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Phages could help to tackle antimicrobial resistance

Drug Target Review

Phage have been of interest to scientists as tools to understand fundamental molecular biology, as vectors of horizontal gene transfer and drivers of bacterial evolution, as sources of diagnostic and genetic tools, and as novel therapeutic agents. In bacteria , cGAS-like cyclases are central parts of the CBASS immune response.

RNA 59
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Unlocking Undruggable Targets: Shifting Paradigms in Modern Drug Discovery

DrugBank

But as molecular biology has advanced, so too has our approach to finding new drugs. In the early 20th century, the discovery process was largely random , focused on cytotoxic agents that kill cells by disrupting key cellular functions like DNA replication. This method was more about serendipity than science.

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The democratisation of cell and gene therapy

Drug Discovery World

DNA purification “Plasmid DNA is an incredibly important part of molecular biology”, says Hummersone. He says: “What we are seeing from a molecular biology perspective is that the genetic material that we want to pack into viral vectors is becoming increasingly complicated.

Therapies 273
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A surprising new role for a major immune regulator

Broad Institute

Related people Paul Blainey Nir Hacohen A signaling protein known as STING is a critical player in the human immune system, detecting signs of danger within cells and then activating a variety of defense mechanisms. Paper Cited Liu B, Carlson R, et al. Human STING is a proton channel. Online August 3, 2023.

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A Look Back

Dark Matter Blog

The only subject in school that held my interest was biology. As soon as I learned about DNA and RNA, I wanted to be a molecular biologist. I wanted to use molecular biology to create drugs. Last stops at RNA My last roles in biotech were where my original passion began: DNA and RNA.

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A Molecular Biologist’s Advice For Life

LifeSciVC

The central dogma of molecular biology is that information generally (with few exceptions) flows from DNA to RNA to Protein. Build your social immunity. The adaptive immune response identifies and responds to highly specific antigens associated with infections and cancer. Remember life’s Central Dogma.

Science 85
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Codon Digest: Seeing Colors After Gene Therapy

Codon

They’ve just finished sequencing the patient’s genome, but they don’t have “DNA sorting” software. billion units of DNA code are transcribed into more than a hundred volumes, each a thousand pages long, in type so small as to be barely legible.” a lower risk of immune responses.