DNA - Drug Discovery Digest

DNA nanorobots can alter artificial cells

Science Daily: Pharmacology News

JANUARY 13, 2025

Scientists have succeeded in controlling the structure and function of biological membranes with the help of 'DNA origami'. The system they developed may facilitate the transportation of large therapeutic loads into cells. This opens up a new way for the targeted administration of medication and other therapeutic interventions.

DNA

Nanorobot hand made of DNA grabs viruses for diagnostics and blocks cell entry

Science Daily: Pharmacology News

NOVEMBER 27, 2024

A tiny, four-fingered 'hand' folded from a single piece of DNA can pick up the virus that causes COVID-19 for highly sensitive rapid detection and can even block viral particles from entering cells to infect them, researchers report.

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DNA Virus Treatment Research

Mitochondria are flinging their DNA into our brain cells

Science Daily: Pharmacology News

AUGUST 22, 2024

A new study finds that mitochondria in our brain cells frequently fling their DNA into the cells' nucleus, where the mitochondrial DNA integrates into chromosomes, possibly causing harm.

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Scientists preserve DNA in an amber-like polymer

Science Daily: Pharmacology News

JUNE 13, 2024

With their 'T-REX' method, researchers developed a glassy, amber-like polymer that can be used for long-term storage of DNA, such as entire human genomes or digital files such as photos.

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DNA Research

Cracking the code of life: new AI model learns DNA's hidden language

Science Daily: Pharmacology News

AUGUST 5, 2024

With GROVER, a new large language model trained on human DNA, researchers could now attempt to decode the complex information hidden in our genome. GROVER treats human DNA as a text, learning its rules and context to draw functional information about the DNA sequences.

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DNA Research

Researchers flip genes on and off with AI-designed DNA switches

Science Daily: Pharmacology News

OCTOBER 23, 2024

Researchers have used artificial intelligence to design thousands of new DNA switches that can precisely control the expression of a gene in different cell types.

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DNA Research

Ancient viral DNA shapes early embryo development

Science Daily: Pharmacology News

JANUARY 20, 2025

Over half of our genomes consists of thousands of remnants of ancient viral DNA, known as transposable elements, which are widespread across the tree of life. Once dismissed as the 'dark side' of the genome, researchers have now revealed their crucial role in early embryo development.

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DNA Research

Ancient DNA unlocks new understanding of migrations in the first millennium AD

Science Daily: Pharmacology News

JANUARY 1, 2025

Waves of human migration across Europe during the first millennium AD have been revealed using a more precise method of analysing ancestry with ancient DNA, in research led by the Francis Crick Institute.

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DNA Research

DNA tech offers both data storage and computing functions

Science Daily: Pharmacology News

AUGUST 22, 2024

Researchers have demonstrated a technology capable of a suite of data storage and computing functions -- repeatedly storing, retrieving, computing, erasing or rewriting data -- that uses DNA rather than conventional electronics. Previous DNA data storage and computing technologies could complete some but not all of these tasks.

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DNA Research

Ancient viral DNA in the human genome linked to major psychiatric disorders

Science Daily: Pharmacology News

MAY 22, 2024

New research has found that thousands of DNA sequences originating from ancient viral infections are expressed in the brain, with some contributing to susceptibility for psychiatric disorders such as schizophrenia, bipolar disorder, and depression.

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DNA Research

DNA origami folded into tiny motor

Science Daily: Pharmacology News

JANUARY 19, 2024

The science team designed a turbine engineered from DNA that is powered by hydrodynamic flow inside a nanopore, a nanometer-sized hole in a membrane of solid-state silicon nitride. Scientists have created a working nanoscale electomotor.

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DNA Engineering Science Research

Ancient DNA reveals Indigenous dog lineages found at Jamestown, Virginia

Science Daily: Pharmacology News

AUGUST 16, 2024

To better understand the timing of this replacement, researchers sequenced mitochondrial DNA from archaeological dogs. Previous scientific studies have indicated that North American dog lineages were replaced with European ones between 1492 and the present day.

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DNA Research

When it comes to DNA replication, humans and baker's yeast are more alike than different

Science Daily: Pharmacology News

AUGUST 1, 2024

Humans and baker's yeast have more in common than meets the eye, including an important mechanism that helps ensure DNA is copied correctly, reports a pair of studies.

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Researchers map 50,000 of DNA's mysterious 'knots' in the human genome

Science Daily: Pharmacology News

AUGUST 29, 2024

Innovative study of DNA's hidden structures may open up new approaches for treatment and diagnosis of diseases, including cancer.

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DNA Research Treatment Disease

Shared Your DNA With 23andMe? Experts Say It’s Time To Delete It

Drugs.com

MARCH 25, 2025

TUESDAY, March 25, 2025 -- If you’re one of the 15 million people who shared your DNA with 23andMe, stop whatever you're doing. Experts say now is the time to delete your data. The genetic testing company filed for bankruptcy March 23 and is.

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Scientists can reverse brain aging in fruit flies by preventing buildup of a common protein

Science Daily: Pharmacology News

OCTOBER 28, 2024

Buildup of a protein called filamentous actin, or F-actin, in the brain inhibits the removal of cellular wastes, including DNA, lipids, proteins and organelles. The resulting accumulation of waste diminishes neuronal functions and contributes to cognitive decline.

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DNA Research

Insights into South African population history from 10,000-year-old human DNA

Science Daily: Pharmacology News

SEPTEMBER 19, 2024

Ancient DNA has provided spectacular insights into human history, particularly in Europe and Asia, where researchers have reconstructed the genomes of thousands of people.

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DNA Research

Scientists use ancient DNA to shed light on adaptation of early Europeans

Science Daily: Pharmacology News

NOVEMBER 19, 2024

Leveraging a unique statistical analysis and applying it to ancient DNA extracted from human skeletal remains, a team of researchers has revealed new insights into how ancient Europeans adapted to their environments over 7,000 years of European history.

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DNA Research

The growing role for cfHPV-DNA testing in OPSCC therapeutic development

BioPharma Drive: Drug Pricing

APRIL 15, 2024

Learn about why access to robust biomarkers such as cfHPV-DNA is pivotal in determining eligibility, assessing treatment response and detecting recurrence early to improve patient outcomes.

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DNA Treatment

A turtle time capsule: DNA found in ancient shell

Science Daily: Pharmacology News

SEPTEMBER 28, 2023

Paleontologists discover possible DNA remains in fossil turtle that lived 6 million years ago in Panama, where continents collide.

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Dog diversity unveiled by international DNA database

Science Daily: Pharmacology News

SEPTEMBER 7, 2023

An international consortium of scientists is using an unprecedentedly large database of canine DNA to take an unbiased look at how our furry friends evolved into the various breeds we know and love.

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DNA International

Strength is in this glass's DNA

Science Daily: Pharmacology News

SEPTEMBER 27, 2023

Scientists were able to fabricate a pure form of glass and coat specialized pieces of DNA with it to create a material that was not only stronger than steel, but incredibly lightweight.

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Ancient DNA reveals Down syndrome in past human societies

Science Daily: Pharmacology News

FEBRUARY 20, 2024

By analysing ancient DNA, an international team of researchers have uncovered cases of chromosomal disorders, including what could be the first case of Edwards syndrome ever identified from prehistoric remains.

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DNA International Research

DNA study IDs descendants of George Washington from unmarked remains, findings to aid service member IDs going back to World War II

Science Daily: Pharmacology News

MARCH 28, 2024

New DNA sequencing technologies have identified the historical remains of George Washington's grandnephews, Samuel Walter Washington and George Steptoe Washington Jr., and their mother, Lucy Payne Washington, from unmarked, fragmentary bones left at the Harewood family cemetery in Charles Town, West Virginia, in the mid-1800s.

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Ancient DNA reveals diverse community in 'Lost City of the Incas'

Science Daily: Pharmacology News

JULY 26, 2023

DNA analysis of 34 individuals buried at Machu Picchu revealed that many traveled alone from throughout the Inca Empire.

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DNA Origami nanoturbine sets new horizon for nanomotors

Science Daily: Pharmacology News

OCTOBER 26, 2023

Researchers introduce a pioneering breakthrough in the world of nanomotors -- the DNA origami nanoturbine. The core of this pioneering discovery is the design, construction, and driven motion of a 'DNA origami' turbine, which features three chiral blades, all within a minuscule 25-nanometer frame, operating in a solid-state nanopore.

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DNA Research

Enzymes can't tell artificial DNA from the real thing

Science Daily: Pharmacology News

DECEMBER 13, 2023

Researchers have come one step closer to unlocking the potential of synthetic DNA, which could help scientists develop never-before-seen proteins in the lab.

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DNA Research

An Orbimed-backed biotech launches with $85M and plans for a new kind of DNA medicine

BioPharma Drive: Drug Pricing

OCTOBER 24, 2023

Rampart Biosciences closed a Series A round that will fund its goal to develop more potent DNA-based medicines that avoid immune responses.

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DNA Immune Response

Art with DNA -- Digitally creating 16 million colors by chemistry

Science Daily: Pharmacology News

OCTOBER 17, 2023

The DNA double helix is composed of two DNA molecules whose sequences are complementary to each other. Fluorescent markers bound to one of the matching DNA strands make the duplex visible, and fluorescence intensity increases with increasing duplex stability.

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DNA Research

DNA damage can last unrepaired for years, changing our view of mutations

Science Daily: Pharmacology News

JANUARY 15, 2025

While most known types of DNA damage are fixed by our cells' in-house DNA repair mechanisms, some forms of DNA damage evade repair and can persist for many years, new research shows. This means that the damage has multiple chances to generate harmful mutations, which can lead to cancer.

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DNA Research

DNA can fold into complex shapes to execute new functions

Science Daily: Pharmacology News

JUNE 21, 2023

DNA can mimic protein functions by folding into elaborate, three-dimensional structures, according to a new study.

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Discovering cancers of epigenetic origin without DNA mutation

Science Daily: Pharmacology News

APRIL 24, 2024

A research team has discovered that cancer, one of the leading causes of death worldwide, can be caused entirely by epigenetic changes, in other words, changes that contribute to how gene expression is regulated, and partly explain why, despite an identical genome, an individual develops very different cells (neurons, skin cells, etc.).

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DNA Regulations Research

The physics of fat droplets reveal DNA danger

Science Daily: Pharmacology News

AUGUST 28, 2023

The stakes of their findings are high: a ruptured nucleus can lead to elevated DNA damage that is characteristic of many diseases, including cancer.

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DNA Regulations Disease Research

International team develops novel DNA nano engine

Science Daily: Pharmacology News

OCTOBER 19, 2023

An international team of scientists has recently developed a novel type of nano engine made of DNA. It is driven by a clever mechanism and can perform pulsing movements. The researchers are now planning to fit it with a coupling and install it as a drive in complex nano machines.

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DNA Engineering International Research

Researchers engineer bacteria that can detect tumor DNA

Science Daily: Pharmacology News

AUGUST 10, 2023

Creating new technologically advanced sensors, scientists have engineered bacteria that detect the presence of tumor DNA in live organisms. Their innovation could pave the way to new biosensors capable of identifying various infections, cancers and other diseases.

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DNA Engineering Research Disease

How the motion of DNA controls gene activity

Science Daily: Pharmacology News

JUNE 29, 2023

A group of scientists now visualized this dynamic process and give novel insights into the physical characteristics of DNA. This allows specific regions to come into contact and thereby activate a gene.

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Ancient DNA from Rapa Nui (Easter Island) refutes best-selling population collapse theory

Science Daily: Pharmacology News

SEPTEMBER 11, 2024

Rapa Nui (Easter Island) with its gigantic statues and treeless landscape has fascinated researchers for centuries. A new genetic study disproves the popular theory that the Rapanui population collapsed as a result of an 'ecocide' and shows that the Rapanui admixed with Indigenous Americans centuries before Europeans arrived on the island.

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DNA Research

Capturing the immense potential of microscopic DNA for data storage

Science Daily: Pharmacology News

JULY 11, 2023

A 'biological camera' bypasses the constraints of current DNA storage methods, harnessing living cells and their inherent biological mechanisms to encode and store data. This represents a significant breakthrough in encoding and storing images directly within DNA, creating a new model for information storage reminiscent of a digital camera.

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DNA Engineering

Ancient DNA analysis reveals how the rise and fall of the Roman Empire shifted populations in the Balkans

Science Daily: Pharmacology News

DECEMBER 7, 2023

Despite the Roman Empire's extensive military and cultural influence on the nearby Balkan peninsula, a DNA analysis of individuals who lived in the region between 1 and 1000 CE found no genetic evidence of Iron Age Italian ancestry.

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DNA element with a murky past is borrowing cell's repair machinery

Science Daily: Pharmacology News

JULY 12, 2023

They hijack a little-known piece of the cell's DNA repair function to close themselves into a ring-like shape and then create a matching double strand. Like their viral cousins, retrotransposons have been found borrowing the cell's own machinery to achieve their goals.

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DNA Immune Response

Researchers engineer colloidal quasicrystals using DNA-modified building blocks

Science Daily: Pharmacology News

NOVEMBER 2, 2023

A new study unveils a novel methodology to engineer colloidal quasicrystals using DNA-modified building blocks. The implications of this breakthrough are far-reaching, offering a potential blueprint for the controlled synthesis of other complex structures previously considered beyond reach.

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DNA Engineering Research

First ever 3D reconstruction of 52,000-year-old woolly mammoth chromosomes thanks to serendipitously freeze-dried skin

Science Daily: Pharmacology News

JULY 11, 2024

An international research team has assembled the genome and 3D chromosomal structures of a 52,000-year-old woolly mammoth -- the first time such a feat has been achieved for any ancient DNA sample.

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DNA International Research

Scientists discover new code governing gene activity

Science Daily: Pharmacology News

AUGUST 20, 2024

A newly discovered code within DNA -- coined 'spatial grammar' -- holds a key to understanding how gene activity is encoded in the human genome. This breakthrough finding revealed a long-postulated hidden spatial grammar embedded in DNA.

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Government DNA Regulations Disease

Smoking, Vaping Tied to Similar Unhealthy Changes in DNA

Drugs.com

AUGUST 13, 2024

TUESDAY, Aug. 13, 2024 -- New research suggests that switching from smoking to vaping won't prevent some dangerous changes to a person's genome.A new study conducted in young adults shows similar cancer-linked gene changes in both vapers and.

DNA

DNA Research

DNA nanorobots can alter artificial cells

Nanorobot hand made of DNA grabs viruses for diagnostics and blocks cell entry

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Mitochondria are flinging their DNA into our brain cells

Webinars

Scientists preserve DNA in an amber-like polymer

Cracking the code of life: new AI model learns DNA's hidden language

Researchers flip genes on and off with AI-designed DNA switches

Ancient viral DNA shapes early embryo development

Ancient DNA unlocks new understanding of migrations in the first millennium AD

DNA tech offers both data storage and computing functions

Ancient viral DNA in the human genome linked to major psychiatric disorders

DNA origami folded into tiny motor

Ancient DNA reveals Indigenous dog lineages found at Jamestown, Virginia

When it comes to DNA replication, humans and baker's yeast are more alike than different

Researchers map 50,000 of DNA's mysterious 'knots' in the human genome

Shared Your DNA With 23andMe? Experts Say It’s Time To Delete It

Scientists can reverse brain aging in fruit flies by preventing buildup of a common protein

Insights into South African population history from 10,000-year-old human DNA

Scientists use ancient DNA to shed light on adaptation of early Europeans

The growing role for cfHPV-DNA testing in OPSCC therapeutic development

A turtle time capsule: DNA found in ancient shell

Dog diversity unveiled by international DNA database

Strength is in this glass's DNA

Ancient DNA reveals Down syndrome in past human societies

DNA study IDs descendants of George Washington from unmarked remains, findings to aid service member IDs going back to World War II

Ancient DNA reveals diverse community in 'Lost City of the Incas'

DNA Origami nanoturbine sets new horizon for nanomotors

Enzymes can't tell artificial DNA from the real thing

An Orbimed-backed biotech launches with $85M and plans for a new kind of DNA medicine

Art with DNA -- Digitally creating 16 million colors by chemistry

DNA damage can last unrepaired for years, changing our view of mutations

DNA can fold into complex shapes to execute new functions

Discovering cancers of epigenetic origin without DNA mutation

The physics of fat droplets reveal DNA danger

International team develops novel DNA nano engine

Researchers engineer bacteria that can detect tumor DNA

How the motion of DNA controls gene activity

Ancient DNA from Rapa Nui (Easter Island) refutes best-selling population collapse theory

Capturing the immense potential of microscopic DNA for data storage

Ancient DNA analysis reveals how the rise and fall of the Roman Empire shifted populations in the Balkans

DNA element with a murky past is borrowing cell's repair machinery

Researchers engineer colloidal quasicrystals using DNA-modified building blocks

First ever 3D reconstruction of 52,000-year-old woolly mammoth chromosomes thanks to serendipitously freeze-dried skin

Scientists discover new code governing gene activity

Smoking, Vaping Tied to Similar Unhealthy Changes in DNA

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