DNA, Hospitals, RNA and Virus - Drug Discovery Digest

Targeted drug treatment leads tumor cells to imitate viral infection

Broad Institute

JULY 11, 2024

Targeted drug treatment leads tumor cells to imitate viral infection By Ari Navetta July 11, 2024 Breadcrumb Home Targeted drug treatment leads tumor cells to imitate viral infection Exploiting "viral mimicry," mIDH1 inhibitors trick tumors into thinking they are infected with a virus. paper cited Wu M, Kondo H, et al.

Treatment

Treatment Immune Response Virus Drugs

Eclectic Genomics: Cat Flu, Dolphin Adaptation to Climate Change, Predicting Cancer, and Diagnosing Rare Disease

PLOS: DNA Science

JULY 27, 2023

Genomics applies to all species, revealing evolution in action, because we all use the same genetic code – that is, the correspondence between DNA sequences and the amino acid sequences of proteins. Cats and Bird Flu Comparing DNA sequences is a little like linguistic research that connects languages. emerged in late 2021.

Disease

Disease DNA Virus RNA

Pfizer to supply UNICEF up to 4 million treatment courses of novel COVID-19 oral treatment for low- and middle-income countries

The Pharma Data

MARCH 22, 2022

Co-administration with a low dose of ritonavir helps slow the metabolism, or breakdown, of nirmatrelvir in order for it to remain active in the body for longer periods of time at higher concentrations to help combat the virus. In preclinical studies, nirmatrelvir did not demonstrate evidence of mutagenic DNA interactions.

Treatment

Treatment Virus Hospitals RNA

Winship Cancer Institute of Emory University Joins Caris’ Precision Oncology Alliance

The Pharma Data

OCTOBER 19, 2020

” The Caris Precision Oncology Alliance comprises over 40 academic, hospital and community-based cancer institutions, including 17 NCI-designated Comprehensive Cancer Centers.

Clinical Trials

Clinical Trials RNA DNA Science

World RNA Day: What impact RNA it had on drug discovery?

Drug Discovery World

AUGUST 1, 2023

1 August was first chosen as World RNA Day in 2018 as a play on AUG (adenine, uracil and guanine), a triple sequence of RNA (called a codon) that initiates protein synthesis by the cell. Since then, it has been observed to publicise the importance of this molecule in the generation of proteins in the body.

RNA

RNA Vaccine Drugs Disease

Driving Toward Nanopores

Codon

JUNE 11, 2024

And unlike traditional DNA sequencers, which parse genetic material by breaking it up into fragments and interpreting it chunk-by-chunk, a nanopore device unspools a long strand of DNA and reads it all at once. A scientist can isolate DNA and load up a flow cell in fifteen minutes. Nanopore devices work incredibly fast.

DNA

DNA Engineering RNA Small Molecule

Codon Digest: Seeing Colors After Gene Therapy

Codon

JULY 27, 2023

There’s a TV show where a bunch of doctors are walking through a hospital corridor. They’ve just finished sequencing the patient’s genome, but they don’t have “DNA sorting” software. Transcription factors are proteins that bind to DNA and control gene expression. From McKyton et al.

Therapies

Therapies RNA DNA Engineering

Codon Digest: Seeing Colors After Gene Therapy

Codon

JULY 27, 2023

There’s a TV show where a bunch of doctors are walking through a hospital corridor. They’ve just finished sequencing the patient’s genome, but they don’t have “DNA sorting” software. Transcription factors are proteins that bind to DNA and control gene expression. From McKyton et al.

Therapies

Therapies RNA DNA Engineering

Bioprospecting in Dental Tartar from Neanderthals for Novel Antibiotics and Revisiting the Discovery of Penicillin

PLOS: DNA Science

MAY 4, 2023

Over time, the mineralized microbes of tooth tartar come to comprise a mouthful of tiny fossils, including snippets of degraded bacterial DNA. ” But long DNA molecules fray as they’re copied as bacteria reproduce, from ancient times leaving pieces too small to match entries in DNA databases from modern species.

DNA

DNA Production RNA Science

Scientists map the locations of hundreds to thousands of cell types across a mammalian brain

Broad Institute

DECEMBER 13, 2023

One study was led by senior authors Evan Macosko , an institute member at the Broad and associate professor and attending psychiatrist at Massachusetts General Hospital, and Fei Chen , a core institute member at the Broad and an assistant professor in the Department of Stem Cell and Regenerative Biology at Harvard University.

DNA

DNA Virus Engineering Research

The New Fungus Among Us, Candida auris

PLOS: DNA Science

MARCH 30, 2023

It is also difficult to identify with standard laboratory methods,” summed up Mahmoud Ghannoum, director of the Center for Medical Mycology at University Hospitals Cleveland Medical Center. Comparing genome sequences is important because they provide a 4-letter language in the bases A, C, G, and T (for DNA) or A, C, G, and U (for RNA).

DNA

DNA Hospitals Laboratories Virus

Codon Digest: CAR-T Therapy for Neuroblastoma

Codon

APRIL 9, 2023

Small snippets of double-stranded RNA were sprayed onto hot pepper plants to control a pest, called Frankliniella occidentalis. The RNA strands shut down a specific gene in the insects, and killed half after 7 days. RNA may offer a safer form of pest control in the future. The new sequences might help de-extinction efforts.

Therapies

Therapies RNA Engineering Vaccine

Clinical Catch-Up: December 21-25 | BioSpace

The Pharma Data

DECEMBER 27, 2020

Vir Biotechnology and GlaxoSmithKline dosed the first patient in a new sub-trial of a Phase III study of monoclonal antibody VIR-7831 for hospitalized adults with COVID-19. Galidesivir is a broad-spectrum antiviral, an adenosine nucleoside analog that blocks viral RNA polymerase. Here’s a look. COVID-19-Related. Most Read Today.

Clinical Trials

Clinical Trials Trials Therapies RNA

Tackling the Challenges of Limited Resources During a Pandemic

The Pharma Data

MARCH 20, 2021

Biogazelle, an innovative bioanalytical services company offering RNA and. DNA biomarker services in an accredited environment. Ghent University Hospital for SARS-CoV-2 virus screening. study RNA virus replication and virus-host interactions and in particular the use of single-cell proteomics to aid in this research.

Laboratories

Laboratories Virus RNA Bioinformatics

Johnson & Johnson’s One-Dose COVID Vaccine Promising in Early Trial

The Pharma Data

JANUARY 13, 2021

“It certainly would be very helpful, having one dose instead of two,” said Dr. Aaron Glatt, chair of the department of medicine and a hospital epidemiologist at Mount Sinai South Nassau Hospital in Oceanside, N.Y. If you only have to give one dose, that would be great.”

Vaccine

Vaccine Trials Immune Response Clinical Trials

The 500th Blog Post at DNA Science: In Celebration of Vaccines

PLOS: DNA Science

DECEMBER 21, 2023

A few weeks ago, I noticed a surprising metric when posting my weekly DNA Science blog – at year’s end, I’d hit #500! The Birth of DNA Science When St. The book that kickstarted DNA Science was The Forever Fix: Gene Therapy and the Boy Who Saved It. We renamed it DNA Science. That got me thinking.

DNA

DNA Vaccine Science Therapies

Drug Discovery Digest

Targeted drug treatment leads tumor cells to imitate viral infection

Eclectic Genomics: Cat Flu, Dolphin Adaptation to Climate Change, Predicting Cancer, and Diagnosing Rare Disease

Trending Sources

Pfizer to supply UNICEF up to 4 million treatment courses of novel COVID-19 oral treatment for low- and middle-income countries

Winship Cancer Institute of Emory University Joins Caris’ Precision Oncology Alliance

World RNA Day: What impact RNA it had on drug discovery?

Driving Toward Nanopores

Codon Digest: Seeing Colors After Gene Therapy

Codon Digest: Seeing Colors After Gene Therapy

Bioprospecting in Dental Tartar from Neanderthals for Novel Antibiotics and Revisiting the Discovery of Penicillin

Scientists map the locations of hundreds to thousands of cell types across a mammalian brain

The New Fungus Among Us, Candida auris

Codon Digest: CAR-T Therapy for Neuroblastoma

Clinical Catch-Up: December 21-25 | BioSpace

Tackling the Challenges of Limited Resources During a Pandemic

Johnson & Johnson’s One-Dose COVID Vaccine Promising in Early Trial

The 500th Blog Post at DNA Science: In Celebration of Vaccines

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