Science Daily: Pharmacology News

AUGUST 16, 2024

To better understand the timing of this replacement, researchers sequenced mitochondrial DNA from archaeological dogs. Previous scientific studies have indicated that North American dog lineages were replaced with European ones between 1492 and the present day.

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Broad Institute

AUGUST 16, 2023

Nuclear DNA influences variation in mitochondrial DNA By Allessandra DiCorato August 16, 2023 Breadcrumb Home Nuclear DNA influences variation in mitochondrial DNA Whole genomes from hundreds of thousands of people reveal new complexity in how the nuclear and mitochondrial genomes interact, which may influence how cells produce energy.

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DNA Molecular Biology Disease Regulations 98

Science Daily: Pharmacology News

MAY 22, 2024

New research has found that thousands of DNA sequences originating from ancient viral infections are expressed in the brain, with some contributing to susceptibility for psychiatric disorders such as schizophrenia, bipolar disorder, and depression.

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DNA Research 130

Science Daily: Pharmacology News

AUGUST 1, 2024

Humans and baker's yeast have more in common than meets the eye, including an important mechanism that helps ensure DNA is copied correctly, reports a pair of studies.

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DNA 125

Science Daily: Pharmacology News

AUGUST 29, 2024

Innovative study of DNA's hidden structures may open up new approaches for treatment and diagnosis of diseases, including cancer.

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DNA Research Treatment Disease 122

Science Daily: Pharmacology News

NOVEMBER 19, 2024

Leveraging a unique statistical analysis and applying it to ancient DNA extracted from human skeletal remains, a team of researchers has revealed new insights into how ancient Europeans adapted to their environments over 7,000 years of European history.

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DNA Research 118

Chemical Biology and Drug Design

JANUARY 29, 2024

MGMT mRNA expression was significantly increased in CD138+ myeloma cells compared with their matched CD138-nontumorigenic cells and inhibition of MGMT by its specific inhibitor lomeguatrib in MM cells reduced DNA repair, cell viability, and S phase entry and increased DNA damage and apoptosis.

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DNA Treatment Disease Research 100

PLOS: DNA Science

AUGUST 17, 2023

The Maui firestorm was so vast and fast that most identification of human remains will come from bits of persisting DNA from mitochondria. MtDNA in Forensics and Genealogy Mitochondrial DNA (mtDNA) is used in forensics to match the tiniest bits of human remains to families. Mitochondrial DNA is also far more abundant than nuclear DNA.

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DNA Disease Science Research 98

PLOS: DNA Science

DECEMBER 14, 2023

“Meet Invisible Woods: a clean, refreshing scent revived from extinct flower DNA ,” beneath an image of “origin flower” Wendlandia angustifolia. • compare the DNA sequence to similar genes in other species. • tweak a lab-made copy of the DNA sequence using clues from other plant species.

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DNA Production Science Disease 119

Science Daily: Pharmacology News

SEPTEMBER 19, 2024

Ancient DNA has provided spectacular insights into human history, particularly in Europe and Asia, where researchers have reconstructed the genomes of thousands of people.

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BioPharma Drive: Drug Pricing

APRIL 15, 2024

Learn about why access to robust biomarkers such as cfHPV-DNA is pivotal in determining eligibility, assessing treatment response and detecting recurrence early to improve patient outcomes.

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DNA Treatment 105

Drug Target Review

JANUARY 10, 2024

There is extensive crosstalk between the DNA damage response (DDR) and innate immune pathways. Both are a focus for exciting new small-molecule drug therapeutics that target cancers and autoimmune disorders.

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DNA Biochemical Assays Small Molecule Drugs 104

Science Daily: Pharmacology News

SEPTEMBER 28, 2023

Paleontologists discover possible DNA remains in fossil turtle that lived 6 million years ago in Panama, where continents collide.

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DNA 109

Science Daily: Pharmacology News

MARCH 28, 2024

New DNA sequencing technologies have identified the historical remains of George Washington's grandnephews, Samuel Walter Washington and George Steptoe Washington Jr., and their mother, Lucy Payne Washington, from unmarked, fragmentary bones left at the Harewood family cemetery in Charles Town, West Virginia, in the mid-1800s.

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DNA 128

Science Daily: Pharmacology News

FEBRUARY 20, 2024

By analysing ancient DNA, an international team of researchers have uncovered cases of chromosomal disorders, including what could be the first case of Edwards syndrome ever identified from prehistoric remains.

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Science Daily: Pharmacology News

SEPTEMBER 7, 2023

An international consortium of scientists is using an unprecedentedly large database of canine DNA to take an unbiased look at how our furry friends evolved into the various breeds we know and love.

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DNA International 101

Science Daily: Pharmacology News

SEPTEMBER 27, 2023

Scientists were able to fabricate a pure form of glass and coat specialized pieces of DNA with it to create a material that was not only stronger than steel, but incredibly lightweight.

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DNA 97

Drug Discovery Today

MAY 25, 2023

The Facility will have capacity that exceeds today’s global plasmid DNA demand and can enable commercialisation of genetic medicines. Transformation of Grade II-listed Victorian waterworks on the River Thames in Hampton, London.

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DNA Drugs 113

Chemical Biology and Drug Design

AUGUST 6, 2023

Radiotherapy induced DNA damage in rat lymphocytes. DNA damage was significantly reduced by 4 mg/kg/day Astaxanthin for 7 days. Astaxanthin may be a promising agent against radiotherapy induced DNA damage. Abstract Astaxanthin, a carotenoid pigment, is believed to be effective in the repair of DNA damage.

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DNA Research 100

Science Daily: Pharmacology News

OCTOBER 26, 2023

Researchers introduce a pioneering breakthrough in the world of nanomotors -- the DNA origami nanoturbine. The core of this pioneering discovery is the design, construction, and driven motion of a 'DNA origami' turbine, which features three chiral blades, all within a minuscule 25-nanometer frame, operating in a solid-state nanopore.

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DNA Research 93

BioPharma Drive: Drug Pricing

OCTOBER 24, 2023

Rampart Biosciences closed a Series A round that will fund its goal to develop more potent DNA-based medicines that avoid immune responses.

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DNA Immune Response 111

Science Daily: Pharmacology News

DECEMBER 13, 2023

Researchers have come one step closer to unlocking the potential of synthetic DNA, which could help scientists develop never-before-seen proteins in the lab.

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DNA Research 95

Chemical Biology and Drug Design

FEBRUARY 26, 2024

The mechanism research revealed that cinnamaldehyde activated the Nrf2 pathway to attenuate lipid peroxidation and repair DNA damage to protect cardiomyocytes from ischemia/reperfusion injury in the OGD/R-induced H9C2 cardiomyocyte model. The severity of DNA damage was assessed by tail moment (TM) values using alkaline comet assay.

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DNA Treatment Disease Research 100

Science Daily: Pharmacology News

APRIL 24, 2024

A research team has discovered that cancer, one of the leading causes of death worldwide, can be caused entirely by epigenetic changes, in other words, changes that contribute to how gene expression is regulated, and partly explain why, despite an identical genome, an individual develops very different cells (neurons, skin cells, etc.).

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DNA Regulations Research 124

ASPET

NOVEMBER 17, 2023

SM cytotoxicity emerges, in part, through DNA alkylation and double-strand breaks (DSBs). Because DSBs can naturally be repaired by DNA damage response pathways with low efficiency, we hypothesized that enhancing the HR pathway could pose a novel approach to mitigate SM injury.

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DNA Treatment Drugs Research 100

Science Daily: Pharmacology News

SEPTEMBER 11, 2024

Rapa Nui (Easter Island) with its gigantic statues and treeless landscape has fascinated researchers for centuries. A new genetic study disproves the popular theory that the Rapanui population collapsed as a result of an 'ecocide' and shows that the Rapanui admixed with Indigenous Americans centuries before Europeans arrived on the island.

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DNA Research 135

Science Daily: Pharmacology News

DECEMBER 7, 2023

Despite the Roman Empire's extensive military and cultural influence on the nearby Balkan peninsula, a DNA analysis of individuals who lived in the region between 1 and 1000 CE found no genetic evidence of Iron Age Italian ancestry.

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DNA 92

Science Daily: Pharmacology News

JANUARY 18, 2024

A new paper describes a significant leap forward in assembling polyhedral nanoparticles. The researchers introduce and demonstrate the power of a novel synthetic strategy that expands possibilities in metamaterial design. These are the unusual materials that underpin 'invisibility cloaks' and ultrahigh-speed optical computing systems.

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DNA Research 108

Broad Institute

JANUARY 18, 2024

McAlpine January 18, 2024 Credit: Susanna Hamilton, Broad Communications One of the new "priming agents" works by preventing immune cells from engulfing tumor DNA circulating in the bloodstream. Liquid biopsies promise to transform how cancers are diagnosed, monitored, and treated by detecting DNA that tumors shed into the blood.

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DNA Engineering Science Disease 133

Science Daily: Pharmacology News

JULY 11, 2024

An international research team has assembled the genome and 3D chromosomal structures of a 52,000-year-old woolly mammoth -- the first time such a feat has been achieved for any ancient DNA sample.

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DNA International Research 130

Science Daily: Pharmacology News

AUGUST 20, 2024

A newly discovered code within DNA -- coined 'spatial grammar' -- holds a key to understanding how gene activity is encoded in the human genome. This breakthrough finding revealed a long-postulated hidden spatial grammar embedded in DNA.

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Government DNA Regulations Disease 133

Drugs.com

AUGUST 13, 2024

TUESDAY, Aug. 13, 2024 -- New research suggests that switching from smoking to vaping won't prevent some dangerous changes to a person's genome.A new study conducted in young adults shows similar cancer-linked gene changes in both vapers and.

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DNA Research 97

BioPharma Drive: Drug Pricing

JANUARY 4, 2024

Moonwalk Biosciences, the latest biotech cofounded by the gene editing scientist, joins other startups aiming to alter gene expression without changing DNA.

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DNA 140

Broad Institute

JUNE 28, 2023

By Leah Eisenstadt June 28, 2023 Credit: Courtesy of the Zhang lab Cryo-EM map of a Fanzor protein in complex with ωRNA and its target DNA. They showed that Fanzor proteins use RNA as a guide to target DNA precisely, and that Fanzors can be reprogrammed to edit the genome of human cells.

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RNA DNA Research Engineering 139

Science Daily: Pharmacology News

MARCH 8, 2024

For the first time, scientists have developed artificial nucleotides, the building blocks of DNA, with several additional properties in the laboratory.

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Science Daily: Pharmacology News

MARCH 27, 2024

Just as you can't make an omelet without breaking eggs, scientists have found that you can't make long-term memories without DNA damage and brain inflammation.

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DNA 137

Science Daily: Pharmacology News

FEBRUARY 8, 2024

The results, which are contrary to prevailing opinion, are based on DNA analysis of skeletons and teeth found in what is now Denmark. Following the arrival of the first farmers in Scandinavia 5,900 years ago, the hunter-gatherer population was wiped out within a few generations, according to a new study.

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DNA 142