sptlabtech

JUNE 9, 2023

However, with so many individual processes involved in NGS library preparation, you might think that automating this workflow requires several instruments costing large amounts of laboratory space. Enter firefly ®. What benefits can you expect to see from making the switch to automated liquid handling with firefly?

Laboratories 98

Laboratories Molecular Biology DNA Engineering 98

Drug Target Review

SEPTEMBER 28, 2023

After some time in that role and launching several products, I received a call from Bill Banyai and Bill Peck, or ‘The Bills’ as we call them, who were building a company around technology that creates DNA by ‘writing’ it on a silicon chip. We’ve miniaturised the chemical process to making DNA and synthesize or ‘write’ DNA on a silicon chip.

DNA 116

DNA Organic Chemistry Science Virus 116

NIH Director's Blog: Drug Development

MARCH 11, 2014

Credit: Jane Ades, National Human Genome Research Institute, NIH Type 2 diabetes (T2D) tends to run in families, and over the last five years the application of genomic technologies has led to discovery of more than 60 specific DNA variants that contribute to risk.

DNA 52

DNA Drugs Disease Research Laboratories 52

Drug Target Review

APRIL 17, 2024

Dr Chowell spent a year as a visiting graduate student at the Moe Win Laboratory for Information and Decision Systems at MIT. During residency, he conducted laboratory research with Dr Timothy Chan investigating predictors of response to immunotherapy as part of the American Board of Radiology Holman Research pathway.

Immune Response 105

Immune Response Laboratories DNA Virus 105

Conversations in Drug Development Trends

NOVEMBER 12, 2024

For example, once considered incurable and terminal, patients with sickle cell disease may reach new summits in their lives with gene editing technologies such as CRISPR to repair affected DNA and, in some cases, functionally cure the condition. Modifying and expanding the cells in a GMP laboratory.

Therapies 72

Therapies Clinical Supply Clinical Trials Trials 72

Codon

DECEMBER 10, 2023

The Higgs boson was discovered at CERN, a sprawling particle physics laboratory that cost more than $10 billion to build. This last variable could be just about anything; there are proteins that bind to other proteins (like antibodies), cut other proteins (proteases), or bind DNA (transcription factors).

Protein Expression 103

Protein Expression Laboratories DNA Engineering 103

DrugBank

MARCH 28, 2024

Astronauts face a myriad of ongoing and long-term risks that include reduced muscle mass and bone density loss, accelerated cancer cell metastasizing, and DNA damage.   The primary hazards in space, such as microgravity and cosmic radiation, have serious implications for human health.

DNA 144

DNA Laboratories Disease Engineering 144

SCIENMAG: Medicine & Health

JULY 3, 2023

A research team led by Xianghong Jasmine Zhou, PhD, professor of Pathology and Laboratory Medicine at the David Geffen School of Medicine at UCLA, has made an important advancement to address one of the major challenges in cell-free DNA (cfDNA) testing, also known as liquid biopsy.

Research 62

Research DNA Laboratories 62

LifeSciVC

APRIL 26, 2024

Beyond simply backing great science (separating the wheat from the chafe), setting a company up properly is critical, and early choices can get locked into the DNA of the company. Some continue to do so today, unfortunately, but there appears to be less of it happening. Second, great teams of truly experienced leaders are scarce.

DNA 112

DNA Science Marketing Clinical Trials 112

DrugBaron

JANUARY 8, 2021

The underlying assumption of most gene therapy procedures, irrespective of the disease being targeted, is that restoration of a wild-type DNA sequence will alone be sufficient to normalise the phenotype of the individual. Surely, then, a correct set of DNA plans will ensure a correctly functioning cell?

DNA 100

DNA Therapies Disease Production 100

addgene Blog

MAY 30, 2023

Adeno-associated virus (AAV) is a single stranded, Parvoviridae DNA virus, packaged in a non-enveloped icosahedral capsid, that can be used to express genes of interest in cell and animal models. This post was contributed by guest blogger Didem Goz Ayturk with edits and updates from Addgenies Karen Guerin and Susanna Stroik.

Virus 63

Virus Packaging DNA Laboratories 63

Codon

DECEMBER 10, 2023

The Higgs boson was discovered at CERN, a sprawling particle physics laboratory that cost more than $10 billion to build. This last variable could be just about anything; there are proteins that bind to other proteins (like antibodies), cut other proteins (proteases), or bind DNA (transcription factors).

Protein Expression 81

Protein Expression Laboratories DNA Engineering 81

Drug Target Review

JULY 5, 2023

However, some groups will decide to complete this stage within their own laboratories. After binding, the transposase enzyme will excise the flanked section of DNA (termed the transposon) and insert it into sites in the genome at specific target sequences. We talk about personalised medicine; how about personalised host cell lines?

Engineering 105

Engineering DNA Laboratories Production 105

Alta Sciences

APRIL 16, 2024

Gene therapy requires DNA and/or RNA delivery and analysis, and while most ongoing research involves therapies being delivered in vivo via adeno-associated viral (AAV) vectors, other in vivo delivery methods are on the rise. The process utilizes short synthetic DNA fragments called primers to choose a section of the genome to be amplified.

Therapies 52

Therapies DNA RNA Laboratories 52

Drug Target Review

DECEMBER 7, 2023

Researchers from the Laboratory of Bacteriology at The Rockefeller University have now found that bacteria sense phages by a defensive response named CBASS (cyclic oligonucleotide-based antiphage signalling system) which detects viral RNA. Its presence elsewhere would indicate something is wrong. But what, exactly?”

RNA 59

RNA Immune Response DNA Molecular Biology 59

sptlabtech

JUNE 9, 2023

However, with so many individual processes involved in NGS library preparation, you might think that automating this workflow requires several instruments costing large amounts of laboratory space. What benefits can you expect to see from making the switch to automated liquid handling with firefly?

Molecular Biology 52

Molecular Biology DNA Laboratories Disease 52

KIF1A

JANUARY 27, 2024

The Jackson Laboratory, who has developed 3 KAND mouse models and 9 KAND cell models, is working on Prime/base gene editing, which replaces large sections of mutant KIF1A DNA with the healthy sequence. Simran Kaur’s 2023 conference talk briefly describes the KIF1A mini-gene approach.

Therapies 111

Therapies Small Molecule Treatment DNA 111

Drug Target Review

SEPTEMBER 8, 2023

The cell’s nucleus, containing compacted DNA, is centrally positioned within the cell. It didn’t have the tools that are important for nuclear receptors, namely the ability to interact with DNA and the ability to translocate from the cytoplasm to the nucleus,” says Cheroutre. Does it modulate the signalling strength or duration?

Regulations 98

Regulations Research DNA Immune Response 98

Conversations in Drug Development Trends

DECEMBER 12, 2022

What is the difference between a Clinical Laboratory Improvement Amendments (CLIA)-approved laboratory vs a research laboratory? The Centers for Medicare & Medicaid Services (CMS) regulates all clinical laboratory testing performed on human samples in the US through CLIA.

Clinical Trials 52

Clinical Trials Trials Laboratories Research Laboratories 52

The Pharma Data

OCTOBER 19, 2020

Spectrum and Rutgers Clinical Genomics Laboratory (RUCDR, now IBX) first identified, then introduced the nation to the key benefits of using saliva collected exclusively with the SDNA-1000 saliva collection system as a better viral diagnostic biomaterial for COVID-19 detection. ABOUT SPECTRUM SOLUTIONS AND SPECTRUM DNA.

RNA 52

RNA DNA Engineering Virus 52

The Pharma Data

OCTOBER 26, 2021

This is the first time that research scientists can conduct oncology research with Foundation Medicine’s comprehensive genomic profiling in their own laboratories to gain meaningful genomic insights and deepen their understanding of cancer biology. Roche today announced that it has launched the AVENIO Tumor Tissue CGP Kit.

Research 52

Research Clinical Trials Laboratories DNA 52

sptlabtech

FEBRUARY 13, 2023

SLAS San Diego 2023 has come and gone, and SPT Labtech were thrilled to be exhibiting at this premier event for life sciences and laboratory automation. As a global leader in laboratory automation, we're proud to have been a part of this exciting event, showcasing our latest products and services to attendees from all around the world.

DNA 52

DNA Laboratories Production Science 52

PLOS: DNA Science

JUNE 8, 2023

That was so in 1977, when “intervening DNA sequences” – aka “introns” – were discovered to interrupt protein-encoding genes. Because the edits are in RNA, and not DNA, they are fleeting. The post How (and Why) the Octopus Edits its RNA appeared first on DNA Science.

RNA 52

RNA DNA Science Laboratories 52

Broad Institute

AUGUST 24, 2022

Data from standard DNA and RNA sequencing approaches were integrated with mass spectrometry-based proteomics and phosphoproteomic analyses to derive more complete molecular portraits of treatment-responsive versus treatment-resistant tumors. "The These data suggest a multi-omics predictor for chemotherapy response is within reach.

DNA 52

DNA Treatment Protein Expression Protein Production 52

Drug Target Review

NOVEMBER 6, 2023

At AstraZeneca and beyond we are exploring the use of cell-free DNA (cfDNA) methods to assess minimal residual disease as a possible intermediate endpoint across several disease types. To be successful, surrogate or intermediate endpoints will need to be established to accelerate the development of the new regimens.

Small Molecule 111

Small Molecule Therapies Treatment Disease 111

Drug Target Review

DECEMBER 5, 2024

2 Structure and function of AAV capsids in gene therapy Wild-type AAV is composed of a protein shell (capsid) that contains a single-stranded DNA genome encoding proteins involved in viral replication, structure and assembly. Dr Chelsea B Pratt is the Biopharma Segment Marketing Manager at Bio-Rad Laboratories.

Therapies 52

Therapies Virus DNA Compliance 52

DrugBaron

JULY 19, 2022

But whatever the number is, it is so much larger than the number of compounds that have ever been synthesised in a chemistry laboratory (which is over the order of 10^12) that the limitation of virtual screening instantly becomes clear: we are hardly scratching the surface of the small molecule diversity.

Small Molecule 100

Small Molecule Drugs DNA Pharma Companies 100

The Pharma Data

JANUARY 31, 2021

Illumina , the world’s leading DNA sequencing and array-based technologies company, is partnering with Sequoia Capital China, an investment firm, to launch a life sciences incubator in China. All will be in a fully operational laboratory space in Shanghai, China. The first funding cycle will start in the Fall of 2021. Here’s the link.

Science 52

Science Laboratories DNA Therapies 52

Drug Target Review

JANUARY 9, 2024

Prior to the new study, the laboratories of Dr Michael Levin, Vannevar Bush Professor of Biology at Tufts University School of Arts & Sciences, and Dr Josh Bongard at the University of Vermont, created multicellular biological robots from frog embryo cells, named xenobots.

Laboratories 59

Laboratories Immune Response DNA Science 59

The Open Targets Blog

APRIL 25, 2023

Although the estate was undoubtedly pretty, the Hall had seen better days and was rather dominated by a 1950s building that provided laboratories for the light engineering company that had owned the site. Only later were the first computers established to automate intelligence gathering.

DNA 52

DNA Government Engineering Laboratories 52

Alta Sciences

AUGUST 21, 2024

I have also learned a lot about the nuances of micropipettes that I would have never learned at school.” — Sheridan Moore , Research Associate Intern, Laboratory Sciences “My favorite part about interning at Altasciences is the potential for creating a long, meaningful career that I would be passionate about.

International 40

International Laboratories Science Molecular Biology 40

The Premier Consulting Blog

JULY 9, 2023

Impurities or degradants that exceed qualification thresholds and have not been adequately tested in Good Laboratory Practices (GLPs) toxicology studies are often encountered during development. In addition, this guidance focuses on DNA reactive substances that could potentially cause cancer. link] ICH M7 (R2)- Q&A.

Small Molecule 52

Small Molecule DNA Drugs Clinical Development 52

Conversations in Drug Development Trends

AUGUST 14, 2024

The analysis of circulating tumor DNA (ctDNA) in a liquid biopsy can also permit genotyping and help monitor the effectiveness of chemotherapy. In hematological cancers, a liquid biopsy can help identify mutations otherwise absent in a tissue biopsy.

Treatment 78

Treatment Therapies Disease Protein Expression 78

Alta Sciences

MARCH 1, 2024

The new cells are then grown in high numbers in a laboratory and then are re-administered to the patient, where the genetically modified cells will attack more specific cancer cells. This technology extensively utilizes immunofluorescence and flow cytometry technology, which is a platform offered in our laboratories.

Therapies 52

Therapies Laboratories Molecular Biology RNA 52

The Pharma Data

JANUARY 7, 2021

OraSure, together with its wholly-owned subsidiaries, DNA Genotek, Diversigen, and Novosanis, provides its customers with end-to-end solutions that encompass tools, services and diagnostics. OraSure Technologies empowers the global community to improve health and wellness by providing access to accurate, essential information.

DNA 40

DNA Laboratories Government Hospitals 40

Drug Target Review

APRIL 9, 2024

For his postdoctoral stay he joined the group of André Nussenzweig, where he started to work on DNA repair, particularly focusing on the role of histone H2AX. Today, several companies have ATR inhibitors at various stages of clinical development, which to a significant extent was influenced by early works from the laboratory.

RNA 64

RNA Cell Biology Clinical Development Disease 64

PPD

AUGUST 5, 2024

Our end-to-end global capabilities — including site networks and investigators, regulatory support, integrated laboratory services , patient access , and digital and decentralized solutions — support your study from Phase I through peri-and post-approval. Set up your respiratory studies for success.

Clinical Trials 98

Clinical Trials Trials Clinical Research Disease 98