DNA, Medical Schools and Therapies - Drug Discovery Digest

Ancient viruses may hold key to gene therapy treatments

Drug Discovery World

DECEMBER 5, 2022

It was led by scientists at the MRC-University of Glasgow Centre for Virus Research (CVR) and University of Massachusetts Chan Medical School. . Some have even been successfully harnessed as gene therapy vectors for the treatment of genetic diseases. . Parvovirus gene therapy is a cutting-edge biomedical technology.

Virus

Virus Therapies Treatment Medical Schools

Gerstner Center for Cancer Diagnostics receives additional commitment from Louis V. Gerstner, Jr., to advance technologies that could transform cancer care

Broad Institute

NOVEMBER 13, 2023

Liquid biopsies enable clinicians to find and analyze tumor DNA in a patient’s blood sample to detect cancer early, monitor cancer recurrence, assess the patient’s response to treatment, and measure other clinically important features in real time, without invasive procedures.

DNA

DNA Medical Schools Treatment Therapies

Not all neoantigens are created equal

Drug Target Review

DECEMBER 28, 2023

During the process of transformation from a normal cell into a cancer cell, a cell acquires a series of changes, or mutations, in its DNA. In most cancers, the tumour evolves by acquiring mutations that confer growth advantages or resistance to therapies. This allows the cancer to evolve and develop resistance to the therapy.

Bioinformatics

Bioinformatics Immune Response DNA Vaccine

Revolutionary nanoparticles enable gene-editing in lungs

Drug Target Review

APRIL 26, 2023

Scientists from the Massachusetts Institute of Technology (MIT) and the University of Massachusetts Medical School (UMass), US, have collaborated to create a novel type of nanoparticle that can deliver messenger RNA that encodes for beneficial proteins to the lungs. The study appears in Nature Biotechnology.

RNA

RNA Medical Schools Engineering DNA

Personalised mRNA cancer vaccine prolongs survival in melanoma

Drug Discovery World

APRIL 16, 2023

The randomised KEYNOTE-942 trial assessed the efficacy of mRNA-4157/V940 in prolonging RFS in patients with resected, stages IIIB/IIIC/IIID and IV melanoma when given in combination with pembrolizumab, the standard-of-care adjuvant therapy in this patient population. in the combination arm and 62.2%

Vaccine

Vaccine Immune Response Medical Schools Trials

Could Gene Therapy Cure Sickle Cell Disease? Two New Studies Raise Hopes

The Pharma Data

DECEMBER 5, 2020

5, 2020 — A pair of new gene therapies promise a potentially lasting cure for sickle cell disease by subtly altering the genetic information in patients’ bone marrow cells, researchers report. Both of the new gene therapy studies were published online Dec. SATURDAY, Dec. 5 in the New England Journal of Medicine.

Therapies

Therapies Disease Medical Schools Virus

Scientists link certain gut bacteria to lower heart disease risk

Broad Institute

APRIL 2, 2024

He is also a professor at Harvard Medical School and Massachusetts General Hospital. But scientists haven’t been able to target those connections with therapies in part because they lack a complete understanding of metabolic pathways in the gut.

Disease

Disease Medical Schools Hospitals DNA

Targeting the immunotherapy potential of cytokines IL-12 and IL-18 with new advancements in protein engineering

Drug Target Review

JUNE 6, 2023

We are in an era of immuno-oncology (IO) revolution with many approved therapies now available to treat a broad range of cancers. For the last several years, the field has worked to unlock the potential of IO therapies for additional tumour types, and has explored options beyond checkpoint inhibitors.

Engineering

Engineering Immune Response Biochemical Pharmacology Clinical Trials

Women in STEM with Charlotte Owens

Drug Target Review

AUGUST 16, 2024

After medical school and residency I decided to dedicate my life to women and specialised in obstetrics and gynaecology. I graduated with my BS in physiology and later attended the University of Michigan Medical School. Biotechnology revolutionises healthcare : Biotechnology is transforming medicine and healthcare.

Medical Schools

Medical Schools Nurses Research Production

#ScienceSaturday: April 6, 2024

KIF1A

APRIL 6, 2024

When a mutation causes a deletion or duplication of larger areas of DNA, we call it Copy Number Variation. DNA deletion and duplication may impact large sections of genes, or multiple neighboring genes. The altered expression of so many genes has profound consequences for the nervous system. She graduated from UC San Diego with a B.S.

DNA

DNA Medical Schools Therapies Research

T-cell receptors offer window to the cell for a new class of cancer therapeutics

Drug Target Review

JANUARY 15, 2024

Unlike almost every other cell type (except B cells), T cells do not have the exact same chromosomal DNA sequences as other cells in the body. In previous decades, isolation, sequencing and characterisation of DNA encoding a specific TCR was laborious and technically challenging. Engineering soluble T-cell receptors for therapy.

Engineering

Engineering DNA Virus Medical Schools

Multi-ancestry study reveals genetic risk factors for two common pregnancy complications

Broad Institute

JUNE 1, 2023

The work was co-led by senior author Pradeep Natarajan , an associate member at the Broad, the director of preventive cardiology at Massachusetts General Hospital, and an assistant professor of medicine at Harvard Medical School. Maternal meta-analysis Scientists have long thought that HDPs are caused in part by genetics.

Doctors

Doctors Medical Schools Hospitals DNA

Molecular map reveals insights into the genetic drivers of chronic lymphocytic leukemia

Broad Institute

AUGUST 4, 2022

To build the CLL map, the team analyzed variations in genetic sequences, gene expression patterns, and chemical modifications to DNA — or genomic, transcriptomic, and epigenomic data — from 1,148 patients.

Bioinformatics

Bioinformatics Medical Schools Hospitals DNA

CRISPR Cas-9 System Doubles Life Expectancy in Mice with Aggressive Cancers

The Pharma Data

NOVEMBER 22, 2020

Back in September, Vertex Pharmaceuticals and CRISPR Therapeutics – the company behind the CRISPR Cas-9 platform – announced that the European Medicines Agency (EMA) had granted Priority Medicines (PRIME) designation to CTX001, an investigational ex vivo CRISPR Cas-9 gene-edited therapy for the treatment of severe sickle cell disease.

DNA

DNA Medical Schools RNA Science

The Year In Review: 2023

KIF1A

MAY 31, 2024

In addition to her role as Chief of the Department of Pediatrics, Dr. Chung serves as the Mary Ellen Avery Professor at Harvard Medical School (HMS), and President of the Children’s Hospital Pediatric Associates. Chung Chief of the Department of Pediatrics. Dr. Markus Terrey described this approach during his conference talk.

Small Molecule

Small Molecule Treatment International Research

#WhyIScience Q&A: How a computational biologist balances work with life as an elite rower

Broad Institute

MAY 2, 2024

Today, she is a senior associate computational biologist in the Getz lab, where she applies computational techniques to DNA and RNA sequencing data to analyze rapid autopsy samples, taken from multiple sites throughout the body at the time of a cancer patient’s death. I love that in all forms of science, you solve problems.

Science

Science Medical Schools Hospitals Disease

Codon Digest: Hackathon Prize Winners

Codon

JUNE 26, 2023

Since the last Codon Digest, I’ve published: Reasons to Be Grateful for Biotechnology (with Avadhoot Jadhav) AAV Foundations (Part I) An overview of AAV-based gene therapies, how they get made, and where they go wrong. DNA sequences are designed on a computer, and it takes a dozen or more clicks to change a single nucleotide.

DNA

DNA Therapies Engineering Clinical Trials

Codon Digest: Hackathon Prize Winners

Codon

JUNE 26, 2023

Since the last Codon Digest, I’ve published: Reasons to Be Grateful for Biotechnology (with Avadhoot Jadhav) AAV Foundations (Part I) An overview of AAV-based gene therapies, how they get made, and where they go wrong. DNA sequences are designed on a computer, and it takes a dozen or more clicks to change a single nucleotide.

DNA

DNA Therapies Engineering Clinical Trials

Drug Discovery Digest

Ancient viruses may hold key to gene therapy treatments

Gerstner Center for Cancer Diagnostics receives additional commitment from Louis V. Gerstner, Jr., to advance technologies that could transform cancer care

Trending Sources

Not all neoantigens are created equal

Revolutionary nanoparticles enable gene-editing in lungs

Personalised mRNA cancer vaccine prolongs survival in melanoma

Could Gene Therapy Cure Sickle Cell Disease? Two New Studies Raise Hopes

Scientists link certain gut bacteria to lower heart disease risk

Targeting the immunotherapy potential of cytokines IL-12 and IL-18 with new advancements in protein engineering

Women in STEM with Charlotte Owens

#ScienceSaturday: April 6, 2024

T-cell receptors offer window to the cell for a new class of cancer therapeutics

Multi-ancestry study reveals genetic risk factors for two common pregnancy complications

Molecular map reveals insights into the genetic drivers of chronic lymphocytic leukemia

CRISPR Cas-9 System Doubles Life Expectancy in Mice with Aggressive Cancers

The Year In Review: 2023

#WhyIScience Q&A: How a computational biologist balances work with life as an elite rower

Codon Digest: Hackathon Prize Winners

Codon Digest: Hackathon Prize Winners

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