LifeSciVC

AUGUST 5, 2024

The genomic capabilities that were brought online for drug discovery (cheaper & faster next-gen DNA sequencing) did not diminish the need for biologists and translational scientists in target and patient selection, respectively. One final parallel to 2001.

Molecular Biology 90

Molecular Biology Production Small Molecule Drug Development 90

Codon

JULY 17, 2024

In a quiet New York town, an amateur scientist has constructed a fully equipped research laboratory in which to advance plant biology research. It traces his journey to construct a new research path separate from—but in dialogue with—traditional academia, while safeguarding his mother’s home in the process.

Laboratories 91

Laboratories Engineering Molecular Biology Science 91

Drug Target Review

DECEMBER 7, 2023

Phage have been of interest to scientists as tools to understand fundamental molecular biology, as vectors of horizontal gene transfer and drivers of bacterial evolution, as sources of diagnostic and genetic tools, and as novel therapeutic agents. Its presence elsewhere would indicate something is wrong.

RNA 59

RNA Immune Response DNA Molecular Biology 59

Drug Discovery World

NOVEMBER 17, 2022

The rapidly growing area of synthetic biology – including molecular biology, biotechnology, biophysics, and genetic engineering – is having a marked impact on the drug discovery landscape. These factors can significantly contribute to the growth of the synthetic biology market, it adds. .

Engineering 130

Engineering Molecular Biology Synthetic Chemistry DNA 130

Broad Institute

AUGUST 7, 2023

STING is primarily on the lookout for DNA, which can indicate either a foreign invader such as a virus or damage to the host tissue or cell. Now, a team of MIT, Massachusetts General Hospital (MGH), Broad Institute of MIT and Harvard, and Harvard Medical School (HMS) researchers has discovered how STING activates those two pathways.

Regulations 91

Regulations Engineering Clinical Trials DNA 91

Drug Discovery World

MAY 29, 2024

Marc Hummersone, Senior Director of Research and Development (R&D) at Astrea Bioseparations, shares insight on the challenges and opportunities in cell and gene therapy (CGT) with DDW’s Megan Thomas. DNA purification “Plasmid DNA is an incredibly important part of molecular biology”, says Hummersone.

Therapies 273

Therapies Molecular Biology DNA Immune Response 273

Drug Discovery World

JANUARY 26, 2023

The molecule, known as lissodendoric acid A, appears to counteract other molecules that can damage DNA, RNA and proteins and even destroy whole cells.

Organic Chemistry 130

Organic Chemistry Laboratories RNA DNA 130

DrugBank

FEBRUARY 9, 2023

DrugBank is passionate about equipping leading researchers with the data they need for new discoveries. As a trusted partner to world-renowned researchers, we are proud to be contributing to groundbreaking research and aiding in solving some of the industry's most pressing issues. Throughout their research, Dutta et al.

Clinical Pharmacology 52

Clinical Pharmacology Molecular Biology DNA Licensing 52

Drug Target Review

MAY 22, 2024

What are the key findings of Circio’s in vivo proof-of-concept for its circVec circular RNA platform technology compared to conventional mRNA-based expression with DNA vectors? DNA vectors in mouse models? Circular RNA (circRNA) has two major advantages versus mRNA in a vector-expression context.

Therapies 59

Therapies RNA Protein Expression DNA 59

Alta Sciences

MARCH 1, 2024

NM: One of the specializations of our research facility in Seattle, WA, is gene therapy. Our biomarker team has a number of cytokine and complement panels designed to detect and quantify these changes in research subjects. Q: How do Your Preclinical and Bioanalytical Teams Work Together to Accelerate Sponsors’ Gene Therapy Research?

Therapies 52

Therapies Laboratories Molecular Biology RNA 52

Alta Sciences

AUGUST 21, 2024

Everyone at Altasciences has been incredibly warm and kind.” — Griffin Harlow , Research Associate Intern, Laboratory Sciences What's a key takeaway from your internship at altasciences? They are supportive of our future endeavors and provide guidance that is invaluable to improving our work.

International 40

International Laboratories Science Molecular Biology 40

Drug Discovery World

AUGUST 3, 2023

With this in mind, the FDA claims to be committed to sound scientific research into the area and has a number of processes in place for those in the medical research community who intend to study cannabis 1. He said: “But for this market to become a reality, we need much more research into cannabis products and potential indications.

Clinical Trials 130

Clinical Trials Regulations Production FDA 130

The Pharma Data

OCTOBER 18, 2020

NASDAQ:CDXC) today highlighted a new study published in The European Molecular Biology Organization Journal looking at the effect of nicotinamide riboside (NR) on maintaining telomeres, the protective regions at the end of DNA strands. LOS ANGELES–( BUSINESS WIRE )– ChromaDex Corp.

DNA 52

DNA Molecular Biology Disease Trials 52

Broad Institute

AUGUST 16, 2023

Nuclear DNA influences variation in mitochondrial DNA By Allessandra DiCorato August 16, 2023 Breadcrumb Home Nuclear DNA influences variation in mitochondrial DNA Whole genomes from hundreds of thousands of people reveal new complexity in how the nuclear and mitochondrial genomes interact, which may influence how cells produce energy.

DNA 98

DNA Molecular Biology Disease Regulations 98

Drug Target Review

JUNE 19, 2024

The other powerful benefit is that our cell lines can become any of the cell types of the human body – these cells have within their DNA the capability to become any of the more than 200 human cell types which you might want to manufacture. This provides some regulatory advantages, and of course, significant cost advantages.

Therapies 84

Therapies Small Molecule Pharmaceutical Companies Molecular Biology 84

The Pharma Data

NOVEMBER 22, 2021

Within close propinquity to AstraZeneca’s new centre is the University of Cambridge’s School of Clinical Medicine, the Medical Research Council Laboratory of Molecular Biology, Cancer Research UK and the Royal Papworth and Addenbrooke’s Hospitals, among others.

Molecular Biology 52

Molecular Biology Laboratories Engineering Hospitals 52

Dark Matter Blog

JULY 16, 2021

As soon as I learned about DNA and RNA, I wanted to be a molecular biologist. I wanted to use molecular biology to create drugs. I am now at the end of a career that has comprised nearly 10 years of academic research and 35 years in biotechnology. Arrakis is the capstone of my career.

Small Molecule 52

Small Molecule RNA Clinical Trials DNA 52

Broad Institute

MAY 14, 2024

His T7 expression technology can be used to make large quantities of nearly any RNA or protein and has been for decades, and continues to be, a mainstay of biomedical research and pharmaceutical production. There’s not a single molecular biology or biochemistry lab I know that doesn’t use T7.” My interest is in basic research."

RNA 84

RNA Production Molecular Biology Laboratories 84

Drug Discovery World

NOVEMBER 15, 2022

Here we outline four synthetic biology approaches that are improving and accelerating drug discovery: . Rapid and accurate DNA synthesis . As such, the synthesis of DNA oligonucleotides for routine molecular biology applications is often outsourced to service provider companies that operate DNA synthesisers to meet these demands.

DNA 246

DNA Engineering Drugs Vaccine 246

Drug Discovery World

JULY 29, 2022

Scientists from seven research institutions including the University of Oxford and the University of Edinburgh have used pioneering bioinformatic modelling to investigate the molecular interactions of the p53 protein known to give protection against cancers.

Molecular Biology 130

Molecular Biology DNA Bioinformatics Regulations 130

Drug Discovery World

APRIL 30, 2024

Whilst research into mRNA has been ongoing for decade, interest has sparked in recent years and research has begun to expand into areas of vaccinology, infectious diseases and other indications. As such, teams are now researching a variety of medical applications for mRNA-based drugs.

Therapies 130

Therapies RNA Vaccine Small Molecule 130

Drug Discovery World

JULY 15, 2022

The remaining 8% of the genome was often referred to as the dark matter of the genome or sometimes even ‘Junk DNA’ 2. The sequencing technology relied on could only yield sequences of relatively short DNA fragments, so the assembly of sequences from highly repetitive regions was a huge challenge.

DNA 130

DNA Disease Molecular Biology Science 130

Codon

JUNE 25, 2024

However, they plod along as they clone plasmids—the loops of DNA that biologists use to manipulate and study organisms—because propagating them relies, in part, on the pace at which cells grow and divide. Due to the nearly ubiquitous use of cloning in life science research, this lost time adds up. However, E.

DNA 73

DNA RNA Laboratories Engineering 73

Drug Discovery World

NOVEMBER 9, 2023

Novel platforms This session will begin with chariperson’s remarks from Lars Linden, PhD, Vice President, Head, Biologics Research, Bayer HealthCare, which will be followed by a keynote presentation by Agnieszka Kielczewska, PhD, Director, Research, Antibody Discovery and Screening, Biologics Discovery, Amgen.

Engineering 130

Engineering Therapies Protein Production Science 130

Codon

JUNE 13, 2024

billion bases of DNA which, if unfurled, would extend for more than 100 meters—taller than the Statue of Liberty. billion bases of DNA, the human genome measures just 2 meters in length when stretched end-to-end. Credit: Oriane Hidalgo Per the book Cell Biology by the Numbers , each base pair of DNA occupies 1 nm 3 of space.

DNA 62

DNA Molecular Biology Virus Cell Biology 62

Drug Discovery World

OCTOBER 25, 2023

DDW Editor Reece Armstrong speaks to Dr Darrell Green , Lecturer in RNA Biology Biomedical Research Centre Norwich Medical School University of East Anglia, about his work using next generation sequencing (NGS) and the areas the technology is impacting within drug discovery and development.

Bioinformatics 287

Bioinformatics Pharmacogenetics RNA Medical Schools 287

sptlabtech

JUNE 9, 2023

One of the key technologies driving this transformation has been Next-Generation Sequencing (NGS), which has allowed scientists and researchers to obtain sequencing data at a much higher scale and lower cost than ever before. What benefits can you expect to see from making the switch to automated liquid handling with firefly?

Molecular Biology 52

Molecular Biology DNA Laboratories Production 52

Drug Discovery World

JANUARY 23, 2023

Kevin Hemphill, R&D Manager at PerkinElmer’s Horizon Discovery explores how base editing has emerged as an attractive gene editing option for researchers wanting to develop stem cell-based therapies. 2016/17 saw the emergence of this novel CRISPR-Cas9-based approach.

Therapies 130

Therapies DNA Engineering RNA 130

Codon

FEBRUARY 13, 2024

Goodsell, RCSB Protein Data Bank and Scripps Research. 1 Yet even after more than two decades of research, media hype, and dozens of clinical trials and biotech start-ups that have come and gone, phage therapy has not scaled. Still, researchers are trying. Read it on our website here. Illustration by David S.

Therapies 121

Therapies Virus DNA Clinical Trials 121

Drug Target Review

JUNE 11, 2024

Biology won that battle, and I pursued a bachelor’s and master’s degree in biochemistry and molecular biology. We had to pursue our research work with very limited resources and resolve to some creative solutions to get our experiments done, sometimes we even had to buy some of the reagents ourselves.

Engineering 64

Engineering Science Doctors Molecular Biology 64

sptlabtech

JUNE 9, 2023

One of the key technologies driving this transformation has been Next-Generation Sequencing (NGS), which has allowed scientists and researchers to obtain sequencing data at a much higher scale and lower cost than ever before. What benefits can you expect to see from making the switch to automated liquid handling with firefly?

Laboratories 89

Laboratories Molecular Biology DNA Engineering 89

Drug Discovery World

OCTOBER 11, 2023

Until recently, many large pharmaceutical companies had stopped antibiotic research entirely as the returns on investment were too low and regulatory requirements too stringent 5. Additionally, drugs like quinolones and rifampin disrupt the synthesis of nucleic acids, which are essential for bacterial DNA replication.

Protein Production 147

Protein Production Pharmaceutical Companies Production DNA 147

Elrig

APRIL 29, 2024

With a background in Bioinformatics and Computational Biology, she has a keen interest in using technology to solve problems in healthcare and medicine. Miguel Gancedo Rodrigo Miguel Gancedo Rodrigo Research Investigator, Isomorphic Labs My name is Miguel, and I’m from Murcia, Spain.

Bioinformatics 59

Bioinformatics Molecular Biology Drugs Cell Based Assays 59

Codon

JULY 27, 2023

For a recent study, researchers edited 21 different genes in poplar trees, a species commonly used to make paper. The researchers studied trees with 70,000 different gene-editing combinations, just 0.5% They’ve just finished sequencing the patient’s genome, but they don’t have “DNA sorting” software.

Therapies 52

Therapies RNA DNA Engineering 52

Codon

JULY 27, 2023

For a recent study, researchers edited 21 different genes in poplar trees, a species commonly used to make paper. The researchers studied trees with 70,000 different gene-editing combinations, just 0.5% They’ve just finished sequencing the patient’s genome, but they don’t have “DNA sorting” software.

Therapies 52

Therapies RNA DNA Engineering 52

Codon

JULY 11, 2023

That’s because proteins are made, in the laboratory, using synthetic DNA and cells; and DNA is expensive. Our machine would make proteins without using any DNA or cells. All cells make proteins in two steps: DNA is transcribed into messenger RNA, which is then translated into protein.

RNA 66

RNA DNA Engineering Laboratories 66

Codon

JULY 11, 2023

That’s because proteins are made, in the laboratory, using synthetic DNA and cells; and DNA is expensive. Our machine would make proteins without using any DNA or cells. All cells make proteins in two steps: DNA is transcribed into messenger RNA, which is then translated into protein.

RNA 52

RNA DNA Engineering Laboratories 52