Drug Target Review

APRIL 26, 2023

Scientists from the Massachusetts Institute of Technology (MIT) and the University of Massachusetts Medical School (UMass), US, have collaborated to create a novel type of nanoparticle that can deliver messenger RNA that encodes for beneficial proteins to the lungs.

RNA 98

RNA Medical Schools Engineering DNA 98

Broad Institute

OCTOBER 23, 2023

Participants will answer questions about their background, lifestyle, and medical history. Some participants will receive a kit in the mail that they can use to send a saliva sample for DNA analysis. Participants will be updated as the study progresses on how their contributions are enabling new discoveries.

Disease 145

Disease Research Hospitals DNA 145

Drug Target Review

DECEMBER 28, 2023

During the process of transformation from a normal cell into a cancer cell, a cell acquires a series of changes, or mutations, in its DNA. But DNA mutations can also result in changes to the proteins that are displayed on the surface of the cancer cell.

Bioinformatics 105

Bioinformatics Immune Response DNA Vaccine 105

PLOS: DNA Science

JULY 27, 2023

Genomics applies to all species, revealing evolution in action, because we all use the same genetic code – that is, the correspondence between DNA sequences and the amino acid sequences of proteins. Cats and Bird Flu Comparing DNA sequences is a little like linguistic research that connects languages.

Disease 68

Disease DNA Virus RNA 68

Broad Institute

JUNE 28, 2023

Such large-scale changes in DNA have been difficult to study. Since the deleted or duplicated DNA regions involved in an aneuploidy can include hundreds or thousands of genes, pinning down any molecular mechanism by which an aneuploidy impacts tumor growth has been difficult.

DNA 122

DNA Medical Schools Treatment Research 122

Drug Discovery World

APRIL 16, 2023

According to Sullivan, a technical limitation of the neoantigen vaccine approach is that it is based on DNA and RNA sequencing of tumour tissue, therefore it may not be applicable to patients with earlier-stage disease, whose tumours may be smaller and not provide enough tissue.

Vaccine 130

Vaccine Immune Response Medical Schools Trials 130

Broad Institute

APRIL 2, 2024

He is also a professor at Harvard Medical School and Massachusetts General Hospital. They combined shotgun metagenomic sequencing, which profiles all of the microbial DNA in a sample, with metabolomics, which measures the levels of hundreds of known and thousands of unknown metabolites.

Disease 145

Disease Medical Schools Hospitals DNA 145

KIF1A

MAY 4, 2024

Her undergraduate research focused on lipid metabolism of NASH at UCSD Medical School and DNA breakage and repair mechanism at Scripps Research. Lyu is currently working in a lab at Columbia University Irving Medical Center studying the influence of cholesterol on cardiovascular health. degree in human biology in 2023.

Science 116

Science Medical Schools RNA Research 116

Broad Institute

JULY 6, 2023

Strikingly, the team was able to identify 3% of unaffected individuals who – based on common DNA variation alone – have a risk for a future cardiac event such as a heart attack as high as people who’ve already been diagnosed with the disease.

Disease 97

Disease DNA Hospitals Medical Schools 97

Broad Institute

AUGUST 7, 2023

STING is primarily on the lookout for DNA, which can indicate either a foreign invader such as a virus or damage to the host tissue or cell. Now, a team of MIT, Massachusetts General Hospital (MGH), Broad Institute of MIT and Harvard, and Harvard Medical School (HMS) researchers has discovered how STING activates those two pathways.

Regulations 91

Regulations Engineering Clinical Trials DNA 91

Broad Institute

MARCH 8, 2024

First author Zoë Levine is an MD-PhD candidate at Harvard Medical School and graduate student in the lab of Pardis Sabeti at the Broad. Tags: Infectious Disease DNA sequencing RNA sequencing Investigating the etiologies of non-malarial febrile illness in Senegal using metagenomic sequencing. Nature Communications.

Research 111

Research Disease Medical Schools RNA 111

Drug Target Review

AUGUST 16, 2024

After medical school and residency I decided to dedicate my life to women and specialised in obstetrics and gynaecology. I graduated with my BS in physiology and later attended the University of Michigan Medical School.

Medical Schools 106

Medical Schools Nurses Research Production 106

Broad Institute

FEBRUARY 29, 2024

In the new microbes’ DNA, the researchers found hundreds of novel genes that may offer clues to how enterococci are able to resist antibiotic treatment and thrive in the hospital environment. The findings could one day help monitor the emergence of new drug-resistant threats or highlight possible ways to prevent or treat those infections.

Hospitals 116

Hospitals Medical Schools International Research 116

Drug Target Review

JUNE 6, 2023

Delivery of therapy is being evaluated through injections of DNA and RNA encoding IL-12, viral vectors, and other exploratory platforms designed to bring IL-12 in close proximity to the tumour and avoid excessive IL-12 in systemic circulation.

Engineering 98

Engineering Immune Response Biochemical Pharmacology Clinical Trials 98

The Pharma Data

DECEMBER 5, 2020

The first of the new therapies, developed at Harvard Medical School by a team led by Dr. David Williams, uses a virus to introduce RNA into the extracted bone marrow that turns off BCL11A. The CRISPR gene editing method won the 2020 Nobel Prize in Chemistry, and uses chemicals to open up and directly edit DNA sequences, Hsu said.

Therapies 52

Therapies Disease Medical Schools Virus 52

KIF1A

APRIL 6, 2024

When a mutation causes a deletion or duplication of larger areas of DNA, we call it Copy Number Variation. DNA deletion and duplication may impact large sections of genes, or multiple neighboring genes. The altered expression of so many genes has profound consequences for the nervous system. She graduated from UC San Diego with a B.S.

DNA 111

DNA Medical Schools Therapies Research 111

Broad Institute

AUGUST 14, 2023

In three new studies, researchers including a team from the Broad Institute of MIT and Harvard have harmonized and analyzed data on proteins, DNA, RNA, as well as clinical data from more than 1,000 patients across nearly a dozen different cancer types. Zamecnik Chair in Oncology at the Massachusetts General Hospital Cancer Center.

DNA 98

DNA RNA Regulations Medical Schools 98

Drug Target Review

JANUARY 15, 2024

Unlike almost every other cell type (except B cells), T cells do not have the exact same chromosomal DNA sequences as other cells in the body. In previous decades, isolation, sequencing and characterisation of DNA encoding a specific TCR was laborious and technically challenging. References Robinson R, McMurran C, McCully M, Cole D.

Engineering 110

Engineering DNA Virus Medical Schools 110

Broad Institute

FEBRUARY 16, 2024

The way that clinicians subdivide diabetes patients now is based on symptoms, but in this study, the frequency of genetic risk factors seems to vary among patients with youth-onset T2D,” said Jason Flannick , Broad associate member and assistant professor at Boston Children’s Hospital and Harvard Medical School. “We

Medical Schools 133

Medical Schools Hospitals Disease DNA 133

Drug Discovery World

OCTOBER 25, 2023

DDW Editor Reece Armstrong speaks to Dr Darrell Green , Lecturer in RNA Biology Biomedical Research Centre Norwich Medical School University of East Anglia, about his work using next generation sequencing (NGS) and the areas the technology is impacting within drug discovery and development.

Bioinformatics 288

Bioinformatics Pharmacogenetics RNA Medical Schools 288

PLOS: DNA Science

SEPTEMBER 21, 2023

George Church , who leads Synthetic Biology at the Wyss Institute and is the Robert Winthrop Professor of Genetics at Harvard Medical School, will present another Fireside Chat. What steps should researchers take when attempting to acquire DNA samples from modern descendants? From people who have died?”

DNA 52

DNA Science Medical Schools Government 52

Broad Institute

JUNE 1, 2023

The work was co-led by senior author Pradeep Natarajan , an associate member at the Broad, the director of preventive cardiology at Massachusetts General Hospital, and an assistant professor of medicine at Harvard Medical School. Maternal meta-analysis Scientists have long thought that HDPs are caused in part by genetics.

Doctors 133

Doctors Medical Schools Hospitals DNA 133

Broad Institute

JULY 10, 2023

At the Broad, Martin is also helping lead data analysis in two large international studies that are sequencing the DNA of people from Africa and Latin America to learn about the genetics of severe mental illness. And Martin is helping train scientists abroad to run these kinds of analyses in their home countries.

Bioinformatics 98

Bioinformatics Disease Medical Schools Research 98

Broad Institute

AUGUST 4, 2022

To build the CLL map, the team analyzed variations in genetic sequences, gene expression patterns, and chemical modifications to DNA — or genomic, transcriptomic, and epigenomic data — from 1,148 patients.

Bioinformatics 52

Bioinformatics Medical Schools Hospitals DNA 52

The Pharma Data

NOVEMBER 22, 2020

Cas-9 represents the Cas9 protein, an enzyme that cuts foreign DNA. “Operationally, you design a stretch of 20 [nucleotide] base pairs that match a gene that you want to edit,” George Church, a professor of genetics at Harvard Medical School, told the news source. ” Source link.

DNA 52

DNA Medical Schools RNA Science 52

Broad Institute

MAY 2, 2024

Today, she is a senior associate computational biologist in the Getz lab, where she applies computational techniques to DNA and RNA sequencing data to analyze rapid autopsy samples, taken from multiple sites throughout the body at the time of a cancer patient’s death. I love that in all forms of science, you solve problems.

Science 124

Science Medical Schools Hospitals Disease 124

Broad Institute

JULY 20, 2023

Please register at broad.io/stanleysymposium Please register at broad.io/stanleysymposium

Medical Schools 52

Medical Schools Hospitals DNA Disease 52

Broad Institute

JUNE 13, 2023

To better understand this process, researchers did a deep dive into the genetics of patients' bone marrow, blood, and skin leukemia cells – sequencing the DNA and RNA in individual cells. "We

Hospitals 52

Hospitals Medical Schools Disease Research 52

KIF1A

MAY 31, 2024

In addition to her role as Chief of the Department of Pediatrics, Dr. Chung serves as the Mary Ellen Avery Professor at Harvard Medical School (HMS), and President of the Children’s Hospital Pediatric Associates. Chung Chief of the Department of Pediatrics.

Small Molecule 52

Small Molecule Treatment International Research 52

Broad Institute

NOVEMBER 23, 2023

Exome screening currently requires genetic testing with an invasive medical procedure such as amniocentesis that involves significant cost and carries some inherent risks to the mother and fetus. The method is referred to by the team as non-invasive fetal sequencing (NIFS).

DNA 87

DNA Hospitals Medical Schools Laboratories 87

PLOS: DNA Science

FEBRUARY 29, 2024

The DNA in these packets from each gamete replicate, and then the pronuclei meet and merge, within 12 hours. Following the first mitotic division, the information present in the DNA sequences of some genes from the new genome are accessed to make proteins. That’s conception. Pronuclei merge. Social milestones. My answer? #14.

DNA 77

DNA Medical Schools Science RNA 77

Codon

JUNE 26, 2023

DNA sequences are designed on a computer, and it takes a dozen or more clicks to change a single nucleotide. DNA sequences are also checked by hand, so it’s easy to make a mistake. The tool outputs a DNA sequence that encodes all the required enzymes. Anyone who has tried to engineer a cell knows how tedious it can be.

DNA 52

DNA Therapies Engineering Clinical Trials 52

Codon

JUNE 26, 2023

DNA sequences are designed on a computer, and it takes a dozen or more clicks to change a single nucleotide. DNA sequences are also checked by hand, so it’s easy to make a mistake. The tool outputs a DNA sequence that encodes all the required enzymes. Anyone who has tried to engineer a cell knows how tedious it can be.

DNA 52

DNA Therapies Engineering Clinical Trials 52