Drug Discovery Today

MAY 25, 2023

The Facility will have capacity that exceeds today’s global plasmid DNA demand and can enable commercialisation of genetic medicines. Transformation of Grade II-listed Victorian waterworks on the River Thames in Hampton, London.

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DNA Drugs 113

Chemical Biology and Drug Design

MARCH 6, 2025

The availability of safer anticancer drugs with exceptional selectivity for healthy cells and great efficacy against various cancer forms continues to be a significant obstacle. Piperazine also has a flexible binding feature that allows it to interact with a variety of biological targets, which makes it effective against cancers.

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Drug Target Review

JANUARY 10, 2024

There is extensive crosstalk between the DNA damage response (DDR) and innate immune pathways. Both are a focus for exciting new small-molecule drug therapeutics that target cancers and autoimmune disorders.

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DNA Biochemical Assays Small Molecule Drugs 104

Covalent Modifiers

APRIL 25, 2024

Kinsella Nature , 2024 [link] WRN helicase is a promising target for treatment of cancers with microsatellite instability (MSI) due to its essential role in resolving deleterious non-canonical DNA structures that accumulate in cells with faulty mismatch repair mechanisms 1 , 2 , 3 , 4 , 5.

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Broad Institute

JUNE 28, 2023

Merkin Prize in Biomedical Technology for developing an efficient, automated technology for synthesizing DNA. The chemical reactions that he discovered in the early 1980s to accurately and quickly assemble nucleotides into strands of DNA provided an essential element in the development of modern molecular medicine.

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ASPET

NOVEMBER 17, 2023

SM cytotoxicity emerges, in part, through DNA alkylation and double-strand breaks (DSBs). Because DSBs can naturally be repaired by DNA damage response pathways with low efficiency, we hypothesized that enhancing the HR pathway could pose a novel approach to mitigate SM injury.

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ASPET

JUNE 30, 2023

It was found that combining these drugs with lower doses and for shorter treatment periods induced greater or equal toxicity in cancer cells than using either as a single agent. Here, we develop a mathematical model to investigate the effects of ceralasertib and olaparib, two drugs that target DNA damage response pathways.

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Covalent Modifiers

JANUARY 28, 2024

Whitehurst, Hua Xu, SLAS Discovery, 2024 [link] Covalent hits for drug discovery campaigns are neither fantastic beasts nor mythical creatures, they can be routinely identified through electrophile-first screening campaigns using a suite of different techniques. Employing best practice, however, is critical to success.

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DNA Drugs 173

PLOS: DNA Science

MAY 18, 2023

Perhaps more telling, I recently discovered a previously unknown branch of my own family tree that includes a dozen half-siblings that I know of, from a DNA test that I didn’t even remember taking. It was eerily like forensic scientists using familial DNA to track down serial killers. Du Bois quotation. Which one was our biodad?

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DNA Doctors Research Science 91

Alta Sciences

FEBRUARY 19, 2025

Regulatory Guidance for Oligonucleotide Bioanalysis in Drug Development pmjackson Wed, 02/19/2025 - 21:30 The unique physicochemical properties of oligonucleotides require the use of specialized bioanalytical approaches, with key considerations including selectivity and specificity, sensitivity, stability, and matrix effects.

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ASPET

SEPTEMBER 16, 2024

GBM has a poor prognosis despite aggressive treatment, in part due to lack of adequate drug permeability at the BBB. Standard of care GBM therapies include radiation and cytotoxic chemotherapy that lead to DNA damage. Subsequent activation of DNA damage response (DDR) pathways can induce resistance.

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Broad Institute

JUNE 14, 2024

Some CRISPR screens may be missing cancer drug targets By Allessandra DiCorato June 14, 2024 Breadcrumb Home Some CRISPR screens may be missing cancer drug targets Current CRISPR guides don’t work equally well in cells from people of all ancestries, which could lead to false negative results.

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Drug Target Review

SEPTEMBER 4, 2023

There have been several studies that have reported the ability of infectious disease agents to be drug resistant. Studies have shown that targeting some expression gene sites could lead to the production of new drugs as indicated. 7,13 The use of Plants extract is important in drug discovery.

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Drug Target Review

JUNE 28, 2023

When faced with a viral threat, bacterial cells developed an immune response by capturing and copying DNA fragments of viruses. This allowed bacteria to recognise subsequent attacks and cleave the viral DNA to stop the viral infection. It was also discovered that the Cas enzyme was responsible for DNA cleavage.

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Drug Target Review

DECEMBER 21, 2023

To provide comprehensive insights into ongoing developments, we are pleased to present the latest edition of Drug Target Review. Within the pages of this publication, readers will find in-depth articles that elucidate the latest advancements, challenges, and breakthroughs within the field of drug discovery.

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ASPET

MARCH 20, 2024

DNA topoisomerase IIβ (TOP2β/180; 180 kDa) is a nuclear enzyme that regulates DNA topology by generation of short-lived DNA double-strand breaks primarily during transcription. TOP2β/180 can be a target for DNA damage-stabilizing anticancer drugs, whose efficacy is often limited by chemoresistance.

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DrugBank

JUNE 13, 2024

The landscape of medicine is constantly evolving, and one of the most exciting areas of progress lies in the development of advanced drug delivery systems. These microscopic particles, which are smaller than 100 nanometers, can be engineered to deliver drugs to specific targets with precision.   Take cancer treatment, for example.

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Drug Target Review

OCTOBER 4, 2023

Antibody-drug conjugates (ADCs) have been a groundbreaking approach to cancer treatment with their ability to deliver cytotoxic drugs directly to diseased cells while sparing healthy tissues. 1 However, efforts proved less effective than the original drugs, owing mostly to insufficient toxicity against cancer cells.

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Small Molecule Drugs Immune Response Targeted Protein Degradation 126

PLOS: DNA Science

MARCH 28, 2024

A new drug has entered the arsenal against Duchenne muscular dystrophy (DMD), a genetic disease that affects boys and is challenging to treat. These drugs affect which parts of specific genes are transcribed and translated into protein, and which parts are shielded – aka gene expression. million DNA bases.

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Drug Target Review

SEPTEMBER 28, 2023

After some time in that role and launching several products, I received a call from Bill Banyai and Bill Peck, or ‘The Bills’ as we call them, who were building a company around technology that creates DNA by ‘writing’ it on a silicon chip. We’ve miniaturised the chemical process to making DNA and synthesize or ‘write’ DNA on a silicon chip.

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DNA Organic Chemistry Science Virus 116

Codon

NOVEMBER 3, 2024

As an undergraduate biology student, I spent some time in a TB lab working on antibiotic resistance — a growing concern for drug developers. Antibiotics From the Ground Up Researchers unearthed the first TB drug from the ground. We need better vaccines — and medicines — to quash TB.

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Vaccine Trials Therapies Treatment 102

Covalent Modifiers

SEPTEMBER 1, 2024

4c07920 Proximity-enhanced chemical cross-linking is an invaluable tool for probing protein–protein interactions and enhancing the potency of potential peptide and protein drugs. Derivatives of the CsgG:CsgF pore have been used for DNA sequencing, which places high demands on the structural stability and homogeneity of the complex.

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DNA Drugs 124

Drug Target Review

OCTOBER 23, 2024

Technologies for the rapid and efficient testing of small molecules and biologics have greatly accelerated drug discovery. Limitations of DNA-encoded chemical libraries in drug discovery DNA-encoded chemical libraries (DEL) are widely used in the pharmaceutical industry for drug discovery of small molecules.

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DrugBank

MAY 22, 2024

In the dynamic world of drug discovery, the notion of "undruggable" targets presents both a significant challenge and an intriguing frontier for researchers and pharmaceutical companies. A big part of the puzzle is selectivity—the ability of a drug to zero in on specific biological molecules without affecting others.

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Chemical Biology and Drug Design

APRIL 3, 2023

In this manuscript, we have discussed various biological targets of cancer with their drugs containing heterocyclic compound as benzimidazole shows effective response and better inhibitory activity against various cancer. Abstract Cancer is the second leading cause of death globally, with 9.6 million million deaths yearly.

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DNA Therapies FDA Treatment 100

DrugBaron

JULY 19, 2022

Despite the current hype around so called “advanced therapies”, which range from gene editing to cell therapies, and the inexorable advance of biologic therapeutics such as monoclonal antibodies, even in 2022 the majority of drugs in development and reaching patients are still small organic molecules. But it has its limitations too.

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SCIENMAG: Medicine & Health

JUNE 16, 2023

• Genomic sequencing panels are tests that analyse the DNA of the patient’s tumour to look for genetic variants for which there are effective drugs. Credit: underbau / CNIO • Genomic sequencing panels are tests that analyse the DNA of the patient’s tumour to look […]

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Treatment DNA Drugs 86

DrugBank

MAY 15, 2024

The road to developing effective drugs is fraught with both promise and challenge, particularly when it comes to what scientists call "undruggable" targets. The Evolution of Drug Discovery: From Dark Rooms to Precision Targets In the past, drug discovery often felt like a lucky guess.

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Small Molecule Molecular Biology Drugs Disease 98

Broad Institute

OCTOBER 4, 2023

Related links Merkin Prize Inaugural Merkin Prize in Biomedical Technology awarded to Dr. Marvin Caruthers for developing technology that efficiently synthesizes DNA The inaugural Richard N. Caruthers was announced as the winner in June for his development, in 1981, of an efficient, automated technology for synthesizing DNA.

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DNA RNA Science Protein Expression 52

Conversations in Drug Development Trends

JUNE 13, 2024

Pharmacogenomics (PGx), the study of how genes affect a person’s response to drugs, has brought significant changes to the clinical trial industry. This groundbreaking approach can help tailor medical treatments to an individual’s genetic makeup, considerably enhancing drug efficacy and safety while minimizing adverse drug reactions.

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PLOS: DNA Science

JULY 27, 2023

Genomics applies to all species, revealing evolution in action, because we all use the same genetic code – that is, the correspondence between DNA sequences and the amino acid sequences of proteins. Cats and Bird Flu Comparing DNA sequences is a little like linguistic research that connects languages.

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DrugBank

OCTOBER 17, 2024

Data science has emerged as an innovative tool in the biopharmaceutical industry, leveraging the power of machine learning and artificial intelligence to drive innovation and efficiency across the entire drug development lifecycle.

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Drug Development Metabolic Stability Clinical Trials Drugs 98

DrugBank

JULY 24, 2024

In the constantly evolving field of drug discovery, the term “undruggable” refers to proteins and targets in the body that, until recently, were considered impossible to treat with traditional drugs. Peptides and peptidomimetics, for instance, mimic natural peptides and can target specific proteins with high precision.

Small Molecule 98

Small Molecule Drugs Clinical Trials Therapies 98

Chemical Biology and Drug Design

DECEMBER 13, 2024

ABSTRACT Overexpression of c-Myc is a key factor in the development of leukemia and other malignancies, highlighting the urgent need for novel drugs to inhibit c-Myc protein levels. DNA G-quadruplexes (G4) have emerged as potential regulatory targets for c-Myc expression.

DNA 100

DNA Therapies Drugs Research 100

Codon

FEBRUARY 13, 2024

doi: 10.2210/rcsb_pdb/goodsell-gallery-048 The Virus that Cures It’s been over 25 years since the science magazine Discover first ran an extraordinary article about how a long-forgotten medical treatment, used in the former Soviet country of Georgia, could save us from the growing threat of untreatable, drug-resistant infections.

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Drug Hunter

MAY 18, 2023

Dian Su’s journey from chemistry and proteomics to the DMPK of drug conjugates Following a different path comes naturally to Dian Su, Senior Director of DMPK at Bicycle Therapeutics. researching DNA photoproducts related to skin cancer. About Dian “I grew up in a village famous for its Fuji apples.

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Small Molecule DNA Pharmacokinetics Engineering 131

Broad Institute

JUNE 28, 2023

Such large-scale changes in DNA have been difficult to study. The findings, published today in Nature , could lead to new ways of guiding cancer treatment or developing targeted drugs. Certain cancer types are known to rely on WRN and drugs are already under development to block the gene.

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