Codon

MARCH 12, 2023

“The recombinant DNA breakthrough has provided us with a new and powerful approach to the questions that have intrigued and plagued man for centuries. The central dogma is often depicted as DNA→RNA→protein, but it’s much more: A biophysical marvel inside the smallest of vessels. Biology is a Burrito. 6 of 31.

DNA 52

DNA Engineering Therapies RNA 52

Codon

MAY 30, 2023

This week: A way to measure a transgene’s expression in the brain using ultrasound, a DNA sequencing method that uses 1000x less reagents, and base editors get even smaller. An engineered version of this protein can convert DNA bases with efficiencies up to 92%. so this Digest will be published more irregularly.

DNA 52

DNA RNA Engineering Vaccine 52

Codon

MAY 30, 2023

This week: A way to measure a transgene’s expression in the brain using ultrasound, a DNA sequencing method that uses 1000x less reagents, and base editors get even smaller. An engineered version of this protein can convert DNA bases with efficiencies up to 92%. so this Digest will be published more irregularly.

DNA 52

DNA RNA Engineering Vaccine 52

Codon

JUNE 26, 2023

DNA sequences are designed on a computer, and it takes a dozen or more clicks to change a single nucleotide. DNA sequences are also checked by hand, so it’s easy to make a mistake. The tool outputs a DNA sequence that encodes all the required enzymes. Anyone who has tried to engineer a cell knows how tedious it can be.

DNA 52

DNA Therapies Engineering Clinical Trials 52

Codon

JUNE 26, 2023

DNA sequences are designed on a computer, and it takes a dozen or more clicks to change a single nucleotide. DNA sequences are also checked by hand, so it’s easy to make a mistake. The tool outputs a DNA sequence that encodes all the required enzymes. Anyone who has tried to engineer a cell knows how tedious it can be.

DNA 52

DNA Therapies Engineering Clinical Trials 52

PLOS: DNA Science

JUNE 22, 2023

A “DNA damage checkpoint” rests the cell cycle while special proteins repair damaged DNA. I visited Erin Zammett Ruddy at the headquarters of Glamour magazine in Manhattan, where she was an editor. The post How Targeted Cancer Drugs Disrupt the Cell Cycle appeared first on DNA Science.

Drugs 52

Drugs Small Molecule DNA Bioethics 52

Codon

MARCH 24, 2024

Water accounts for 70 percent of a bacterium by mass; the other 30 percent includes everything else: proteins, RNA, DNA, lipids, and so on. If the technology proved successful in human beings, it would take Moderna weeks, not years, to make a new product,” wrote Catherine Elton in Boston Magazine.

Engineering 84

Engineering Vaccine Production RNA 84

Drug Target Review

SEPTEMBER 10, 2024

To achieve an aggressive timeline from DNA to investigational new drug (IND) application, drug developers have strengthened collaborations with contract development & manufacturing organisations (CDMOs) to expedite drug development. Network Pharma Magazine. 2023 Jan-Dec;15(1):2220150. 4 Berrie J, Donninger R.

Drug Development 64

Drug Development Clinical Supply Production Protein Expression 64

Codon

MAY 11, 2023

Read more in IFL Science & Asterisk Magazine 2/ Little Cloned Horse Wild Mongolian horses, called takhi , once roamed the mighty Asian steppes. link ) A more representative human genome sequence, based on DNA from 47 ethnically diverse people, was published yesterday. Consider it our moonshot for food.

Vaccine 52

Vaccine Engineering Licensing Licensing 52

Codon

MAY 11, 2023

Read more in IFL Science & Asterisk Magazine 2/ Little Cloned Horse Wild Mongolian horses, called takhi , once roamed the mighty Asian steppes. link ) A more representative human genome sequence, based on DNA from 47 ethnically diverse people, was published yesterday. Consider it our moonshot for food.

Vaccine 52

Vaccine Engineering Licensing Licensing 52

PLOS: DNA Science

MARCH 16, 2023

” That means the genome of the doomed fetus-within-a-fetus had lots of copies of certain short DNA sequences that aren’t in the parents’ genomes (“ de novo ” means new). In addition to their roles in development, DNA repeats are used in DNA profiling and are behind a class of inherited diseases.

DNA 52

DNA Disease Science Doctors 52

Codon

AUGUST 25, 2024

pestis DNA in the dental pulp of skeletons in various medieval burial sites across Europe, which corresponded to recorded outbreaks, including in cemeteries used exclusively for Black Death victims. Saloni Dattani is a co-founder of Works in Progress magazine and a researcher on global health at Our World in Data. ” Asimov Press.

Disease 107

Disease Research Government DNA 107

Codon

OCTOBER 6, 2024

By combining mammoth DNA recovered from ancient permafrost with stem cells of the species’ closest living ancestor, the Asian elephant, the company aims to make hybrid embryos. These embryos must then be nurtured and able to grow to term, ideally inside of an Asian elephant. .” Presumably, Lamm aims to fill in these gaps.

FDA 100

FDA Hospitals Engineering Research 100

Codon

MARCH 26, 2023

Link A DNA tumor virus globally reprograms host 3D genome architecture to achieve immortal growth. Link DNA storage in thermoresponsive microcapsules for repeated random multiplexed data access. Link Semi-rational evolution of a recombinant DNA polymerase for modified nucleotide incorporation efficiency. Quanta Magazine.

DNA 52

DNA Engineering RNA Science 52

PLOS: DNA Science

MAY 2, 2024

Will an effort to determine the sex chromosome constitutions of nearly 600,000 men whose DNA is being analyzed in the Million Veteran Program provide helpful health information – or highlight another possible source of genetic judgment? appeared first on DNA Science. Of twelve men with unusual chromosomes, seven had an extra Y.

DNA 52

DNA Engineering Disease Hospitals 52

Codon

AUGUST 10, 2023

Technologies DNA Sequencing →DNA sequencing at 40: past, present and future , by Shendure J. Link DNA Cost and Productivity Data, aka "Carlson Curves" , by Carlson R. Link Next-Generation DNA Sequencing Methods , by Mardis E.R. Link DNA synthesis technologies to close the gene writing gap , by Hoose et al.

DNA 91

DNA Cell Biology Molecular Biology Engineering 91

Codon

AUGUST 10, 2023

Technologies DNA Sequencing →DNA sequencing at 40: past, present and future , by Shendure J. Link DNA Cost and Productivity Data, aka "Carlson Curves" , by Carlson R. Link Next-Generation DNA Sequencing Methods , by Mardis E.R. Link DNA synthesis technologies to close the gene writing gap , by Hoose et al.

DNA 52

DNA Cell Biology Engineering Molecular Biology 52

Codon

APRIL 16, 2023

Short DNA strands were discovered that can specifically and tightly bind to zinc and cadmium ions. Perhaps there is now a way to use DNA to extract metals: You could fuse the DNA strands to an antibody, coat them onto electronics, and then use a column to isolate the DNA:metal compounds? coli DNA using a Retro-Cascorder.

Engineering 52

Engineering DNA RNA Science 52

Codon

APRIL 23, 2023

The country has now ruled that the gene-edited bananas are exempt from GMO regulations because they do not carry additional DNA sequences, and so they will not have to pass through strict safety testing. 📎 Papers Strands of DNA can be used to build molecular logic gates. ” Quanta Magazine. Nature Communications.

Vaccine 52

Vaccine DNA Virus Engineering 52

Codon

APRIL 23, 2023

The country has now ruled that the gene-edited bananas are exempt from GMO regulations because they do not carry additional DNA sequences, and so they will not have to pass through strict safety testing. 📎 Papers Strands of DNA can be used to build molecular logic gates. ” Quanta Magazine. Nature Communications.

Vaccine 52

Vaccine DNA Virus Engineering 52

Codon

NOVEMBER 24, 2024

A 1944 TIME magazine article reported on Rock’s work in heroic terms: Man will never be happy until he has proved that he is at least as smart as nature. Enzmann received favorable coverage from TIME magazine. One thing he would like to show the world is that he can reproduce himself scientifically.

Regulations 59

Regulations DNA Hospitals Trials 59