Broad Institute

DECEMBER 13, 2023

The studies are part of a package of 10 papers in Nature that take distinct, yet complementary, approaches to mapping the mouse nervous system at the single-cell level. The package also includes the spatial, single-cell atlas of the mouse brain and spinal cord that was led by Wang and Liu and was first published online in September in Nature.

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PLOS: DNA Science

OCTOBER 19, 2023

Last week DNA Science covered a setback in a clinical trial of a gene therapy for Duchenne muscular dystrophy (DMD). It aims to correct the faulty instructions at the DNA level, straightforward, at least conceptually, because mutations are deletions, of part or all of the gene. That’s not the case for ALS.

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The Pharma Data

OCTOBER 19, 2020

“It’s exciting to offer labs the opportunity and freedom to explore additional DNA or viral RNA avenues for combating this pandemic and other viral infections with a safer biomaterial and a single biosample collection device.”. ABOUT SPECTRUM SOLUTIONS AND SPECTRUM DNA.

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RNA DNA Engineering Virus 52

The Premier Consulting Blog

MARCH 7, 2024

The analytical package, consisting of release, stability, and characterization tests, includes data generated throughout the product development and manufacturing process. A more rigorous identity test may sometimes be required, such as DNA sequencing of the entire AAV genome.

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Production Therapies DNA Virus 52

Drug Target Review

JULY 18, 2023

I think it is astonishing that The Human Genome Project was completed exactly 20 years ago and DNA was discovered by Franklin and published by Watson and Crick exactly 70 years ago, yet that 10 percent success rate has still not improved. This means that we are not doing something right.

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Drug Target Review

DECEMBER 5, 2024

2 Structure and function of AAV capsids in gene therapy Wild-type AAV is composed of a protein shell (capsid) that contains a single-stranded DNA genome encoding proteins involved in viral replication, structure and assembly. Therefore, vectors based on these serotypes may enable targeted gene delivery and optimal transduction efficiency.

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Dark Matter Blog

APRIL 4, 2023

We sampled several screening platforms in the course of our efforts, including fragment screening using ligand-observed nuclear magnetic resonance (NMR), DNA-encoded libraries (DEL), and SEC-MS. And unproductive interactions between the RNA target and the DNA barcodes complicated DEL screening.

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Small Molecule RNA Fragment Screening DNA 52

Drug Target Review

SEPTEMBER 10, 2024

To achieve an aggressive timeline from DNA to investigational new drug (IND) application, drug developers have strengthened collaborations with contract development & manufacturing organisations (CDMOs) to expedite drug development.

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The Pharma Data

OCTOBER 14, 2020

Assistant Professor of Medical Sciences at Columbia University Vagelos College of Physicians and Surgeons, is designed to generate DNA aptamer-based anti-idiotypes to selected monoclonal antibodies identified in Dr. Ilya Trakht’s study. The study led by Dr. Sergei Rudchenko, Ph.D.,

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Vaccine Pharmaceuticals Small Molecule Virus 40

Broad Institute

JANUARY 14, 2025

The treatment, which uses base editing to make a single-letter change in DNA, reduced levels of the disease-causing prion protein in the brain by as much as 60 percent. In 2018, Liu, who works on the same floor as Minikel and Vallabh at Broad, approached them and proposed a collaboration.

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Agency IQ

MARCH 29, 2024

The ideal scenario is to have a clinical trial that prospectively evaluates these endpoints, he said, providing a data package the FDA can use to evaluate such alternative endpoints. The FDA’s ask of sponsors, he said, is to “provide us the data to support that these endpoints will be reasonably likely to predict clinical benefit.”

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The Pharma Data

SEPTEMBER 1, 2020

In general, antigen tests have a high specificity, though are not as sensitive as molecular tests that amplify the target viral DNA or RNA sequence in order to generate a quantifiable signal to indicate the presence of the virus in a sample. SARS-CoV-2 Rapid Antigen Test package insert [2] European Centre for Disease Prevention and Control.

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Virus Laboratories Clinical Trials Treatment 52

Agency IQ

AUGUST 11, 2023

EMA’s investigation ended up revealing even more causes of nitrosamine impurities in drugs, discovering, for example , that formation happened during the heat-sealing process of in certain products using blister-packaging. Exposure to high heat during the storage process could also cause nitrosamines to form, according to the investigation.

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Agency IQ

APRIL 12, 2024

Additionally, six of these comments came from the same organization (Integrated DNA Technologies). Now the comments on the draft are in, and stakeholders had a lot to say The draft document was open for public comment for 90 days, during which time it received more than 160 comments.

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Broad Institute

JUNE 27, 2024

Unlike gene editing, this “epigenetic” editing does not modify the underlying DNA sequence, but it should switch the gene off permanently, which means that this could be a one-time treatment. Like Cas9, ZFPs can serve as guide proteins to direct the tool to a target site in DNA.

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Codon

FEBRUARY 13, 2024

Some algorithms simply look for important similarities between phage and bacterial DNA sequences, a signal of the extensive gene-swapping that goes on when a particular virus and bacteria have shared history. Middle and Right) Once a bacteriophage lands on a cell, it injects its DNA through a tube (purple) into the unwilling host.

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Therapies Virus DNA Clinical Trials 135

Codon

APRIL 23, 2024

While astronauts are easily protected from UV by glass or a thin sheet of metal, microbes placed outside on Mars would be killed in mere minutes as the ultraviolet radiation shreds through DNA and destabilizes proteins that carry out important cellular processes. ” Those little packets keep foods dry to prevent spoilage.

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Engineering DNA Hospitals International 102

Codon

APRIL 2, 2023

But now, by studying DNA extracted from microbes in the blood of almost 10,000 healthy people, this paper shows that there is no such thing. Read Transcription factors bind to DNA and control gene expression. Read Switchable hydrophobic pockets in DNA protocells enhance chemical conversion. Nature Microbiology. Meeussen J.V.W.

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The Pharma Data

MARCH 7, 2022

The new technique controls gene activity without altering the DNA sequence of the genome by targeting chemical modifications that help package genes in our chromosomes and regulate their activity. In this experiment, however, the cutting function of the Cas9 protein is disabled so the genomic DNA sequence is unaltered.

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RNA DNA Packaging Small Molecule 52

Drug Target Review

MAY 22, 2024

What are the key findings of Circio’s in vivo proof-of-concept for its circVec circular RNA platform technology compared to conventional mRNA-based expression with DNA vectors? DNA vectors in mouse models? Circular RNA (circRNA) has two major advantages versus mRNA in a vector-expression context.

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Codon

APRIL 23, 2023

Most people would take the two CRISPR gene-editing components (a Cas9 protein and guide RNA), package them up inside of a virus, and then inject the viruses into the skulls of mice. 📎 Papers Strands of DNA can be used to build molecular logic gates. Stahl et al. on bioRxiv. Nature Communications. Nature Communications.

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Vaccine DNA Virus Engineering 52

Codon

APRIL 23, 2023

Most people would take the two CRISPR gene-editing components (a Cas9 protein and guide RNA), package them up inside of a virus, and then inject the viruses into the skulls of mice. 📎 Papers Strands of DNA can be used to build molecular logic gates. Stahl et al. on bioRxiv. Nature Communications. Nature Communications.

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Vaccine DNA Virus Engineering 52

Codon

JULY 27, 2023

They’ve just finished sequencing the patient’s genome, but they don’t have “DNA sorting” software. billion units of DNA code are transcribed into more than a hundred volumes, each a thousand pages long, in type so small as to be barely legible.” At least, that’s what every textbook says.

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Therapies RNA DNA Engineering 52

Codon

JULY 27, 2023

They’ve just finished sequencing the patient’s genome, but they don’t have “DNA sorting” software. billion units of DNA code are transcribed into more than a hundred volumes, each a thousand pages long, in type so small as to be barely legible.” At least, that’s what every textbook says.

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Therapies RNA DNA Engineering 52

PLOS: DNA Science

OCTOBER 12, 2023

The package insert for the drug, Elevidys , warns of adverse effects of acute liver injury and inflammation around the heart and muscles. million DNA bases. The DMD gene therapy delivers a shortened version of the dystrophin gene, just 4,558 DNA bases. appeared first on DNA Science. Muscles stop working.

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Codon

JUNE 26, 2023

DNA sequences are designed on a computer, and it takes a dozen or more clicks to change a single nucleotide. DNA sequences are also checked by hand, so it’s easy to make a mistake. The tool outputs a DNA sequence that encodes all the required enzymes. Anyone who has tried to engineer a cell knows how tedious it can be.

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DNA Therapies Engineering Clinical Trials 52

Codon

JUNE 26, 2023

DNA sequences are designed on a computer, and it takes a dozen or more clicks to change a single nucleotide. DNA sequences are also checked by hand, so it’s easy to make a mistake. The tool outputs a DNA sequence that encodes all the required enzymes. Anyone who has tried to engineer a cell knows how tedious it can be.

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DNA Therapies Engineering Clinical Trials 52

The Pharma Data

AUGUST 3, 2021

The company confirmed the tirzepatide SURPASS program has met global regulatory submission requirements for evaluating cardiovascular risk and its intention to submit the registration package to regulatory authorities by the end of 2021.

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The Pharma Data

AUGUST 3, 2021

We are very pleased that our comprehensive nonclinical data package has addressed all issues identified related to DRG toxicity and the FDA has reached the decision that we may proceed with our OAV-101 IT clinical trial program and initiate the STEER trial,” said Shephard Mpofu, M.D., SVP, Chief Medical Officer, Novartis Gene Therapies.

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Clinical Trials Trials Therapies Licensing 52

The Pharma Data

JANUARY 21, 2021

CABENUVA, a co-packaged kit with two injectable medicines, offers people living with HIV a new approach for maintaining viral suppression. INSTIs, like cabotegravir, inhibit HIV replication by preventing the viral DNA from integrating into the genetic material of human immune cells (T-cells).

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Codon

APRIL 2, 2024

in physics at Princeton University, he had a remarkable idea: What if it were possible to build a circuit out of DNA, rather than electronics, and use it to “program” a living cell? So we engineered a system that allows the cell to package up RNAs and then secrete them in extracellular vesicles.

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Agency IQ

MAY 31, 2024

Specifically , the sponsor is proposing an indication for the detection of “colorectal cancer derived alterations in cell-free DNA from blood collected in the Guardant Blood Collection Kit.” The Shield blood test is an in vitro diagnostic (IVD) product intended to screen for colorectal cancer (CRC) markers in blood.

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Codon

MARCH 24, 2024

In the case of semaglutide, those cells are Saccharomyces cerevisiae— also known as Baker’s yeast — engineered to secrete a peptide precursor that is later purified, chemically modified, packaged into an injectable or tablet form, and then shipped around the world. Continuing this method may not scale.

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PLOS: DNA Science

MARCH 14, 2024

Biotechnology has solved many problems, from recombinant DNA and monoclonal antibody-derived drugs, to gene therapy and stem cell transplants, to RNA-based vaccines and genetically modified plants that resist diseases and pesticides. We package them into a range of branded consumer products.” ” Why Did It Have to be Snakes?

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The Pharma Data

MAY 13, 2021

FACT: A recent study conducted by the Grocery Manufacturer’s Association states that OVER 80% of packaged foods eaten in the U.S. food is “A food in which the gene from one species has been forced into the DNA of another species and the process itself creates all sorts of unpredicted side effects.”. A better definition of a G.M.O.

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Production Doctors Disease Packaging 52

Codon

MARCH 14, 2023

There are even differences in how their genomic DNA is packaged inside of neurons. DNA differences accumulate over generations of breeding. Mice raised at five different animal facilities in Europe, under otherwise identical conditions , have “persistent differences in body weight” and behavior.

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DNA Laboratories Engineering Animal Testing 52

The Pharma Data

MAY 13, 2021

Stimulates DNA and RNA synthesis. You should apply the MindBody Matrix Pain Relief cream 3-4 times per day for the first week after you receive your package. Increases your energy levels by increasing ATP production. Activates and speeds up the lymphatic system. Reduces painful symptoms associated with arthritis.

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Pharmacy Doctors Production Therapies 52