Drug Discovery World

APRIL 26, 2023

The term ‘PCR’ has been on everybody’s lips since the outbreak of the Covid-19 pandemic, but only laboratory professionals know how difficult it can be to achieve success with this well-established technique. If your PCR reactions are driving you to despair, look no further than INTEGRA’s comprehensive eBook !

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DNA Laboratories Drugs 130

Drug Discovery World

SEPTEMBER 14, 2023

Many clinical and research laboratories today are having to do more with less: faced with ongoing staffing shortages, increased workloads, and budgetary constraints, many laboratory managers are feeling the stress, which is where the benefits of automation can be truly realised for labs in both academia and industry.

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Laboratories Research Laboratories Science DNA 278

Drug Discovery World

OCTOBER 25, 2022

A new laboratory specialising in genomics is set to open at the North Carolina Research Campus (NCRC) in Kannapolis, North Carolina. The Bill and Shari Graham Genomics Laboratory is a collaborative project from Catawba College and Eremid Genomic Services.

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Laboratories DNA Science Research 130

Drug Discovery World

MAY 25, 2023

DNA Script: SYNTAX DNA printing platform Using the company’s EDS technology, the SYNTAX platform can synthesise up to 96 highly accurate, ready-to-use DNA oligos with maximum lengths of up to 120nt in less than 24 hours in the laboratory.

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Production DNA Assay Development Drugs 130

Drug Discovery World

AUGUST 7, 2024

GIGA-2339 consists of more than 1,000 anti-HBV antibodies developed in the laboratory by capturing and then reproducing the natural antibody response from donors who have been vaccinated against HBV. In mouse models, GIGA-2339 neutralised and cleared HBV’s viral DNA along with its antigens.

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Drug Trials FDA Trials Immune Response 147

Drug Discovery World

FEBRUARY 6, 2023

CFX Opus Deepwell Dx Real-Time PCR System – Bio-Rad Laboratories Bio-Rad Laboratories has launched the CFX Opus Deepwell Dx Real-Time PCR System, which offers accurate and precise quantification with flexibility for reactions up to 125 µl in a 96-well format for quantitative PCR (qPCR) diagnostic assays.

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Production DNA Laboratories Drugs 130

Drug Discovery World

AUGUST 6, 2024

The research was led by Senior Researcher Dr Vanessa Conn and Professor Simon Conn, who leads the Circular RNAs in Cancer Laboratory at the Flinders Health and Medical Research Institute (FHMRI). We’ve also discovered that high levels of circRNAs in certain people can cause mutations in their DNA which results in leukaemia.”

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Therapies RNA Immune Response DNA 147

Drug Discovery World

DECEMBER 14, 2023

The Bio X AI policy recommendations address the need for oversight of biodesign AI tools, biosecurity screening of synthetic DNA and guidance on biosecurity practices for automated laboratories.

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Government DNA Laboratories Science 130

Broad Institute

OCTOBER 4, 2023

Related links Merkin Prize Inaugural Merkin Prize in Biomedical Technology awarded to Dr. Marvin Caruthers for developing technology that efficiently synthesizes DNA The inaugural Richard N. Caruthers was announced as the winner in June for his development, in 1981, of an efficient, automated technology for synthesizing DNA.

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DNA RNA Science Protein Expression 52

Drug Discovery World

JUNE 24, 2024

In a previous study, researchers investigated the role that specific sections of our DNA, named ‘endogenous retrovirus HERV-K’, play in tumour development. Furthermore, several drugs were identified that target these proteins, reducing the growth of schwannoma and grade I meningioma cells in the laboratory.

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Clinical Trials Trials Drugs DNA 147

Drug Discovery World

AUGUST 21, 2024

Following initial viral vector transduction, treated samples, typically whole blood and/or enriched cell populations, are collected and the genomic DNA is isolated. The enriched DNA is then sequenced. With this approach, high molecular weight DNA must be extracted from the treated samples, to ensure the best results.

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Therapies Bioinformatics DNA FDA 147

Drug Discovery World

FEBRUARY 21, 2023

Charles River Laboratories and Pioneering Medicines have entered a multi-programme agreement that gives Pioneering Medicines access to artificial intelligence (AI) model Logica.

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Small Molecule DNA Drugs Laboratories 130

Drug Discovery World

JUNE 28, 2023

Many clinical and research laboratories today are having to do more with less: faced with ongoing staffing shortages, increased workloads, and budgetary constraints, many laboratory managers are feeling the stress, which is where the benefits of automation can be truly realised for labs in both academia and industry.

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Laboratories Research Laboratories Science DNA 246

The Pharma Data

NOVEMBER 26, 2020

26, 2020 /PRNewswire/ — BASE10 Genetics and DNA Link today announced their collaboration on a research project to evaluate the usability of DNA Link ‘ s AccuFind COVID-19 IgG antibody test in a healthcare setting. Study will expand access to antibody testing outside of laboratory settings. About DNA Link, Inc.

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DNA Nurses Research Laboratories 52

Drug Discovery World

AUGUST 5, 2022

Three key members of the team – Dr Raquel Sanches-Kuiper, Vice President of Technology, Dr Matthew Hayes, Chief Technology Officer and John Edgell, Head of Cloud Engineering – explain how the company is doing this and what it means for the advancement of DNA synthesis in the lab. Why enzymatic synthesis? “We

DNA 130

DNA Engineering Cell Biology Doctors 130

Drug Discovery World

JUNE 11, 2024

In research published in Nature today, scientists at the Crick journeyed into a ‘gene desert’ – an area of DNA that doesn’t code for proteins – which has previously been linked to IBD and several other autoimmune diseases. The researchers are now working with LifeArc to find ways to deliver MEK inhibitors directly to macrophages.

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Disease Research DNA Laboratories 147

Drug Discovery World

MARCH 7, 2023

Both CureLab Oncology and CureLab Veterinary are developing therapies that employ plasmids (circular DNA encoding a gene called p62/SQSTM1). The two sister companies have developed an anti-cancer and anti-inflammatory drug that was contract-manufactured by Aldevron at the time Dr Ballantyne served there as chief scientific officer.

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Clinical Trials DNA Laboratories Therapies 130

Broad Institute

AUGUST 31, 2023

Now researchers at the Broad Institute of MIT and Harvard have used cutting-edge continuous laboratory evolution and engineering methods to develop improved versions of the gene-editing tool. Reverse transcriptase proteins that copy RNA templates into strands of DNA are found naturally in all plant and animal cells and in many viruses.

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DNA Engineering RNA Laboratories 145

Drug Discovery World

OCTOBER 20, 2023

BioCina will provide process development and GMP manufacturing for Minicircle DNA and Plasmid DNA. Anders Grøn, CEO at Clinical Microbiomics, said: “We are a company made up of scientists – Innovation is at the heart of our DNA.

DNA 130

DNA Clinical Trials Engineering Virus 130

Drug Discovery World

JANUARY 26, 2023

The molecule, known as lissodendoric acid A, appears to counteract other molecules that can damage DNA, RNA and proteins and even destroy whole cells. Provided by Sophia Kolesnikova of the Laboratory of Marine Natural Compounds Chemistry at the GB Elyakov Pacific Institute of Bioorganic Chemistry.

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Organic Chemistry Laboratories RNA DNA 130

Drug Discovery World

FEBRUARY 6, 2024

From finding potential active substances and identifying novel targets, to simulating how drugs will function in the human body and optimising laboratory workflows, digital technologies are having a significant impact on drug discovery and development.

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Marketing Laboratories Engineering Clinical Trials 173

Alta Sciences

APRIL 16, 2024

Gene therapy requires DNA and/or RNA delivery and analysis, and while most ongoing research involves therapies being delivered in vivo via adeno-associated viral (AAV) vectors, other in vivo delivery methods are on the rise. The process utilizes short synthetic DNA fragments called primers to choose a section of the genome to be amplified.

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Therapies DNA RNA Laboratories 52

SCIENMAG: Medicine & Health

JULY 3, 2023

A research team led by Xianghong Jasmine Zhou, PhD, professor of Pathology and Laboratory Medicine at the David Geffen School of Medicine at UCLA, has made an important advancement to address one of the major challenges in cell-free DNA (cfDNA) testing, also known as liquid biopsy.

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Research DNA Laboratories 62

Codon

AUGUST 26, 2024

Brian Wang (co-founder of the nonprofit Panoplia Laboratories ) outlines his approach to making broad-spectrum antivirals. Last year, several colleagues and I joined these efforts by co-founding Panoplia Laboratories , a nonprofit organization developing broad-spectrum antivirals using tools from synthetic biology.

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RNA Virus DNA Vaccine 87

Drug Target Review

APRIL 17, 2024

Dr Chowell spent a year as a visiting graduate student at the Moe Win Laboratory for Information and Decision Systems at MIT. During residency, he conducted laboratory research with Dr Timothy Chan investigating predictors of response to immunotherapy as part of the American Board of Radiology Holman Research pathway.

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Immune Response Laboratories DNA Virus 105

Drug Target Review

JANUARY 26, 2024

Researchers from Columbia University and the US Department of Energy (DOE)’s Brookhaven National Laboratory have elucidated a method to produce large quantities of the receptor that the SARS-CoV-2 spike protein uses to bind to the surface of human cells.

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Production DNA Virus Protein Expression 114

Drug Target Review

DECEMBER 7, 2023

Researchers from the Laboratory of Bacteriology at The Rockefeller University have now found that bacteria sense phages by a defensive response named CBASS (cyclic oligonucleotide-based antiphage signalling system) which detects viral RNA. Its presence elsewhere would indicate something is wrong. But what, exactly?”

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RNA Immune Response DNA Molecular Biology 59

Drug Discovery World

NOVEMBER 7, 2022

To do so, they tested how using a genomic medicine team of specialist doctors, bioinformaticians, and scientists could boost the capabilities of NHS diagnostic laboratories beyond the standard semi-automated analysis of data. . It can also permit targeted screening of known disease complications and access to drug studies.

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Disease Bioinformatics Laboratories DNA 130

Codon

AUGUST 28, 2024

Tessa Alexanian and Max Langenkamp build computational DNA screening tools for a living. A concerned employee at a laboratory supply company had called the Centers for Disease Control, or CDC, after fielding repeated calls from Harris asking when his samples of plague would arrive in the mail. This article concludes our mini-issue.

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DNA Bioinformatics Virus Government 80

Drug Discovery World

APRIL 11, 2023

The molecule, known as lissodendoric acid A, appears to counteract other molecules that can damage DNA, RNA and proteins and even destroy whole cells.

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Drug Research Research Drugs RNA 130

Drug Discovery World

NOVEMBER 7, 2022

From a general healthcare perspective, access to this sort of data is invaluable, but this is particularly noteworthy in that DNA tests have historically been limited in these regions on account of cost and availability of practitioners, services and resources.

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Therapies DNA Disease Research 246

Drug Target Review

FEBRUARY 6, 2024

Advances in DNA and RNA-focused molecular diagnostic methods have made blood-based multi-cancer early detection (MCED) tests a reality, but not for all patients. His more than 30 years of experience ranges from start-ups such as Exact Sciences and Good Start Genetics to established multinationals such as Abbott Laboratories.

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DNA RNA Science Laboratories 105

Alta Sciences

AUGUST 21, 2024

I have also learned a lot about the nuances of micropipettes that I would have never learned at school.” — Sheridan Moore , Research Associate Intern, Laboratory Sciences “My favorite part about interning at Altasciences is the potential for creating a long, meaningful career that I would be passionate about.

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International Laboratories Science Molecular Biology 40

LifeSciVC

APRIL 26, 2024

Beyond simply backing great science (separating the wheat from the chafe), setting a company up properly is critical, and early choices can get locked into the DNA of the company. Some continue to do so today, unfortunately, but there appears to be less of it happening. Second, great teams of truly experienced leaders are scarce.

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DNA Science Marketing Clinical Trials 111

NIH Director's Blog: Drug Development

MARCH 11, 2014

Credit: Jane Ades, National Human Genome Research Institute, NIH Type 2 diabetes (T2D) tends to run in families, and over the last five years the application of genomic technologies has led to discovery of more than 60 specific DNA variants that contribute to risk.

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DNA Drugs Research Laboratories Disease 52

Drug Discovery World

AUGUST 29, 2024

High-throughput MS with automation In 2023, SCIEX launched the Echo MS Center of Excellence, equipped with the Echo MS+ system, which delivers qualitative and quantitative results through a panel of high-throughput assays, and is compatible with automated laboratory systems, such as the Beckman Coulter Life Sciences Biomek i7 liquid handler.

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Small Molecule Drugs Protein Expression Assay Development 147

DrugBank

MARCH 28, 2024

Astronauts face a myriad of ongoing and long-term risks that include reduced muscle mass and bone density loss, accelerated cancer cell metastasizing, and DNA damage.   The primary hazards in space, such as microgravity and cosmic radiation, have serious implications for human health.

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DNA Laboratories Engineering Disease 115