Drug Target Review

MAY 22, 2024

What are the key findings of Circio’s in vivo proof-of-concept for its circVec circular RNA platform technology compared to conventional mRNA-based expression with DNA vectors? Circular RNA (circRNA) has two major advantages versus mRNA in a vector-expression context. DNA vectors in mouse models?

Therapies 59

Therapies RNA Protein Expression DNA 59

Broad Institute

JUNE 27, 2024

By Greta Friar, Whitehead Institute June 27, 2024 Images of a mouse brain show the effect of a technology called CHARM in turning off the expression of a gene in the brain. Previous research has shown that as little as 21 percent elimination of the protein can improve symptoms. Credit: Neumann EN, Bertozzi TM, et al.

Disease 142

Disease Therapies Engineering Clinical Trials 142

Drug Discovery World

NOVEMBER 9, 2023

Ahead of protein and antibody engineering conference PEGS Europe 2024 in Lisbon, DDW’s Megan Thomas looks at what to expect from each track of the annual biologics technology meeting. Klaus Wagenbauer, PhD, Founder & CEO, Plectonic, on: ‘Programmable DNA-origami-based T cell engagers: PTE’.

Engineering 130

Engineering Therapies Protein Production Science 130

Drug Discovery World

NOVEMBER 30, 2023

This presentation covered three primary drivers for a protein expression model: speed, cost and sustainability. “It Sphere Fluidics presence on the exhibition floor was bolstered by a presentation from Richard Hammond: ‘Picodroplets for cell Line engineering: A novel automation approach’.

Protein Expression 147

Protein Expression Engineering DNA Therapies 147

Codon

DECEMBER 10, 2023

A zoologist, ecologist, and protein engineer all call themselves “biologists,” but rarely attend the same conferences. Such a model would make it possible to discover protein functions by scraping metagenomic databases , or to create proteins with functions that exist nowhere in nature.

Protein Expression 95

Protein Expression DNA Laboratories Engineering 95

Drug Discovery World

NOVEMBER 13, 2023

Ahead of protein and antibody engineering conference PEGS Europe 2024 in Lisbon, DDW’s Megan Thomas looks at what to expect from each track of the annual biologics technology meeting. Ali Madani, PhD, Founder and CEO, Profluent Bio, on: ‘Protein engineering with large language models’.

Engineering 147

Engineering Science Bioinformatics Vaccine 147

Codon

DECEMBER 10, 2023

A zoologist, ecologist, and protein engineer all call themselves “biologists,” but rarely attend the same conferences. Such a model would make it possible to discover protein functions by scraping metagenomic databases , or to create proteins with functions that exist nowhere in nature.

Protein Expression 71

Protein Expression DNA Laboratories Engineering 71