Broad Institute

JUNE 27, 2024

By Greta Friar, Whitehead Institute June 27, 2024 Images of a mouse brain show the effect of a technology called CHARM in turning off the expression of a gene in the brain. Like Cas9, ZFPs can serve as guide proteins to direct the tool to a target site in DNA. Credit: Neumann EN, Bertozzi TM, et al.

Disease 142

Disease Therapies Engineering Clinical Trials 142

Drug Discovery World

NOVEMBER 30, 2023

This presentation covered three primary drivers for a protein expression model: speed, cost and sustainability. “It To demonstrate the utility of the company’s SYNTAX system in gene assembly, the 1.7 kb Influenza A hemagglutinin gene was used as a model system.

Protein Expression 147

Protein Expression Engineering DNA Therapies 147

Drug Target Review

SEPTEMBER 10, 2024

The current landscape of protein drug development is characterised by accelerated timelines where new drugs are approved in months rather than years. For example, advances in media and feeds have contributed to higher cell protein expression by optimising nutrient availability and reducing accumulation of waste products within a culture.

Clinical Supply 64

Clinical Supply Drug Development Production Animal Testing 64

Conversations in Drug Development Trends

AUGUST 14, 2024

The analysis of circulating tumor DNA (ctDNA) in a liquid biopsy can also permit genotyping and help monitor the effectiveness of chemotherapy. Proteomics Proteomics involves studying the entire set of proteins expressed in a cell or tissue.

Treatment 78

Treatment Protein Expression Therapies Disease 78

Drug Target Review

JULY 5, 2023

This selectable marker enables the identification of cells which have taken up the GOIs and aids the initial selection of recombinant protein expressing cell lines. However, some groups will decide to complete this stage within their own laboratories. We talk about personalised medicine; how about personalised host cell lines?

Engineering 105

Engineering DNA Laboratories Production 105

Drug Discovery World

NOVEMBER 9, 2023

Klaus Wagenbauer, PhD, Founder & CEO, Plectonic, on: ‘Programmable DNA-origami-based T cell engagers: PTE’. They will present on expression and characterisation of novel GCN-related N-acetyltransferases by Nucleras rapid protein assess system.

Engineering 130

Engineering Therapies Protein Production Science 130

Drug Discovery World

NOVEMBER 13, 2023

Michael Traxlmayr, PhD, Group leader, CD Laboratory for Next-Generation CAR T Cells, University of Natural Resources & Life Sciences, on: ‘Novel concepts to regulate CAR T cell activity with small molecule drugs in vivo’.

Engineering 147

Engineering Science Bioinformatics Vaccine 147

Codon

APRIL 9, 2023

Marine sponges were cultured in the laboratory continuously for the first time. ” This technology could be used to design protein therapeutics that can bind to, and “shut down,” harmful or misfolded proteins in living cells. The RNA strands shut down a specific gene in the insects, and killed half after 7 days.

Therapies 52

Therapies RNA Engineering Vaccine 52