ASPET

MARCH 20, 2024

DNA topoisomerase IIβ (TOP2β/180; 180 kDa) is a nuclear enzyme that regulates DNA topology by generation of short-lived DNA double-strand breaks primarily during transcription. TOP2β/180 can be a target for DNA damage-stabilizing anticancer drugs, whose efficacy is often limited by chemoresistance.

DNA 100

DNA Laboratories Therapies Regulations 100

The Pharma Data

NOVEMBER 26, 2020

26, 2020 /PRNewswire/ — BASE10 Genetics and DNA Link today announced their collaboration on a research project to evaluate the usability of DNA Link ‘ s AccuFind COVID-19 IgG antibody test in a healthcare setting. Study will expand access to antibody testing outside of laboratory settings. About DNA Link, Inc.

DNA 52

DNA Nurses Research Laboratories 52

Drug Target Review

JANUARY 26, 2024

Researchers from Columbia University and the US Department of Energy (DOE)’s Brookhaven National Laboratory have elucidated a method to produce large quantities of the receptor that the SARS-CoV-2 spike protein uses to bind to the surface of human cells.

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Production DNA Virus Protein Expression 114

Broad Institute

MAY 14, 2024

William Studier for development of widely used protein- and RNA-production platform The $400,000 award recognizes the far-reaching medical impacts of Studier’s development, in the 1980s, of an efficient and scalable technology to produce mass amounts of RNA and proteins in laboratories that is widely used today all over the world.

RNA 84

RNA Production Molecular Biology Laboratories 84

Codon

AUGUST 27, 2024

Allison Berke makes the case for real-time DNA sequencing and AI tools to detect pathogens before they spread widely. Reading DNA The first step in detecting a novel pathogen is recognizing it as an anomaly amidst a noisy background of other material. After copying the DNA to form a big pool, each piece is sequenced.

DNA 84

DNA Laboratories Hospitals Virus 84

sptlabtech

JUNE 9, 2023

However, with so many individual processes involved in NGS library preparation, you might think that automating this workflow requires several instruments costing large amounts of laboratory space. Enter firefly ®. What benefits can you expect to see from making the switch to automated liquid handling with firefly?

Laboratories 98

Laboratories Molecular Biology DNA Engineering 98

Drug Target Review

SEPTEMBER 28, 2023

After some time in that role and launching several products, I received a call from Bill Banyai and Bill Peck, or ‘The Bills’ as we call them, who were building a company around technology that creates DNA by ‘writing’ it on a silicon chip. We’ve miniaturised the chemical process to making DNA and synthesize or ‘write’ DNA on a silicon chip.

DNA 116

DNA Organic Chemistry Science Virus 116

PLOS: DNA Science

APRIL 20, 2023

DNA is a sleek double helix, with “rungs” consisting of a purine base paired with a smaller pyrimidine base: adenine (A) with thymine (T) and guanine (G) with cytosine (C). . ” DNA encodes amino acid sequences comprising proteins, which impart traits. Watson and F.

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DNA Virus Science RNA 52

NIH Director's Blog: Drug Development

MARCH 11, 2014

Credit: Jane Ades, National Human Genome Research Institute, NIH Type 2 diabetes (T2D) tends to run in families, and over the last five years the application of genomic technologies has led to discovery of more than 60 specific DNA variants that contribute to risk.

DNA 52

DNA Drugs Disease Research Laboratories 52

Drug Target Review

APRIL 17, 2024

Dr Chowell spent a year as a visiting graduate student at the Moe Win Laboratory for Information and Decision Systems at MIT. During residency, he conducted laboratory research with Dr Timothy Chan investigating predictors of response to immunotherapy as part of the American Board of Radiology Holman Research pathway.

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Immune Response Laboratories DNA Virus 105

PLOS: DNA Science

MAY 16, 2024

That’s thanks to accelerated genome sequencing technologies, expanded laboratory capabilities, and interacting infrastructure on a global level. Many of the links below are to some of the 100+ DNA Science posts that I wrote during the pandemic. But I think about that time often, and the warning that it sounded.

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Virus DNA RNA Vaccine 97

Drug Target Review

FEBRUARY 6, 2024

Advances in DNA and RNA-focused molecular diagnostic methods have made blood-based multi-cancer early detection (MCED) tests a reality, but not for all patients. His more than 30 years of experience ranges from start-ups such as Exact Sciences and Good Start Genetics to established multinationals such as Abbott Laboratories.

DNA 105

DNA RNA Science Laboratories 105

Broad Institute

OCTOBER 4, 2023

Related links Merkin Prize Inaugural Merkin Prize in Biomedical Technology awarded to Dr. Marvin Caruthers for developing technology that efficiently synthesizes DNA The inaugural Richard N. Caruthers was announced as the winner in June for his development, in 1981, of an efficient, automated technology for synthesizing DNA.

DNA 52

DNA RNA Science Protein Expression 52

Broad Institute

JUNE 27, 2024

Unlike gene editing, this “epigenetic” editing does not modify the underlying DNA sequence, but it should switch the gene off permanently, which means that this could be a one-time treatment. Like Cas9, ZFPs can serve as guide proteins to direct the tool to a target site in DNA.

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Disease Therapies Engineering Clinical Trials 142

SCIENMAG: Medicine & Health

JULY 3, 2023

A research team led by Xianghong Jasmine Zhou, PhD, professor of Pathology and Laboratory Medicine at the David Geffen School of Medicine at UCLA, has made an important advancement to address one of the major challenges in cell-free DNA (cfDNA) testing, also known as liquid biopsy.

Research 62

Research DNA Laboratories 62

Codon

DECEMBER 10, 2023

The Higgs boson was discovered at CERN, a sprawling particle physics laboratory that cost more than $10 billion to build. This last variable could be just about anything; there are proteins that bind to other proteins (like antibodies), cut other proteins (proteases), or bind DNA (transcription factors).

Protein Expression 87

Protein Expression DNA Laboratories Engineering 87

DrugBaron

JANUARY 8, 2021

The underlying assumption of most gene therapy procedures, irrespective of the disease being targeted, is that restoration of a wild-type DNA sequence will alone be sufficient to normalise the phenotype of the individual. Surely, then, a correct set of DNA plans will ensure a correctly functioning cell?

DNA 100

DNA Therapies Disease Production 100

DrugBank

MARCH 28, 2024

Astronauts face a myriad of ongoing and long-term risks that include reduced muscle mass and bone density loss, accelerated cancer cell metastasizing, and DNA damage.   The primary hazards in space, such as microgravity and cosmic radiation, have serious implications for human health.

DNA 115

DNA Laboratories Disease Engineering 115

Codon

JUNE 30, 2024

Modern biotechnology began in 1972 when biochemists at Stanford University spliced together DNA from two different organisms. The race to exploit recombinant DNA technology was on. Stanley Cohen’s laboratory bench from 1973. General Electric Research Laboratory in Schenectady, New York. Join Asimov Press.

DNA 86

DNA Engineering Laboratories Production 86

LifeSciVC

APRIL 26, 2024

Beyond simply backing great science (separating the wheat from the chafe), setting a company up properly is critical, and early choices can get locked into the DNA of the company. Some continue to do so today, unfortunately, but there appears to be less of it happening. Second, great teams of truly experienced leaders are scarce.

DNA 107

DNA Science Marketing Clinical Trials 107

Codon

JUNE 25, 2024

However, they plod along as they clone plasmids—the loops of DNA that biologists use to manipulate and study organisms—because propagating them relies, in part, on the pace at which cells grow and divide. Most medicines, including insulin and semaglutide (the weight loss drug), are made using DNA cloning. However, E.

DNA 69

DNA RNA Laboratories Research 69

Codon

AUGUST 26, 2024

Brian Wang (co-founder of the nonprofit Panoplia Laboratories ) outlines his approach to making broad-spectrum antivirals. Last year, several colleagues and I joined these efforts by co-founding Panoplia Laboratories , a nonprofit organization developing broad-spectrum antivirals using tools from synthetic biology.

RNA 85

RNA Virus DNA Vaccine 85

Codon

DECEMBER 12, 2024

DNA and RNA molecules are also built from exclusively right-handed nucleic acids. Across the tree of life, organisms strictly require exactly one of the two chiral forms of their molecular building blocks — amino acids, nucleotides of RNA and DNA. 4 As far as we know, right-handed proteins never occur naturally.

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DNA RNA Vaccine Virus 99

Drug Target Review

JULY 5, 2023

However, some groups will decide to complete this stage within their own laboratories. After binding, the transposase enzyme will excise the flanked section of DNA (termed the transposon) and insert it into sites in the genome at specific target sequences. We talk about personalised medicine; how about personalised host cell lines?

Engineering 105

Engineering DNA Laboratories Production 105

Alta Sciences

APRIL 16, 2024

Gene therapy requires DNA and/or RNA delivery and analysis, and while most ongoing research involves therapies being delivered in vivo via adeno-associated viral (AAV) vectors, other in vivo delivery methods are on the rise. The process utilizes short synthetic DNA fragments called primers to choose a section of the genome to be amplified.

Therapies 52

Therapies DNA RNA Laboratories 52

Drug Target Review

JULY 24, 2023

In addition, we have concluded that the gene product is an apicpolast RNA polymerase sigma factor because of the localisation of the gene product, ApSIGMA, in the apicoplast interaction with apicoplast promoter DNA sequences, and the activity of an ApSIGMA- E.coli _RpoS chimeric sigma factor protein.

RNA 98

RNA Regulations Bioinformatics Laboratories 98

Drug Target Review

DECEMBER 7, 2023

Researchers from the Laboratory of Bacteriology at The Rockefeller University have now found that bacteria sense phages by a defensive response named CBASS (cyclic oligonucleotide-based antiphage signalling system) which detects viral RNA. Its presence elsewhere would indicate something is wrong. But what, exactly?”

RNA 59

RNA Immune Response DNA Molecular Biology 59

Drug Target Review

SEPTEMBER 4, 2023

5 Cytology-based profiling can facilitate antibiotic discovery efforts and, these assays assess cell cycle progression, nuclear and mitochondrial DNA content, mitochondrial DNA replication, nuclear DNA damage, mitochondrial membrane potential, and lysosome structure and function. References: Antunes Luisa (2023).

Drugs 111

Drugs RNA DNA Disease 111

addgene Blog

MAY 30, 2023

Adeno-associated virus (AAV) is a single stranded, Parvoviridae DNA virus, packaged in a non-enveloped icosahedral capsid, that can be used to express genes of interest in cell and animal models. This post was contributed by guest blogger Didem Goz Ayturk with edits and updates from Addgenies Karen Guerin and Susanna Stroik.

Virus 53

Virus Packaging DNA Laboratories 53

Codon

DECEMBER 10, 2023

The Higgs boson was discovered at CERN, a sprawling particle physics laboratory that cost more than $10 billion to build. This last variable could be just about anything; there are proteins that bind to other proteins (like antibodies), cut other proteins (proteases), or bind DNA (transcription factors).

Protein Expression 68

Protein Expression DNA Laboratories Engineering 68

KIF1A

JANUARY 27, 2024

The Jackson Laboratory, who has developed 3 KAND mouse models and 9 KAND cell models, is working on Prime/base gene editing, which replaces large sections of mutant KIF1A DNA with the healthy sequence. Simran Kaur’s 2023 conference talk briefly describes the KIF1A mini-gene approach.

Therapies 111

Therapies Small Molecule DNA Treatment 111

KIF1A

MAY 4, 2024

Her undergraduate research focused on lipid metabolism of NASH at UCSD Medical School and DNA breakage and repair mechanism at Scripps Research. During her undergraduate studies, she worked on heart disease research in Chi Kueng Lam’s laboratory at the University of Delaware. She graduated from UC San Diego with a B.S.

Science 116

Science Medical Schools RNA Research 116

sptlabtech

JUNE 9, 2023

However, with so many individual processes involved in NGS library preparation, you might think that automating this workflow requires several instruments costing large amounts of laboratory space. What benefits can you expect to see from making the switch to automated liquid handling with firefly?

Molecular Biology 52

Molecular Biology DNA Laboratories Disease 52

Codon

JULY 11, 2023

That’s because proteins are made, in the laboratory, using synthetic DNA and cells; and DNA is expensive. Our machine would make proteins without using any DNA or cells. All cells make proteins in two steps: DNA is transcribed into messenger RNA, which is then translated into protein.

RNA 63

RNA DNA Engineering Laboratories 63

Drug Target Review

DECEMBER 5, 2024

2 Structure and function of AAV capsids in gene therapy Wild-type AAV is composed of a protein shell (capsid) that contains a single-stranded DNA genome encoding proteins involved in viral replication, structure and assembly. Dr Chelsea B Pratt is the Biopharma Segment Marketing Manager at Bio-Rad Laboratories.

Therapies 52

Therapies Virus DNA Compliance 52

Drug Target Review

SEPTEMBER 8, 2023

The cell’s nucleus, containing compacted DNA, is centrally positioned within the cell. It didn’t have the tools that are important for nuclear receptors, namely the ability to interact with DNA and the ability to translocate from the cytoplasm to the nucleus,” says Cheroutre. Does it modulate the signalling strength or duration?

Regulations 98

Regulations Research DNA Immune Response 98

Conversations in Drug Development Trends

DECEMBER 12, 2022

What is the difference between a Clinical Laboratory Improvement Amendments (CLIA)-approved laboratory vs a research laboratory? The Centers for Medicare & Medicaid Services (CMS) regulates all clinical laboratory testing performed on human samples in the US through CLIA.

Clinical Trials 52

Clinical Trials Trials Laboratories Research Laboratories 52