Broad Institute

JUNE 27, 2024

By Greta Friar, Whitehead Institute June 27, 2024 Images of a mouse brain show the effect of a technology called CHARM in turning off the expression of a gene in the brain. Previous research has shown that as little as 21 percent elimination of the protein can improve symptoms. Credit: Neumann EN, Bertozzi TM, et al.

Disease 142

Disease Therapies Engineering Clinical Trials 142

Codon

DECEMBER 10, 2023

A zoologist, ecologist, and protein engineer all call themselves “biologists,” but rarely attend the same conferences. Such a model would make it possible to discover protein functions by scraping metagenomic databases , or to create proteins with functions that exist nowhere in nature.

Protein Expression 88

Protein Expression DNA Laboratories Engineering 88

Drug Target Review

JULY 5, 2023

This selectable marker enables the identification of cells which have taken up the GOIs and aids the initial selection of recombinant protein expressing cell lines. They work in the following way: the genes in an expression vector are flanked by inverted terminal repeat sequences (ITRs) to which a specific transposase enzyme can bind.

Engineering 105

Engineering DNA Laboratories Production 105

Codon

DECEMBER 10, 2023

A zoologist, ecologist, and protein engineer all call themselves “biologists,” but rarely attend the same conferences. Such a model would make it possible to discover protein functions by scraping metagenomic databases , or to create proteins with functions that exist nowhere in nature.

Protein Expression 69

Protein Expression DNA Laboratories Engineering 69

Drug Target Review

MAY 22, 2024

What are the key findings of Circio’s in vivo proof-of-concept for its circVec circular RNA platform technology compared to conventional mRNA-based expression with DNA vectors? Circular RNA (circRNA) has two major advantages versus mRNA in a vector-expression context. DNA vectors in mouse models?

Therapies 59

Therapies RNA Protein Expression DNA 59

Codon

APRIL 9, 2023

LanzaTech announced a partnership with H&M Move to convert factory carbon emissions into fabrics using engineered microbes. Sponge cells double in population quite quickly — around 40 minutes — and could be engineered to manufacture drugs. Read Biological Engineering *Self-healable spider dragline silk materials.

Therapies 52

Therapies RNA Engineering Vaccine 52

Drug Target Review

SEPTEMBER 10, 2024

The current landscape of protein drug development is characterised by accelerated timelines where new drugs are approved in months rather than years. For example, advances in media and feeds have contributed to higher cell protein expression by optimising nutrient availability and reducing accumulation of waste products within a culture.

Drug Development 64

Drug Development Clinical Supply Production Protein Expression 64