Drug Target Review

JUNE 28, 2023

When faced with a viral threat, bacterial cells developed an immune response by capturing and copying DNA fragments of viruses. This allowed bacteria to recognise subsequent attacks and cleave the viral DNA to stop the viral infection. It was also discovered that the Cas enzyme was responsible for DNA cleavage.

Engineering 98

Engineering DNA Immune Response RNA 98

Drug Target Review

MAY 14, 2024

Which natural agonists impede the activation of intracellular DNA sensors in APCs, and what challenges do they pose? What potential therapeutic advantages do the engineered cationic polypeptides offer in the context of generating antitumour immune responses?

Engineering 59

Engineering Immune Response FDA Approval DNA 59

SCIENMAG: Medicine & Health

JUNE 19, 2023

Aleksandra Radenovic, head of the Laboratory of Nanoscale Biology in the School of Engineering, has worked for years to improve nanopore technology, which involves passing a molecule like DNA through a tiny pore in a membrane to measure an ionic current.

DNA 62

DNA Engineering Research Laboratories 62

Science Daily: Pharmacology News

JANUARY 31, 2024

In the new study, researchers successfully modified DNA from four types of phages to kill a deadly pathogen. Antimicrobial resistance is an urgent and growing global crisis. Researchers are exploring phages, viruses that infect bacteria, as a possible solution.

Virus 108

Virus Engineering DNA Research 108

Science Daily: Pharmacology News

JULY 11, 2023

A 'biological camera' bypasses the constraints of current DNA storage methods, harnessing living cells and their inherent biological mechanisms to encode and store data. This represents a significant breakthrough in encoding and storing images directly within DNA, creating a new model for information storage reminiscent of a digital camera.

DNA 68

DNA Engineering 68

Drug Discovery World

FEBRUARY 27, 2024

The epigenome is a system of reversible marks that regulate how the DNA is read, translated, and used. While DNA encodes the fundamental building blocks of life, the epigenome controls which blocks are accessible for use. These factors can be harnessed to improve CAR T-cell engineering.

DNA 148

DNA Engineering Therapies Regulations 148

SCIENMAG: Medicine & Health

JUNE 21, 2023

HOUSTON – (June 21, 2023) – Rice University bioengineers have demonstrated a low-cost, point-of-care DNA test for HPV infections that could make cervical cancer screening more accessible in low- and middle-income countries where the disease kills more than 300,000 women each year.

DNA 89

DNA Disease Engineering 89

Drug Discovery World

MAY 5, 2023

Eterna Therapeutics, a life science company focused on mRNA cell engineering, has acquired Exacis Biotherapeutics’ immuno-oncology platform. In contrast to DNA-based reprogramming and gene editing, the mRNA-based approach does not expose cells to expensive and potentially harmful viruses or DNA vectors.

Engineering 130

Engineering DNA Therapies Licensing 130

Advarra

JUNE 13, 2024

Recombinant DNA technologies and genetically modified biological agents are being adapted for a wide scope of therapeutic applications, and their use is becoming increasingly common in clinical trials. The post The Importance of Hazard Communications in Clinical Trials Involving Genetic Engineering appeared first on Advarra.

Clinical Trials 52

Clinical Trials Engineering Trials Virus 52

Drug Discovery World

AUGUST 5, 2022

Three key members of the team – Dr Raquel Sanches-Kuiper, Vice President of Technology, Dr Matthew Hayes, Chief Technology Officer and John Edgell, Head of Cloud Engineering – explain how the company is doing this and what it means for the advancement of DNA synthesis in the lab. The next goal is to optimise the technology. “At

DNA 130

DNA Engineering Cell Biology Doctors 130

Advarra

MARCH 31, 2023

The use of engineered genetic materials in clinical trials is rapidly expanding, with potential applications for genetic vaccines, gene-modified cellular therapies, and gene therapies. A key part of the IBC’s evaluation is assessing the risks posed by the engineered genetic materials. Why Does the IBC Need to do a Risk Assessment?

Engineering 52

Engineering Clinical Research Research Virus 52

Drug Target Review

JUNE 6, 2023

At Alkermes , our interdisciplinary team of protein engineers, immunologists, pharmacologists, and analytical scientists is investigating the biology of several immunomodulatory cytokines including IL-12 and IL-18 to develop novel versions of these molecules with the goal of harnessing their therapeutic potential.

Engineering 98

Engineering Immune Response Biochemical Pharmacology Clinical Trials 98

Drug Discovery World

MAY 25, 2023

DNA Script: SYNTAX DNA printing platform Using the company’s EDS technology, the SYNTAX platform can synthesise up to 96 highly accurate, ready-to-use DNA oligos with maximum lengths of up to 120nt in less than 24 hours in the laboratory.

Production 130

Production DNA Assay Development Drugs 130

Drug Discovery World

SEPTEMBER 15, 2023

Under the terms of the agreement, Orbit will deploy its bead-based peptide display engine to discover peptide leads specific to targets related to specific tumours. The collaboration will harness the capabilities of Orbit’s peptide display engine to identify peptide candidates specific to tumour-associated targets.

Therapies 130

Therapies Engineering DNA Marketing 130

SCIENMAG: Medicine & Health

JUNE 22, 2023

The living cell harbors physiologically relevant components such as the genetic material (DNA) and proteins in a ‘self-organized’ setting. Understanding this process of self-assembly can reveal the underlying mechanism of self-organization of living matter.

DNA 72

DNA Engineering 72

Drug Discovery World

AUGUST 21, 2024

The composition of engineered cells in vivo can change over time as clones proliferate at varying rates. Following initial viral vector transduction, treated samples, typically whole blood and/or enriched cell populations, are collected and the genomic DNA is isolated. The enriched DNA is then sequenced.

Therapies 148

Therapies Bioinformatics DNA FDA 148

SCIENMAG: Medicine & Health

JUNE 29, 2023

Performing cutting-edge science requires thinking outside the box and bringing together different scientific disciplines. Sometimes this even means being in the right place at the right time.

DNA 87

DNA Science Research Engineering 87

Drug Discovery World

OCTOBER 20, 2023

BioCina will provide process development and GMP manufacturing for Minicircle DNA and Plasmid DNA. GenomeFrontier will use their virus-free cell and gene engineering platforms and Quantum Engine cell-engineering system to manufacture the CAR-T therapy for use in a Phase I clinical trial.

DNA 130

DNA Clinical Trials Engineering Bioinformatics 130

Broad Institute

AUGUST 31, 2023

Now researchers at the Broad Institute of MIT and Harvard have used cutting-edge continuous laboratory evolution and engineering methods to develop improved versions of the gene-editing tool. Reverse transcriptase proteins that copy RNA templates into strands of DNA are found naturally in all plant and animal cells and in many viruses.

DNA 145

DNA Engineering RNA Laboratories 145

Drug Discovery World

JULY 12, 2023

Klaas Zuideveld’s presentation discusses Versameb’s approach to engineering mRNA to reprogram biology and cure hard-to-treat and prevalent diseases. This enables them to eliminate several steps of their traditional process to save time.

DNA 130

DNA Drugs Engineering Drug Development 130

Drug Discovery World

JULY 5, 2023

Klaas Zuideveld’s presentation discusses Versameb’s approach to engineering mRNA to reprogram biology and cure hard-to-treat and prevalent diseases. This enables them to eliminate several steps of their traditional process to save time.

DNA 130

DNA Engineering Drug Development Disease 130

Drug Discovery World

JUNE 28, 2023

Klaas Zuideveld’s presentation discusses Versameb’s approach to engineering mRNA to reprogram biology and cure hard-to-treat and prevalent diseases. This enables them to eliminate several steps of their traditional process to save time.

DNA 130

DNA Drugs Engineering Drug Development 130

Drug Discovery World

JUNE 21, 2023

Klaas Zuideveld’s presentation discusses Versameb’s approach to engineering mRNA to reprogram biology and cure hard-to-treat and prevalent diseases. This enables them to eliminate several steps of their traditional process to save time.

DNA 130

DNA Drugs Engineering Drug Development 130

The Pharma Data

MARCH 18, 2022

Columbia Engineering researchers report that they have developed a “cloaking” system that temporarily hides therapeutic bacteria from immune systems, enabling them to more effectively deliver drugs to tumors and kill cancer cells in mice. Sheng Professor of Biomedical Engineering. ” An Effective On/Off Switch.

Engineering 52

Engineering Small Molecule Drugs Therapies 52

BioPharma Drive: Drug Pricing

JANUARY 2, 2024

The deal is the second startup sale engineered by University of California, Berkeley scientist Shakked Halperin, and gives Tome a way to insert or delete small DNA sequences into the genome.

DNA 70

DNA Engineering 70

Drug Discovery World

JANUARY 6, 2023

Orbit’s technology enables the screening of large libraries of peptides using a combination of DNA encoded libraries and bead-based presentation. The peptide display engine addresses soluble targets and targets in situ, both on and in cells. .

RNA 130

RNA DNA Engineering Drugs 130

Drug Discovery World

AUGUST 1, 2023

Partnerships Earlier this year cell-engineering company MaxCyte signed a strategic platform license (SPL) with biotechnology company Catamaran Bio. The agreement will see Catamaran gain access to MaxCyte’s technology platforms which enable the complex engineering of cells.

Licensing 130

Licensing Licensing Drugs Engineering 130

Fierce BioTech

OCTOBER 26, 2023

The company has developed a disruptive DNA synthesis platform that pioneers a new method of manufacturing synthetic DNA by “writing” DNA on a silicon chip. Listing Image oracle Listing Introduction Twist Bioscience’s DNA-based products are powering research to improve the lives of millions of people.

DNA 52

DNA Bioinformatics Engineering Science 52

Science Daily: Pharmacology News

AUGUST 11, 2023

Using scaffolds of folded DNA, engineers assembled arrays of quantum rods with desirable photonic properties that could enable them to be used as highly efficient micro-LEDs for televisions or virtual reality devices.

DNA 72

DNA Engineering 72

Broad Institute

AUGUST 8, 2024

His work focuses on developing novel technologies to improve the performance of liquid biopsies for cancer detection, using approaches in protein engineering to create agents that can improve the recovery of cell-free DNA from the body.

Medical Schools 52

Medical Schools Hospitals DNA Engineering 52

Drug Discovery World

MAY 16, 2023

New South African company NewBiologix has launched with the aim of developing a proprietary and breakthrough platform for the advanced engineering of cell lines used to manufacture gene and cell therapies.

Production 130

Production Bioinformatics Therapies Virus 130

Drug Discovery World

JULY 22, 2022

Synthetic biology is an emerging field of science that combines methodologies from engineering and biology to design or re-design biological systems to produce useful and sustainable new products. Now, using the funding, SynbiCITE will extend its services to start-ups and emerging SMEs working within the synthetic biology sector. .

DNA 130

DNA Science Engineering Production 130

Drug Discovery World

MAY 7, 2024

However, despite these advancements in process optimisation and cell culture engineering, there remain areas that we need to improve. AEX chromatography has primarily been used in the polishing AEX step for the removal of impurities, such as DNA, HCP, etc., RA: What are some of the current limitations for producing mAbs?

Production 148

Production Engineering Packaging Science 148

Codon

AUGUST 28, 2024

Tessa Alexanian and Max Langenkamp build computational DNA screening tools for a living. But today, rapid advances in DNA synthesis have made it possible for would-be bioterrorists to make pathogens, rather than buy them. government must order synthetic DNA from providers who publicly state that they follow the U.S.

DNA 88

DNA Bioinformatics Virus Government 88

Drug Discovery World

AUGUST 14, 2023

When working with adeno-associated virus (AAV) vectors – an engineered technology and the most common platform for gene delivery – the FDA requires specific information on the percentage of empty capsids from the AAV or capsids that might have other sequences in them.

Marketing 130

Marketing DNA Therapies FDA 130

Broad Institute

JULY 10, 2024

The new method, published today in Nature Biomedical Engineering , precisely and durably corrects the mutation in human lung cells, restoring cell function to levels similar to that of Trikafta. Nature Biomedical Engineering. Paper cited Sousa AA and Hemez C et al. Online July 10, 2024. DOI:10.1038/s41551-024-01233-3.

Engineering 145

Engineering Packaging DNA Treatment 145

Codon

JULY 17, 2024

Backyard astronomers discovered 42 new planets in 2012 , hobbyist paleontologists discovered the world’s largest dinosaur footprint near the Yorkshire coast in 2021, and Sebastian himself open-sourced protocols that make it easier for scientists to engineer plants. And what genes will I need to engineer these flowers?

Laboratories 94

Laboratories Engineering Molecular Biology Science 94