Drug Target Review

APRIL 9, 2024

In a previous study, we showed that these peptides decorate all cellular RNAs and thus impair the binding of RNA-binding proteins to RNA. For his postdoctoral stay he joined the group of André Nussenzweig, where he started to work on DNA repair, particularly focusing on the role of histone H2AX.

RNA 64

RNA Cell Biology Clinical Development Disease 64

Vial

DECEMBER 5, 2023

It has become a fundamental tool for researchers to explore the complexities of genetic information and conduct genetic-informed drug development. Sponsors have used NGS to screen patients for clinical trial eligibility and patient stratification , expanded CDx development, and comprehensive genomic profiling (CGP).

Clinical Trials 52

Clinical Trials Trials RNA Bioinformatics 52

Conversations in Drug Development Trends

AUGUST 14, 2024

Molecular Biomarkers : Encompass various molecules, such as RNA and metabolites, to reflect the physiological state of the cells and their disease pathways. The analysis of circulating tumor DNA (ctDNA) in a liquid biopsy can also permit genotyping and help monitor the effectiveness of chemotherapy.

Treatment 78

Treatment Therapies Disease Protein Expression 78

The Pharma Data

OCTOBER 19, 2020

The company’s suite of market-leading molecular profiling offerings assesses DNA, RNA and proteins to reveal a molecular blueprint that helps physicians and cancer patients make more precise and personalized treatment decisions.

Clinical Trials 52

Clinical Trials RNA DNA Science 52

Drug Target Review

SEPTEMBER 18, 2024

Companies are planning their drug development strategies with automated unit operations in mind, and how to incorporate them earlier in the development pipeline. Throughout his career in the industry, Dalip has been engaged in developing technologies and methods for use in cell therapy applications.

Therapies 52

Therapies Doctors RNA Production 52

Elrig

APRIL 29, 2024

Harini joined Serna Bio in early 2021 and has been an integral part of the multidisciplinary teamworking on target ID platform development to drug discovery. She has played a key role inbuilding the target identification platform and a proprietary database of transcriptome-wide, functional RNA structures.

Bioinformatics 59

Bioinformatics Drugs Molecular Biology Cell Based Assays 59

New Drug Approvals

JANUARY 9, 2024

CDK7 also plays a role in transcription and possibly in DNA repair. The trimeric Cak complex CDK7/CyclinH/MATl is also a component of TFIIH, the general transcription/DNA repair factor IIH (Morgan, DO., As a TFIIH subunit, CDK7 phosphorylates the CTD (Carboxy-Terminal-Domain) of the largest subunit of RNA polymerase II (pol II).

Production 62

Production DNA RNA Regulations 62

Broad Institute

OCTOBER 11, 2023

The method prevents the mouse’s immune system from rejecting the CRISPR machinery while also leaving behind RNA barcodes that can be sequenced to determine which gene had been deactivated in each cell. “I

Research 137

Research Immune Response Clinical Trials Therapies 137

Drug Target Review

DECEMBER 6, 2023

Dear readers, RNA, or ribonucleic acid, plays a pivotal role in the intricate dance of cellular processes. We are committed to providing you with the highest quality content, and we believe that this report will deliver a different perspective on the topics covered.

RNA 52

RNA DNA Vaccine Drug Development 52

Codon

SEPTEMBER 29, 2024

But, regardless of which was first, they all operated with the same core data as their mechanism for understanding life: messenger RNA ( mRNA ). It wasn’t a silver bullet to the hard problem of drug development, but it wasn’t too far off either. A flurry of new, promising therapeutic targets arose.

Engineering 144

Engineering Virus DNA Therapies 144

PerkinElmer

AUGUST 18, 2020

HTRF is a common in-vitro assay modality used in drug development. Amplified luminescent proximity homogeneous assays, or Alpha assays, measure response to non-radioactive fluorescent emission by tagged molecules located near the target molecule.

Virus 52

Virus Vaccine RNA DNA 52

Codon

NOVEMBER 3, 2024

As an undergraduate biology student, I spent some time in a TB lab working on antibiotic resistance — a growing concern for drug developers. Some fluoroquinolones — a class of antibiotics that inhibits DNA replication — may even cause psychosis. The researchers were left with 40 drug candidates.

Vaccine 106

Vaccine Trials Therapies Treatment 106

NIH Director's Blog: Drug Development

JANUARY 5, 2016

This gene-editing system consists of a short segment of RNA that is attached to an enzyme. The RNA is preprogrammed to find a distinct short sequence of DNA and deliver the enzyme, which acts like a scalpel to slice the sequence out of the genome. It’s fast and pretty precise.

Vaccine 52

Vaccine Science Disease Engineering 52