Drug Discovery World

JANUARY 3, 2023

Matthew Clark , CEO of X-Chem, looks at what the future could hold for DNA-encoded library (DEL) technology. In the 13 years since it was first described, DNA-encoded library (DEL) technology has become a firmly established approach to small molecule hit generation in drug discovery. Artificial intelligence. Wu Z, et al.

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Drug Discovery World

SEPTEMBER 9, 2024

This capability enables their use in various bioinformatics and cheminformatics applications, including predicting DNA regulatory elements and optimising drug properties. Leverage AI across the organization, not just for R&D users Beyond revolutionising drug discovery, AI can also optimise internal processes.

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Sygnature Discovery

JUNE 17, 2024

We advocate a collaborative approach, engaging both with our clients and within our internal team. Diverse Target Classes We Work With: Soluble Proteins: This includes kinases, ligases, transcription factors, helicases, polymerases, and DNA/RNA modifying enzymes, among others.

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Drug Discovery World

JUNE 5, 2023

How best to communicate this strategy to both internal and external stakeholders? New approaches to partnering In this event in the Biotech track, Clive Cookson, Science Editor at the Financial Times, interviewed John McDonald, Corporate Vice President, Global R&D Business Development, Novo Nordisk. How to improve its pipeline?

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Drug Discovery World

OCTOBER 16, 2023

A company within this ecosystem is STORM Therapeutics, a clinical stage biotechnology company creating novel small molecule therapies that inhibit RNA modifying enzymes (RME) for use in oncology and other diseases. The UK is additionally able to serve the US market with excellent international cultural and linguistic links.

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The Pharma Data

NOVEMBER 18, 2020

Title: A phase I cohort expansion trial of OBI-833 in non-small cell lung cancer patients. Department of Internal Medicine, Tri-Service General Hospital, Taipei, Taiwan. .” Presentation number: 397P / Poster: ID 680. Presenter: Ching-Liang Ho MD, et.al. Session Title: E-poster Display session – Thoracic tumours, metastatic.

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Drug Discovery World

NOVEMBER 17, 2022

It is believed that the term synthetic biology was created in 1970 by geneticist, Waclaw Szybalski 1 as work was being carried out on the development of DNA sequencing and synthesis techniques. These factors can significantly contribute to the growth of the synthetic biology market, it adds. . Brady and colleagues turned to algorithms.

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The Pharma Data

DECEMBER 14, 2020

. The current standard of care for GBM consists of de-bulking surgery followed by combined treatments with fractionated ionizing radiation (IR) and the DNA alkylating agent temozolomide (TMZ). Over the period of treatment, tumors can evolve and begin to overexpress MGMT and therefore become largely resistant to TMZ.

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Codon

JUNE 11, 2024

And unlike traditional DNA sequencers, which parse genetic material by breaking it up into fragments and interpreting it chunk-by-chunk, a nanopore device unspools a long strand of DNA and reads it all at once. A scientist can isolate DNA and load up a flow cell in fifteen minutes. Nanopore devices work incredibly fast.

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Codon

AUGUST 27, 2024

Allison Berke makes the case for real-time DNA sequencing and AI tools to detect pathogens before they spread widely. Reading DNA The first step in detecting a novel pathogen is recognizing it as an anomaly amidst a noisy background of other material. After copying the DNA to form a big pool, each piece is sequenced.

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Drug Discovery World

APRIL 29, 2024

Jean-Baptiste Agnus, Chief Business Officer, and Peter Carbone, Chief Quality Officer, KBI Biopharma: Agnus brings more than two decades of experience in the biopharmaceutical industry with expertise in biologics, small molecule APIs, antibody-drug conjugates (ADCs), and cell and gene therapies.

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Drug Discovery World

JUNE 6, 2023

However, what he found particularly interesting at the meeting is the emergence of more small molecule immune oncology agents that are actually starting to look as though they might work. ” Meet the exhibitor At AACR, Integrated DNA Technologies (IDT) announced the launch of a new core solid tumour panel for cancer research.

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Drug Discovery World

JANUARY 12, 2023

The genome is the blueprint for life, consisting of genes made up of thousands of pairs of DNA bases. Small molecule drugs or biologics need to be delivered via blood vessels and penetrate tissue to get into cells. About the author . Dr Oksana Sirenko is an internationally known cell biologist and imaging specialist.

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Drug Target Review

JULY 31, 2023

When it came time to graduate, I thought I wanted to go to graduate school in chemistry, but first I took a year abroad and worked as a teacher at the international school in Israel. For my PhD project, I chose an advisor who worked on DNA and I started working with her on the physical properties of DNA.

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The Pharma Data

AUGUST 3, 2021

announced an exclusive collaboration focused on the discovery, development and commercialization of potential novel small molecules that stimulate tumor-specific immune responses. and international governments and near-term expiry dates of COVID-19 antibodies. Loxo Oncology at Lilly and Kumquat Biosciences Inc.

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Nvidia Developer: Drug Discovery

MARCH 21, 2023

New supercomputing-scale large language models (LLMs) that understand biology and chemistry text are helping scientists understand proteins, small molecules, DNA, and biomedical text. These state-of-the-art AI models help generate de novo proteins and molecules and predict the 3D structures of proteins.

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KIF1A

MAY 31, 2024

Trail Blazing in Australia International KAND Speech Study Our new research network partners at the Translation Centre for Speech Disorders in Australia welcomed families to take part in a study on speech and nonverbal communication in KIF1A Associated Neurological Disorder (KAND). You can read about her journey and first dose in our blog.

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The Pharma Data

OCTOBER 26, 2020

V590 — a SARS-CoV-2 vaccine candidate in development in collaboration with the International AIDS Vaccine Initiative (IAVI) that uses a recombinant vesicular stomatitis virus (rVSV) platform, the same platform used for Merck’s approved Ebola Zaire virus vaccine, will enter Phase 1 development shortly. Canada and Europe.

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Codon

MAY 30, 2023

This week: A way to measure a transgene’s expression in the brain using ultrasound, a DNA sequencing method that uses 1000x less reagents, and base editors get even smaller. An engineered version of this protein can convert DNA bases with efficiencies up to 92%. so this Digest will be published more irregularly.

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Codon

MAY 30, 2023

This week: A way to measure a transgene’s expression in the brain using ultrasound, a DNA sequencing method that uses 1000x less reagents, and base editors get even smaller. An engineered version of this protein can convert DNA bases with efficiencies up to 92%. so this Digest will be published more irregularly.

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DNA RNA Engineering Vaccine 52

KIF1A

AUGUST 20, 2024

We often call members of our community Superheroes, but internally I default to another term Luke Rosen and advocates use often: Pioneers. The effects of an ASO administered to the eye have yet to be determined, and we are also investigating small-molecule therapies to treat this high-priority symptom.

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Vial

FEBRUARY 19, 2024

We can link small molecule drugs to a payload that would enter in the cell and kill it. We have the capability of different types of targets, whether small molecules or antibodies. Also, payloads that are permeable payloads and specifically microtubule inhibitors or DNA alkylators or chemo.

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The Pharma Data

DECEMBER 21, 2020

Five national health authorities collaborated with the FDA on this review through Project Orbis, an initiative of the FDA Oncology Center of Excellence, which provides a framework for concurrent submission and review of oncology medicines among international partners. International Agency for Research on Cancer. 2003;123: 2096–2103.

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The Pharma Data

DECEMBER 27, 2020

Transgene and BioInvent International received regulatory approval in Belgium for a Phase I/IIa trial of oncolytic Vaccinia virus BT-001. Avacopan is an oral small molecule selective inhibitor of the complement C5a receptor Cf1R1. BT-001 is a best-in-class oncolytic Vaccinia virus generated using Transgene’s Invir.IO

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Agency IQ

AUGUST 11, 2023

Briefly, the guidance document follows other international guidelines and advises sponsors to “assess the risk of nitrosamine impurities in APIs, marketed products, and products under approved and pending applications.” In a study of more than 12,000 small molecule drugs , researchers found 40.4%

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Agency IQ

JULY 26, 2024

For additional information on this process, sponsors should refer to International Council for Harmonisation (ICH) guidelines Q8, Q9 and Q10 on the development of quality risk management processes, and the steps to conducting the risk assessment. including well before and after product approval). Any CMC changes (e.g.,

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Agency IQ

APRIL 19, 2024

The approvals were granted on the basis of two intermediate endpoints – overall response rate (ORR) and duration of response (DOR), based on International Myeloma Working Group (IMWG) criteria. Note: Both analyses focused only on studies of small molecules, antibodies and biologics; studies of CAR T therapies were not included.

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The Premier Consulting Blog

APRIL 25, 2023

In the US, new small molecule drugs are developed under the requirements of Sections 505(b)(1) and 505(b)(2) of the FFDCA. 4] International Council for Harmonisation of Technical Requirements for Pharmaceuticals for Human Use (ICH). ICH Harmonised Guideline S10: Photosafety evaluation of pharmaceuticals.

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