Broad Institute

AUGUST 7, 2023

STING is primarily on the lookout for DNA, which can indicate either a foreign invader such as a virus or damage to the host tissue or cell. Now, a team of MIT, Massachusetts General Hospital (MGH), Broad Institute of MIT and Harvard, and Harvard Medical School (HMS) researchers has discovered how STING activates those two pathways.

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Codon

FEBRUARY 13, 2024

Goodsell, RCSB Protein Data Bank and Scripps Research. 1 Yet even after more than two decades of research, media hype, and dozens of clinical trials and biotech start-ups that have come and gone, phage therapy has not scaled. Still, researchers are trying. Read it on our website here. Illustration by David S.

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Codon

JULY 17, 2024

In a quiet New York town, an amateur scientist has constructed a fully equipped research laboratory in which to advance plant biology research. It traces his journey to construct a new research path separate from—but in dialogue with—traditional academia, while safeguarding his mother’s home in the process.

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Codon

JUNE 25, 2024

However, they plod along as they clone plasmids—the loops of DNA that biologists use to manipulate and study organisms—because propagating them relies, in part, on the pace at which cells grow and divide. Due to the nearly ubiquitous use of cloning in life science research, this lost time adds up. However, E.

DNA 70

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Drug Target Review

DECEMBER 7, 2023

Phage have been of interest to scientists as tools to understand fundamental molecular biology, as vectors of horizontal gene transfer and drivers of bacterial evolution, as sources of diagnostic and genetic tools, and as novel therapeutic agents. Its presence elsewhere would indicate something is wrong.

RNA 59

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sptlabtech

JUNE 9, 2023

One of the key technologies driving this transformation has been Next-Generation Sequencing (NGS), which has allowed scientists and researchers to obtain sequencing data at a much higher scale and lower cost than ever before. What benefits can you expect to see from making the switch to automated liquid handling with firefly?

Molecular Biology 52

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Codon

JUNE 13, 2024

billion bases of DNA which, if unfurled, would extend for more than 100 meters—taller than the Statue of Liberty. billion bases of DNA, the human genome measures just 2 meters in length when stretched end-to-end. Credit: Oriane Hidalgo Per the book Cell Biology by the Numbers , each base pair of DNA occupies 1 nm 3 of space.

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DNA Molecular Biology Virus Cell Biology 59

DrugBank

FEBRUARY 9, 2023

DrugBank is passionate about equipping leading researchers with the data they need for new discoveries. As a trusted partner to world-renowned researchers, we are proud to be contributing to groundbreaking research and aiding in solving some of the industry's most pressing issues. Throughout their research, Dutta et al.

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PLOS: DNA Science

AUGUST 22, 2024

When Crichton died of cancer in 2008, he left behind a staggering trove of research about an eruption of Mauna Loa on the Big Island of Hawaii. ” The explanation continues, and here’s where it ceases to make sense, to anyone who knows anything about DNA, genes, and genomes. The DNA double helix is exquisitely symmetrical.

DNA 52

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Drug Target Review

MAY 22, 2024

What are the key findings of Circio’s in vivo proof-of-concept for its circVec circular RNA platform technology compared to conventional mRNA-based expression with DNA vectors? DNA vectors in mouse models? Circular RNA (circRNA) has two major advantages versus mRNA in a vector-expression context.

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Elrig

APRIL 29, 2024

With a background in Bioinformatics and Computational Biology, she has a keen interest in using technology to solve problems in healthcare and medicine. Miguel Gancedo Rodrigo Miguel Gancedo Rodrigo Research Investigator, Isomorphic Labs My name is Miguel, and I’m from Murcia, Spain.

Bioinformatics 59

Bioinformatics Drugs Molecular Biology Cell Based Assays 59

Codon

JULY 11, 2023

That’s because proteins are made, in the laboratory, using synthetic DNA and cells; and DNA is expensive. Our machine would make proteins without using any DNA or cells. All cells make proteins in two steps: DNA is transcribed into messenger RNA, which is then translated into protein.

RNA 64

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Alta Sciences

MARCH 1, 2024

NM: One of the specializations of our research facility in Seattle, WA, is gene therapy. Our biomarker team has a number of cytokine and complement panels designed to detect and quantify these changes in research subjects. Q: How do Your Preclinical and Bioanalytical Teams Work Together to Accelerate Sponsors’ Gene Therapy Research?

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Drug Target Review

JUNE 11, 2024

Biology won that battle, and I pursued a bachelor’s and master’s degree in biochemistry and molecular biology. We had to pursue our research work with very limited resources and resolve to some creative solutions to get our experiments done, sometimes we even had to buy some of the reagents ourselves.

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Drug Target Review

JUNE 19, 2024

The other powerful benefit is that our cell lines can become any of the cell types of the human body – these cells have within their DNA the capability to become any of the more than 200 human cell types which you might want to manufacture. This provides some regulatory advantages, and of course, significant cost advantages.

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The Pharma Data

NOVEMBER 22, 2021

Within close propinquity to AstraZeneca’s new centre is the University of Cambridge’s School of Clinical Medicine, the Medical Research Council Laboratory of Molecular Biology, Cancer Research UK and the Royal Papworth and Addenbrooke’s Hospitals, among others.

Molecular Biology 52

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Dark Matter Blog

JULY 16, 2021

As soon as I learned about DNA and RNA, I wanted to be a molecular biologist. I wanted to use molecular biology to create drugs. I am now at the end of a career that has comprised nearly 10 years of academic research and 35 years in biotechnology. Arrakis is the capstone of my career.

Small Molecule 52

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Codon

JULY 27, 2023

For a recent study, researchers edited 21 different genes in poplar trees, a species commonly used to make paper. The researchers studied trees with 70,000 different gene-editing combinations, just 0.5% They’ve just finished sequencing the patient’s genome, but they don’t have “DNA sorting” software.

Therapies 52

Therapies RNA DNA Engineering 52

Codon

JULY 27, 2023

For a recent study, researchers edited 21 different genes in poplar trees, a species commonly used to make paper. The researchers studied trees with 70,000 different gene-editing combinations, just 0.5% They’ve just finished sequencing the patient’s genome, but they don’t have “DNA sorting” software.

Therapies 52

Therapies RNA DNA Engineering 52

Codon

JULY 11, 2023

That’s because proteins are made, in the laboratory, using synthetic DNA and cells; and DNA is expensive. Our machine would make proteins without using any DNA or cells. All cells make proteins in two steps: DNA is transcribed into messenger RNA, which is then translated into protein.

RNA 52

RNA DNA Engineering Laboratories 52

Codon

JUNE 26, 2023

DNA sequences are designed on a computer, and it takes a dozen or more clicks to change a single nucleotide. DNA sequences are also checked by hand, so it’s easy to make a mistake. The tool outputs a DNA sequence that encodes all the required enzymes. Goodsell, Scripps Research and RCSB Protein Data Bank.

DNA 52

DNA Therapies Engineering Clinical Trials 52

Codon

JUNE 26, 2023

DNA sequences are designed on a computer, and it takes a dozen or more clicks to change a single nucleotide. DNA sequences are also checked by hand, so it’s easy to make a mistake. The tool outputs a DNA sequence that encodes all the required enzymes. Goodsell, Scripps Research and RCSB Protein Data Bank.

DNA 52

DNA Therapies Engineering Clinical Trials 52

Codon

MARCH 12, 2023

Notes on Progress is a monthly roundup of papers and ideas about biology and the future. “The recombinant DNA breakthrough has provided us with a new and powerful approach to the questions that have intrigued and plagued man for centuries. Biology is a Burrito. A new base editor to edit mitochondrial DNA.

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DNA Engineering Therapies RNA 52

DrugBaron

NOVEMBER 22, 2022

To enable that research, the team at Methuselah Health needed a proteomics approach that would accurately quantify post-translational modifications across the proteome – and since that didn’t exist, their Chief Technology Officer, David Mosedale, set about creating it.

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LifeSciVC

JULY 1, 2024

So when I was asked recently to share advice to a group of undergraduate students doing research at Penn State, I was drawn to the idea of connecting scientific principles to some life lessons. The central dogma of molecular biology is that information generally (with few exceptions) flows from DNA to RNA to Protein.

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Alta Sciences

AUGUST 21, 2024

Everyone at Altasciences has been incredibly warm and kind.” — Griffin Harlow , Research Associate Intern, Laboratory Sciences What's a key takeaway from your internship at altasciences? They are supportive of our future endeavors and provide guidance that is invaluable to improving our work.

International 40

International Laboratories Science Molecular Biology 40

BMG Labtech

MARCH 8, 2023

In biology , scientific research on cell metabolism focuses on different topics such as understanding the fundamental metabolic processes, metabolic changes and their role in diseases (including cancer cell and tumor metabolism), the development of therapies, the identification of unknown metabolic processes and metabolites, etc.

Molecular Biology 52

Molecular Biology Production Cell Based Assays Disease 52

Codon

JUNE 18, 2024

Even after a half-century of molecular biology research, scientists didn’t know until recently how gas vesicles physically trap gas while occluding water. By 2016, Shapiro had set up a research laboratory at the California Institute of Technology in Pasadena and began to devote his attention entirely to gas vesicles.

Engineering 65

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The Pharma Data

OCTOBER 18, 2020

NASDAQ:CDXC) today highlighted a new study published in The European Molecular Biology Organization Journal looking at the effect of nicotinamide riboside (NR) on maintaining telomeres, the protective regions at the end of DNA strands. LOS ANGELES–( BUSINESS WIRE )– ChromaDex Corp.

DNA 52

DNA Molecular Biology Disease Trials 52

Codon

NOVEMBER 1, 2024

Amodei also imagines the ways AI could accelerate biological research and yield miraculous cures in the 21st century; everything from the prevention and treatment of nearly all infectious and inherited diseases to the elimination of most cancers. Still, many of the bottlenecks slowing biology today are biophysical , rather than computational.

DNA 107

DNA RNA Molecular Biology Laboratories 107

Codon

JULY 10, 2024

But in the 1950s, at the dawn of molecular biology, scientists gained a new appreciation for it after searching for organisms that were easy to work with and quick to grow. In 1952, when the famous Hershey-Chase experiment indicated that DNA—and not protein—was the source of genetic material, just 285 papers mentioned E.

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Laboratories DNA Molecular Biology Engineering 75

Codon

AUGUST 10, 2023

Link The second decade of synthetic biology: 2010–2020 , by Meng F. & Link Synthetic biology in mammalian cells: next generation research tools and therapeutics , by Lienert F. Nature Reviews Molecular Cell Biology (2014). Journal of Molecular Biology (1961). Nucleic Acids Research (2010).

DNA 91

DNA Cell Biology Molecular Biology Engineering 91

Codon

AUGUST 10, 2023

Link The second decade of synthetic biology: 2010–2020 , by Meng F. & Link Synthetic biology in mammalian cells: next generation research tools and therapeutics , by Lienert F. Nature Reviews Molecular Cell Biology (2014). Journal of Molecular Biology (1961). Nucleic Acids Research (2010).

DNA 52

DNA Cell Biology Engineering Molecular Biology 52

Drug Target Review

DECEMBER 12, 2024

Enter epigenetics Broadly speaking, epigenetics refers to the system of proteins and marks that sits atop our genome a system that modifies gene expression, guides cell differentiation, and functionally organises our DNA. Progress in molecular biology and translational science [Internet]. 2024 Jan 1 [cited 2024 Oct 22];185209.

Therapies 59

Therapies DNA Molecular Biology Immune Response 59

Codon

DECEMBER 1, 2024

By Matthew Cobb The Central Dogma is a linchpin for understanding how cells work, and yet it is one of the most widely misunderstood concepts in molecular biology. Many students are taught that the Central Dogma is simply “DNA → RNA → protein.”

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