Broad Institute

OCTOBER 11, 2023

The drugs work by blocking a protein, PD-1 — which helps keep immune responses in check — and stimulating the immune system to attack tumors. The team studied the immune response to CRISPR and designed a new technology that they published in 2021 — a way of removing immune-triggering molecules from CRISPR-edited cells.

Research 137

Research Immune Response Clinical Trials Therapies 137

Codon

SEPTEMBER 29, 2024

mRNA was the intermediate stage between DNA and protein, a dynamic entity that shifted depending on the second-to-second needs of the cell, able to point out if a cell was cancerous or stressed, what kind of cell it was, and so on. Most crops were now genetically-engineered to tolerate flood, drought, pests, and disease.

Engineering 141

Engineering Virus DNA Therapies 141

Drug Target Review

OCTOBER 26, 2023

Genome engineering and gene therapies that manipulate DNA sequences in cells have driven a biotechnological revolution over the past decade. 9 In addition, host immune responses further add to the complexity of developing cell-specific AAV capsids for clinical applications. His mentorship produced numerous publications.

Engineering 105

Engineering Virus Therapies Immune Response 105

Drug Target Review

APRIL 26, 2023

Gene-editing methods allow researchers to modify DNA, resulting in alterations in physical characteristics such as eye colour and susceptibility to diseases. To achieve this, scientists utilise various technologies that function similarly to scissors, precisely cutting the DNA at a particular location.

RNA 98

RNA Medical Schools Engineering Disease 98

PLOS: DNA Science

OCTOBER 12, 2023

Can they deliver healing genes without triggering an overactive immune response? The details are disturbingly reminiscent of the famous case of Jesse Gelsinger , who died from a ferocious immune response to experimental gene therapy in September 1999. million DNA bases. Muscles stop working.

Therapies 69

Therapies Immune Response DNA Virus 69

Broad Institute

JULY 11, 2024

Treatment with mIDH1 blockers unearths these remnants, triggering an immune response against the tumor cells. IDH1 normally facilitates the activity of enzymes called demethylases, which remove chemical flags called methylation marks from DNA, allowing genes to be transcribed into RNA.

Treatment 72

Treatment Immune Response Drugs Virus 72

Broad Institute

AUGUST 7, 2023

Related people Paul Blainey Nir Hacohen A signaling protein known as STING is a critical player in the human immune system, detecting signs of danger within cells and then activating a variety of defense mechanisms.

Regulations 91

Regulations Clinical Trials Engineering Science 91

Codon

NOVEMBER 3, 2024

If present before vaccination, memory immune cells primed to destroy the environmental relatives might cross-react with and neutralize the BCG strain before it has a chance to set up an immune response against itself and M. Testing the engineered cells against four common drugs, I found that the M. tuberculosis.

Vaccine 96

Vaccine Trials Therapies Clinical Trials 96

Codon

FEBRUARY 13, 2024

Such contaminants could have the same toxic effects as the bacterial infection, or provoke a severe immune response in the patient, and therefore the phage mixtures must go through extensive purification and testing procedures. This process would begin by taking a sample of bacteria from the patient and sequencing its DNA.

Therapies 128

Therapies Virus DNA Clinical Trials 128

Drug Target Review

JUNE 9, 2023

Genentech is responsible for engineering adaptive-discovered TCRs into T cells and manufacturing the T cell therapy product candidate. An antigen is a protein that can induce an immune response in the body. While tumour cells share a majority of their DNA with healthy cells, they also carry numerous unique mutations.

Treatment 105

Treatment Packaging Clinical Research Therapies 105

PLOS: DNA Science

OCTOBER 3, 2024

The idea to redirect an immune response against a pathogen to fight cancer goes back to 1891, when Manhattan bone surgeon William Coley became intrigued by a man’s neck tumor that melted away after he contracted a nasty Streptococcus skin infection. .’” The fishy strategy is both fast and patient-specific.

Vaccine 52

Vaccine Immune Response DNA Treatment 52

PerkinElmer

MAY 6, 2022

One approach currently being explored involves stimulating innate immune response pathways. For example, the STimulator of InterferoN Genes (STING) pathway, which is known to play a critical role in innate immunity in response to viral and bacterial DNA, has also been shown to promote anti-tumor immune responses.

Immune Response 52

Immune Response DNA Clinical Trials Engineering 52

Drug Target Review

OCTOBER 2, 2024

Tissue engineering techniques using induced pluripotent stem cells (iPSC), which are differentiated into cardiomyocytes, are being developed to create functional cardiac tissues from patient-derived cells. While commonly used, AAVs have limitations, including immune reactions and difficulties with re-dosing due to pre-existing antibodies.

Therapies 98

Therapies Disease Engineering RNA 98

Broad Institute

AUGUST 11, 2022

Microbial armory In an earlier study, the researchers scanned data on the DNA sequences of hundreds of thousands of bacteria and archaea, which revealed several thousand genes harboring signatures of microbial defense. Most known bacterial defense systems work by sensing viral DNA or RNA, or cellular stress due to the infection.

DNA 52

DNA Virus Immune Response Bioinformatics 52

Codon

DECEMBER 12, 2024

DNA and RNA molecules are also built from exclusively right-handed nucleic acids. As Richard Dawkins said of biological wheels : “the engineering solution can be seen in plain view, yet [it is] unattainable in evolution because it lies [on] the other side of a deep valley.”

RNA 102

RNA DNA Vaccine Virus 102

Codon

APRIL 30, 2023

Read more at Nature Biotechnology ( Similar paper at Nature Biomedical Engineering.) But now, their engineered brethren can live about 82 percent longer. But now, their engineered brethren can live about 82 percent longer. Engineered yeast live longer than their “normal” brethren. From Zhang et al.

Vaccine 52

Vaccine DNA Engineering RNA 52

Codon

APRIL 30, 2023

Read more at Nature Biotechnology ( Similar paper at Nature Biomedical Engineering.) But now, their engineered brethren can live about 82 percent longer. But now, their engineered brethren can live about 82 percent longer. Engineered yeast live longer than their “normal” brethren. From Zhang et al.

Vaccine 52

Vaccine DNA Engineering RNA 52

PLOS: DNA Science

JANUARY 4, 2024

.” CRISPRs are short DNA sequences, peppered with repeats, that latch onto DNA-cutting enzymes, commandeering and directing them to snip certain parts of a chromosome. The microbes deploy them to dismantle the genetic material of infecting viruses, a little like an immune response. What’s Next?

FDA Approval 52

FDA Approval DNA Therapies Clinical Trials 52

Codon

JULY 27, 2023

They’ve just finished sequencing the patient’s genome, but they don’t have “DNA sorting” software. billion units of DNA code are transcribed into more than a hundred volumes, each a thousand pages long, in type so small as to be barely legible.” At least, that’s what every textbook says.

Therapies 52

Therapies RNA DNA Engineering 52

Codon

JULY 27, 2023

They’ve just finished sequencing the patient’s genome, but they don’t have “DNA sorting” software. billion units of DNA code are transcribed into more than a hundred volumes, each a thousand pages long, in type so small as to be barely legible.” At least, that’s what every textbook says.

Therapies 52

Therapies RNA DNA Engineering 52

Drug Target Review

DECEMBER 5, 2024

2 Structure and function of AAV capsids in gene therapy Wild-type AAV is composed of a protein shell (capsid) that contains a single-stranded DNA genome encoding proteins involved in viral replication, structure and assembly. Therefore, vectors based on these serotypes may enable targeted gene delivery and optimal transduction efficiency.

Therapies 52

Therapies Virus DNA Compliance 52

Drug Target Review

DECEMBER 13, 2024

Engineering sites on the antibody to enable specific and consistent attachment of the cytotoxic drug to achieve an optimal drug-to-antibody ratio (DAR). Innovations in payload substances, such as topoisomerase inhibitors (topo-1i), and next-generation DNA- damaging agents to replace older, more toxic agents.

Therapies 98

Therapies Treatment Clinical Trials Drugs 98

Drug Target Review

JANUARY 9, 2024

Dr Levin explained: “It is fascinating and completely unexpected that normal patient tracheal cells, without modifying their DNA, can move on their own and encourage neuron growth across a region of damage.” He continued: “We’re now looking at how the healing mechanism works, and asking what else these constructs can do.”

Laboratories 59

Laboratories Immune Response DNA Science 59

Codon

APRIL 9, 2023

LanzaTech announced a partnership with H&M Move to convert factory carbon emissions into fabrics using engineered microbes. Sponge cells double in population quite quickly — around 40 minutes — and could be engineered to manufacture drugs. Read Biological Engineering *Self-healable spider dragline silk materials.

Therapies 52

Therapies RNA Engineering Vaccine 52

The Pharma Data

DECEMBER 27, 2020

It is a selective modulator of neuropilin-2 that downregulates the innate and adaptive immune response in inflammatory diseases. platform and its large-capacity VV Cop TK”RR” oncolytic virus, engineered to encode both a Treg-depleting human recombinant anti-CTLA4 antibody generated by BioInvent’s n-CoDeR/F.I.R.S.T.

Trials 52

Trials Clinical Trials Therapies RNA 52

DrugBank

FEBRUARY 26, 2025

Targeting Novel Bacterial Pathways Traditional antibiotics often target essential bacterial processes such as cell wall synthesis or DNA replication. Advances in genetic engineering have enabled researchers to enhance bacteriophage efficacy and overcome bacterial resistance mechanisms.

Therapies 52

Therapies Pharmaceutical Companies Pharmacokinetics Treatment 52

The Pharma Data

OCTOBER 14, 2020

(Nasdaq: TNXP) (Tonix or the Company), a clinical-stage biopharmaceutical company, today announced that the first participant was enrolled in the observational PRECISION study (TNX-C002), to examine the immune responses to COVID-19 in healthy volunteers who have recovered from COVID-19 or were asymptomatic.

Vaccine 40

Vaccine Pharmaceuticals Small Molecule Virus 40

Codon

APRIL 2, 2024

in physics at Princeton University, he had a remarkable idea: What if it were possible to build a circuit out of DNA, rather than electronics, and use it to “program” a living cell? In 1997, as Michael Elowitz was studying for a Ph.D. Elowitz had created cells that acted as living oscillators. Another one is immunogenicity.

RNA 56

RNA Engineering Molecular Biology Synthetic Chemistry 56

The Pharma Data

AUGUST 3, 2021

whose proprietary peptide- and protein-engineering platform is used to identify and synthesize molecules that can sense glucose or other endogenous modulators of protein activity. The company announced the acquisition of Protomer Technologies Inc., Loxo Oncology at Lilly and Kumquat Biosciences Inc.

Production 52

Production Marketing Research DNA 52

Agency IQ

APRIL 12, 2024

For therapeutic protein products , a critical use of assays is the detection and assessment of potential anti-drug antibody (ADA) formation, signaling a product’s potential to induce an unwanted immune response. Additionally, six of these comments came from the same organization (Integrated DNA Technologies).

Production 40

Production FDA Therapies Biochemical Assays 40

Codon

MARCH 26, 2023

Link A DNA tumor virus globally reprograms host 3D genome architecture to achieve immortal growth. Link Biological Engineering *Photosynthesis re-wired on the pico-second timescale. Link DNA storage in thermoresponsive microcapsules for repeated random multiplexed data access. Metabolic Engineering. Metabolic Engineering.

DNA 52

DNA Engineering RNA Science 52

Broad Institute

JANUARY 9, 2025

Scientists engineer CRISPR enzymes that evade the immune system By Allessandra DiCorato January 9, 2025 Breadcrumb Home Scientists engineer CRISPR enzymes that evade the immune system The new genome-editing tools could lead to safer, more efficient gene therapies.

Engineering 140

Engineering Immune Response Therapies DNA 140

Codon

OCTOBER 27, 2024

Archaeologists have found evidence of ancient Egyptian mummies carrying the pathogen’s DNA , including some that had developed Pott’s disease — a bending of the spine brought on by TB spreading to bones. Interferon gamma release assays pick up an immune response to the infection. The current lineage of M.

Immune Response 89

Immune Response Doctors Disease Laboratories 89

Drug Target Review

DECEMBER 11, 2024

Discovering and optimising potent therapeutics that direct the immune response against these targets. This requires a deep understanding of how the key components of the immune system – antibodies and TCRs – recognise and interact with their targets on cancer cells. Nature Reviews Drug Discovery. Science Advances.

Immune Response 52

Immune Response Engineering Therapies Small Molecule 52

Drug Target Review

DECEMBER 12, 2024

Aside from the ethical questions they raise, ESCs are in limited supply and are generally recognised as foreign by the recipient patients immune system. This can trigger an immune response that causes the body to reject these therapeutic cells.

Therapies 59

Therapies DNA Molecular Biology Immune Response 59

Codon

APRIL 16, 2023

Codon Digest is my weekly roundup of research, news, and industry highlights about engineered biology. Skin microbes can trigger strong immune responses. In other words: Brush some engineered bacteria on the skin, and they activate the immune system to go fight a tumor. Please send me your feedback.

Engineering 52

Engineering DNA RNA Science 52

Codon

APRIL 23, 2023

Unfortunately, they can also trigger immune responses, and they are not super efficient at gene-editing some parts of the brain. These ribonucleoproteins also caused a lower immune response compared to the viruses, and are much easier to make in the lab. in Nature Biomedical Engineering. Ming Li et al. in bioRxiv.

Vaccine 52

Vaccine DNA Virus Engineering 52