DrugBank

FEBRUARY 26, 2025

Targeting Novel Bacterial Pathways Traditional antibiotics often target essential bacterial processes such as cell wall synthesis or DNA replication. Immunomodulatory therapies, which enhance the host immune response to infections, are also being investigated as adjunctive treatments.

Therapies 52

Therapies Pharmaceutical Companies Pharmacokinetics Treatment 52

The Pharma Data

AUGUST 3, 2021

announced an exclusive collaboration focused on the discovery, development and commercialization of potential novel small molecules that stimulate tumor-specific immune responses. As part of Lilly’s response to the COVID-19 pandemic, and at the request of U.S. Loxo Oncology at Lilly and Kumquat Biosciences Inc.

Production 52

Production Marketing Research DNA 52

Codon

JULY 27, 2023

They’ve just finished sequencing the patient’s genome, but they don’t have “DNA sorting” software. billion units of DNA code are transcribed into more than a hundred volumes, each a thousand pages long, in type so small as to be barely legible.” In response, the U.S. Later, the U.S.

Therapies 52

Therapies RNA DNA Engineering 52

Codon

JULY 27, 2023

They’ve just finished sequencing the patient’s genome, but they don’t have “DNA sorting” software. billion units of DNA code are transcribed into more than a hundred volumes, each a thousand pages long, in type so small as to be barely legible.” In response, the U.S. Later, the U.S.

Therapies 52

Therapies RNA DNA Engineering 52

Codon

SEPTEMBER 29, 2024

mRNA was the intermediate stage between DNA and protein, a dynamic entity that shifted depending on the second-to-second needs of the cell, able to point out if a cell was cancerous or stressed, what kind of cell it was, and so on. Collections of mRNA have been understood as a proxy for cell states for decades.

Engineering 142

Engineering Virus DNA Therapies 142

Codon

APRIL 9, 2023

Thousands of transcription factors — proteins that bind DNA and control gene expression — were studied in human cells. Read DNA Sequencing & Synthesis *Quantitative analysis of tRNA abundance and modifications by nanopore RNA sequencing. Bergs A.C.F. Nature Communications. Porta-de-la-Riva M. Nature Methods.

Therapies 52

Therapies RNA Engineering Vaccine 52

Codon

AUGUST 27, 2024

Allison Berke makes the case for real-time DNA sequencing and AI tools to detect pathogens before they spread widely. Reading DNA The first step in detecting a novel pathogen is recognizing it as an anomaly amidst a noisy background of other material. After copying the DNA to form a big pool, each piece is sequenced.

DNA 102

DNA Laboratories Hospitals Virus 102

PLOS: DNA Science

MAY 16, 2024

Many of the links below are to some of the 100+ DNA Science posts that I wrote during the pandemic. The government recently evicted him from his lab, part of the crackdown on anything having to do with the “lab leak” hypothesis. • identifies parts of the virus to target to provoke an immune response from a vaccine.

Virus 98

Virus DNA RNA Vaccine 98

Broad Institute

JANUARY 9, 2025

Researchers at the Broad Institute of MIT and Harvard and Cyrus Biotechnology have now engineered two CRISPR nucleases, Cas9 and Cas12, to mask them from the immune system. The team identified protein sequences on each nuclease that trigger the immune system and used computational modeling to design new versions that evade immune recognition.

Engineering 140

Engineering Immune Response Therapies DNA 140

Codon

DECEMBER 12, 2024

DNA and RNA molecules are also built from exclusively right-handed nucleic acids. Across the tree of life, organisms strictly require exactly one of the two chiral forms of their molecular building blocks — amino acids, nucleotides of RNA and DNA. 4 As far as we know, right-handed proteins never occur naturally.

DNA 104

DNA RNA Vaccine Virus 104

PLOS: DNA Science

JULY 25, 2024

He also repeatedly distinguishes the roles of the NIH, CDC, and FDA, which flummoxed even top government officials during COVID. A virus that directly attacks the immune response presents a special challenge. Throughout, Dr. Fauci discusses his relationships with U.S. presidents and other leaders. Microbes know no boundaries.

Virus 96

Virus Science Vaccine Government 96