Broad Institute

NOVEMBER 13, 2023

Liquid biopsies enable clinicians to find and analyze tumor DNA in a patient’s blood sample to detect cancer early, monitor cancer recurrence, assess the patient’s response to treatment, and measure other clinically important features in real time, without invasive procedures. "We

DNA 116

DNA Medical Schools Treatment Therapies 116

Drug Target Review

APRIL 26, 2023

Scientists from the Massachusetts Institute of Technology (MIT) and the University of Massachusetts Medical School (UMass), US, have collaborated to create a novel type of nanoparticle that can deliver messenger RNA that encodes for beneficial proteins to the lungs. The study appears in Nature Biotechnology.

RNA 98

RNA Medical Schools Engineering DNA 98

Drug Target Review

DECEMBER 28, 2023

During the process of transformation from a normal cell into a cancer cell, a cell acquires a series of changes, or mutations, in its DNA. But DNA mutations can also result in changes to the proteins that are displayed on the surface of the cancer cell.

Bioinformatics 105

Bioinformatics Immune Response DNA Vaccine 105

Broad Institute

JUNE 28, 2023

But for decades, researchers have debated whether aneuploidy promotes the growth of cancers, or is simply a side effect of cancer cells’ fast growth. Such large-scale changes in DNA have been difficult to study. We found that these aneuploidies are being directly selected for or against depending on their impact on cancer cells.”

DNA 122

DNA Medical Schools Treatment Research 122

Broad Institute

APRIL 2, 2024

Now, a team of researchers at the Broad Institute of MIT and Harvard along with Massachusetts General Hospital has found that microbes in the gut may affect cardiovascular disease as well. He is also a professor at Harvard Medical School and Massachusetts General Hospital.

Disease 145

Disease Medical Schools Hospitals DNA 145

KIF1A

MAY 4, 2024

Each week, Dr. Dylan Verden of KIF1A.ORG summarizes newly published KIF1A-related research and highlights progress in rare disease research and therapeutic development. In this week’s article, researchers in Brazil identified a KIF1A mutation in a cohort of patients with congenital ataxia.

Science 116

Science Medical Schools RNA Research 116

PLOS: DNA Science

JULY 27, 2023

Genomics applies to all species, revealing evolution in action, because we all use the same genetic code – that is, the correspondence between DNA sequences and the amino acid sequences of proteins. Cats and Bird Flu Comparing DNA sequences is a little like linguistic research that connects languages.

Disease 68

Disease DNA Virus RNA 68

Drug Discovery World

APRIL 16, 2023

According to Sullivan, a technical limitation of the neoantigen vaccine approach is that it is based on DNA and RNA sequencing of tumour tissue, therefore it may not be applicable to patients with earlier-stage disease, whose tumours may be smaller and not provide enough tissue.

Vaccine 130

Vaccine Immune Response Medical Schools Trials 130

Broad Institute

JULY 6, 2023

A new approach from a team led by researchers in the Cardiovascular Disease Initiative at the Broad Institute of MIT and Harvard and at Massachusetts General Hospital (MGH) significantly improves the accuracy of genetic risk prediction of heart disease across all ancestries.

Disease 97

Disease DNA Hospitals Medical Schools 97

Broad Institute

AUGUST 7, 2023

STING is primarily on the lookout for DNA, which can indicate either a foreign invader such as a virus or damage to the host tissue or cell. Now, a team of MIT, Massachusetts General Hospital (MGH), Broad Institute of MIT and Harvard, and Harvard Medical School (HMS) researchers has discovered how STING activates those two pathways.

Regulations 91

Regulations Engineering Clinical Trials DNA 91

Drug Target Review

AUGUST 16, 2024

After medical school and residency I decided to dedicate my life to women and specialised in obstetrics and gynaecology. I joined the pharmaceutical industry to leverage my passion and hands-on clinical experience to care for people all over the world by bringing a unique perspective to drug and device research and development.

Medical Schools 106

Medical Schools Nurses Research Production 106

Broad Institute

FEBRUARY 29, 2024

To recognize Joseph’s contributions of dozens of animal fecal samples to the study, the research team named the bacteria Enterococcus mansonii , an unlikely distinction for a physicist and farmer. Our findings may improve understanding of how resistance genes spread to hospital bacteria and threaten human health.”

Hospitals 116

Hospitals Medical Schools International Research 116

Drug Target Review

JUNE 6, 2023

Difficult-to-treat and rare, complicated cancers remain a perplexing challenge for IO researchers. Research has shown that these immune system proteins have the ability to trigger anti-cancer immune pathways. Currently he is Alkermes’ Oncology Fellow and Head of a Oncology Preclinical Research at the company. References: M; LWR.

Engineering 98

Engineering Immune Response Biochemical Pharmacology Clinical Trials 98

The Pharma Data

DECEMBER 5, 2020

5, 2020 — A pair of new gene therapies promise a potentially lasting cure for sickle cell disease by subtly altering the genetic information in patients’ bone marrow cells, researchers report. SATURDAY, Dec. Selim Corbacioglu from the University of Regensburg, relies on CRISPR-Cas9 gene editing to switch off BCL11A.

Therapies 52

Therapies Disease Medical Schools Virus 52

KIF1A

APRIL 6, 2024

Each week, Dr. Dylan Verden of KIF1A.ORG summarizes newly published KIF1A-related research and highlights progress in rare disease research and therapeutic development. When a mutation causes a deletion or duplication of larger areas of DNA, we call it Copy Number Variation. She graduated from UC San Diego with a B.S.

DNA 111

DNA Medical Schools Therapies Research 111

Broad Institute

AUGUST 14, 2023

Three studies highlight how proteins are altered in multiple cancer types By Allessandra DiCorato August 14, 2023 Breadcrumb Home Three studies highlight how proteins are altered in multiple cancer types Researchers identify protein modifications that underlie many key cancer processes.

DNA 98

DNA RNA Regulations Medical Schools 98

Drug Discovery World

OCTOBER 25, 2023

DDW Editor Reece Armstrong speaks to Dr Darrell Green , Lecturer in RNA Biology Biomedical Research Centre Norwich Medical School University of East Anglia, about his work using next generation sequencing (NGS) and the areas the technology is impacting within drug discovery and development.

Bioinformatics 287

Bioinformatics Pharmacogenetics RNA Medical Schools 287

Broad Institute

FEBRUARY 16, 2024

Study finds youth-onset diabetes is a genetically distinct form of the disorder By Claire Hendershot February 16, 2024 Breadcrumb Home Study finds youth-onset diabetes is a genetically distinct form of the disorder Researchers suggest diabetes exists in multiple forms on a spectrum of varying genetic factors and symptoms.

Medical Schools 133

Medical Schools Hospitals Disease DNA 133

Drug Target Review

JANUARY 15, 2024

Unlike almost every other cell type (except B cells), T cells do not have the exact same chromosomal DNA sequences as other cells in the body. In previous decades, isolation, sequencing and characterisation of DNA encoding a specific TCR was laborious and technically challenging. References Robinson R, McMurran C, McCully M, Cole D.

Engineering 110

Engineering DNA Virus Medical Schools 110

Broad Institute

JUNE 1, 2023

Researchers at the Broad Institute of MIT and Harvard are beginning to uncover genetic factors contributing to gestational hypertension and preeclampsia, two common HDPs. Buu Truong, a computational researcher and postdoctoral fellow in Natarajan’s lab, was a co-first author as well.

Doctors 133

Doctors Medical Schools Hospitals DNA 133

PLOS: DNA Science

SEPTEMBER 21, 2023

” Researchers, clinicians, and those working in drug discovery and development are welcome. George Church , who leads Synthetic Biology at the Wyss Institute and is the Robert Winthrop Professor of Genetics at Harvard Medical School, will present another Fireside Chat. Front Line Genomics (FLG) is organizing the meeting.

DNA 52

DNA Science Medical Schools Government 52

Broad Institute

JULY 10, 2023

Thanks in part to her research, more geneticists are now studying a wider diversity of people and accounting for genetic ancestry in their analyses. Through this work, Martin is showing how a methodical, data-driven kind of social justice can help improve equity in scientific research and lead to better science.

Bioinformatics 98

Bioinformatics Disease Medical Schools Research 98

Broad Institute

AUGUST 4, 2022

To build the CLL map, the team analyzed variations in genetic sequences, gene expression patterns, and chemical modifications to DNA — or genomic, transcriptomic, and epigenomic data — from 1,148 patients. This work was supported by the National Institutes of Health and the Broad/IBM Cancer Resistance Research Project.

Bioinformatics 52

Bioinformatics Medical Schools Hospitals DNA 52

KIF1A

MAY 31, 2024

With hope, Angie Fuller, Director KIF1A.ORG Research and Therapeutic Development Until we find treatments and cures, our superheroes will continue to lose their hard-fought skills, abilities and even their lives. Your commitment and collaboration have been instrumental in our shared success. This is the fate of KAND unless we change it.

Small Molecule 52

Small Molecule Treatment International Research 52

Broad Institute

JUNE 13, 2023

Although it focused on a rare form of cancer – blastic plasmacytoid dendritic cell neoplasm (BPDCN) – the research may shed light on how other cancers develop, particularly those involving blood or lymph cells that travel the bloodstream to all corners of the body, investigators say.

Hospitals 52

Hospitals Medical Schools Disease Research 52

The Pharma Data

NOVEMBER 22, 2020

Their research – the first of its kind – suggests that the system can be utilized to address cancer in animals, according to Professor Dan Peer, whose peer-reviewed research was published in the Science Advances journal. Cas-9 represents the Cas9 protein, an enzyme that cuts foreign DNA. ” Source link.

DNA 52

DNA Medical Schools RNA Science 52

Broad Institute

MAY 2, 2024

Today, she is a senior associate computational biologist in the Getz lab, where she applies computational techniques to DNA and RNA sequencing data to analyze rapid autopsy samples, taken from multiple sites throughout the body at the time of a cancer patient’s death. Tell us a bit about your research.

Science 124

Science Medical Schools Hospitals Disease 124

Broad Institute

JULY 20, 2023

Please register at broad.io/stanleysymposium Please register at broad.io/stanleysymposium

Medical Schools 52

Medical Schools Hospitals DNA Disease 52

Broad Institute

NOVEMBER 23, 2023

The newly developed test could offer the capacity to discover and interpret variants across the fetal exome from DNA circulating in the mother’s blood. The method is referred to by the team as non-invasive fetal sequencing (NIFS).

DNA 87

DNA Hospitals Medical Schools Laboratories 87

Codon

JUNE 26, 2023

DNA sequences are designed on a computer, and it takes a dozen or more clicks to change a single nucleotide. DNA sequences are also checked by hand, so it’s easy to make a mistake. The tool outputs a DNA sequence that encodes all the required enzymes. Goodsell, Scripps Research and RCSB Protein Data Bank.

DNA 52

DNA Therapies Engineering Clinical Trials 52

Codon

JUNE 26, 2023

DNA sequences are designed on a computer, and it takes a dozen or more clicks to change a single nucleotide. DNA sequences are also checked by hand, so it’s easy to make a mistake. The tool outputs a DNA sequence that encodes all the required enzymes. Goodsell, Scripps Research and RCSB Protein Data Bank.

DNA 52

DNA Therapies Engineering Clinical Trials 52