Broad Institute

AUGUST 7, 2023

STING is primarily on the lookout for DNA, which can indicate either a foreign invader such as a virus or damage to the host tissue or cell. Once it detects DNA, it relocates to the Golgi body, where it begins to activate proteins that turn on genes required for interferon production. Paper Cited Liu B, Carlson R, et al.

Regulations 91

Regulations Engineering Clinical Trials DNA 91

Alta Sciences

AUGUST 21, 2024

I have also learned a lot about the nuances of micropipettes that I would have never learned at school.” — Sheridan Moore , Research Associate Intern, Laboratory Sciences “My favorite part about interning at Altasciences is the potential for creating a long, meaningful career that I would be passionate about.

International 40

International Laboratories Science Molecular Biology 40

Drug Discovery World

NOVEMBER 17, 2022

Lu Rahman selects some recent synthetic biology innovations and the potential they hold to benefit drug discovery. . The rapidly growing area of synthetic biology – including molecular biology, biotechnology, biophysics, and genetic engineering – is having a marked impact on the drug discovery landscape. References .

Engineering 130

Engineering Molecular Biology Synthetic Chemistry DNA 130

DrugBank

FEBRUARY 9, 2023

1 Present address: Functional Genomics and Metabolism Research Unit, Department of Biochemistry and Molecular Biology, University of Southern Denmark, Denmark. Summary: This paper discusses the use of a data science approach to synthesize current knowledge on the pharmacological implications of epigenetic regulation of gene expression.

Clinical Pharmacology 52

Clinical Pharmacology Molecular Biology DNA Licensing 52

Drug Discovery World

AUGUST 3, 2023

These categories are: Analytical Heroes, Processing Pros, Plant Science Pioneers, R&D Trailblazers and Inspirational Mentors. My mission is to see cannabis regulators understand basic science and to consult experienced scientists to refine regulations. This was the largest ever independent study into cannabis use 10.

Clinical Trials 130

Clinical Trials Regulations Production FDA 130

Alta Sciences

MARCH 1, 2024

PJ: At Altasciences, we have a range of leading-edge platforms that include ligand binding assays (LBA), NAb, TAb, flow cytometry, and ELISpot, as well as on-site molecular biology instrumentation such as Bio-Rad’s ddPCR system, the NanoDropTM One spectrophotometer, and dedicated polymerase chain reaction (PCR) chambers.

Therapies 52

Therapies Laboratories Molecular Biology RNA 52

The Pharma Data

OCTOBER 18, 2020

NASDAQ:CDXC) today highlighted a new study published in The European Molecular Biology Organization Journal looking at the effect of nicotinamide riboside (NR) on maintaining telomeres, the protective regions at the end of DNA strands. is a science-based integrated nutraceutical company devoted to improving the way people age.

DNA 52

DNA Molecular Biology Disease Trials 52

Broad Institute

AUGUST 16, 2023

Nuclear DNA influences variation in mitochondrial DNA By Allessandra DiCorato August 16, 2023 Breadcrumb Home Nuclear DNA influences variation in mitochondrial DNA Whole genomes from hundreds of thousands of people reveal new complexity in how the nuclear and mitochondrial genomes interact, which may influence how cells produce energy.

DNA 98

DNA Molecular Biology Disease Regulations 98

Drug Target Review

JUNE 19, 2024

The other powerful benefit is that our cell lines can become any of the cell types of the human body – these cells have within their DNA the capability to become any of the more than 200 human cell types which you might want to manufacture. This provides some regulatory advantages, and of course, significant cost advantages.

Therapies 84

Therapies Small Molecule Pharmaceutical Companies Molecular Biology 84

The Pharma Data

NOVEMBER 22, 2021

State-of-the-art R&D facility designed to foster collaboration across world-class science ecosystem Sustainable environmental engineering aligned to Company’s zero carbon future. Important discoveries have included Francis Crick and James Watson’s DNA advance in 1953, and Professor Sir John Gurdon’s work on stem cells in 2012.

Molecular Biology 52

Molecular Biology Laboratories Engineering Hospitals 52

Broad Institute

MAY 14, 2024

“Bill Studier’s development of T7 phage RNA polymerase for use in preparing RNA templates for multiple uses in research labs worldwide has been a truly revolutionary technical advance for the entire field of molecular biology,” said Joan Steitz, the Sterling Professor of Molecular Biophysics and Biochemistry at Yale University.

RNA 84

RNA Production Molecular Biology Laboratories 84

Drug Discovery World

NOVEMBER 15, 2022

Anita Ramanathan outlines four synthetic biology approaches that are improving and accelerating drug discovery. . Here we outline four synthetic biology approaches that are improving and accelerating drug discovery: . Rapid and accurate DNA synthesis .

DNA 246

DNA Engineering Drugs Vaccine 246

Dark Matter Blog

JULY 16, 2021

The only subject in school that held my interest was biology. As soon as I learned about DNA and RNA, I wanted to be a molecular biologist. I wanted to use molecular biology to create drugs. Last stops at RNA My last roles in biotech were where my original passion began: DNA and RNA.

Small Molecule 52

Small Molecule RNA Clinical Trials DNA 52

Drug Discovery World

JULY 15, 2022

The first complete, gapless sequence of a human genome was published 1 April 2022 in a special issue of the journal Science 1. The remaining 8% of the genome was often referred to as the dark matter of the genome or sometimes even ‘Junk DNA’ 2. Each CLR can be read multiple times, which allows for self-correction.

DNA 130

DNA Disease Molecular Biology Science 130

Drug Discovery World

NOVEMBER 9, 2023

Peter O’Callaghan, PhD, Head of Expression System Sciences, Biologics and Licensing, Lonza, on: ‘Solve bispecific heavy-light chain mispairing with bYlok technology’. Klaus Wagenbauer, PhD, Founder & CEO, Plectonic, on: ‘Programmable DNA-origami-based T cell engagers: PTE’.

Engineering 130

Engineering Therapies Protein Production Science 130

Drug Discovery World

APRIL 30, 2024

For example, mRNA testing can offer deeper insights compared to DNA and give researchers a better understanding of gene expression in relation to certain cancers. The benefits of mRNA mRNA-based therapies have multiple benefits over existing DNA and protein platforms. Wang YS, Kumari M, Chen GH, et al. J Biomed Sci 2023;30;84.

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Therapies RNA Vaccine Small Molecule 130

LifeSciVC

JULY 1, 2024

One thread that has run throughout it has been my passion for science as a lens for looking at the world. In particular, I love connecting science to daily life. Pfizer’s recent campaign around “ Science Will Win ” similarly appealed to the ethos of the power of science to help humanity. Remember life’s Central Dogma.

Science 85

Science Immune Response Molecular Biology RNA 85

Codon

JUNE 25, 2024

However, they plod along as they clone plasmids—the loops of DNA that biologists use to manipulate and study organisms—because propagating them relies, in part, on the pace at which cells grow and divide. Due to the nearly ubiquitous use of cloning in life science research, this lost time adds up. However, E.

DNA 73

DNA RNA Laboratories Engineering 73

Codon

JUNE 13, 2024

billion bases of DNA which, if unfurled, would extend for more than 100 meters—taller than the Statue of Liberty. billion bases of DNA, the human genome measures just 2 meters in length when stretched end-to-end. Credit: Oriane Hidalgo Per the book Cell Biology by the Numbers , each base pair of DNA occupies 1 nm 3 of space.

DNA 62

DNA Molecular Biology Virus Cell Biology 62

Drug Target Review

JUNE 11, 2024

When choosing my bachelor’s degree, the choice was between pursuing a career in biology or in computer science. Biology won that battle, and I pursued a bachelor’s and master’s degree in biochemistry and molecular biology. In math and life and physical sciences, women now make up nearly half of the workforce.

Engineering 64

Engineering Science Doctors Molecular Biology 64

Drug Discovery World

JANUARY 23, 2023

Such stocks have already been created using conventional CRISPR-Cas9 approaches; however, cells edited with CRISPR-Cas9 have an increased risk of random insertions and deletions (indels) which are introduced during a cell’s intrinsic DNA repair process following a DNA double strand break (DSB) from Cas9. doi:10.1126/science.282.5391.1145.

Therapies 130

Therapies DNA Engineering RNA 130

Drug Discovery World

OCTOBER 25, 2023

However, the ligation step is biased and inefficient because the enzymes that ligate the adapters, which are DNA and RNA sequences, prefer some sRNAs that the adapters are ligated to. RA: How accessible have NGS technologies become for life sciences researchers? Plus, this will be for any genetic disorder, not just cancer.

Bioinformatics 287

Bioinformatics Pharmacogenetics RNA Medical Schools 287

Codon

FEBRUARY 13, 2024

doi: 10.2210/rcsb_pdb/goodsell-gallery-048 The Virus that Cures It’s been over 25 years since the science magazine Discover first ran an extraordinary article about how a long-forgotten medical treatment, used in the former Soviet country of Georgia, could save us from the growing threat of untreatable, drug-resistant infections.

Therapies 121

Therapies Virus DNA Clinical Trials 121

Elrig

APRIL 29, 2024

Rising from Research Scientist to Senior Scientist, I supported early-stage DD efforts within their Protein Science group, based in Cambridge, UK. My role involved generating and characterizing complex proteins critical for biological assay development, hit discovery, and structural biology.

Bioinformatics 59

Bioinformatics Molecular Biology Drugs Cell Based Assays 59

Codon

JULY 11, 2023

But “progress in science depends on new techniques, new discoveries and new ideas, probably in that order,” said Nobel Laureate, Sydney Brenner. That’s because proteins are made, in the laboratory, using synthetic DNA and cells; and DNA is expensive. It is the untouchable foundation of molecular biology.

RNA 66

RNA DNA Engineering Laboratories 66

Codon

JULY 27, 2023

From an article in Science : “After 6 months, the most promising varieties had their lignin content reduced by 49.1% in Science. They’ve just finished sequencing the patient’s genome, but they don’t have “DNA sorting” software. of which had reduced lignin levels and extra cellulose.

Therapies 52

Therapies RNA DNA Engineering 52

Codon

JULY 27, 2023

From an article in Science : “After 6 months, the most promising varieties had their lignin content reduced by 49.1% in Science. They’ve just finished sequencing the patient’s genome, but they don’t have “DNA sorting” software. of which had reduced lignin levels and extra cellulose.

Therapies 52

Therapies RNA DNA Engineering 52

Codon

JULY 11, 2023

But “progress in science depends on new techniques, new discoveries and new ideas, probably in that order,” said Nobel Laureate, Sydney Brenner. That’s because proteins are made, in the laboratory, using synthetic DNA and cells; and DNA is expensive. It is the untouchable foundation of molecular biology.

RNA 52

RNA DNA Engineering Laboratories 52

The Open Targets Blog

APRIL 25, 2023

However, there are notable parallels both in the way the science was conducted and, at least for the genome project in the UK, the particular physical settings and sensibilities. Now I don’t want to claim too much. The background and impetus of the two projects were clearly very different. Left: Bletchley Park, photo by Einar H.

DNA 52

DNA Government Engineering Laboratories 52

BMG Labtech

MARCH 8, 2023

DNA, proteins, polysaccharides, etc.). They are strongly oxidizing and, at high concentrations, are deleterious to cells damaging DNA, proteins and lipids, and eventually leading to cell death. Alberts B, How Cells Obtain Energy from Food, Molecular Biology of the Cell (4th ed.). nucleotides, monosaccharides, etc.),

Molecular Biology 52

Molecular Biology Production Cell Based Assays Disease 52

Codon

DECEMBER 17, 2023

Molecular biology, as the field came to be called 3 , pushed biology from an object of study, driven forward by gentleman scientists and precocious country clergymen, into a tool with which to solve urgent problems. Recombinant DNA technologies were invented in the 1970s.

Engineering 52

Engineering Molecular Biology Doctors DNA 52

Codon

MARCH 12, 2023

Notes on Progress is a monthly roundup of papers and ideas about biology and the future. “The recombinant DNA breakthrough has provided us with a new and powerful approach to the questions that have intrigued and plagued man for centuries. Biology is a Burrito. A new base editor to edit mitochondrial DNA.

DNA 52

DNA Engineering RNA Therapies 52

Codon

JUNE 18, 2024

Jensen, reported a much more detailed analysis of gas vesicles in the journal Science. Even after a half-century of molecular biology research, scientists didn’t know until recently how gas vesicles physically trap gas while occluding water. By combining DNA from multiple organisms and inserting it into E.

Engineering 70

Engineering Laboratories International Clinical Trials 70

Codon

JUNE 26, 2023

DNA sequences are designed on a computer, and it takes a dozen or more clicks to change a single nucleotide. DNA sequences are also checked by hand, so it’s easy to make a mistake. The tool outputs a DNA sequence that encodes all the required enzymes. Anyone who has tried to engineer a cell knows how tedious it can be.

DNA 52

DNA Therapies Engineering Clinical Trials 52

Codon

JUNE 26, 2023

DNA sequences are designed on a computer, and it takes a dozen or more clicks to change a single nucleotide. DNA sequences are also checked by hand, so it’s easy to make a mistake. The tool outputs a DNA sequence that encodes all the required enzymes. Anyone who has tried to engineer a cell knows how tedious it can be.

DNA 52

DNA Therapies Engineering Clinical Trials 52

Codon

AUGUST 10, 2023

Journal of Molecular Biology (1961). Technologies DNA Sequencing →DNA sequencing at 40: past, present and future , by Shendure J. Link DNA Cost and Productivity Data, aka "Carlson Curves" , by Carlson R. Link Next-Generation DNA Sequencing Methods , by Mardis E.R. . & Xie X.S. Nature (2011).

DNA 93

DNA Cell Biology Molecular Biology Engineering 93

Codon

AUGUST 10, 2023

Journal of Molecular Biology (1961). Technologies DNA Sequencing →DNA sequencing at 40: past, present and future , by Shendure J. Link DNA Cost and Productivity Data, aka "Carlson Curves" , by Carlson R. Link Next-Generation DNA Sequencing Methods , by Mardis E.R. . & Xie X.S. Nature (2011).

DNA 52

DNA Cell Biology Engineering Molecular Biology 52