DrugBank

FEBRUARY 9, 2023

1 Present address: Functional Genomics and Metabolism Research Unit, Department of Biochemistry and Molecular Biology, University of Southern Denmark, Denmark. 2 Cancer Program, Broad Institute of MIT and Harvard, USA. 3 Research Focus: Network-based drug repositioning strategy to identify drugs targeting obesity and type 2 diabetes.

Clinical Pharmacology 52

Clinical Pharmacology Molecular Biology DNA Licensing 52

The Pharma Data

NOVEMBER 22, 2021

The Centre will help farther nurture hookups, develop the coming generation of wisdom leaders and accelerate AstraZeneca’s assiduity- leading situations of productivity. The life lores cluster in Cambridge The life lores cluster in Cambridge is the most productive in Europe. region in the US, and Gothenburg in Sweden.

Molecular Biology 52

Molecular Biology Laboratories Engineering Hospitals 52

Drug Target Review

JUNE 19, 2024

The other powerful benefit is that our cell lines can become any of the cell types of the human body – these cells have within their DNA the capability to become any of the more than 200 human cell types which you might want to manufacture. This provides some regulatory advantages, and of course, significant cost advantages.

Therapies 84

Therapies Small Molecule Pharmaceutical Companies Molecular Biology 84

Drug Target Review

JUNE 11, 2024

When choosing my bachelor’s degree, the choice was between pursuing a career in biology or in computer science. Biology won that battle, and I pursued a bachelor’s and master’s degree in biochemistry and molecular biology. The product we are developing at OMINI is unique.

Engineering 64

Engineering Science Molecular Biology Doctors 64

LifeSciVC

JULY 1, 2024

The central dogma of molecular biology is that information generally (with few exceptions) flows from DNA to RNA to Protein. This heterodimer will bring more meaning to your work, enhance your productivity, and open doors over time. Remember life’s Central Dogma. Don’t differentiate too quickly.

Science 90

Science Immune Response Molecular Biology RNA 90

Dark Matter Blog

JULY 16, 2021

The only subject in school that held my interest was biology. As soon as I learned about DNA and RNA, I wanted to be a molecular biologist. I wanted to use molecular biology to create drugs. Last stops at RNA My last roles in biotech were where my original passion began: DNA and RNA.

Small Molecule 52

Small Molecule RNA Clinical Trials DNA 52

Codon

JUNE 25, 2024

However, they plod along as they clone plasmids—the loops of DNA that biologists use to manipulate and study organisms—because propagating them relies, in part, on the pace at which cells grow and divide. Most medicines, including insulin and semaglutide (the weight loss drug), are made using DNA cloning. However, E.

DNA 90

DNA RNA Laboratories Research 90

Codon

FEBRUARY 13, 2024

By 2004, over a dozen companies were working on developing phage products and therapies, in locations ranging from Baltimore to Bangalore, where ten years previously, there had been none. Phage-based products have been licensed for use as antibacterial agents in the sanitation , food production , and animal health industries.

Therapies 135

Therapies Virus DNA Clinical Trials 135

Broad Institute

AUGUST 7, 2023

STING is primarily on the lookout for DNA, which can indicate either a foreign invader such as a virus or damage to the host tissue or cell. The mechanism by which STING stimulates interferon production is well characterized, but it has not been understood how it activates the other two processes. Paper Cited Liu B, Carlson R, et al.

Regulations 91

Regulations Clinical Trials Engineering Science 91

DrugBaron

NOVEMBER 22, 2022

For example, it is well known that glycation of haemoglobin through non-enzymatic reaction with glucose to generate a product known as Hba1c is a useful measure of glycemic control in diabetic subjects. This can be useful to quantify protein adducts (for example when radiolabelling a protein or preparing antigens for vaccine production).

Bioinformatics 100

Bioinformatics Regulations Molecular Biology Engineering 100

Drug Target Review

MAY 22, 2024

What are the key findings of Circio’s in vivo proof-of-concept for its circVec circular RNA platform technology compared to conventional mRNA-based expression with DNA vectors? DNA vectors in mouse models? Circular RNA (circRNA) has two major advantages versus mRNA in a vector-expression context.

Therapies 59

Therapies RNA Protein Expression DNA 59

Broad Institute

MAY 14, 2024

William Studier for development of widely used protein- and RNA-production platform By Corie Lok May 14, 2024 Breadcrumb Home Merkin Prize in Biomedical Technology awarded to F. There’s not a single molecular biology or biochemistry lab I know that doesn’t use T7.” Merkin Prize in Biomedical Technology awarded to F.

RNA 84

RNA Production Molecular Biology Laboratories 84

BMG Labtech

MARCH 8, 2023

This coordinated series of biochemical reactions where the product of one conversion becomes the substrate for another reaction is known as metabolic pathways. Metabolism also includes the disposal of waste and by-products. Anabolism consists of three basic steps: the production of precursor molecules (e.g.,

Molecular Biology 52

Molecular Biology Production Cell Based Assays Disease 52

Codon

APRIL 2, 2024

in physics at Princeton University, he had a remarkable idea: What if it were possible to build a circuit out of DNA, rather than electronics, and use it to “program” a living cell? So over time, waste products pile up in the media, and the cells grow more slowly. In 1997, as Michael Elowitz was studying for a Ph.D.

RNA 56

RNA Engineering Molecular Biology Synthetic Chemistry 56

Codon

JUNE 26, 2023

DNA sequences are designed on a computer, and it takes a dozen or more clicks to change a single nucleotide. DNA sequences are also checked by hand, so it’s easy to make a mistake. The tool outputs a DNA sequence that encodes all the required enzymes. Anyone who has tried to engineer a cell knows how tedious it can be.

DNA 52

DNA Therapies Engineering Clinical Trials 52

Codon

JUNE 26, 2023

DNA sequences are designed on a computer, and it takes a dozen or more clicks to change a single nucleotide. DNA sequences are also checked by hand, so it’s easy to make a mistake. The tool outputs a DNA sequence that encodes all the required enzymes. Anyone who has tried to engineer a cell knows how tedious it can be.

DNA 52

DNA Therapies Engineering Clinical Trials 52

Codon

JULY 27, 2023

They’ve just finished sequencing the patient’s genome, but they don’t have “DNA sorting” software. billion units of DNA code are transcribed into more than a hundred volumes, each a thousand pages long, in type so small as to be barely legible.” You can read all of them here.

Therapies 52

Therapies RNA DNA Engineering 52

Codon

JULY 27, 2023

They’ve just finished sequencing the patient’s genome, but they don’t have “DNA sorting” software. billion units of DNA code are transcribed into more than a hundred volumes, each a thousand pages long, in type so small as to be barely legible.” You can read all of them here.

Therapies 52

Therapies RNA DNA Engineering 52

Codon

MARCH 12, 2023

Notes on Progress is a monthly roundup of papers and ideas about biology and the future. “The recombinant DNA breakthrough has provided us with a new and powerful approach to the questions that have intrigued and plagued man for centuries. Biology is a Burrito. A new base editor to edit mitochondrial DNA.

DNA 52

DNA Engineering Therapies RNA 52

Drug Target Review

DECEMBER 12, 2024

Major scientific leaps have brought us closer than ever to harnessing the power of epigenetics to shape stem cell journeys for scalable therapeutic production. A prime example of this is DNA binding proteins, such as those found in the CRISPR-Cas system made famous by 2020 Nobel Prize winners Emmanuelle Charpentier and Jennifer Doudna.

Therapies 59

Therapies DNA Molecular Biology Immune Response 59

Codon

AUGUST 10, 2023

Journal of Molecular Biology (1961). Technologies DNA Sequencing →DNA sequencing at 40: past, present and future , by Shendure J. Link DNA Cost and Productivity Data, aka "Carlson Curves" , by Carlson R. Link Next-Generation DNA Sequencing Methods , by Mardis E.R. . & Xie X.S. Nature (2011).

DNA 98

DNA Cell Biology Molecular Biology Engineering 98

Codon

NOVEMBER 1, 2024

I’ve chosen these two because I think they are the linchpin by which we’ll be able to build broadly useful AI models for cell and molecular biology. Synthesizing a single human protein-coding gene costs several hundred dollars and even a simple PCR machine (used for amplifying DNA) costs between $1,500 and $50,000.

DNA 128

DNA RNA Molecular Biology Laboratories 128

Codon

AUGUST 10, 2023

Journal of Molecular Biology (1961). Technologies DNA Sequencing →DNA sequencing at 40: past, present and future , by Shendure J. Link DNA Cost and Productivity Data, aka "Carlson Curves" , by Carlson R. Link Next-Generation DNA Sequencing Methods , by Mardis E.R. . & Xie X.S. Nature (2011).

DNA 52

DNA Cell Biology Engineering Molecular Biology 52

Codon

JANUARY 12, 2025

He also posited the existence of a physical material to explain inheritance, which he called “elementen,” or “elements,” many years before nucleic acid had even been isolated 4 and more than 80 years before British biologists unveiled DNA’s structure and founded the field of molecular biology.

DNA 116

DNA Nurses Research Molecular Biology 116