Drug Target Review

APRIL 17, 2024

Dr Chowell spent a year as a visiting graduate student at the Moe Win Laboratory for Information and Decision Systems at MIT. During residency, he conducted laboratory research with Dr Timothy Chan investigating predictors of response to immunotherapy as part of the American Board of Radiology Holman Research pathway.

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Immune Response Laboratories DNA Virus 105

Drug Discovery World

FEBRUARY 6, 2024

From finding potential active substances and identifying novel targets, to simulating how drugs will function in the human body and optimising laboratory workflows, digital technologies are having a significant impact on drug discovery and development. Obulytix is not alone.

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Marketing Laboratories Engineering Clinical Trials 173

Codon

AUGUST 28, 2024

Tessa Alexanian and Max Langenkamp build computational DNA screening tools for a living. A concerned employee at a laboratory supply company had called the Centers for Disease Control, or CDC, after fielding repeated calls from Harris asking when his samples of plague would arrive in the mail. This article concludes our mini-issue.

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DNA Bioinformatics Virus Government 80

Drug Discovery World

SEPTEMBER 20, 2022

Visualising the whole genome is especially useful when sequencing new organisms, or stretches of DNA with many repeats or translocations, which are difficult to see from short sections of DNA code. Long-read data allows researchers to comprehensively discover, design and confirm AAV gene therapy approaches.

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Therapies DNA Disease Research 130

Drug Target Review

SEPTEMBER 4, 2023

Infectious agent includes bacteria, virus, fungi, and parasites, and they are capable of causing disease in a living organism. I had earlier proposed the use of Palmatine and Silver Nitrate in the efficacy against the RNA structure of the COVID-19 virus. He has over two years of experience in research and laboratory work.

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Drugs RNA DNA Disease 111

Alta Sciences

MARCH 1, 2024

The new cells are then grown in high numbers in a laboratory and then are re-administered to the patient, where the genetically modified cells will attack more specific cancer cells. This technology extensively utilizes immunofluorescence and flow cytometry technology, which is a platform offered in our laboratories.

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The Pharma Data

AUGUST 3, 2020

Thousands of DNA test machines will be rolled out in hospitals from September. The “on-the-spot” swab and DNA tests will help distinguish between Covid-19 and other seasonal illnesses, the government said. Image copyright. DnaNudge 2020. Image caption. Good news – but breakthrough will be judged on results.

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Drug Target Review

SEPTEMBER 8, 2023

The cell’s nucleus, containing compacted DNA, is centrally positioned within the cell. It didn’t have the tools that are important for nuclear receptors, namely the ability to interact with DNA and the ability to translocate from the cytoplasm to the nucleus,” says Cheroutre. Does it modulate the signalling strength or duration?

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Regulations Research DNA Immune Response 98

Drug Discovery World

NOVEMBER 17, 2022

It is believed that the term synthetic biology was created in 1970 by geneticist, Waclaw Szybalski 1 as work was being carried out on the development of DNA sequencing and synthesis techniques. These factors can significantly contribute to the growth of the synthetic biology market, it adds. . Brady and colleagues turned to algorithms.

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Engineering Molecular Biology Synthetic Chemistry DNA 130

The Pharma Data

MARCH 22, 2022

Nirmatrelvir [PF-07321332], which originated in Pfizer laboratories, is designed to block the activity of the Mpro, an enzyme that the coronavirus needs to replicate. In preclinical studies, nirmatrelvir did not demonstrate evidence of mutagenic DNA interactions. Alpha, Beta, Delta, Gamma, Lambda, Mu, and Omicron).

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Treatment Virus Hospitals Therapies 52

Codon

AUGUST 27, 2024

Allison Berke makes the case for real-time DNA sequencing and AI tools to detect pathogens before they spread widely. Reading DNA The first step in detecting a novel pathogen is recognizing it as an anomaly amidst a noisy background of other material. After copying the DNA to form a big pool, each piece is sequenced.

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DNA Hospitals Laboratories Virus 84

PLOS: DNA Science

FEBRUARY 15, 2024

Jessica is the only one in the present, it seems, to notice the decrepitude of the once-majestic crops, “how the wheat towered over the farmland in the afternoon light before her husband started using the seeds fixed in a laboratory and the wheat only reached her waist.” But dirt is dead, depleted of life.

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Science DNA Laboratories Virus 96

The Pharma Data

SEPTEMBER 1, 2020

Point of care testing increases access to high quality diagnostics solutions for the detection of a current SARS-CoV-2 infection, regardless of laboratory testing infrastructure or patient mobility. This is highly beneficial where timely decisions are needed or laboratory testing is inaccessible.

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Virus Laboratories Clinical Trials Treatment 52

The Pharma Data

OCTOBER 28, 2020

(Nasdaq: BIOC), a leading commercial provider of molecular diagnostic tests and services for physicians treating patients with cancer, announces an update on its COVID-19 testing with more than 80,000 samples received to date for processing through its RT-PCR technology at its CLIA-certified, CAP-accredited high-complexity molecular laboratory.

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PLOS: DNA Science

APRIL 20, 2023

DNA is a sleek double helix, with “rungs” consisting of a purine base paired with a smaller pyrimidine base: adenine (A) with thymine (T) and guanine (G) with cytosine (C). . ” DNA encodes amino acid sequences comprising proteins, which impart traits. Watson and F.

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DNA Virus Science RNA 52

PLOS: DNA Science

MAY 16, 2024

That’s thanks to accelerated genome sequencing technologies, expanded laboratory capabilities, and interacting infrastructure on a global level. Many of the links below are to some of the 100+ DNA Science posts that I wrote during the pandemic. A Novel Virus Appears In retrospect, everything unfolded with astonishing speed.

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Drug Target Review

SEPTEMBER 28, 2023

After some time in that role and launching several products, I received a call from Bill Banyai and Bill Peck, or ‘The Bills’ as we call them, who were building a company around technology that creates DNA by ‘writing’ it on a silicon chip. These are synthetic, not the live virus, so do not pose a risk of infection.

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DNA Organic Chemistry Science Virus 116

Broad Institute

MAY 14, 2024

William Studier for development of widely used protein- and RNA-production platform The $400,000 award recognizes the far-reaching medical impacts of Studier’s development, in the 1980s, of an efficient and scalable technology to produce mass amounts of RNA and proteins in laboratories that is widely used today all over the world.

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RNA Production Molecular Biology Laboratories 84

Drug Discovery World

NOVEMBER 15, 2022

Rapid and accurate DNA synthesis . Conventional DNA synthesis, typically used for making sequences such as primers, employs phosphoramidite chemistry, a method that was developed in the 1980s and is still considered the gold standard for DNA synthesis. .

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DNA Engineering Drugs Vaccine 246

Codon

MAY 11, 2023

It is used to prevent respiratory syncytial virus, or RSV, which causes about 60,000 hospitalizations in this age group each year. Then, three participants visited a laboratory in Austin, Texas and spent 16 hours over several days listening to the podcasts while in an fMRI scanner, according to reporting in The New York Times.

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Vaccine Engineering Licensing Licensing 52

Codon

MAY 11, 2023

It is used to prevent respiratory syncytial virus, or RSV, which causes about 60,000 hospitalizations in this age group each year. Then, three participants visited a laboratory in Austin, Texas and spent 16 hours over several days listening to the podcasts while in an fMRI scanner, according to reporting in The New York Times.

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Vaccine Engineering Licensing Licensing 52

Drug Discovery World

AUGUST 10, 2022

To create these cells, a physician draws a patient’s blood and sends it to a laboratory where the cells are isolated, engineered to express the CAR protein, and amplified in a bioreactor before being infused back into the patient. The challenge of manufacturing CAR T cells. Unfortunately, transfection is not a predictable process.

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Therapies Virus Treatment Engineering 246

Drug Discovery World

JULY 18, 2023

Rolf Turk , Senior Manager, Genomics Medicine at Integrated DNA Technologies, examines how CRISPR is being used to enhance cancer therapies. Nucleic acid-based diagnostics, which typically require PCR reagents and laboratory equipment, are crucial for identifying, treating, and preventing common infectious diseases.

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Disease DNA RNA Therapies 246

Codon

JUNE 25, 2024

However, they plod along as they clone plasmids—the loops of DNA that biologists use to manipulate and study organisms—because propagating them relies, in part, on the pace at which cells grow and divide. Most medicines, including insulin and semaglutide (the weight loss drug), are made using DNA cloning. However, E.

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DNA RNA Laboratories Engineering 70

Broad Institute

JUNE 27, 2024

Unlike gene editing, this “epigenetic” editing does not modify the underlying DNA sequence, but it should switch the gene off permanently, which means that this could be a one-time treatment. They used an engineered adeno-associated virus (AAV) that crosses the blood-brain barrier after intravenous administration.

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Disease Therapies Engineering Clinical Trials 142

Drug Discovery World

AUGUST 1, 2022

Chief of the Virus Persistence and Dynamics Section in the VRC Laboratory of Immunology, described NIAID’s long-standing collaboration with a bioengineering research group at the University of California, San Francisco. In the presentation, Eli Boritz, M.D.,

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Virus RNA DNA Therapies 130

Drug Discovery World

MAY 23, 2024

The product is differentiated in that it clears both the lesions and the HPV virus, which is the root-cause of the disease. Before Nutcracker, Deutsch led the DNA synthesis platform at the Joint Genome Institute of Lawrence Berkeley National Laboratory.

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RNA Therapies Engineering Disease 147

New Drug Approvals

APRIL 18, 2023

Approximately 76% of HIV-patients with measurable viral load are infected with a strain of virus that is resistant to one or more classes of antiretroviral agents, thus reducing treatment options. AMD-070 targets the CXCR4 receptor on HIV and prevents the virus from entering and infecting healthy cells. They are for reference only.

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Clinical Trials Virus Small Molecule Trials 52

addgene Blog

MAY 30, 2023

Adeno-associated virus (AAV) is a single stranded, Parvoviridae DNA virus, packaged in a non-enveloped icosahedral capsid, that can be used to express genes of interest in cell and animal models. This post was contributed by guest blogger Didem Goz Ayturk with edits and updates from Addgenies Karen Guerin and Susanna Stroik.

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Packaging Virus DNA Laboratories 53

Codon

JULY 27, 2023

They’ve just finished sequencing the patient’s genome, but they don’t have “DNA sorting” software. billion units of DNA code are transcribed into more than a hundred volumes, each a thousand pages long, in type so small as to be barely legible.” At least, that’s what every textbook says.

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Therapies RNA DNA Engineering 52

Codon

JULY 27, 2023

They’ve just finished sequencing the patient’s genome, but they don’t have “DNA sorting” software. billion units of DNA code are transcribed into more than a hundred volumes, each a thousand pages long, in type so small as to be barely legible.” At least, that’s what every textbook says.

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Therapies RNA DNA Engineering 52

Codon

APRIL 2, 2023

But now, by studying DNA extracted from microbes in the blood of almost 10,000 healthy people, this paper shows that there is no such thing. Read Transcription factors bind to DNA and control gene expression. Read Switchable hydrophobic pockets in DNA protocells enhance chemical conversion. Nature Microbiology. Meeussen J.V.W.

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DNA RNA Engineering Licensing 52

The Pharma Data

NOVEMBER 26, 2020

Researchers at Heidelberg University in Germany performed detailed imaging analysis to determine how SARS-CoV-2, the virus that causes COVID-19, reprograms infected cells. The virus causes changes in the membrane so it can produce its own replication organelles, amplifying the viral genome. It only takes 24 to 48 hours.

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Research Virus Vaccine DNA 52

The Pharma Data

OCTOBER 26, 2020

V590 — a SARS-CoV-2 vaccine candidate in development in collaboration with the International AIDS Vaccine Initiative (IAVI) that uses a recombinant vesicular stomatitis virus (rVSV) platform, the same platform used for Merck’s approved Ebola Zaire virus vaccine, will enter Phase 1 development shortly.

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Vaccine Trials Licensing Licensing 40

Codon

FEBRUARY 27, 2024

Patient YY’s neighbors quickly started to become infected, passing on the virus in turn. While the consensus that emerged among experts was that the virus spread primarily via airborne transmission , it also made use of another route: fomite transmission. Puzzled, epidemiologists sought to understand the source of the outbreak.

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The Pharma Data

SEPTEMBER 28, 2021

Respiratory infections are caused by a good sort of pathogens, like influenza viruses, respiratory syncytial virus, parainfluenza viruses, metapneumovirus, rhinovirus, enterovirus, coronavirus and adenovirus, and other bacteria pathogens. Open channel assays may include IVD assays, also as routine lab developed tests (LDTs).

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Marketing Virus DNA Disease 52

The Pharma Data

SEPTEMBER 7, 2020

Immunocompromised transplant patients are at risk of major complications when infected with BK virus. cobas BKV test addresses critical need for hospitals and laboratories to have standardised and comparable results across institutions. to obtain comparable results when measuring levels of BKV DNA.

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