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Researchers develop artificial building blocks of life

Science Daily: Pharmacology News

For the first time, scientists have developed artificial nucleotides, the building blocks of DNA, with several additional properties in the laboratory.

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David Liu receives Breakthrough Prize in Life Sciences

Broad Institute

Base editing, which Lius team developed in 2016, is a gene editing technique that directly converts an individual DNA base pair into a different base pair. Prime editing, which Lius group pioneered three years later, can make insertions, deletions, and substitutions up to hundreds of base pairs long in the genome.

Science 139
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Extreme DNA resolution: Researchers slow down and scan multiple times individual DNA molecules

SCIENMAG: Medicine & Health

Aleksandra Radenovic, head of the Laboratory of Nanoscale Biology in the School of Engineering, has worked for years to improve nanopore technology, which involves passing a molecule like DNA through a tiny pore in a membrane to measure an ionic current.

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Machine learning guides researchers to new synthetic genetic switches

Broad Institute

What is special about these synthetically designed elements is that they show remarkable specificity to the target cell type they were designed for," said Ryan Tewhey, an associate professor at The Jackson Laboratory and co-senior author of the work with Steven Reilly of Yale, and Pardis Sabeti of the Broad. In a paper published in Oct.

Research 136
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Evolved prime editors are smaller and more efficient for therapeutic applications

Broad Institute

Now researchers at the Broad Institute of MIT and Harvard have used cutting-edge continuous laboratory evolution and engineering methods to develop improved versions of the gene-editing tool. Reverse transcriptase proteins that copy RNA templates into strands of DNA are found naturally in all plant and animal cells and in many viruses.

DNA 145
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Driving Digital Transformation Through Laboratory Automation

The Connected Lab

The automation of processes, workflows, and data enables laboratories to reduce downtime, increase scalability, and optimize efficiency. Automation provides the time and space for biotech R&D laboratories to focus on innovations and improvements, which is crucial to a laboratory’s success.

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Use of CRISPR/Cas9 with Homology-Directed Repair (HDR) to Gene-Edit Topoisomerase II{beta} in Human Leukemia K562 Cells: Generation of a Resistance Phenotype [Chemotherapy, Antibiotics, and Gene Therapy]

ASPET

DNA topoisomerase IIβ (TOP2β/180; 180 kDa) is a nuclear enzyme that regulates DNA topology by generation of short-lived DNA double-strand breaks primarily during transcription. TOP2β/180 can be a target for DNA damage-stabilizing anticancer drugs, whose efficacy is often limited by chemoresistance.

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