DNA, Medical Schools and RNA - Drug Discovery Digest

To help his daughter living with an ultra-rare disorder, this dad brought together a squad of genetic detectives

Broad Institute

OCTOBER 23, 2024

By Leah Eisenstadt, Broad Communications October 23, 2024 Credit: Courtesy of the Broadbent family Brian and Julia Broadbent are raising their daughters Claire, top left, and Emma, seated, who is the first person to be diagnosed with a rare genetic disorder caused by the long noncoding RNA CHASERR.

DNA

DNA RNA Disease Hospitals

A close research partnership with African scientists helps solve the mystery of malaria-like illnesses

Broad Institute

MARCH 8, 2024

First author Zoë Levine is an MD-PhD candidate at Harvard Medical School and graduate student in the lab of Pardis Sabeti at the Broad. Tags: Infectious Disease DNA sequencing RNA sequencing Investigating the etiologies of non-malarial febrile illness in Senegal using metagenomic sequencing. Nature Communications.

Research

Research Disease Medical Schools RNA

CRISPR Cas-9 System Doubles Life Expectancy in Mice with Aggressive Cancers

The Pharma Data

NOVEMBER 22, 2020

Cas-9 represents the Cas9 protein, an enzyme that cuts foreign DNA. “Operationally, you design a stretch of 20 [nucleotide] base pairs that match a gene that you want to edit,” George Church, a professor of genetics at Harvard Medical School, told the news source. ” Source link.

DNA

DNA Medical Schools Treatment Science

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Women in STEM with Charlotte Owens

Drug Target Review

AUGUST 16, 2024

After medical school and residency I decided to dedicate my life to women and specialised in obstetrics and gynaecology. I graduated with my BS in physiology and later attended the University of Michigan Medical School.

Medical Schools

Medical Schools Nurses Research Production

Targeting the immunotherapy potential of cytokines IL-12 and IL-18 with new advancements in protein engineering

Drug Target Review

JUNE 6, 2023

Delivery of therapy is being evaluated through injections of DNA and RNA encoding IL-12, viral vectors, and other exploratory platforms designed to bring IL-12 in close proximity to the tumour and avoid excessive IL-12 in systemic circulation.

Engineering

Engineering Immune Response Biochemical Pharmacology Clinical Trials

Three studies highlight how proteins are altered in multiple cancer types

Broad Institute

AUGUST 14, 2023

In three new studies, researchers including a team from the Broad Institute of MIT and Harvard have harmonized and analyzed data on proteins, DNA, RNA, as well as clinical data from more than 1,000 patients across nearly a dozen different cancer types. Zamecnik Chair in Oncology at the Massachusetts General Hospital Cancer Center.

DNA

DNA RNA Regulations Treatment

#WhyIScience Q&A: How a computational biologist balances work with life as an elite rower

Broad Institute

MAY 2, 2024

Today, she is a senior associate computational biologist in the Getz lab, where she applies computational techniques to DNA and RNA sequencing data to analyze rapid autopsy samples, taken from multiple sites throughout the body at the time of a cancer patient’s death. I love that in all forms of science, you solve problems.

Science

Science Medical Schools Disease Hospitals

#ScienceSaturday: May 4, 2024

KIF1A

MAY 4, 2024

Later, she developed an interest in the RNA world, specifically focusing on alternative splicing and its correlation with neuron cell properties within and across cell types. Her undergraduate research focused on lipid metabolism of NASH at UCSD Medical School and DNA breakage and repair mechanism at Scripps Research.

Science

Science Medical Schools Research RNA

Revolutionary nanoparticles enable gene-editing in lungs

Drug Target Review

APRIL 26, 2023

Scientists from the Massachusetts Institute of Technology (MIT) and the University of Massachusetts Medical School (UMass), US, have collaborated to create a novel type of nanoparticle that can deliver messenger RNA that encodes for beneficial proteins to the lungs.

RNA

RNA Medical Schools Engineering Disease

Could Gene Therapy Cure Sickle Cell Disease? Two New Studies Raise Hopes

The Pharma Data

DECEMBER 5, 2020

The first of the new therapies, developed at Harvard Medical School by a team led by Dr. David Williams, uses a virus to introduce RNA into the extracted bone marrow that turns off BCL11A. Selim Corbacioglu from the University of Regensburg, relies on CRISPR-Cas9 gene editing to switch off BCL11A.

Therapies

Therapies Disease Medical Schools Virus

UV radiation plays role in development of rare leukemia in the skin

Broad Institute

JUNE 13, 2023

To better understand this process, researchers did a deep dive into the genetics of patients' bone marrow, blood, and skin leukemia cells – sequencing the DNA and RNA in individual cells. "We

Hospitals

Hospitals Disease Medical Schools Research

Codon Digest: Hackathon Prize Winners

Codon

JUNE 26, 2023

DNA sequences are designed on a computer, and it takes a dozen or more clicks to change a single nucleotide. DNA sequences are also checked by hand, so it’s easy to make a mistake. The tool outputs a DNA sequence that encodes all the required enzymes. Anyone who has tried to engineer a cell knows how tedious it can be.

DNA

DNA Therapies Engineering Clinical Trials

Codon Digest: Hackathon Prize Winners

Codon

JUNE 26, 2023

DNA sequences are designed on a computer, and it takes a dozen or more clicks to change a single nucleotide. DNA sequences are also checked by hand, so it’s easy to make a mistake. The tool outputs a DNA sequence that encodes all the required enzymes. Anyone who has tried to engineer a cell knows how tedious it can be.

DNA

DNA Therapies Engineering Clinical Trials

Eclectic Genomics: Cat Flu, Dolphin Adaptation to Climate Change, Predicting Cancer, and Diagnosing Rare Disease

PLOS: DNA Science

JULY 27, 2023

Genomics applies to all species, revealing evolution in action, because we all use the same genetic code – that is, the correspondence between DNA sequences and the amino acid sequences of proteins. Cats and Bird Flu Comparing DNA sequences is a little like linguistic research that connects languages.

Disease

Disease DNA Virus RNA

Study finds surprising way that genetic mutation causes Huntington’s disease, transforming understanding of the disorder

Broad Institute

JANUARY 16, 2025

Scientists at the Broad Institute of MIT and Harvard, Harvard Medical School, and McLean Hospital have discovered a surprising mechanism by which the inherited genetic mutation known to cause Huntingtons disease leads to the death of brain cells. The cumulative death of many such cells leads to the symptoms of Huntingtons disease.

Disease

Disease DNA Medical Schools RNA

A clinical genomicist harnesses team-based science to help rare-disease patients

Broad Institute

JANUARY 7, 2025

These stories and diagnoses, made possible by clinical genomics labs around the world analyzing DNA from patients and sharing their findings with each other to improve medical care, werent always so common. She is also the chief genomics officer at Mass General and a professor of pathology at Harvard Medical School.

Disease

Disease Science Laboratories Medical Schools

17 Timepoints When a Human Life Begins: 2024 Version in the Wake of the Alabama Ruling

PLOS: DNA Science

FEBRUARY 29, 2024

The DNA in these packets from each gamete replicate, and then the pronuclei meet and merge, within 12 hours. Following the first mitotic division, the information present in the DNA sequences of some genes from the new genome are accessed to make proteins. That’s conception. Pronuclei merge. Cleavage divisions ensue. My answer?

DNA

DNA Science Medical Schools RNA

Drug Discovery Digest

To help his daughter living with an ultra-rare disorder, this dad brought together a squad of genetic detectives

A close research partnership with African scientists helps solve the mystery of malaria-like illnesses

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CRISPR Cas-9 System Doubles Life Expectancy in Mice with Aggressive Cancers

Webinars

Women in STEM with Charlotte Owens

Targeting the immunotherapy potential of cytokines IL-12 and IL-18 with new advancements in protein engineering

Three studies highlight how proteins are altered in multiple cancer types

#WhyIScience Q&A: How a computational biologist balances work with life as an elite rower

#ScienceSaturday: May 4, 2024

Revolutionary nanoparticles enable gene-editing in lungs

Could Gene Therapy Cure Sickle Cell Disease? Two New Studies Raise Hopes

UV radiation plays role in development of rare leukemia in the skin

Codon Digest: Hackathon Prize Winners

Codon Digest: Hackathon Prize Winners

Eclectic Genomics: Cat Flu, Dolphin Adaptation to Climate Change, Predicting Cancer, and Diagnosing Rare Disease

Study finds surprising way that genetic mutation causes Huntington’s disease, transforming understanding of the disorder

A clinical genomicist harnesses team-based science to help rare-disease patients

17 Timepoints When a Human Life Begins: 2024 Version in the Wake of the Alabama Ruling

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