Disease and Science - Drug Discovery Digest

A therapy candidate for fatal prion diseases turns off disease-causing gene

Broad Institute

JUNE 27, 2024

Science (2024) Related content New gene delivery vehicle shows promise for human brain gene therapy My Quest to Cure Prion Disease — Before It’s Too Late | Sonia Vallabh | TED Prion diseases lead to rapid neurodegeneration and death and are caused by misshapen versions of the prion protein in the brain.

A therapy candidate for fatal prion diseases turns off disease-causing gene

Parkinson's Disease: New theory on the disease's origins and spread

Trending Sources

The science of ageing and restoring healthspan

Science Shows How Night Shifts Help Bring on Disease

New biomarkers found for diabetic kidney disease

With retinal images and genetic data, researchers predict cardiovascular, metabolic, and other disease risks

Researchers roll out a more accurate way to estimate genetic risks of disease

Patient-derived organoids in disease modelling

50 years after founding, NIDA urges following science to move beyond stigma

Macrophage cell therapy: a new hope for chronic liver disease patients

Alcohol raises heart disease risk, particularly among women

At Long Last, FDA Unveils Plan for Rare Disease Innovation Hub

AI Uses Zero-Shot Learning to Find Existing Drugs for Treating Rare Diseases

Sweat health monitor measures levels of disease markers

New patient-partnered research project will study heart disease and diabetes risk in South Asian populations

New research alliance with Novo Nordisk to identify therapeutic targets for type 2 diabetes and cardiometabolic diseases

Discovery of how limiting damage from an asthma attack could stop disease

Bile acids and the microbiome: revolutionising disease approaches

Moderate coffee and caffeine consumption is associated with lower risk of developing multiple cardiometabolic diseases, new study finds

Experts warn climate change will fuel spread of infectious diseases

Physical activity reduces stress-related brain activity to lower cardiovascular disease risk

Genetic Matchmaker: Finding Patients for Rare Disease Trials

Improving community engagement in addiction science

Population shifts, risk factors may triple U.S. cardiovascular disease costs by 2050

Taming Parkinson's disease with intelligent brain pacemakers

Some diabetes drugs tied to lower risk of dementia, Parkinson's disease

Prevent Fungal Diseases in the Workplace

Popular diabetes and weight-loss drug may reduce risk of Alzheimer's disease

'Weekend warrior' physical activity may help protect against more than 200 diseases

Startup AIRNA emerges from stealth to bring RNA editing to a rare disease

Doctors could soon use facial temperature for early diagnosis of metabolic diseases

Microrobot-packed pill shows promise for treating inflammatory bowel disease in mice

Immunovant data show potential for autoimmune disease drug

Ignore antifungal resistance in fungal disease at your peril, warn top scientists

Restricting sugar consumption in utero and in early childhood significantly reduces risk of midlife chronic disease

Discovery of 'new rules of the immune system' could improve treatment of inflammatory diseases, say scientists

Link between high levels of niacin -- a common b vitamin -- and heart disease, study suggests

Mapping 1.6 million gut cells to find new ways treat disease

A new way to measure aging and disease risk with the protein aggregation clock

Common hair loss and prostate drug may also cut heart disease risk in men and mice

New research shows relationship between heart shape and risk of cardiovascular disease

Regular mobile phone use may increase the risk of cardiovascular diseases, study suggests

Genetic analysis of 25,000 Chinese mothers and infants reveals unique genes associated with disease risk

Rates of a tick-borne parasitic disease are on the rise

Stay Connected