Broad Institute

JANUARY 14, 2025

The treatment, which uses base editing to make a single-letter change in DNA, reduced levels of the disease-causing prion protein in the brain by as much as 60 percent. In 2018, Liu, who works on the same floor as Minikel and Vallabh at Broad, approached them and proposed a collaboration.

Disease 144

Disease DNA Protein Production Treatment 144

SCIENMAG: Medicine & Health

AUGUST 10, 2023

Pushing into a new chapter of technologically advanced biological sensors, scientists from the University of California San Diego and their colleagues in Australia have engineered bacteria that can detect the presence of tumor DNA in a live organism.

DNA 86

DNA Engineering Research Science 86

Broad Institute

JANUARY 8, 2024

A team of researchers at the Broad Institute of MIT and Harvard has engineered virus-like particles to deliver prime editors to cells in mice at a high enough efficiency to rescue a genetic disorder. Prime editing, described in 2019 by Liu’s group, can make longer and more diverse types of DNA changes than other types of editing.

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Engineering Research Virus DNA 144

Science Daily: Pharmacology News

AUGUST 11, 2023

Using scaffolds of folded DNA, engineers assembled arrays of quantum rods with desirable photonic properties that could enable them to be used as highly efficient micro-LEDs for televisions or virtual reality devices.

DNA 189

DNA Engineering 189

Drug Target Review

JUNE 28, 2023

When faced with a viral threat, bacterial cells developed an immune response by capturing and copying DNA fragments of viruses. This allowed bacteria to recognise subsequent attacks and cleave the viral DNA to stop the viral infection. It was also discovered that the Cas enzyme was responsible for DNA cleavage.

Engineering 98

Engineering DNA Immune Response RNA 98

BioPharma Drive: Drug Pricing

JANUARY 2, 2024

The deal is the second startup sale engineered by University of California, Berkeley scientist Shakked Halperin, and gives Tome a way to insert or delete small DNA sequences into the genome.

DNA 173

DNA Engineering 173

Broad Institute

FEBRUARY 27, 2025

An ancient RNA-guided system could simplify delivery of gene editing therapies By Corie Lok February 27, 2025 Breadcrumb Home An ancient RNA-guided system could simplify delivery of gene editing therapies The programmable proteins are compact, modular, and can be directed to modify DNA in human cells. Lisa Yang and Hock E.

RNA 66

RNA Therapies DNA Virus 66

SCIENMAG: Medicine & Health

JUNE 21, 2023

HOUSTON – (June 21, 2023) – Rice University bioengineers have demonstrated a low-cost, point-of-care DNA test for HPV infections that could make cervical cancer screening more accessible in low- and middle-income countries where the disease kills more than 300,000 women each year.

DNA 89

DNA Disease Engineering 89

Broad Institute

JUNE 10, 2024

The new method uses a combination of prime editing, which can directly make a wide range of edits up to about 100 or 200 base pairs, and newly developed recombinase enzymes that efficiently insert large pieces of DNA thousands of base pairs in length at specific sites in the genome.

DNA 144

DNA Engineering Therapies Disease 144

SCIENMAG: Medicine & Health

JUNE 19, 2023

Aleksandra Radenovic, head of the Laboratory of Nanoscale Biology in the School of Engineering, has worked for years to improve nanopore technology, which involves passing a molecule like DNA through a tiny pore in a membrane to measure an ionic current.

DNA 62

DNA Engineering Laboratories Research 62

Broad Institute

AUGUST 31, 2023

Now researchers at the Broad Institute of MIT and Harvard have used cutting-edge continuous laboratory evolution and engineering methods to develop improved versions of the gene-editing tool. Reverse transcriptase proteins that copy RNA templates into strands of DNA are found naturally in all plant and animal cells and in many viruses.

DNA 145

DNA RNA Engineering Laboratories 145

Broad Institute

JANUARY 18, 2024

McAlpine January 18, 2024 Credit: Susanna Hamilton, Broad Communications One of the new "priming agents" works by preventing immune cells from engulfing tumor DNA circulating in the bloodstream. Liquid biopsies promise to transform how cancers are diagnosed, monitored, and treated by detecting DNA that tumors shed into the blood.

DNA 133

DNA Engineering Science Disease 133

Codon

FEBRUARY 13, 2025

They synthesized DNA encoding each protein variant, expressed the proteins in E. Abhishaike Mahajan is a senior ML engineer at Dyno Therapeutics, a biotech startup working to create better adeno-associated viral vectors using AI. Lab Validation After each computational design step, the researchers tested their designs in the lab.

Small Molecule 123

Small Molecule Engineering Production DNA 123

Broad Institute

JUNE 28, 2023

By Leah Eisenstadt June 28, 2023 Credit: Courtesy of the Zhang lab Cryo-EM map of a Fanzor protein in complex with ωRNA and its target DNA. They showed that Fanzor proteins use RNA as a guide to target DNA precisely, and that Fanzors can be reprogrammed to edit the genome of human cells.

RNA 139

RNA DNA Research Engineering 139

Drug Target Review

MAY 14, 2024

Which natural agonists impede the activation of intracellular DNA sensors in APCs, and what challenges do they pose? What potential therapeutic advantages do the engineered cationic polypeptides offer in the context of generating antitumour immune responses?

Engineering 59

Engineering Immune Response FDA Approval Clinical Trials 59

Drug Target Review

JUNE 6, 2023

At Alkermes , our interdisciplinary team of protein engineers, immunologists, pharmacologists, and analytical scientists is investigating the biology of several immunomodulatory cytokines including IL-12 and IL-18 to develop novel versions of these molecules with the goal of harnessing their therapeutic potential.

Engineering 98

Engineering Immune Response Biochemical Pharmacology Clinical Trials 98

SCIENMAG: Medicine & Health

JUNE 29, 2023

Performing cutting-edge science requires thinking outside the box and bringing together different scientific disciplines. Sometimes this even means being in the right place at the right time.

DNA 87

DNA Science Research Engineering 87

Drug Target Review

JULY 5, 2023

iPSC-derived lymphocytes, eg, T cells and natural killer (NK) cells, engineered to express targeting molecules such as chimeric antigen receptors (CARs) have shown clinical promise to treat haematological malignancies. We believe this lays the groundwork for engineering these kinds of myeloid cells to potentially target any cancer antigen.

Therapies 103

Therapies DNA Engineering Virus 103

Drug Target Review

JULY 7, 2023

The reasons for this are multifaceted, including concerns over the safety of directly altering DNA sequences and subsequent regulatory restrictions that have arisen as a result. The epigenome (meaning ‘above the genome’) is a system of reversible marks regulating how the DNA is read, translated and used. What is epigenetic editing?

DNA 105

DNA Engineering Therapies Regulations 105

Broad Institute

JUNE 27, 2024

Unlike gene editing, this “epigenetic” editing does not modify the underlying DNA sequence, but it should switch the gene off permanently, which means that this could be a one-time treatment. They used an engineered adeno-associated virus (AAV) that crosses the blood-brain barrier after intravenous administration. Online June 27, 2024.

Disease 142

Disease Therapies Clinical Trials Engineering 142

SCIENMAG: Medicine & Health

JUNE 22, 2023

The living cell harbors physiologically relevant components such as the genetic material (DNA) and proteins in a ‘self-organized’ setting. Understanding this process of self-assembly can reveal the underlying mechanism of self-organization of living matter.

DNA 72

DNA Engineering 72

Broad Institute

NOVEMBER 23, 2023

The scientists found a surprising number and diversity of CRISPR systems, including ones that could make edits to DNA in human cells, others that can target RNA, and many with a variety of other functions. Zhang’s team showed that two of these systems could make short edits in the DNA of human cells.

RNA 135

RNA DNA Engineering Science 135

Drug Target Review

SEPTEMBER 28, 2023

After some time in that role and launching several products, I received a call from Bill Banyai and Bill Peck, or ‘The Bills’ as we call them, who were building a company around technology that creates DNA by ‘writing’ it on a silicon chip. Because I was put into the highest tier, I was automatically mapped to the engineering track.

DNA 116

DNA Organic Chemistry Science Virus 116

Broad Institute

MARCH 22, 2024

Messenger RNAs with multiple “tails” could lead to more effective therapeutics By Corie Lok March 22, 2024 Breadcrumb Home Messenger RNAs with multiple “tails” could lead to more effective therapeutics Scientists have engineered long lasting mRNAs that increased therapeutic protein production in cells and animals.

Engineering 140

Engineering Protein Production RNA Vaccine 140

Codon

JUNE 30, 2024

Modern biotechnology began in 1972 when biochemists at Stanford University spliced together DNA from two different organisms. By 1978, Genentech was making human insulin using engineered E. The race to exploit recombinant DNA technology was on. But in the 1970s, it was unclear whether patents could apply to engineered organisms.

DNA 101

DNA Engineering Laboratories Production 101

Broad Institute

JULY 10, 2024

The new method, published today in Nature Biomedical Engineering , precisely and durably corrects the mutation in human lung cells, restoring cell function to levels similar to that of Trikafta. Nature Biomedical Engineering. Paper cited Sousa AA and Hemez C et al. Online July 10, 2024. DOI:10.1038/s41551-024-01233-3.

Engineering 145

Engineering Packaging DNA Treatment 145

SCIENMAG: Medicine & Health

AUGUST 3, 2023

Novel blood testing technology being developed by researchers at the Johns Hopkins Kimmel Cancer Center that combines genome-wide sequencing of single molecules of DNA shed from tumors and machine learning may allow earlier detection of lung and other cancers.

DNA 63

DNA Research Engineering 63

PLOS: DNA Science

FEBRUARY 8, 2024

Already, engineered probiotics have been used to treat metabolic disorders like inflammatory bowel disease and obesity, single-gene conditions like PKU, and bacterial infections common in people who have cystic fibrosis. appeared first on DNA Science. Probiotics are an enticing target. The post Designing a Better Probiotic.

Immune Response 98

Immune Response DNA Engineering Virus 98

Broad Institute

NOVEMBER 13, 2023

Liquid biopsies enable clinicians to find and analyze tumor DNA in a patient’s blood sample to detect cancer early, monitor cancer recurrence, assess the patient’s response to treatment, and measure other clinically important features in real time, without invasive procedures.

DNA 116

DNA Medical Schools Treatment Therapies 116

Codon

JUNE 11, 2024

And unlike traditional DNA sequencers, which parse genetic material by breaking it up into fragments and interpreting it chunk-by-chunk, a nanopore device unspools a long strand of DNA and reads it all at once. A scientist can isolate DNA and load up a flow cell in fifteen minutes. Nanopore devices work incredibly fast.

DNA 83

DNA Engineering RNA Small Molecule 83

Drug Target Review

JANUARY 15, 2024

Unlike almost every other cell type (except B cells), T cells do not have the exact same chromosomal DNA sequences as other cells in the body. In previous decades, isolation, sequencing and characterisation of DNA encoding a specific TCR was laborious and technically challenging. Engineering soluble T-cell receptors for therapy.

Engineering 110

Engineering DNA Virus Immune Response 110

Drug Target Review

JULY 3, 2023

Dr David Baram from gene therapy company EmendoBio provides a snapshot of the history of therapeutic genetic engineering, explaining the early pitfalls and reasons for recent renewed optimism.

Therapies 98

Therapies Clinical Trials DNA Engineering 98

Advarra

MARCH 31, 2023

The use of engineered genetic materials in clinical trials is rapidly expanding, with potential applications for genetic vaccines, gene-modified cellular therapies, and gene therapies. A key part of the IBC’s evaluation is assessing the risks posed by the engineered genetic materials. Why Does the IBC Need to do a Risk Assessment?

Engineering 52

Engineering Clinical Research Research Virus 52

PLOS: DNA Science

JUNE 20, 2024

Instead, the genomes of plant cells cultured in a lab receive the DNA sequences – genes – that enable them to manufacture specific enzymes required for the biochemical pathways to produce certain molecules of value to us. The post Can Engineered Tobacco Plants that Make Human Sugars Improve Infant Formula and Plant-Based Milks?

Engineering 52

Engineering DNA Vaccine Production 52

Codon

SEPTEMBER 29, 2024

mRNA was the intermediate stage between DNA and protein, a dynamic entity that shifted depending on the second-to-second needs of the cell, able to point out if a cell was cancerous or stressed, what kind of cell it was, and so on. Most crops were now genetically-engineered to tolerate flood, drought, pests, and disease.

Engineering 140

Engineering Virus DNA Therapies 140

Advarra

JUNE 13, 2024

Recombinant DNA technologies and genetically modified biological agents are being adapted for a wide scope of therapeutic applications, and their use is becoming increasingly common in clinical trials. The post The Importance of Hazard Communications in Clinical Trials Involving Genetic Engineering appeared first on Advarra.

Clinical Trials 52

Clinical Trials Engineering Trials Virus 52

PLOS: DNA Science

AUGUST 24, 2023

“Pangenomics” is a newish term, referring to ways that a species’ genome can vary, DNA base by DNA base. I wrote The Age of the Pangenome Dawns here at DNA Science last year, about the Human Pangenome Reference Consortium. A genome of 3,054,832 billion DNA base pairs can vary in many ways.

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DNA Disease Science Research 97