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Combination therapy halts lung cancer tumour growth in mice

Drug Discovery World

A pathway to better therapies. The findings suggest a pathway to better therapies for one of the least treatable forms of cancer. One of the challenges we will face is convincing doctors to go back to an old drug. But the nice thing about this strategy is that it may work where current therapies have failed.

Therapies 130
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Pauline’s Superhero Story

KIF1A

So the pediatrician doctor requested the first cranial tomography, which also gave a normal result. One day later, we arrived at the hospital. A cheek swab DNA test was performed at the hospital, which also resulted as normal. Pauline born weighing 2.645 kg and measuring 45 cm.

Doctors 52
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Largest-ever genetic study of epilepsy finds possible therapeutic targets

Broad Institute

The findings point to factors involved in how neurons communicate and fire, suggesting potential targets for new therapies. In the future, the results could also help doctors tailor treatments to a patient’s genome. Epilepsy is one of the most common neurological disorders.

DNA 72
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How the Classic TB Vaccine Treats Bladder Cancer – Zebrafish Avatars Reveal Mechanism

PLOS: DNA Science

McCarthy in the Iowa Orthopaedic Journal : “Over the next forty years, as head of the Bone Tumor Service at Memorial Hospital in New York, Coley injected more than 1000 cancer patients with bacteria or bacterial products. He and other doctors who used them reported excellent results, especially in bone and soft-tissue sarcomas.

Vaccine 52
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Not all neoantigens are created equal

Drug Target Review

During the process of transformation from a normal cell into a cancer cell, a cell acquires a series of changes, or mutations, in its DNA. In most cancers, the tumour evolves by acquiring mutations that confer growth advantages or resistance to therapies. This allows the cancer to evolve and develop resistance to the therapy.

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Comment: LSX World Congress 2023 

Drug Discovery World

Megan Thomas caught up with Debora Lucarelli, CEO of Enhanc3D Genomics, to learn more about the company. She said: “We are a functional genomics company with a proprietary platform that allows us to charter the non-coding DNA, from which we extract a lot of valuable information to identify novel targets and biomarkers.

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Who are the AACR Scientific Achievement Award winners?

Drug Discovery World

He is being recognised for his revolutionary contributions to developing the first gene-edited cell-based therapy for cancer that involves the genetic re-engineering of a patient’s own T cells to combat their disease, and for demonstrating that adoptive T-cell therapy can induce remission and in some cases cure patients with advanced cancer.