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A therapy candidate for fatal prion diseases turns off disease-causing gene

Broad Institute

Science (2024) Related content New gene delivery vehicle shows promise for human brain gene therapy My Quest to Cure Prion Disease — Before It’s Too Late | Sonia Vallabh | TED Prion diseases lead to rapid neurodegeneration and death and are caused by misshapen versions of the prion protein in the brain.

Disease 142
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Herpes virus might drive Alzheimer's pathology

Science Daily: Pharmacology News

Viral infections may play a role in Alzheimer's disease.

Virus 118
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How evolution tamed a deadly virus and why we should still worry

Science Daily: Pharmacology News

Over the last century, a once-deadly mosquito-borne virus has evolved so that it no longer sickens humans. New research shows that changes in the virus's ability to target human cells paralleled the decline in illness and death.

Virus 109
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System to auto-detect new variants will inform better response to future infectious disease outbreaks

Science Daily: Pharmacology News

Researchers have come up with a new way to identify more infectious variants of viruses or bacteria that start spreading in humans -- including those causing flu, COVID, whooping cough and tuberculosis.

Virus 133
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Chewing Gum Reveals Stone Age Diet and Disease

PLOS: DNA Science

DNA Science has described intriguing sources of environmental DNA, aka eDNA: DNA in Strange Places: Hippo Poop, Zoo Air, and Cave Dirt and A Glimpse of the Ocean’s Twilight Zone Through Environmental DNA. The post Chewing Gum Reveals Stone Age Diet and Disease appeared first on DNA Science.

Disease 95
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Researchers engineer in vivo delivery system for prime editing, partially restoring vision in mice

Broad Institute

Williams January 8, 2024 Credit: Susanna Hamilton, Broad Communications Researchers have developed virus-like particles that can deliver gene-editing cargo to cells, including those in the mouse brain. Delivery dilemma Gene editing approaches promise to treat a range of diseases by precisely correcting genetic mutations that cause disease.

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Can Global Genomic Surveillance Forecast the Next Pandemic?

PLOS: DNA Science

These factors are converging to enable both identification of novel infectious diseases as well as microbial resistance, before these threats can impact public health, write a team from the European Society for Clinical Microbiology and Infectious Diseases in Frontiers in Science. COVID clearly caught us off guard.

Virus 97