Codon

FEBRUARY 13, 2024

Regulators traditionally want to see a single, stable, well-characterized drug before giving the green light for it to be tested in a clinical trial, not dozens of different viruses; let alone ones that are best found in unappealing places like sewage , hospital waste, or bird poop. 4 But the same barriers still exist today.

Therapies 131

Therapies Virus DNA Clinical Trials 131

PLOS: DNA Science

SEPTEMBER 5, 2024

This removes the cancer’s blocking of the immune response, so that T cells can fight the cancer. Keytruda’s classification based on mechanism, rather than its structure, is immune checkpoint inhibitor. Analyzing DNA patterns using AI may replace time-consuming process DNA and genomic sequencing tests, Yu said.

Treatment 68

Treatment FDA Approval DNA Small Molecule 68

Drug Target Review

DECEMBER 28, 2023

During the process of transformation from a normal cell into a cancer cell, a cell acquires a series of changes, or mutations, in its DNA. But DNA mutations can also result in changes to the proteins that are displayed on the surface of the cancer cell. Neoantigens are recognised as non-self and trigger an immune response.

Bioinformatics 105

Bioinformatics Immune Response DNA Vaccine 105

Codon

JULY 27, 2023

There’s a TV show where a bunch of doctors are walking through a hospital corridor. They’ve just finished sequencing the patient’s genome, but they don’t have “DNA sorting” software. Transcription factors are proteins that bind to DNA and control gene expression. In response, the U.S.

Therapies 52

Therapies RNA DNA Engineering 52

Codon

JULY 27, 2023

There’s a TV show where a bunch of doctors are walking through a hospital corridor. They’ve just finished sequencing the patient’s genome, but they don’t have “DNA sorting” software. Transcription factors are proteins that bind to DNA and control gene expression. In response, the U.S.

Therapies 52

Therapies RNA DNA Engineering 52

The Pharma Data

AUGUST 3, 2021

The EUA now provides for the use of baricitinib for the treatment of COVID-19 in hospitalized adults and pediatric patients two years of age or older requiring supplemental oxygen, non-invasive or invasive mechanical ventilation or extracorporeal membrane oxygenation (ECMO). The company and Pfizer Inc.

Production 52

Production Marketing Research DNA 52

The Pharma Data

NOVEMBER 29, 2020

Compared to placebo, participants vaccinated with three HB-101 doses had: a 48 percent reduction in CMV viremia (presence of CMV DNA in the blood); a 42 percent reduction in the use of antiviral therapy; and. HOOKIPA’s viral vectors target antigen presenting cells in vivo to activate the immune system.

Vaccine 40

Vaccine Clinical Trials Disease Therapies 40

Codon

SEPTEMBER 29, 2024

mRNA was the intermediate stage between DNA and protein, a dynamic entity that shifted depending on the second-to-second needs of the cell, able to point out if a cell was cancerous or stressed, what kind of cell it was, and so on. The hum of hospital equipment, once a background noise, now carried complex harmonic overtones.

Engineering 142

Engineering Virus DNA Therapies 142

Codon

APRIL 9, 2023

Thousands of transcription factors — proteins that bind DNA and control gene expression — were studied in human cells. Read DNA Sequencing & Synthesis *Quantitative analysis of tRNA abundance and modifications by nanopore RNA sequencing. Bergs A.C.F. Nature Communications. Porta-de-la-Riva M. Nature Methods.

Therapies 52

Therapies RNA Engineering Vaccine 52

Codon

AUGUST 27, 2024

Allison Berke makes the case for real-time DNA sequencing and AI tools to detect pathogens before they spread widely. Consider Alice, a 49-year-old woman (and hypothetical patient) who walked into a hospital in Puerto Rico with joint pain, a headache, nausea, and a low fever. This is the third essay of four in our pandemic mini-issue.

DNA 102

DNA Laboratories Hospitals Virus 102

The Pharma Data

DECEMBER 27, 2020

Vir Biotechnology and GlaxoSmithKline dosed the first patient in a new sub-trial of a Phase III study of monoclonal antibody VIR-7831 for hospitalized adults with COVID-19. It is a selective modulator of neuropilin-2 that downregulates the innate and adaptive immune response in inflammatory diseases. Here’s a look.

Trials 52

Trials Clinical Trials Therapies RNA 52

The Pharma Data

DECEMBER 20, 2020

Pfizer and BioNTech announced additional data on neutralizing antibody and T-cell responses from their Phase I/II trial of their COVID-19 vaccine conducted in Germany. ARCA biopharma enrolled the first patients in ASPEN-COVID-10, its Phase IIb trial of rNAPc2 for hospitalized COVID-19 patients.

Vaccine 52

Vaccine Trials Therapies Small Molecule 52

The Pharma Data

JANUARY 21, 2021

The test valuates mitochondrial DNA levels. When mitochondrial DNA, normally found inside cells, in the mitochondria, spills into the bloodstream, it signals that a particular type of violent cell death is occurring. The research team evaluated 97 patients with COVID-19 at Barnes-Jewish Hospital.

Research 52

Research DNA Vaccine Immune Response 52

PLOS: DNA Science

MARCH 20, 2025

But my mother told me I was very sick for a month, and was a day away from being hospitalized for encephalitis when I finally began to improve. I remember my sister being held down to get her triple vaccine, then given in two shots in the arms, which DNA Science covered here. I was too young to remember having measles.

Virus 84

Virus Immune Response Vaccine DNA 84

Codon

APRIL 4, 2025

In 1746, the London Smallpox Hospital compared the scourge to “a thorny hedge through which all must pass, and some die, to reach a field of safety.” Today, six adjuvants have been approved by the Food and Drug Administration (FDA), each triggering a different kind of immune response. A more pressing issue loomed.

Immune Response 85

Immune Response Vaccine Virus Disease 85