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Injectable agents could improve liquid biopsy for cancer detection and monitoring

Broad Institute

McAlpine January 18, 2024 Credit: Susanna Hamilton, Broad Communications One of the new "priming agents" works by preventing immune cells from engulfing tumor DNA circulating in the bloodstream. Liquid biopsies promise to transform how cancers are diagnosed, monitored, and treated by detecting DNA that tumors shed into the blood.

DNA 133
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Largest-ever genetic study of epilepsy finds possible therapeutic targets

Broad Institute

In the future, the results could also help doctors tailor treatments to a patient’s genome. Since URVs are so rare, and because the scientists wanted to understand many different types of epilepsy, the researchers analyzed DNA from people across the world with a range of different genetic ancestries to find meaningful signals.

DNA 133
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To help his daughter living with an ultra-rare disorder, this dad brought together a squad of genetic detectives

Broad Institute

The DNA change underlying Emma’s disorder is now known, thanks to years of work by an international team of scientists and physicians at the Broad Institute of MIT and Harvard, Northwestern University, University of Nantes, the Weizmann Institute of Science, and the Baylor College of Medicine.

DNA 128
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Pauline’s Superhero Story

KIF1A

So the pediatrician doctor requested the first cranial tomography, which also gave a normal result. One day later, we arrived at the hospital. A cheek swab DNA test was performed at the hospital, which also resulted as normal. Pauline born weighing 2.645 kg and measuring 45 cm.

Doctors 52
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Dr. Lolettima O. Johnson Celebrated for Dedication to the Field of Medicine

The Pharma Data

Doctor Johnson has had an inspiring career that encompasses several aspects of the pharmacy industry. Doctor Johnson aspires to incorporate the latest technologies available in healthcare to care for her patients. Subsequently, she decided to pursue a higher education in pharmacology following her high school graduation.

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A close research partnership with African scientists helps solve the mystery of malaria-like illnesses

Broad Institute

Senegal has a very strong clinical infrastructure, including a strong hospital network with incredible resources like West Africa’s Reference Center for Infectious Disease Diagnostics. Tags: Infectious Disease DNA sequencing RNA sequencing Nature Communications. Online January 25, 2024. DOI: 10.1038/s41467-024-44800-7.

Research 111
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A scientist devotes her career to tackling inequity in genomics

Broad Institute

At the Broad, Martin is also helping lead data analysis in two large international studies that are sequencing the DNA of people from Africa and Latin America to learn about the genetics of severe mental illness. Her parents were terrified, and the family spent the next few years in and out of the hospital.

Disease 98