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Researchers develop artificial building blocks of life

Science Daily: Pharmacology News

For the first time, scientists have developed artificial nucleotides, the building blocks of DNA, with several additional properties in the laboratory.

DNA 343
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Meet the Flower Designer Who Built a Laboratory In His Home

Codon

In a quiet New York town, an amateur scientist has constructed a fully equipped research laboratory in which to advance plant biology research. ” Earlier this year, we sent a photographer to Sebastian’s home laboratory. ” Earlier this year, we sent a photographer to Sebastian’s home laboratory.

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Inaugural Merkin Prize in Biomedical Technology awarded to Dr. Marvin Caruthers for developing technology that efficiently synthesizes DNA

Broad Institute

Merkin Prize in Biomedical Technology for developing an efficient, automated technology for synthesizing DNA. The chemical reactions that he discovered in the early 1980s to accurately and quickly assemble nucleotides into strands of DNA provided an essential element in the development of modern molecular medicine.

DNA 98
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Extreme DNA resolution: Researchers slow down and scan multiple times individual DNA molecules

SCIENMAG: Medicine & Health

Aleksandra Radenovic, head of the Laboratory of Nanoscale Biology in the School of Engineering, has worked for years to improve nanopore technology, which involves passing a molecule like DNA through a tiny pore in a membrane to measure an ionic current.

DNA 62
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Machine learning guides researchers to new synthetic genetic switches

Broad Institute

What is special about these synthetically designed elements is that they show remarkable specificity to the target cell type they were designed for," said Ryan Tewhey, an associate professor at The Jackson Laboratory and co-senior author of the work with Steven Reilly of Yale, and Pardis Sabeti of the Broad. In a paper published in Oct.

Research 136
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Evolved prime editors are smaller and more efficient for therapeutic applications

Broad Institute

Now researchers at the Broad Institute of MIT and Harvard have used cutting-edge continuous laboratory evolution and engineering methods to develop improved versions of the gene-editing tool. Reverse transcriptase proteins that copy RNA templates into strands of DNA are found naturally in all plant and animal cells and in many viruses.

DNA 145
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David Liu receives Breakthrough Prize in Life Sciences

Broad Institute

Base editing, which Lius team developed in 2016, is a gene editing technique that directly converts an individual DNA base pair into a different base pair. Prime editing, which Lius group pioneered three years later, can make insertions, deletions, and substitutions up to hundreds of base pairs long in the genome.

Science 98