Research and Clinical Oncology.

Small Molecule 98

Small Molecule Virus International Clinical Trials 98

The Pharma Data

MARCH 8, 2021

The companies today reported findings on one secondary objective from the Phase 2a study, showing a reduction in time (days) to negativity of infectious virus isolation in nasopharyngeal swabs from participants with symptomatic SARS-CoV-2 infection, as determined by isolation in Vero cell line culture. About Molnupiravir.

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Trials Virus RNA Research Laboratories 69

Drug Target Review

JULY 5, 2023

Induced pluripotent stem cell (iPSC) therapies have the potential to treat a wide variety of devastating diseases. Please summarise Eterna Therapeutics’ ($ERNA) new research at ASGCT on a cell therapy approach that integrates multiple cell types to emulate the natural immune system’s fight against diseases?

Therapies 104

Therapies DNA Engineering Virus 104

Codon

OCTOBER 13, 2024

Through genetic engineering, researchers have developed Golden Rice which can help address the problem of vitamin A deficiency , cotton that produces its own insecticide , virus-resistant papayas , and more. One of these is “citrus canker,” a bacterial disease that causes the fruits to develop necrotic lesions.

Engineering 101

Engineering Virus Production DNA 101

Broad Institute

SEPTEMBER 13, 2023

Developing diagnostics and treatments By Rose Circeo September 13, 2023 Breadcrumb Home Developing diagnostics and treatments At the Broad Institute, researchers are revealing deep biological insights about the causes of disease, which are leading to new ways to monitor, diagnose, and treat patients with greater precision.

Therapies 52

Therapies Engineering Virus Packaging 52

Broad Institute

SEPTEMBER 30, 2024

Today, about a third of Broad’s Terra users are from the public health workforce; in the US, 76 state and local public health labs use the platform for preventing and monitoring infectious disease spread in their communities. This was true in the US and all the more in the Global South, where the burden of infectious disease is the highest.

Bioinformatics 101

Bioinformatics Disease Engineering Virus 101