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Five Promising Treatment Areas in Early-Phase DrugDevelopment in 2024 aasimakopoulos Wed, 04/17/2024 - 15:52 Early-phase drugdevelopment is an ever-changing landscape, as emerging science leads to new promising areas of research for the treatment of human health issues.
This was the first successful drugdevelopment against a transcription factor, opening the door to targeting a whole new class of previously unreachable targets. The Promise of Multispecific Drugs The future of drug discovery looks even brighter with the development of multispecific drugs.
A few notable developments include: Liquid Biopsy Technologies Liquid biopsy technologies involve analyzing biomarkers from bodily fluids to detect and monitor cancers, offering a non-invasive alternative to traditional biopsies. Proteomics Proteomics involves studying the entire set of proteinsexpressed in a cell or tissue.
The current landscape of proteindrugdevelopment is characterised by accelerated timelines where new drugs are approved in months rather than years. Hence, in many cases an earlier IND may be prevented by the timely provision of representative Drug Substance (DS) to execute such toxicology studies.
The oncology drugdevelopment landscape is evolving rapidly, driven by the deployment of targeted therapies in precision medicine and regulatory initiatives like the FDAs Project Optimus. It also covers strategies for drugdevelopers who have yet to identify a biomarker, helping them advance their programs effectively.
Making strategic decisions when designing the protocol, such as including biomarkers like programmed death ligand-1 proteinexpression to guide the use of immune checkpoint inhibitors during treatment, can better assure safety and efficacy.
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