Broad Institute

AUGUST 4, 2022

To build the CLL map, the team analyzed variations in genetic sequences, gene expression patterns, and chemical modifications to DNA — or genomic, transcriptomic, and epigenomic data — from 1,148 patients.

Bioinformatics 52

Bioinformatics Medical Schools Hospitals Treatment 52

KIF1A

MAY 31, 2024

In addition to her role as Chief of the Department of Pediatrics, Dr. Chung serves as the Mary Ellen Avery Professor at Harvard Medical School (HMS), and President of the Children’s Hospital Pediatric Associates. Chung Chief of the Department of Pediatrics. Dr. Markus Terrey described this approach during his conference talk.

Treatment 52

Treatment Small Molecule International Research 52

Broad Institute

JUNE 1, 2023

The work was co-led by senior author Pradeep Natarajan , an associate member at the Broad, the director of preventive cardiology at Massachusetts General Hospital, and an assistant professor of medicine at Harvard Medical School. Maternal meta-analysis Scientists have long thought that HDPs are caused in part by genetics.

Doctors 133

Doctors Medical Schools Hospitals DNA 133

Drug Target Review

JANUARY 15, 2024

Unlike almost every other cell type (except B cells), T cells do not have the exact same chromosomal DNA sequences as other cells in the body. In previous decades, isolation, sequencing and characterisation of DNA encoding a specific TCR was laborious and technically challenging. Engineering soluble T-cell receptors for therapy.

Engineering 110

Engineering DNA Virus Immune Response 110

The Pharma Data

DECEMBER 5, 2020

5, 2020 — A pair of new gene therapies promise a potentially lasting cure for sickle cell disease by subtly altering the genetic information in patients’ bone marrow cells, researchers report. Both of the new gene therapy studies were published online Dec. SATURDAY, Dec. 5 in the New England Journal of Medicine.

Therapies 52

Therapies Disease Medical Schools Virus 52

Broad Institute

MAY 2, 2024

Today, she is a senior associate computational biologist in the Getz lab, where she applies computational techniques to DNA and RNA sequencing data to analyze rapid autopsy samples, taken from multiple sites throughout the body at the time of a cancer patient’s death. I love that in all forms of science, you solve problems.

Science 124

Science Medical Schools Disease Hospitals 124

Drug Target Review

APRIL 26, 2023

Scientists from the Massachusetts Institute of Technology (MIT) and the University of Massachusetts Medical School (UMass), US, have collaborated to create a novel type of nanoparticle that can deliver messenger RNA that encodes for beneficial proteins to the lungs. The study appears in Nature Biotechnology.

RNA 98

RNA Medical Schools Engineering Disease 98

PLOS: DNA Science

SEPTEMBER 5, 2024

Researchers from Harvard Medical School describe a new ChatGPT-like model that can guide clinical decision-making to diagnose, treat, and predict survival for several types of cancer. Analyzing DNA patterns using AI may replace time-consuming process DNA and genomic sequencing tests, Yu said.

Treatment 68

Treatment FDA Approval DNA Small Molecule 68

Codon

JUNE 26, 2023

Since the last Codon Digest, I’ve published: Reasons to Be Grateful for Biotechnology (with Avadhoot Jadhav) AAV Foundations (Part I) An overview of AAV-based gene therapies, how they get made, and where they go wrong. DNA sequences are designed on a computer, and it takes a dozen or more clicks to change a single nucleotide.

DNA 52

DNA Therapies Engineering Clinical Trials 52

Codon

JUNE 26, 2023

Since the last Codon Digest, I’ve published: Reasons to Be Grateful for Biotechnology (with Avadhoot Jadhav) AAV Foundations (Part I) An overview of AAV-based gene therapies, how they get made, and where they go wrong. DNA sequences are designed on a computer, and it takes a dozen or more clicks to change a single nucleotide.

DNA 52

DNA Therapies Engineering Clinical Trials 52

Drug Target Review

DECEMBER 28, 2023

During the process of transformation from a normal cell into a cancer cell, a cell acquires a series of changes, or mutations, in its DNA. In most cancers, the tumour evolves by acquiring mutations that confer growth advantages or resistance to therapies. This allows the cancer to evolve and develop resistance to the therapy.

Bioinformatics 105

Bioinformatics Immune Response DNA Vaccine 105

Broad Institute

MARCH 6, 2025

In one effort , researchers analyzed results from dozens of large genetic studies and uncovered more than 350 common DNA variants associated with AF risk, doubling the number of common genetic risk factors for the condition. These studies open up new potential targets for therapeutic development.

DNA 126

DNA Medical Schools Disease Therapies 126

KIF1A

NOVEMBER 1, 2024

Additional KAND patients are also progressing through n-Lorem’s program for their own tailored ASO therapies, with plans for further expansion. The screen used DNA from dried blood spots typically collected for newborn screening and identified mutations in 3.7%

Treatment 52

Treatment Medical Schools Research Disease 52

Broad Institute

JANUARY 16, 2025

Scientists at the Broad Institute of MIT and Harvard, Harvard Medical School, and McLean Hospital have discovered a surprising mechanism by which the inherited genetic mutation known to cause Huntingtons disease leads to the death of brain cells. The cumulative death of many such cells leads to the symptoms of Huntingtons disease.

Disease 130

Disease DNA Medical Schools RNA 130

Broad Institute

NOVEMBER 21, 2024

Bernstein is also chair of the Department of Cancer Biology at Dana-Farber Cancer Institute, a professor in cell biology and pathology at Harvard Medical School, and holds the Richard and Nancy Lubin Family Chair. In IDH-driven gliomas, the mutated IDH enzyme fosters the addition of methyl groups to the cells’ DNA.

Research 124

Research Medical Schools DNA Hospitals 124