Broad Institute

AUGUST 14, 2023

In three new studies, researchers including a team from the Broad Institute of MIT and Harvard have harmonized and analyzed data on proteins, DNA, RNA, as well as clinical data from more than 1,000 patients across nearly a dozen different cancer types. Zamecnik Chair in Oncology at the Massachusetts General Hospital Cancer Center.

DNA 98

DNA RNA Regulations Treatment 98

Broad Institute

JUNE 1, 2023

Without prompt diagnosis and treatment, hypertensive disorders of pregnancy (HDPs) can lead to organ failure and potentially fatal complications. But scientists lack the tools to predict, prevent, and treat them. Buu Truong, a computational researcher and postdoctoral fellow in Natarajan’s lab, was a co-first author as well.

Doctors 133

Doctors Medical Schools Hospitals DNA 133

Drug Target Review

JANUARY 15, 2024

Monoclonal antibodies (mAbs) targeting tumour-specific antigens play an essential role in the treatment of many cancers. Unlike almost every other cell type (except B cells), T cells do not have the exact same chromosomal DNA sequences as other cells in the body. References Robinson R, McMurran C, McCully M, Cole D.

Engineering 110

Engineering DNA Virus Immune Response 110

Broad Institute

MARCH 8, 2024

Levine and Siddle say that these findings could improve the precision of diagnostics and treatments in areas with high numbers of NMFI cases. First author Zoë Levine is an MD-PhD candidate at Harvard Medical School and graduate student in the lab of Pardis Sabeti at the Broad. Nature Communications. Online January 25, 2024.

Research 111

Research Disease Medical Schools RNA 111

The Pharma Data

NOVEMBER 22, 2020

The mice who received the treatment had double the life expectancy as their counterparts, with a 30% higher survival rate. Peer stated that his team plans to develop a treatment for all cancers and that their technique could be ready for humans within the next two years. ” Source link.

DNA 52

DNA Medical Schools RNA Treatment 52

Broad Institute

AUGUST 7, 2023

STING is primarily on the lookout for DNA, which can indicate either a foreign invader such as a virus or damage to the host tissue or cell. Now, a team of MIT, Massachusetts General Hospital (MGH), Broad Institute of MIT and Harvard, and Harvard Medical School (HMS) researchers has discovered how STING activates those two pathways.

Regulations 91

Regulations Clinical Trials Engineering Science 91

Broad Institute

FEBRUARY 29, 2024

In the new microbes’ DNA, the researchers found hundreds of novel genes that may offer clues to how enterococci are able to resist antibiotic treatment and thrive in the hospital environment. Our findings may improve understanding of how resistance genes spread to hospital bacteria and threaten human health.”

Hospitals 116

Hospitals Medical Schools International Research 116

Drug Target Review

JUNE 6, 2023

In this IO arena, we continue to search for additional treatments that can further benefit patients. Immune checkpoint inhibitors, a well-established class of IO treatments, are designed to improve the ability of T-cells to fight cancer by removing inhibitory or suppressive mechanisms that may dampen the anti-cancer functions of T cells.

Engineering 98

Engineering Immune Response Biochemical Pharmacology Clinical Trials 98

Broad Institute

MAY 2, 2024

Today, she is a senior associate computational biologist in the Getz lab, where she applies computational techniques to DNA and RNA sequencing data to analyze rapid autopsy samples, taken from multiple sites throughout the body at the time of a cancer patient’s death. I love that in all forms of science, you solve problems.

Science 124

Science Medical Schools Disease Hospitals 124

Broad Institute

JULY 10, 2023

At the Broad, Martin is also helping lead data analysis in two large international studies that are sequencing the DNA of people from Africa and Latin America to learn about the genetics of severe mental illness. And Martin is helping train scientists abroad to run these kinds of analyses in their home countries.

Disease 98

Disease Bioinformatics Medical Schools Research 98

Broad Institute

AUGUST 4, 2022

To build the CLL map, the team analyzed variations in genetic sequences, gene expression patterns, and chemical modifications to DNA — or genomic, transcriptomic, and epigenomic data — from 1,148 patients.

Bioinformatics 52

Bioinformatics Medical Schools Hospitals Treatment 52

Broad Institute

JULY 20, 2023

Please register at broad.io/stanleysymposium Please register at broad.io/stanleysymposium

Medical Schools 52

Medical Schools Hospitals DNA Disease 52

The Pharma Data

DECEMBER 5, 2020

The first of the new therapies, developed at Harvard Medical School by a team led by Dr. David Williams, uses a virus to introduce RNA into the extracted bone marrow that turns off BCL11A. The CRISPR gene editing method won the 2020 Nobel Prize in Chemistry, and uses chemicals to open up and directly edit DNA sequences, Hsu said.

Therapies 52

Therapies Disease Medical Schools Virus 52

KIF1A

MAY 31, 2024

From hosting a conference to scientific projects and collaborations to the dedicated efforts of our team, this review encapsulates the relentless pursuit to accelerate treatments and a cure for all KAND warriors. The Chung Lab spearheads a robust KAND program to better understand the disorder and discover treatments.

Treatment 52

Treatment Small Molecule International Research 52

Broad Institute

JUNE 13, 2023

The results add to our understanding of the development of BPDCN, which is critical to devising new and better treatments for the disease," he continues. To better understand this process, researchers did a deep dive into the genetics of patients' bone marrow, blood, and skin leukemia cells – sequencing the DNA and RNA in individual cells. "We

Hospitals 52

Hospitals Disease Medical Schools Research 52

Codon

OCTOBER 6, 2024

Such coatings have been in development for years, but mostly to complement blood thinning treatments during ECMO, rather than replace them. ” In particular, Kemp has concerns surrounding the lack of studies involving animals of comparable birth weight to the infants that would be the most likely candidates for this type of treatment.

FDA 111

FDA Hospitals Engineering Research 111

Broad Institute

JANUARY 16, 2025

Scientists at the Broad Institute of MIT and Harvard, Harvard Medical School, and McLean Hospital have discovered a surprising mechanism by which the inherited genetic mutation known to cause Huntingtons disease leads to the death of brain cells. The cumulative death of many such cells leads to the symptoms of Huntingtons disease.

Disease 130

Disease DNA Medical Schools RNA 130

Broad Institute

NOVEMBER 21, 2024

Their results underscore the importance of early detection and treatment, such as with vorasidenib , which targets IDH and was recently approved by the FDA for low-grade gliomas. In IDH-driven gliomas, the mutated IDH enzyme fosters the addition of methyl groups to the cells’ DNA.

Research 124

Research Medical Schools DNA Hospitals 124

Broad Institute

MARCH 6, 2025

In one effort , researchers analyzed results from dozens of large genetic studies and uncovered more than 350 common DNA variants associated with AF risk, doubling the number of common genetic risk factors for the condition. These studies open up new potential targets for therapeutic development. million people without the condition.

DNA 126

DNA Medical Schools Disease Therapies 126

Broad Institute

JANUARY 7, 2025

These stories and diagnoses, made possible by clinical genomics labs around the world analyzing DNA from patients and sharing their findings with each other to improve medical care, werent always so common. She is also the chief genomics officer at Mass General and a professor of pathology at Harvard Medical School.

Disease 121

Disease Science Laboratories Medical Schools 121

KIF1A

NOVEMBER 1, 2024

Among them, 2 KAND patients are currently receiving treatment with KIF1A ASO-001, and 5 more KAND patients have been accepted to receive the same ASO. By enrolling in this online research study, you are not just a participant; you are a crucial partner in the fight to understand and ultimately find treatments for KAND.

Treatment 52

Treatment Medical Schools Research Disease 52