Drug Target Review

APRIL 16, 2024

By delivering radiation directly to the tumour cells, RLT can induce DNA damage, leading to cell death and tumour regression. Peptides are relatively small molecules compared to mAbs, making them easier and less costly to produce and modulate. In contrast, development of mAbs is typically resource intensive.

Small Molecule 59

Small Molecule Therapies Treatment Pharmaceutical Companies 59

Dark Matter Blog

AUGUST 31, 2020

The majority of small molecule drugs induce their therapeutic effects by seeking out and binding to their intended target while avoiding most other molecules in the dense milieu of the cell interior. Our overall mission at Arrakis is to expand the set of “druggable” targets for small-molecule medicines to include RNA.

RNA 52

RNA Small Molecule Bioinformatics Computational Chemistry 52

Codon

MARCH 20, 2023

🧪 Papers AI + Bio Protein-specific signal peptides for mammalian vector engineering. Biological Engineering Generation of functional oocytes from male mice in vitro. Marine biofilm engineered to produce current in response to small molecules. Metabolic Engineering. Metabolic Engineering.

Virus 52

Virus Engineering RNA Small Molecule 52

Codon

APRIL 2, 2023

This is Codon Digest, a weekly roundup of research papers, news articles, and industry highlights about engineered biology. But now, by studying DNA extracted from microbes in the blood of almost 10,000 healthy people, this paper shows that there is no such thing. Read Transcription factors bind to DNA and control gene expression.

DNA 52

DNA RNA Engineering Licensing 52

Codon

MAY 30, 2023

Codon Digest is my weekly roundup of research, news, and industry highlights about engineered biology. This week: A way to measure a transgene’s expression in the brain using ultrasound, a DNA sequencing method that uses 1000x less reagents, and base editors get even smaller. Please send me your feedback. Thanks for reading.

DNA 52

DNA RNA Engineering Vaccine 52

Codon

MAY 30, 2023

Codon Digest is my weekly roundup of research, news, and industry highlights about engineered biology. This week: A way to measure a transgene’s expression in the brain using ultrasound, a DNA sequencing method that uses 1000x less reagents, and base editors get even smaller. Please send me your feedback. Thanks for reading.

DNA 52

DNA RNA Engineering Vaccine 52

Nvidia Developer: Drug Discovery

MARCH 21, 2023

New supercomputing-scale large language models (LLMs) that understand biology and chemistry text are helping scientists understand proteins, small molecules, DNA, and biomedical text. These state-of-the-art AI models help generate de novo proteins and molecules and predict the 3D structures of proteins.

Small Molecule 52

Small Molecule Drugs Clinical Trials DNA 52

Codon

DECEMBER 12, 2024

DNA and RNA molecules are also built from exclusively right-handed nucleic acids. Glucose is a chiral molecule because its structure allows for two distinct configurations, or enantiomers, which cannot be superimposed on each other. The mirrored enzyme seamlessly transcribed 2,900 bases of mirrored DNA into mirrored RNA.

RNA 102

RNA DNA Vaccine Virus 102

LifeSciVC

DECEMBER 6, 2022

These hair clip-like molecules clamp onto DNA, thereby turning many genes on and off. As Darnell observed, the prospect of being able to regulate Transcription Factor function holds the potential to reframe the way we treat disease but achieving that goal with traditional small molecule screening approaches is impossible.

Small Molecule 40

Small Molecule DNA Regulations Science 40

Codon

APRIL 30, 2023

Read more at Nature Biotechnology ( Similar paper at Nature Biomedical Engineering.) But now, their engineered brethren can live about 82 percent longer. But now, their engineered brethren can live about 82 percent longer. Engineered yeast live longer than their “normal” brethren. From Zhang et al.

Vaccine 52

Vaccine DNA Engineering RNA 52

Codon

APRIL 30, 2023

Read more at Nature Biotechnology ( Similar paper at Nature Biomedical Engineering.) But now, their engineered brethren can live about 82 percent longer. But now, their engineered brethren can live about 82 percent longer. Engineered yeast live longer than their “normal” brethren. From Zhang et al.

Vaccine 52

Vaccine DNA Engineering RNA 52

Drug Target Review

DECEMBER 13, 2024

Engineering sites on the antibody to enable specific and consistent attachment of the cytotoxic drug to achieve an optimal drug-to-antibody ratio (DAR). Innovations in payload substances, such as topoisomerase inhibitors (topo-1i), and next-generation DNA- damaging agents to replace older, more toxic agents.

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Therapies Treatment Clinical Trials Drugs 98

The Pharma Data

DECEMBER 14, 2020

engine along with algorithms tuned to predict BBB permeability played an important role in helping determine which CNS cancers and which genomically-defined subtypes of CNS cancer should be prioritized for development. . Many drugs fail in clinical trials because of their low blood brain barrier permeability. Lantern’s A.I.

Clinical Trials 52

Clinical Trials DNA Drugs Therapies 52

DrugBank

JANUARY 9, 2025

In contrast, targeted therapies are engineered to exploit specific vulnerabilities in cancer cells, such as oncogenic mutations or irregular signaling pathways. This targeted therapy is a small molecule inhibitor of the BCR-ABL tyrosine kinase, the oncogenic driver of CML.

Therapies 52

Therapies Disease Treatment Small Molecule 52

The Pharma Data

OCTOBER 14, 2020

Assistant Professor of Medical Sciences at Columbia University Vagelos College of Physicians and Surgeons, is designed to generate DNA aptamer-based anti-idiotypes to selected monoclonal antibodies identified in Dr. Ilya Trakht’s study. The study led by Dr. Sergei Rudchenko, Ph.D., 1 Noyce RS, et al. 2018) PLoS One. 13(1):e0188453.

Vaccine 40

Vaccine Pharmaceuticals Small Molecule Virus 40

The Pharma Data

DECEMBER 27, 2020

platform and its large-capacity VV Cop TK”RR” oncolytic virus, engineered to encode both a Treg-depleting human recombinant anti-CTLA4 antibody generated by BioInvent’s n-CoDeR/F.I.R.S.T. Avacopan is an oral small molecule selective inhibitor of the complement C5a receptor Cf1R1. platforms and the human GM-CSF cytokine.

Trials 52

Trials Clinical Trials Therapies RNA 52

DrugBank

FEBRUARY 26, 2025

Targeting Novel Bacterial Pathways Traditional antibiotics often target essential bacterial processes such as cell wall synthesis or DNA replication. Advances in genetic engineering have enabled researchers to enhance bacteriophage efficacy and overcome bacterial resistance mechanisms.

Therapies 52

Therapies Pharmaceutical Companies Pharmacokinetics Treatment 52

Elrig

APRIL 29, 2024

Srinivasan has led the development of multiple computational pipelines to process data from different next generation sequencing techniques with applications in oncology, genome editing systems including CRISPR-Cas mediated DNA editing, and ADAR-mediated RNA editing. There, I supported AI-enabled DD efforts in their small molecule portfolio.

Bioinformatics 59

Bioinformatics Drugs Molecular Biology Cell Based Assays 59

Alta Sciences

APRIL 17, 2024

Several viral vectors are being used currently, in addition to non-viral vectors, such as oligonucleotides, naked DNA, and lipoplexes and polyplexes. Several small molecule GLP-1R agonists, such as oral orforglipron, are in late-stage clinical development. Asia, and Europe.

Drug Development 52

Drug Development Treatment FDA Approval Drugs 52

The Pharma Data

AUGUST 3, 2021

whose proprietary peptide- and protein-engineering platform is used to identify and synthesize molecules that can sense glucose or other endogenous modulators of protein activity. The company announced the acquisition of Protomer Technologies Inc., Loxo Oncology at Lilly and Kumquat Biosciences Inc.

Production 52

Production Marketing Research Treatment 52

Codon

MARCH 26, 2023

Link A DNA tumor virus globally reprograms host 3D genome architecture to achieve immortal growth. Link Biological Engineering *Photosynthesis re-wired on the pico-second timescale. Link Biological Engineering *Photosynthesis re-wired on the pico-second timescale. Metabolic Engineering. Metabolic Engineering.

DNA 52

DNA Engineering RNA Science 52

Codon

FEBRUARY 16, 2025

Synthetic biologists have recently designed interacting protein clusters that act as neural networks inside living cells, gene circuits that can switch between OR and AND logic gates based on small molecule triggers , and even programmed a community of cells to execute a hashing function widely used in cryptography.

DNA 80

DNA RNA Engineering Small Molecule 80

Drug Target Review

DECEMBER 11, 2024

An alternative and potentially more effective strategy is to start from a position of success, by studying the immune systems of cancer survivors and reverse-engineer the immune responses that led to remissiona method known as de-orphanization. TCR-engineered T cell therapy in solid tumors: State of the art and perspectives.

Immune Response 52

Immune Response Engineering Therapies Small Molecule 52

Codon

APRIL 16, 2023

Codon Digest is my weekly roundup of research, news, and industry highlights about engineered biology. These microbes were engineered to express tumor antigens that could “elicit T cells that were licensed by the commensal immune program but specific for a tumor,” including both CD4+ and CD8+ T cells, according to the study.

Engineering 52

Engineering DNA RNA Science 52