PLOS: DNA Science

JULY 27, 2023

Genomics applies to all species, revealing evolution in action, because we all use the same genetic code – that is, the correspondence between DNA sequences and the amino acid sequences of proteins. Cats and Bird Flu Comparing DNA sequences is a little like linguistic research that connects languages.

Disease 94

Disease DNA Virus RNA 94

Broad Institute

OCTOBER 3, 2024

Since URVs are so rare, and because the scientists wanted to understand many different types of epilepsy, the researchers analyzed DNA from people across the world with a range of different genetic ancestries to find meaningful signals. The study’s 54,000 participants included about 21,000 patients with epilepsy and 33,000 controls.

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DNA Doctors Treatment Disease 133

Broad Institute

OCTOBER 4, 2023

Related links Merkin Prize Inaugural Merkin Prize in Biomedical Technology awarded to Dr. Marvin Caruthers for developing technology that efficiently synthesizes DNA The inaugural Richard N. Caruthers was announced as the winner in June for his development, in 1981, of an efficient, automated technology for synthesizing DNA.

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DNA RNA Science Protein Expression 52

Codon

JUNE 11, 2024

And unlike traditional DNA sequencers, which parse genetic material by breaking it up into fragments and interpreting it chunk-by-chunk, a nanopore device unspools a long strand of DNA and reads it all at once. A scientist can isolate DNA and load up a flow cell in fifteen minutes. Nanopore devices work incredibly fast.

DNA 87

DNA Engineering RNA Small Molecule 87

Broad Institute

FEBRUARY 16, 2024

The way that clinicians subdivide diabetes patients now is based on symptoms, but in this study, the frequency of genetic risk factors seems to vary among patients with youth-onset T2D,” said Jason Flannick , Broad associate member and assistant professor at Boston Children’s Hospital and Harvard Medical School. “We

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Medical Schools Hospitals Disease DNA 133

Broad Institute

JUNE 1, 2023

“This is potentially an ideal use case for polygenic risk scores to refine risk assessment,” said Michael Honigberg , a co-first author on the study, associate member at the Broad, and a cardiologist at Massachusetts General Hospital.

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Doctors Medical Schools Hospitals DNA 133

Broad Institute

JUNE 28, 2023

Such large-scale changes in DNA have been difficult to study. Since the deleted or duplicated DNA regions involved in an aneuploidy can include hundreds or thousands of genes, pinning down any molecular mechanism by which an aneuploidy impacts tumor growth has been difficult.

DNA 122

DNA Medical Schools Treatment Research 122

Broad Institute

APRIL 2, 2024

Now, a team of researchers at the Broad Institute of MIT and Harvard along with Massachusetts General Hospital has found that microbes in the gut may affect cardiovascular disease as well. He is also a professor at Harvard Medical School and Massachusetts General Hospital.

Disease 145

Disease Medical Schools Hospitals DNA 145

PLOS: DNA Science

SEPTEMBER 7, 2023

As genetics morphed into genomics, artificial intelligence stepped in, layering the combinatorial information of comparative genomics onto DNA sequences. Train an algorithm on the DNA sequences of a known disease-causing gene, then search for identical or highly similar sequences in cells from other individuals to assist diagnosis.

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DNA Science Therapies Licensing 98

PLOS: DNA Science

NOVEMBER 30, 2023

The new cat study compared the DNA sequences of a gene commonly used in evolutionary investigations, to identify bacterial species residing in domestic feline anal glands. The post Why Cats Sniff Each Other’s Butts appeared first on DNA Science. I love when chemistry explains biology.

DNA 97

DNA Organic Chemistry Hospitals Science 97

Broad Institute

FEBRUARY 29, 2024

In the new microbes’ DNA, the researchers found hundreds of novel genes that may offer clues to how enterococci are able to resist antibiotic treatment and thrive in the hospital environment. Our findings may improve understanding of how resistance genes spread to hospital bacteria and threaten human health.”

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Hospitals Medical Schools International Research 116

Broad Institute

JULY 6, 2023

A new approach from a team led by researchers in the Cardiovascular Disease Initiative at the Broad Institute of MIT and Harvard and at Massachusetts General Hospital (MGH) significantly improves the accuracy of genetic risk prediction of heart disease across all ancestries. Paper cited: Patel A, et al.

Disease 97

Disease DNA Hospitals Medical Schools 97

Drug Target Review

DECEMBER 28, 2023

During the process of transformation from a normal cell into a cancer cell, a cell acquires a series of changes, or mutations, in its DNA. But DNA mutations can also result in changes to the proteins that are displayed on the surface of the cancer cell.

Bioinformatics 105

Bioinformatics Immune Response DNA Vaccine 105

Codon

AUGUST 26, 2024

One large-scale clinical trial found that it only reduces the relative risk of death by about ten percent in hospitalized patients. If we’re unlucky, however, our immune system goes into overdrive even as viral load subsides, causing damage to our lungs and sending us to the hospital. Unsubscribe any time.

RNA 102

RNA Virus DNA Vaccine 102

Broad Institute

AUGUST 14, 2023

In three new studies, researchers including a team from the Broad Institute of MIT and Harvard have harmonized and analyzed data on proteins, DNA, RNA, as well as clinical data from more than 1,000 patients across nearly a dozen different cancer types. Zamecnik Chair in Oncology at the Massachusetts General Hospital Cancer Center.

DNA 98

DNA RNA Regulations Treatment 98

Broad Institute

AUGUST 8, 2024

Postdoctoral scholar Shervin Tabrizi is a physician-scientist and postdoctoral scholar at the Gerstner Center for Cancer Diagnostics at the Broad Institute of MIT and Harvard, and a radiation oncologist at Massachusetts General Hospital. He is co-advised by Chris Love at the Koch Institute at MIT.

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Medical Schools Hospitals DNA Engineering 52

Codon

FEBRUARY 13, 2024

Regulators traditionally want to see a single, stable, well-characterized drug before giving the green light for it to be tested in a clinical trial, not dozens of different viruses; let alone ones that are best found in unappealing places like sewage , hospital waste, or bird poop. 4 But the same barriers still exist today.

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Therapies Virus DNA Clinical Trials 131

The Pharma Data

DECEMBER 23, 2020

” Dr. Stanley Plotkin , Professor Emeritus at The Wistar Institute, said, “INOVIO’s DNA vaccine appeared to be quite safe with few significant reactions but yet induced both antibody and T cell responses to SARS-CoV-2.” About INOVIO’s DNA Medicines Platform. mg and 2.0

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DNA Vaccine Clinical Trials Immune Response 40

PLOS: DNA Science

SEPTEMBER 5, 2024

After training, CHIEF was given more than 19,400 whole-slide images from 32 independent datasets, collected from 24 hospitals and patient cohorts from all over the planet. Analyzing DNA patterns using AI may replace time-consuming process DNA and genomic sequencing tests, Yu said. More information enables more treatment choices.

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Treatment FDA Approval DNA Small Molecule 70

Broad Institute

DECEMBER 13, 2023

One study was led by senior authors Evan Macosko , an institute member at the Broad and associate professor and attending psychiatrist at Massachusetts General Hospital, and Fei Chen , a core institute member at the Broad and an assistant professor in the Department of Stem Cell and Regenerative Biology at Harvard University.

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DNA Virus Research Engineering 140

DrugBank

JUNE 13, 2024

This approach targets the fundamental instructions within a cell's DNA, either by correcting faulty genes or introducing entirely new ones to combat disease. These viral vectors act as microscopic shuttles, carrying the therapeutic DNA into the host cell's nucleus, where it can integrate into the genome.

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Therapies Drugs DNA Treatment 98

Broad Institute

DECEMBER 13, 2023

One cell at a time Slide-seq, reported in 2019 , involves transferring slices of tissue onto arrays of special beads, each one tagged with a DNA barcode that identifies its location in the array.

RNA 145

RNA Research DNA Hospitals 145

The Pharma Data

SEPTEMBER 1, 2020

The 20,000-member Hospital Authority Employees Alliance said more effort should be put into focused tests rather than mass testing. This mass testing system will be voluntary and utilise medical staff from mainland China, which has sparked fears the programme could be used for mass surveillance. .

DNA 52

DNA Virus Government Hospitals 52

Broad Institute

JULY 11, 2024

Reporting in Science , researchers at Massachusetts General Hospital and the Broad Institute of MIT and Harvard have made a surprising discovery about these drugs. IDH1 normally facilitates the activity of enzymes called demethylases, which remove chemical flags called methylation marks from DNA, allowing genes to be transcribed into RNA.

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Treatment Immune Response Drugs Virus 72

The Pharma Data

AUGUST 3, 2020

Thousands of DNA test machines will be rolled out in hospitals from September. New 90-minute tests that can detect coronavirus and flu will be rolled out in hospitals and care homes from next week. In hospital, most tests – 9 in 10 – are currently turned around in 24 hours. Image copyright. DnaNudge 2020.

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Government DNA Hospitals Laboratories 52

The Pharma Data

OCTOBER 20, 2020

CureLab’s partners in the region will test the efficacy of the company’s DNA-based products against cancers and non-cancerous diseases of chronic inflammation. ” About Elenagen CureLab’s lead product, Elenagen , is a DNA encoding gene called p62/SQSTM1.

DNA 52

DNA Hospitals International Trials 52

KIF1A

AUGUST 20, 2024

Trying to solve the problems with vomiting, we went to the gastroenterologist who requested some gastric exams, the results were normal, so the doctor began to suspect that as a metabolic disease and advice us to go to the HOSPITAL PEQUENO PRINCIPE (Little Prince, a children hospital), in Curitiba, to start an investigation.

Doctors 52

Doctors Hospitals DNA Therapies 52

Broad Institute

AUGUST 7, 2023

STING is primarily on the lookout for DNA, which can indicate either a foreign invader such as a virus or damage to the host tissue or cell. Now, a team of MIT, Massachusetts General Hospital (MGH), Broad Institute of MIT and Harvard, and Harvard Medical School (HMS) researchers has discovered how STING activates those two pathways.

Regulations 91

Regulations Clinical Trials Engineering Science 91

Broad Institute

MAY 2, 2024

Today, she is a senior associate computational biologist in the Getz lab, where she applies computational techniques to DNA and RNA sequencing data to analyze rapid autopsy samples, taken from multiple sites throughout the body at the time of a cancer patient’s death. When your code runs perfectly or you fix a bug, it feels very rewarding.

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Science Medical Schools Disease Hospitals 124

PLOS: DNA Science

MAY 4, 2023

Over time, the mineralized microbes of tooth tartar come to comprise a mouthful of tiny fossils, including snippets of degraded bacterial DNA. ” But long DNA molecules fray as they’re copied as bacteria reproduce, from ancient times leaving pieces too small to match entries in DNA databases from modern species.

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DNA Production RNA Science 52

The Pharma Data

JUNE 26, 2021

It inhibits folate-dependent enzymes critical to the de-novo biosynthesis of nucleotides leading to the disruption of DNA replication. Patients receive the treatment via a 10-minute intravenous infusion in a hospital setting. Further launches across Europe are expected throughout the second half of 2021. Source link: [link].

Hospitals 52

Hospitals DNA Treatment Production 52

Codon

SEPTEMBER 29, 2024

mRNA was the intermediate stage between DNA and protein, a dynamic entity that shifted depending on the second-to-second needs of the cell, able to point out if a cell was cancerous or stressed, what kind of cell it was, and so on. The hum of hospital equipment, once a background noise, now carried complex harmonic overtones.

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Engineering Virus DNA Therapies 142

Broad Institute

MARCH 8, 2024

Senegal has a very strong clinical infrastructure, including a strong hospital network with incredible resources like West Africa’s Reference Center for Infectious Disease Diagnostics. Tags: Infectious Disease DNA sequencing RNA sequencing Nature Communications. Online January 25, 2024. DOI: 10.1038/s41467-024-44800-7.

Research 111

Research Disease Medical Schools RNA 111

Broad Institute

JULY 10, 2023

At the Broad, Martin is also helping lead data analysis in two large international studies that are sequencing the DNA of people from Africa and Latin America to learn about the genetics of severe mental illness. Her parents were terrified, and the family spent the next few years in and out of the hospital.

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Disease Bioinformatics Medical Schools Research 98

PLOS: DNA Science

APRIL 18, 2024

from Massachusetts General Hospital, told the Alzheimer’s Association. ” The post Mutations in Three Genes Protect Against Alzheimer’s appeared first on DNA Science. Quiroz, Ph.D.,

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Disease Research Therapies DNA 97

PLOS: DNA Science

MARCH 30, 2023

It is also difficult to identify with standard laboratory methods,” summed up Mahmoud Ghannoum, director of the Center for Medical Mycology at University Hospitals Cleveland Medical Center. Comparing genome sequences is important because they provide a 4-letter language in the bases A, C, G, and T (for DNA) or A, C, G, and U (for RNA).

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DNA Hospitals Laboratories Virus 52

The Pharma Data

NOVEMBER 18, 2020

Department of Internal Medicine, Tri-Service General Hospital, Taipei, Taiwan. Department of Hematology and Oncology, Taipei Medical University Hospital, Taipei, Taiwan. current affiliation: Department of Hematology and Oncology, Taipei Tzu Chi Hospital, Taipei, Taiwan. Presenter: Ching-Liang Ho MD, et.al.

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Vaccine Small Molecule Immune Response Hospitals 52