Broad Institute

JUNE 28, 2023

Such large-scale changes in DNA have been difficult to study. Since the deleted or duplicated DNA regions involved in an aneuploidy can include hundreds or thousands of genes, pinning down any molecular mechanism by which an aneuploidy impacts tumor growth has been difficult.

DNA 122

DNA Medical Schools Treatment Research 122

PLOS: DNA Science

JULY 27, 2023

Genomics applies to all species, revealing evolution in action, because we all use the same genetic code – that is, the correspondence between DNA sequences and the amino acid sequences of proteins. Cats and Bird Flu Comparing DNA sequences is a little like linguistic research that connects languages.

Disease 95

Disease DNA Virus RNA 95

Broad Institute

OCTOBER 23, 2024

The DNA change underlying Emma’s disorder is now known, thanks to years of work by an international team of scientists and physicians at the Broad Institute of MIT and Harvard, Northwestern University, University of Nantes, the Weizmann Institute of Science, and the Baylor College of Medicine.

DNA 128

DNA RNA Disease Hospitals 128

Broad Institute

JUNE 1, 2023

The work was co-led by senior author Pradeep Natarajan , an associate member at the Broad, the director of preventive cardiology at Massachusetts General Hospital, and an assistant professor of medicine at Harvard Medical School. Maternal meta-analysis Scientists have long thought that HDPs are caused in part by genetics.

Doctors 133

Doctors Medical Schools Hospitals DNA 133

Drug Target Review

DECEMBER 28, 2023

During the process of transformation from a normal cell into a cancer cell, a cell acquires a series of changes, or mutations, in its DNA. But DNA mutations can also result in changes to the proteins that are displayed on the surface of the cancer cell.

Bioinformatics 105

Bioinformatics Immune Response DNA Vaccine 105

Broad Institute

APRIL 2, 2024

He is also a professor at Harvard Medical School and Massachusetts General Hospital. They combined shotgun metagenomic sequencing, which profiles all of the microbial DNA in a sample, with metabolomics, which measures the levels of hundreds of known and thousands of unknown metabolites.

Disease 145

Disease Medical Schools Hospitals DNA 145

Broad Institute

AUGUST 14, 2023

In three new studies, researchers including a team from the Broad Institute of MIT and Harvard have harmonized and analyzed data on proteins, DNA, RNA, as well as clinical data from more than 1,000 patients across nearly a dozen different cancer types. Zamecnik Chair in Oncology at the Massachusetts General Hospital Cancer Center.

DNA 98

DNA RNA Regulations Treatment 98

KIF1A

MAY 4, 2024

Her undergraduate research focused on lipid metabolism of NASH at UCSD Medical School and DNA breakage and repair mechanism at Scripps Research. Lyu is currently working in a lab at Columbia University Irving Medical Center studying the influence of cholesterol on cardiovascular health. degree in human biology in 2023.

Science 116

Science Medical Schools Research RNA 116

Broad Institute

AUGUST 8, 2024

His work focuses on developing novel technologies to improve the performance of liquid biopsies for cancer detection, using approaches in protein engineering to create agents that can improve the recovery of cell-free DNA from the body. Tabrizi earned his M.D.

Medical Schools 52

Medical Schools Hospitals DNA Engineering 52

Drug Target Review

JANUARY 15, 2024

Unlike almost every other cell type (except B cells), T cells do not have the exact same chromosomal DNA sequences as other cells in the body. In previous decades, isolation, sequencing and characterisation of DNA encoding a specific TCR was laborious and technically challenging. References Robinson R, McMurran C, McCully M, Cole D.

Engineering 110

Engineering DNA Virus Immune Response 110

PLOS: DNA Science

SEPTEMBER 5, 2024

Researchers from Harvard Medical School describe a new ChatGPT-like model that can guide clinical decision-making to diagnose, treat, and predict survival for several types of cancer. Analyzing DNA patterns using AI may replace time-consuming process DNA and genomic sequencing tests, Yu said.

Treatment 71

Treatment FDA Approval DNA Small Molecule 71

Broad Institute

JULY 6, 2023

Strikingly, the team was able to identify 3% of unaffected individuals who – based on common DNA variation alone – have a risk for a future cardiac event such as a heart attack as high as people who’ve already been diagnosed with the disease.

Disease 97

Disease DNA Hospitals Medical Schools 97

PLOS: DNA Science

AUGUST 22, 2024

Crichton had an MD from Harvard Medical School, but he never practiced medicine. ” The explanation continues, and here’s where it ceases to make sense, to anyone who knows anything about DNA, genes, and genomes. A plant genome consists of DNA, and NOT pieces of 2,4-D, which is a completely unrelated organic acid.

DNA 71

DNA Virus Organic Chemistry Science 71

Broad Institute

AUGUST 7, 2023

STING is primarily on the lookout for DNA, which can indicate either a foreign invader such as a virus or damage to the host tissue or cell. Now, a team of MIT, Massachusetts General Hospital (MGH), Broad Institute of MIT and Harvard, and Harvard Medical School (HMS) researchers has discovered how STING activates those two pathways.

Regulations 91

Regulations Clinical Trials Engineering Science 91

Broad Institute

MARCH 8, 2024

First author Zoë Levine is an MD-PhD candidate at Harvard Medical School and graduate student in the lab of Pardis Sabeti at the Broad. Tags: Infectious Disease DNA sequencing RNA sequencing Investigating the etiologies of non-malarial febrile illness in Senegal using metagenomic sequencing. Nature Communications.

Research 111

Research Disease Medical Schools RNA 111

The Pharma Data

NOVEMBER 22, 2020

Cas-9 represents the Cas9 protein, an enzyme that cuts foreign DNA. “Operationally, you design a stretch of 20 [nucleotide] base pairs that match a gene that you want to edit,” George Church, a professor of genetics at Harvard Medical School, told the news source. ” Source link.

DNA 52

DNA Medical Schools Treatment Science 52

Broad Institute

FEBRUARY 29, 2024

In the new microbes’ DNA, the researchers found hundreds of novel genes that may offer clues to how enterococci are able to resist antibiotic treatment and thrive in the hospital environment. The findings could one day help monitor the emergence of new drug-resistant threats or highlight possible ways to prevent or treat those infections.

Hospitals 116

Hospitals Medical Schools International Research 116

Drug Target Review

AUGUST 16, 2024

After medical school and residency I decided to dedicate my life to women and specialised in obstetrics and gynaecology. I graduated with my BS in physiology and later attended the University of Michigan Medical School.

Medical Schools 111

Medical Schools Nurses Research Production 111

Broad Institute

JULY 10, 2023

At the Broad, Martin is also helping lead data analysis in two large international studies that are sequencing the DNA of people from Africa and Latin America to learn about the genetics of severe mental illness. And Martin is helping train scientists abroad to run these kinds of analyses in their home countries.

Disease 98

Disease Bioinformatics Medical Schools Research 98

Broad Institute

MAY 2, 2024

Today, she is a senior associate computational biologist in the Getz lab, where she applies computational techniques to DNA and RNA sequencing data to analyze rapid autopsy samples, taken from multiple sites throughout the body at the time of a cancer patient’s death. I love that in all forms of science, you solve problems.

Science 124

Science Medical Schools Disease Hospitals 124

Drug Target Review

JUNE 6, 2023

Delivery of therapy is being evaluated through injections of DNA and RNA encoding IL-12, viral vectors, and other exploratory platforms designed to bring IL-12 in close proximity to the tumour and avoid excessive IL-12 in systemic circulation.

Engineering 98

Engineering Immune Response Biochemical Pharmacology Clinical Trials 98

PLOS: DNA Science

SEPTEMBER 21, 2023

George Church , who leads Synthetic Biology at the Wyss Institute and is the Robert Winthrop Professor of Genetics at Harvard Medical School, will present another Fireside Chat. What steps should researchers take when attempting to acquire DNA samples from modern descendants? From people who have died?”

DNA 52

DNA Science Medical Schools Government 52

Broad Institute

JULY 20, 2023

Please register at broad.io/stanleysymposium Please register at broad.io/stanleysymposium

Medical Schools 52

Medical Schools Hospitals DNA Disease 52

Broad Institute

AUGUST 4, 2022

To build the CLL map, the team analyzed variations in genetic sequences, gene expression patterns, and chemical modifications to DNA — or genomic, transcriptomic, and epigenomic data — from 1,148 patients.

Bioinformatics 52

Bioinformatics Medical Schools Hospitals Treatment 52

The Pharma Data

DECEMBER 5, 2020

The first of the new therapies, developed at Harvard Medical School by a team led by Dr. David Williams, uses a virus to introduce RNA into the extracted bone marrow that turns off BCL11A. The CRISPR gene editing method won the 2020 Nobel Prize in Chemistry, and uses chemicals to open up and directly edit DNA sequences, Hsu said.

Therapies 52

Therapies Disease Medical Schools Virus 52

Codon

JUNE 26, 2023

DNA sequences are designed on a computer, and it takes a dozen or more clicks to change a single nucleotide. DNA sequences are also checked by hand, so it’s easy to make a mistake. The tool outputs a DNA sequence that encodes all the required enzymes. Anyone who has tried to engineer a cell knows how tedious it can be.

DNA 52

DNA Therapies Engineering Clinical Trials 52

Codon

JUNE 26, 2023

DNA sequences are designed on a computer, and it takes a dozen or more clicks to change a single nucleotide. DNA sequences are also checked by hand, so it’s easy to make a mistake. The tool outputs a DNA sequence that encodes all the required enzymes. Anyone who has tried to engineer a cell knows how tedious it can be.

DNA 52

DNA Therapies Engineering Clinical Trials 52

Broad Institute

JUNE 13, 2023

To better understand this process, researchers did a deep dive into the genetics of patients' bone marrow, blood, and skin leukemia cells – sequencing the DNA and RNA in individual cells. "We

Hospitals 52

Hospitals Disease Medical Schools Research 52

KIF1A

MAY 31, 2024

In addition to her role as Chief of the Department of Pediatrics, Dr. Chung serves as the Mary Ellen Avery Professor at Harvard Medical School (HMS), and President of the Children’s Hospital Pediatric Associates. Chung Chief of the Department of Pediatrics.

Treatment 52

Treatment Small Molecule International Research 52

Broad Institute

NOVEMBER 23, 2023

Exome screening currently requires genetic testing with an invasive medical procedure such as amniocentesis that involves significant cost and carries some inherent risks to the mother and fetus. The method is referred to by the team as non-invasive fetal sequencing (NIFS).

DNA 87

DNA Hospitals Medical Schools Laboratories 87

Codon

OCTOBER 6, 2024

However, in a recent study using sheep , a team at the University of Michigan Medical School found that a nitric-oxide-rich ECMO circuit allowed them to operate an artificial womb without blood thinners. Finally, transferring the baby to the artificial womb poses several challenges.

FDA 111

FDA Hospitals Engineering Research 111

Broad Institute

JANUARY 16, 2025

Scientists at the Broad Institute of MIT and Harvard, Harvard Medical School, and McLean Hospital have discovered a surprising mechanism by which the inherited genetic mutation known to cause Huntingtons disease leads to the death of brain cells. The cumulative death of many such cells leads to the symptoms of Huntingtons disease.

Disease 130

Disease DNA Medical Schools RNA 130

Broad Institute

NOVEMBER 21, 2024

Bernstein is also chair of the Department of Cancer Biology at Dana-Farber Cancer Institute, a professor in cell biology and pathology at Harvard Medical School, and holds the Richard and Nancy Lubin Family Chair. In IDH-driven gliomas, the mutated IDH enzyme fosters the addition of methyl groups to the cells’ DNA.

Research 124

Research Medical Schools DNA Hospitals 124

Broad Institute

MARCH 6, 2025

In one effort , researchers analyzed results from dozens of large genetic studies and uncovered more than 350 common DNA variants associated with AF risk, doubling the number of common genetic risk factors for the condition. Those efforts yielded more than 140 genetic regions linked to AF risk, but it was clear there were more to find.

DNA 126

DNA Medical Schools Disease Therapies 126

Broad Institute

JANUARY 7, 2025

These stories and diagnoses, made possible by clinical genomics labs around the world analyzing DNA from patients and sharing their findings with each other to improve medical care, werent always so common. She is also the chief genomics officer at Mass General and a professor of pathology at Harvard Medical School.

Disease 121

Disease Science Laboratories Medical Schools 121

KIF1A

NOVEMBER 1, 2024

The screen used DNA from dried blood spots typically collected for newborn screening and identified mutations in 3.7% Currently, Michael works full-time as a grant writer for the anesthesiology and perioperative medicine department at the University of Pittsburgh Medical School.

Treatment 52

Treatment Medical Schools Research Disease 52

Codon

MARCH 16, 2025

Today, decades after the invention of DNA sequencing, it is easy to take the accessibility of genomic data for granted. But in the early 1990s, when Guilford’s group began collecting blood and tumor samples from the MacLeods, DNA sequencing technology was still costly and unwieldy. Even with this path laid out, doubts crept in.

DNA 110

DNA Disease Medical Schools Hospitals 110