Drug Discovery World

OCTOBER 10, 2023

Read more: First oral drug for postpartum depression approved in US The role of genetics In October, scientists discovered the link between gene expression, DNA methylation, and brain structural changes in depression, revealing new potential therapeutic targets.

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Immune Response Drugs FDA Approval DNA 148

PLOS: DNA Science

OCTOBER 12, 2023

Can they deliver healing genes without triggering an overactive immune response? The details are disturbingly reminiscent of the famous case of Jesse Gelsinger , who died from a ferocious immune response to experimental gene therapy in September 1999. million DNA bases. Muscles stop working.

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Therapies Immune Response DNA Virus 69

Drug Discovery World

APRIL 26, 2024

In addition to encoding the target antigens, mRNA vaccines also provide adjuvant properties that amplify the immune response. The vaccines are personalised to each patient after a tumour sample is removed during surgery and then analysed using DNA sequencing.

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Clinical Trials Vaccine Trials Immune Response 130

Broad Institute

JULY 11, 2024

Treatment with mIDH1 blockers unearths these remnants, triggering an immune response against the tumor cells. IDH1 normally facilitates the activity of enzymes called demethylases, which remove chemical flags called methylation marks from DNA, allowing genes to be transcribed into RNA.

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Treatment Immune Response Virus Drugs 72

Drug Discovery World

APRIL 16, 2023

Vaccine strategies over the last 25 years attempted to induce immune responses against tumour-associated antigens that are not absolutely specific to the tumour,” said presenting author Jeffrey Weber, Deputy Director of the NYU Langone Perlmutter Cancer Center and Laura and Isaac Perlmutter Professor of Oncology at NYU Grossman School of Medicine.

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Vaccine Immune Response Medical Schools Trials 130

Drug Target Review

DECEMBER 7, 2023

Researchers from the Laboratory of Bacteriology at The Rockefeller University have now found that bacteria sense phages by a defensive response named CBASS (cyclic oligonucleotide-based antiphage signalling system) which detects viral RNA. In bacteria , cGAS-like cyclases are central parts of the CBASS immune response.

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RNA Immune Response DNA Molecular Biology 59

The Pharma Data

DECEMBER 23, 2020

” Dr. Stanley Plotkin , Professor Emeritus at The Wistar Institute, said, “INOVIO’s DNA vaccine appeared to be quite safe with few significant reactions but yet induced both antibody and T cell responses to SARS-CoV-2.” About INOVIO’s DNA Medicines Platform. mg and 2.0

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DNA Vaccine Immune Response Clinical Trials 40

Drug Target Review

MAY 14, 2024

Since cancer cells are under chronic stimulation of ER stress, the polypeptides cannot activate innate immune sensors in cancer cells even upon the polypeptide treatment. Which natural agonists impede the activation of intracellular DNA sensors in APCs, and what challenges do they pose?

Engineering 59

Engineering Immune Response FDA Approval DNA 59

Drug Target Review

APRIL 17, 2024

HLA are the critical molecules that our immune systems use to present peptides to T cells and facilitate recognition and killing in immune responses to pathogens. HLA-II presents peptides to CD4 T cells thought to be important for indirectly helping immune responses and facilitating antibody production.

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Immune Response Laboratories DNA Virus 105

Drug Discovery World

JULY 5, 2023

Protein therapeutics have been developed which bind to the checkpoint protein and “blockade” it, to prevent the moderation of the T-cell response, thus “turning up” the immune response dramatically. As part of his graduate work he invented the gel-shift or EMSA assay for the study of protein-DNA interactions.

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Research Immune Response Pharmaceutical Companies Treatment 246

Drug Discovery World

FEBRUARY 28, 2024

Using a technique they’ve dubbed ‘cancer shredding’, the researchers at Gladstone Institutes, California, programmed CRISPR to zero-in on repeating DNA sequences present only in recurrent tumour cells – and then obliterate those cells by snipping away at them.

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Drug Development Research Clinical Trials Drugs 163

The Pharma Data

DECEMBER 20, 2020

SN14 works by targeting the coronavirus’ nucleocapsid and spike proteins to prevent viral replication using the company’s ImmunoBody DNA vaccine technology. UK drug developer Scancell said it has chosen a COVID-19 vaccine candidate, SN14, from more than a dozen potential products to advance to a clinical trial. . Source link.

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Clinical Trials Pharma Companies Vaccine Trials 52

PLOS: DNA Science

JANUARY 4, 2024

.” CRISPRs are short DNA sequences, peppered with repeats, that latch onto DNA-cutting enzymes, commandeering and directing them to snip certain parts of a chromosome. The microbes deploy them to dismantle the genetic material of infecting viruses, a little like an immune response.

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FDA Approval DNA Clinical Trials Therapies 52

Drug Discovery World

AUGUST 19, 2024

Join DDW on 9 September 3PM BST to find out how Fujifilm Wako has surmounted these challenges by integrating DNA immunisation with their proprietary single B-cell cloning technique, paving the way for next-generation antibody production. These qualities make them ideal for both therapeutic applications and diagnostic reagents.

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DNA Immune Response Pharmaceuticals Production 130

Conversations in Drug Development Trends

JUNE 21, 2024

Although there are a range of efficacies across different tumor types that require a greater understanding, the use of circulating tumor DNA profiles holds promise for personalized treatment strategies that better target the drug for the patient, potentially revolutionizing how ADCs are deployed in clinical practice.

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Clinical Trials Clinical Research Immune Response Therapies 64

Drug Target Review

JUNE 6, 2023

Natural killer (NK) cells are another immune cell type that, as the name suggests, also have potent cell-killing activity, and have a well-known role in the anti-tumour immune response. In the context of a tumour microenvironment, Tregs are often present in high numbers, preventing an effective immune response to the tumour.

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Engineering Immune Response Biochemical Pharmacology Clinical Trials 98

The Pharma Data

APRIL 8, 2021

Leadership in DNA damage response demonstrated in multiple presentations for AZD5305, a next-generation PARP1 selective inhibitor. Data for AZD5305 will demonstrate how the next wave of DNA damage response medicines can build on the success of PARP inhibitors, potentially allowing patients to stay on treatment longer.

DNA 52

DNA Immune Response Therapies Treatment 52

Drug Target Review

APRIL 26, 2023

Gene-editing methods allow researchers to modify DNA, resulting in alterations in physical characteristics such as eye colour and susceptibility to diseases. To achieve this, scientists utilise various technologies that function similarly to scissors, precisely cutting the DNA at a particular location.

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RNA Medical Schools Engineering DNA 98

Drug Discovery World

JULY 31, 2023

Matt Hill , Founder and CEO of Elegen writes about the importance of innovation in DNA synthesis to address critical bottlenecks in biotherapy development. Regardless of the type of disease targeted, at the core of biotherapy development is synthetic biology and the use of synthetic DNA to programme specific behaviours within living cells.

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DNA Vaccine Therapies Production 130

The Pharma Data

MAY 15, 2023

The team at XinThera has developed research assets with the potential to target the DNA damage repair pathway in treating cancer and direct the body’s immune response in inflammatory diseases, both of which may improve outcomes for people living with these diseases,” said Flavius Martin, M.D.,

Small Molecule 40

Small Molecule DNA Immune Response Science 40

Broad Institute

AUGUST 7, 2023

Related people Paul Blainey Nir Hacohen A signaling protein known as STING is a critical player in the human immune system, detecting signs of danger within cells and then activating a variety of defense mechanisms.

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Regulations Engineering Clinical Trials DNA 91

DrugBank

MAY 15, 2024

In the early 20th century, the discovery process was largely random , focused on cytotoxic agents that kill cells by disrupting key cellular functions like DNA replication. A Historical Perspective on Drug Development The history of drug discovery gives us great insights into the evolution from hit-or-miss strategies to precise interventions.

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Small Molecule Molecular Biology Drugs Disease 83

Drug Target Review

SEPTEMBER 8, 2023

The cell’s nucleus, containing compacted DNA, is centrally positioned within the cell. It didn’t have the tools that are important for nuclear receptors, namely the ability to interact with DNA and the ability to translocate from the cytoplasm to the nucleus,” says Cheroutre.

Regulations 98

Regulations Research DNA Immune Response 98

Drug Target Review

JUNE 9, 2023

An antigen is a protein that can induce an immune response in the body. While tumour cells share a majority of their DNA with healthy cells, they also carry numerous unique mutations. This first T-cell therapy product targets a common shared neoantigen found in patients with solid tumours.

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Treatment Packaging Clinical Research Therapies 105

Drug Discovery World

MAY 29, 2024

DNA purification “Plasmid DNA is an incredibly important part of molecular biology”, says Hummersone. We are now looking at larger plasmid DNA sequences to carry more genetic material, and so we can get a more delicate endpoint with a much larger plasmid DNA sequence. That’s not the case in CGT.”

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Therapies Molecular Biology DNA Immune Response 274

Drug Target Review

OCTOBER 26, 2023

Genome engineering and gene therapies that manipulate DNA sequences in cells have driven a biotechnological revolution over the past decade. 9 In addition, host immune responses further add to the complexity of developing cell-specific AAV capsids for clinical applications.

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Engineering Virus Therapies Immune Response 105

Drug Target Review

NOVEMBER 6, 2023

For example, combining IO agents with ADCs to mount a two-pronged attack against cancer by activating an anti-cancer immune response and directly killing cancer cells may drive stronger and more durable responses in the clinic.

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Small Molecule Therapies Treatment Immune Response 111

Drug Target Review

APRIL 3, 2024

Everything started in school with an experiment on isolating DNA from bananas. Making a little tangle of DNA visible to the eye and understanding that this is the basis of complex organisms, which might be altered in disease, was the defining moment for my future path in life sciences.

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Science Clinical Development DNA Treatment 105

Drug Discovery World

APRIL 15, 2023

As such, Codagenix has previously demonstrated that CodaLytic, a codon-modified influenza virus, can kickstart the cancer immunity cycle at various steps in several mouse models with differing baseline immune contextures.

Virus 130

Virus Clinical Trials Trials Therapies 130

Drug Discovery World

SEPTEMBER 2, 2024

Join DDW on 9 September 3PM BST to find out how Fujifilm Wako has surmounted these challenges by integrating DNA immunisation with their proprietary single B-cell cloning technique, paving the way for next-generation antibody production.

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Production DNA Immune Response Pharmaceuticals 148

The Pharma Data

JANUARY 20, 2021

Nasdaq: INO), a biotechnology company focused on bringing to market precisely designed DNA medicines to treat and protect people from infectious diseases, including COVID-19, cancer and HPV-associated diseases, today announced the pricing of an underwritten public offering of 17,700,000 shares of its common stock at a public offering price of $8.50

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DNA Immune Response Disease Clinical Trials 40

The Pharma Data

NOVEMBER 18, 2020

.” Ming-Tain Lai, PhD, Chief Scientific Officer at OBI Pharma stated, “In the trial, OBI-833 demonstrated a favorable safety profile and generated detectable anti-Globo H IgM/IgG responses. ” Presentation number: 397P / Poster: ID 680. Additional information can be found at www.obipharma.com. Forward-Looking Statements.

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Vaccine Small Molecule Immune Response Hospitals 52

The Pharma Data

AUGUST 6, 2020

Early clinical results showed AstraZeneca’s candidate, AZD1222, triggered both antibody and T-cell immune responses. In addition, Inovio previously teamed up with Beijing Advaccine Biotechnology for work on its DNA vaccine candidate, INO-4800. The vaccine was moved into phase 2/3 in May.

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Vaccine Licensing Licensing Immune Response 52

Drug Discovery World

AUGUST 26, 2024

Join DDW on 9 September 3PM BST to find out how Fujifilm Wako has surmounted these challenges by integrating DNA immunisation with their proprietary single B-cell cloning technique, paving the way for next-generation antibody production.

DNA 148

DNA Immune Response Pharmaceuticals Production 148

LifeSciVC

MARCH 1, 2023

Learning from Past Failures to Drive Toward a More Durable Immune Response Following the initial clinical successes of blocking inhibitory receptors, like CTLA4 and PD1, many in the immuno-oncology field explored the potential to further enhance anti-tumor immunity by simultaneously enhancing co-stimulatory pathways.

Small Molecule 52

Small Molecule Immune Response DNA Therapies 52

Drug Discovery World

AUGUST 12, 2024

Join DDW on 9 September 3PM BST to find out how Fujifilm Wako has surmounted these challenges by integrating DNA immunisation with their proprietary single B-cell cloning technique, paving the way for next-generation antibody production.

DNA 130

DNA Immune Response Pharmaceuticals Production 130

Dark Matter Blog

JULY 16, 2021

As soon as I learned about DNA and RNA, I wanted to be a molecular biologist. Last stops at RNA My last roles in biotech were where my original passion began: DNA and RNA. Delivering the IFN-β gene into tumors caused cancer cell apoptosis and activated both innate and adaptive anti-tumor immune responses.

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Small Molecule RNA Clinical Trials DNA 52