Drug Discovery World

AUGUST 21, 2024

While many different modalities of delivery vectors exist, the two most common viral vectors are lentivirus and adeno-associated virus. The composition of engineered cells in vivo can change over time as clones proliferate at varying rates. The enriched DNA is then sequenced.

Therapies 147

Therapies Bioinformatics DNA FDA 147

Drug Discovery World

MAY 16, 2023

New South African company NewBiologix has launched with the aim of developing a proprietary and breakthrough platform for the advanced engineering of cell lines used to manufacture gene and cell therapies. NewBiologix is currently focused on recombinant adeno-associated virus (rAAV) vectors, the preferred delivery vehicle for gene therapies.

Production 130

Production Bioinformatics Therapies Virus 130

Broad Institute

AUGUST 31, 2023

Now researchers at the Broad Institute of MIT and Harvard have used cutting-edge continuous laboratory evolution and engineering methods to develop improved versions of the gene-editing tool. Reverse transcriptase proteins that copy RNA templates into strands of DNA are found naturally in all plant and animal cells and in many viruses.

DNA 145

DNA Engineering RNA Laboratories 145

Drug Target Review

OCTOBER 26, 2023

Genome engineering and gene therapies that manipulate DNA sequences in cells have driven a biotechnological revolution over the past decade. 1 Adeno-associated virus (AAV) vectors are the leading platform for in vivo gene delivery for the treatment of various human diseases. His mentorship produced numerous publications.

Engineering 105

Engineering Virus Therapies Immune Response 105

PLOS: DNA Science

JUNE 13, 2024

The virus SARS-CoV-2 emerged in Wuhan, home of a premiere research institute that focuses on viruses. Experiments at the Wuhan facility were done at the lowest two of the four standard biosafety levels, which were established at the dawn of recombinant DNA research in the 1970s. An altered virus could have escaped. Coincidence?

Virus 52

Virus RNA DNA Science 52

Drug Discovery World

AUGUST 14, 2023

When working with adeno-associated virus (AAV) vectors – an engineered technology and the most common platform for gene delivery – the FDA requires specific information on the percentage of empty capsids from the AAV or capsids that might have other sequences in them.

Marketing 130

Marketing DNA Therapies FDA 130

Broad Institute

JULY 11, 2024

Targeted drug treatment leads tumor cells to imitate viral infection By Ari Navetta July 11, 2024 Breadcrumb Home Targeted drug treatment leads tumor cells to imitate viral infection Exploiting "viral mimicry," mIDH1 inhibitors trick tumors into thinking they are infected with a virus.

Treatment 72

Treatment Immune Response Virus Drugs 72

Drug Discovery World

FEBRUARY 28, 2024

Using a technique they’ve dubbed ‘cancer shredding’, the researchers at Gladstone Institutes, California, programmed CRISPR to zero-in on repeating DNA sequences present only in recurrent tumour cells – and then obliterate those cells by snipping away at them. expressing cancers.

Drug Development 162

Drug Development Research Clinical Trials Drugs 162

Drug Discovery World

NOVEMBER 17, 2022

The rapidly growing area of synthetic biology – including molecular biology, biotechnology, biophysics, and genetic engineering – is having a marked impact on the drug discovery landscape. In the UK, work being carried out at Imperial College 4 has seen the engineering of designer cells which could help advance treatment for disease. .

Engineering 130

Engineering Molecular Biology Synthetic Chemistry DNA 130

Codon

AUGUST 28, 2024

Tessa Alexanian and Max Langenkamp build computational DNA screening tools for a living. But today, rapid advances in DNA synthesis have made it possible for would-be bioterrorists to make pathogens, rather than buy them. government must order synthetic DNA from providers who publicly state that they follow the U.S.

DNA 85

DNA Bioinformatics Virus Government 85

Drug Discovery World

FEBRUARY 6, 2024

Researchers from the University of Oslo, University of Chicago Pritzker School of Medicine, and Insilico Medicine used an AI target discovery engine to analyse transcriptomic data to identify dual targets for cancer and ageing 5. Digital tech is also helping researchers to find target candidates for some of the most challenging disease areas.

Marketing 173

Marketing Laboratories Engineering Clinical Trials 173

Drug Discovery World

JANUARY 21, 2024

Accelerating biotherapeutics development through technology platforms Anubhav Tripathi is a Professor of Medical Science and Engineering at Brown University. At Brown, Tripathi’s research group develops biotechnology platforms by integrating biological and engineering principles.

Vaccine 130

Vaccine Computational Chemistry Animal Testing Engineering 130

PLOS: DNA Science

OCTOBER 12, 2023

million DNA bases. The DMD gene therapy delivers a shortened version of the dystrophin gene, just 4,558 DNA bases. First, adeno-associated virus (AAV) delivers the genes, rather than the adenovirus (AV) that had entered cells in Jesse’s liver that weren’t the targets. Two other design strategies add precision.

Therapies 69

Therapies Immune Response DNA Virus 69

Codon

MAY 18, 2023

shelves, it’s easy to find DNA in the air , and some weird insect cybernetics. And the article doesn’t mention how Pairwise engineered the mustard to be “less pungent.” 2/ Your DNA is Everywhere. ” DNA from the air gave the longest reads. ” DNA from the air gave the longest reads.

DNA 52

DNA Engineering Therapies Virus 52

Codon

MAY 18, 2023

shelves, it’s easy to find DNA in the air , and some weird insect cybernetics. And the article doesn’t mention how Pairwise engineered the mustard to be “less pungent.” 2/ Your DNA is Everywhere. ” DNA from the air gave the longest reads. ” DNA from the air gave the longest reads.

DNA 52

DNA Engineering Therapies Virus 52

Drug Target Review

DECEMBER 28, 2023

During the process of transformation from a normal cell into a cancer cell, a cell acquires a series of changes, or mutations, in its DNA. But DNA mutations can also result in changes to the proteins that are displayed on the surface of the cancer cell. Our immune system helps us to fight off infections and cancer.

Bioinformatics 105

Bioinformatics Immune Response DNA Vaccine 105

Broad Institute

AUGUST 7, 2023

STING is primarily on the lookout for DNA, which can indicate either a foreign invader such as a virus or damage to the host tissue or cell. Paul Blainey , the Karl Van Tassel Associate Professor of Biological Engineering at MIT, a core institute member of Broad, and a member of the Koch Institute, is also an author of the paper.

Regulations 91

Regulations Engineering Clinical Trials DNA 91

Drug Discovery World

FEBRUARY 14, 2024

While a typical chemisty, manufacturing and controls (CMC) timeline from DNA to Investigational New Drug (IND) application in 2015 would have been approximately 24 months, by 2023 the same pathway was expected to take only 10 months. This would give more people much faster access to more effective vaccines.

Vaccine 147

Vaccine Production Virus DNA 147

Drug Discovery World

APRIL 15, 2023

As such, Codagenix has previously demonstrated that CodaLytic, a codon-modified influenza virus, can kickstart the cancer immunity cycle at various steps in several mouse models with differing baseline immune contextures.

Virus 130

Virus Clinical Trials Trials Therapies 130

Broad Institute

JANUARY 8, 2024

Williams January 8, 2024 Credit: Susanna Hamilton, Broad Communications Researchers have developed virus-like particles that can deliver gene-editing cargo to cells, including those in the mouse brain. Prime editing, described in 2019 by Liu’s group, can make longer and more diverse types of DNA changes than other types of editing.

Engineering 144

Engineering Research Virus DNA 144

DrugBank

JUNE 13, 2024

These microscopic particles, which are smaller than 100 nanometers, can be engineered to deliver drugs to specific targets with precision. This approach targets the fundamental instructions within a cell's DNA, either by correcting faulty genes or introducing entirely new ones to combat disease.

Therapies 76

Therapies Drugs DNA Treatment 76

Drug Discovery World

AUGUST 13, 2024

In this webinar, Professor Susumu Uchiyama, Department of Biotechnology, Graduate School of Engineering, Osaka University, will present his work around adeno-associated virus (AAV) characterisation using cryo-electron microscopy.

Virus 130

Virus Therapies DNA Clinical Trials 130

Drug Target Review

MAY 22, 2024

What are the key findings of Circio’s in vivo proof-of-concept for its circVec circular RNA platform technology compared to conventional mRNA-based expression with DNA vectors? DNA vectors in mouse models? Circular RNA (circRNA) has two major advantages versus mRNA in a vector-expression context.

Therapies 59

Therapies RNA Protein Expression DNA 59

PLOS: DNA Science

JANUARY 4, 2024

” CRISPRs are short DNA sequences, peppered with repeats, that latch onto DNA-cutting enzymes, commandeering and directing them to snip certain parts of a chromosome. Unlike gene therapy as originally-envisioned since the 1950s, which adds a functioning copy of a gene, CRISPR can add, remove, or replace a DNA sequence.

FDA Approval 52

FDA Approval DNA Clinical Trials Therapies 52

Codon

MAY 11, 2023

Scroll to the end for a beautiful chart about the Anthropocene & some details on insect engineering companies. It is used to prevent respiratory syncytial virus, or RSV, which causes about 60,000 hospitalizations in this age group each year. There are many other up-and-coming insect engineering startups. Let’s dive in.

Vaccine 52

Vaccine Engineering Licensing Licensing 52

Codon

MAY 11, 2023

Scroll to the end for a beautiful chart about the Anthropocene & some details on insect engineering companies. It is used to prevent respiratory syncytial virus, or RSV, which causes about 60,000 hospitalizations in this age group each year. There are many other up-and-coming insect engineering startups. Let’s dive in.

Vaccine 52

Vaccine Engineering Licensing Licensing 52

Drug Discovery World

NOVEMBER 15, 2022

The brainchild of multidisciplinary experts in computer science, physics, engineering, and biology, the field of synthetic biology has not only rapidly progressed in the last few decades but it’s also becoming more accessible and cost-effective. Rapid and accurate DNA synthesis .

DNA 246

DNA Engineering Drugs Vaccine 246

Drug Discovery World

AUGUST 26, 2024

In a webinar on 5 September, Professor Susumu Uchiyama, Department of Biotechnology, Graduate School of Engineering, Osaka University, will present his work around adeno-associated virus (AAV) characterisation using cryo-electron microscopy. The event is hosted by DDW and supported by Thermo Fisher Scientific.

Virus 162

Virus DNA Clinical Trials Engineering 162

Drug Discovery World

SEPTEMBER 2, 2024

In a webinar on 5 September, Professor Susumu Uchiyama, Department of Biotechnology, Graduate School of Engineering, Osaka University, will present his work around adeno-associated virus (AAV) characterisation using cryo-electron microscopy. The event is hosted by DDW and supported by Thermo Fisher Scientific.

Virus 130

Virus DNA Clinical Trials Engineering 130

Drug Discovery World

SEPTEMBER 6, 2022

The mysteries of cancer are starting to yield to the range of advanced therapies available and cell therapies – especially engineered cell therapies – are at the leading edge of that progress.” – Carlo Russo, CEO of Genenta.? . “In That may not be the ideal starting point for cell therapies that tailor a patient’s own cells.”

Therapies 130

Therapies Clinical Trials Vaccine Disease 130

Drug Discovery World

AUGUST 19, 2024

In a webinar on 5 September, Professor Susumu Uchiyama, Department of Biotechnology, Graduate School of Engineering, Osaka University, will present his work around adeno-associated virus (AAV) characterisation using cryo-electron microscopy. The event is hosted by DDW and supported by Thermo Fisher Scientific.

Virus 130

Virus DNA Clinical Trials Engineering 130

The Pharma Data

OCTOBER 19, 2020

The company’s suite of market-leading molecular profiling offerings assesses DNA, RNA and proteins to reveal a molecular blueprint that helps physicians and cancer patients make more precise and personalized treatment decisions.

Clinical Trials 52

Clinical Trials RNA DNA Science 52

Broad Institute

JUNE 27, 2024

Unlike gene editing, this “epigenetic” editing does not modify the underlying DNA sequence, but it should switch the gene off permanently, which means that this could be a one-time treatment. They used an engineered adeno-associated virus (AAV) that crosses the blood-brain barrier after intravenous administration.

Disease 142

Disease Therapies Engineering Clinical Trials 142

Codon

JUNE 11, 2024

And unlike traditional DNA sequencers, which parse genetic material by breaking it up into fragments and interpreting it chunk-by-chunk, a nanopore device unspools a long strand of DNA and reads it all at once. A scientist can isolate DNA and load up a flow cell in fifteen minutes. Nanopore devices work incredibly fast.

DNA 77

DNA Engineering RNA Small Molecule 77

Drug Target Review

SEPTEMBER 28, 2023

After some time in that role and launching several products, I received a call from Bill Banyai and Bill Peck, or ‘The Bills’ as we call them, who were building a company around technology that creates DNA by ‘writing’ it on a silicon chip. Because I was put into the highest tier, I was automatically mapped to the engineering track.

DNA 116

DNA Organic Chemistry Science Virus 116

Drug Target Review

JANUARY 15, 2024

Each T cell expresses a TCR specific for an HLA‑presented peptide signal, and when that signal is detected a T cell expressing the relevant TCR can launch a complex array of immune effector responses that can suppress or destroy tumours or virus-infected cells.

Engineering 110

Engineering DNA Virus Medical Schools 110

NIH Director's Blog: Drug Development

JANUARY 5, 2016

The RNA is preprogrammed to find a distinct short sequence of DNA and deliver the enzyme, which acts like a scalpel to slice the sequence out of the genome. The study raised ethical concerns that science was fast approaching a red line of engineering human life. It’s fast and pretty precise. deaths from unintentional overdoses.

Vaccine 52

Vaccine Science Engineering Disease 52