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SARS-CoV-2: advancing the production of the ACE2 protein

Drug Target Review

Researchers from Columbia University and the US Department of Energy (DOE)’s Brookhaven National Laboratory have elucidated a method to produce large quantities of the receptor that the SARS-CoV-2 spike protein uses to bind to the surface of human cells.

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What Biology Can Learn from Physics

Codon

The Higgs boson was discovered at CERN, a sprawling particle physics laboratory that cost more than $10 billion to build. Such a model would make it possible to discover protein functions by scraping metagenomic databases , or to create proteins with functions that exist nowhere in nature.

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A therapy candidate for fatal prion diseases turns off disease-causing gene

Broad Institute

By Greta Friar, Whitehead Institute June 27, 2024 Images of a mouse brain show the effect of a technology called CHARM in turning off the expression of a gene in the brain. Like Cas9, ZFPs can serve as guide proteins to direct the tool to a target site in DNA. Credit: Neumann EN, Bertozzi TM, et al.

Disease 142
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Marvin Caruthers receives inaugural Merkin Prize in ceremony at the Broad Institute for DNA synthesis technology

Broad Institute

Related links Merkin Prize Inaugural Merkin Prize in Biomedical Technology awarded to Dr. Marvin Caruthers for developing technology that efficiently synthesizes DNA The inaugural Richard N. Caruthers was announced as the winner in June for his development, in 1981, of an efficient, automated technology for synthesizing DNA.

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What Biology Can Learn from Physics

Codon

The Higgs boson was discovered at CERN, a sprawling particle physics laboratory that cost more than $10 billion to build. Such a model would make it possible to discover protein functions by scraping metagenomic databases , or to create proteins with functions that exist nowhere in nature.

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Addressing increasingly resistant drugs by infectious agents

Drug Target Review

10 Reported cAMP as the second messenger signalling molecule conserved from bacteria to humans and modulates several biological processes, including protein expression, gene transcription, and cell development and differentiation. He has over two years of experience in research and laboratory work.

Drugs 111
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Key considerations before commencing cell line development

Drug Target Review

This selectable marker enables the identification of cells which have taken up the GOIs and aids the initial selection of recombinant protein expressing cell lines. However, some groups will decide to complete this stage within their own laboratories. We talk about personalised medicine; how about personalised host cell lines?