Broad Institute

MAY 25, 2023

Their findings have major therapeutic implications for people with the MONW phenotype, and Claussnitzer and her lab have been approached by pharmaceutical companies interested in developing drugs that modulate COBLL1 expression. “I

Disease 87

Disease Regulations Pharmaceutical Companies DNA 87

The Pharma Data

DECEMBER 28, 2020

Amphastar’s newly approved synthetic peptide product was determined by the FDA to be bioequivalent and therapeutically equivalent to Eli Lilly’s Glucagon Emergency Kit for Low Blood Sugar, which has a recombinant DNA (rDNA)-origin. Company Information.

FDA 52

FDA Production Biosimilars FDA Approval 52

The Pharma Data

NOVEMBER 23, 2020

24, 2020 /PRNewswire/ — United Therapeutics Corporation (Nasdaq: UTHR) today announced the release of its initial Corporate Responsibility Report with primarily 2019 data and selected 2020 highlights, providing stakeholders important information regarding the company’s commitment to environmental, social, and governance (ESG) priorities.

Bioinformatics 40

Bioinformatics Pharmaceutical Companies DNA Government 40

The Pharma Data

OCTOBER 21, 2020

The complete regimen combines the integrase strand transfer inhibitor (INSTI) cabotegravir, developed by ViiV Healthcare, with rilpivirine, a non-nucleoside reverse transcriptase inhibitor (NNRTI) developed by Janssen Sciences Ireland UC, part of the Janssen Pharmaceutical Companies of Johnson & Johnson.

Clinical Development 52

Clinical Development Therapies Clinical Trials Treatment 52

Elrig

APRIL 29, 2024

Harini Srinivasan is a Principal Scientific Associate at Serna Bio with over 10 years of research experience in academic institutions, health care organizations and pharmaceutical companies.

Bioinformatics 59

Bioinformatics Drugs Molecular Biology Cell Based Assays 59

The Pharma Data

JULY 11, 2021

TAKHZYRO is produced in Chinese Hamster Ovary (CHO) cells by recombinant DNA technology. Analysis of Safety and Efficacy for up to 2.5 TAKHZYRO is a fully human monoclonal antibody that specifically binds and decreases plasma kallikrein activity.

Treatment 52

Treatment Pharmacokinetics Disease Production 52

LifeSciVC

OCTOBER 13, 2022

This puts a premium on companies with a critical mass of know-how today and with real platforms that can more easily and quickly enable programs in different diseases by switching out the DNA construct. Revenue opportunities like this have never existed in the history of the pharmaceutical world — until now.

Therapies 40

Therapies Disease Treatment Marketing 40

Codon

FEBRUARY 13, 2024

3 Another considerable obstacle to pharmaceutical companies’ interest (and investment) is the fact that for a product to be patentable — and therefore profitable — it has to be considered new and inventive. This process would begin by taking a sample of bacteria from the patient and sequencing its DNA.

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Therapies Virus DNA Clinical Trials 133

The Pharma Data

JANUARY 21, 2021

21, 2021 /PRNewswire/ — The Janssen Pharmaceutical Companies of Johnson & Johnson today announced the U.S. INSTIs, like cabotegravir, inhibit HIV replication by preventing the viral DNA from integrating into the genetic material of human immune cells (T-cells). TITUSVILLE, N.J. , cp-51575v4. REFERENCES.

FDA Approval 52

FDA Approval Treatment RNA FDA 52

DrugBank

FEBRUARY 26, 2025

In response, researchers and pharmaceutical companies are exploring novel approaches to antibiotic development. Over the past two decades, many pharmaceutical companies have deprioritized antibiotic research due to high development costs and lower profitability compared to treatments for chronic diseases.

Therapies 52

Therapies Pharmaceutical Companies Pharmacokinetics Treatment 52

Drug Target Review

JANUARY 5, 2024

In this work alone we made more than 22,000 biophysical measurements, a similar number as the total ever made for all proteins before we started harnessing the remarkable strides in DNA sequencing and synthesis methodologies.” The findings showed that KRAS has many more strong allosteric sites than expected.

Regulations 98

Regulations Pharmaceutical Companies DNA Drug Development 98

The Pharma Data

OCTOBER 14, 2020

AOP Orphan – AOP Orphan Pharmaceuticals took over the Viennese pharmaceutical company Amomed and the Luxembourgish health-tech company SciPharm. Talking Medicine uses advanced AI to provide pharmaceutical companies with real-time data intelligence. Growth Programme. Dolmatics – U.K.-based

Clinical Trials 52

Clinical Trials Trials Pharmaceuticals Therapies 52

Drug Target Review

APRIL 16, 2024

By delivering radiation directly to the tumour cells, RLT can induce DNA damage, leading to cell death and tumour regression. Relocating to Germany, Francesco took on the role of Business Developer at a prominent pharmaceutical company specialising in RadioTheranostics.

Small Molecule 59

Small Molecule Therapies Treatment Pharmaceutical Companies 59

The Pharma Data

MARCH 22, 2021

Radioligand therapy combines a targeting compound that binds to markers expressed by tumors and a radioactive isotope, causing DNA damage that inhibits tumor growth and replication. Novartis is the only pharmaceutical company which is pursuing four different cancer treatment platforms.

Therapies 52

Therapies Treatment Trials Pharmaceutical Companies 52

Advarra

AUGUST 10, 2023

Given the relatively small populations affected by any one rare disease or condition, a pharmaceutical company developing an orphan drug may reasonably expect the final approved drug to generate relatively small sales (when compared with the drug development costs) and consequently incur a financial loss.

Drug Development 52

Drug Development Disease Therapies Engineering 52

Codon

JUNE 26, 2023

DNA sequences are designed on a computer, and it takes a dozen or more clicks to change a single nucleotide. DNA sequences are also checked by hand, so it’s easy to make a mistake. The tool outputs a DNA sequence that encodes all the required enzymes. Anyone who has tried to engineer a cell knows how tedious it can be.

DNA 52

DNA Therapies Engineering Clinical Trials 52

Codon

JUNE 26, 2023

DNA sequences are designed on a computer, and it takes a dozen or more clicks to change a single nucleotide. DNA sequences are also checked by hand, so it’s easy to make a mistake. The tool outputs a DNA sequence that encodes all the required enzymes. Anyone who has tried to engineer a cell knows how tedious it can be.

DNA 52

DNA Therapies Engineering Clinical Trials 52

Broad Institute

MAY 14, 2024

By 1984, he and Brookhaven colleague John Dunn successfully identified and cloned the protein within T7 that was responsible for rapidly copying T7 DNA into many corresponding strands of RNA — a critical step in the bacteriophage’s ability to infect E. coli genome and let the E. coli had no built-in way to shut it off.

RNA 84

RNA Production Molecular Biology Laboratories 84

Codon

JUNE 18, 2024

By combining DNA from multiple organisms and inserting it into E. Credit: Mikhail Shapiro Just consider a pharmaceutical company that wants to test whether an engineered immune cell, such as those used for CAR-T therapy , can detect and destroy cancer cells. megaterium. coli , the cells formed functional gas vesicles.

Engineering 67

Engineering Laboratories International Clinical Trials 67

Codon

JUNE 30, 2024

Modern biotechnology began in 1972 when biochemists at Stanford University spliced together DNA from two different organisms. The race to exploit recombinant DNA technology was on. Chakrabarty genetically cross-linked the plasmids using X-rays and then placed the newly assembled sequence into Pseudomonas putida.

DNA 106

DNA Engineering Laboratories Production 106

Codon

SEPTEMBER 29, 2024

mRNA was the intermediate stage between DNA and protein, a dynamic entity that shifted depending on the second-to-second needs of the cell, able to point out if a cell was cancerous or stressed, what kind of cell it was, and so on. Collections of mRNA have been understood as a proxy for cell states for decades.

Engineering 143

Engineering Virus DNA Therapies 143

Codon

MARCH 24, 2024

Water accounts for 70 percent of a bacterium by mass; the other 30 percent includes everything else: proteins, RNA, DNA, lipids, and so on. Experiments around using genetically modified organisms to produce proteins have been taking place since the earliest days of the recombinant DNA revolution.

Engineering 86

Engineering Vaccine Production RNA 86

DrugBank

NOVEMBER 4, 2024

  Pharmaceutical companies are, therefore, exploring innovative approaches. Their joint efforts have led to the development of gepotidacin , a novel first-in-class antibiotic that inhibits the bacterial enzymes topoisomerase II and DNA gyrase, which are essential for DNA replication and repair.

Pharmaceutical Companies 98

Pharmaceutical Companies Pharmaceuticals Government DNA 98

The Pharma Data

NOVEMBER 23, 2021

The study compared the two groups’ plasma CMV DNA concentration levels at the end of the study’s eighth week, with efficacy defined as having a level below what is measurable. The FDA granted the approval of Livtencity to Takeda Pharmaceuticals Company Limited. It’s a type of herpes contagion.

FDA Approval 52

FDA Approval Treatment FDA DNA 52

Codon

DECEMBER 12, 2024

DNA and RNA molecules are also built from exclusively right-handed nucleic acids. A drug called thalidomide, initially made by a West German pharmaceutical company called Chemie Grünenthal, was manufactured and given to patients as a mixture containing both enantiomers.

RNA 103

RNA DNA Vaccine Virus 103

Codon

NOVEMBER 3, 2024

Based on these results, Waksman asked the pharmaceutical company Merck to mass-produce streptomycin for further tests that could provide clearer evidence of its efficacy and safety. Some fluoroquinolones — a class of antibiotics that inhibits DNA replication — may even cause psychosis.

Vaccine 103

Vaccine Trials Therapies Treatment 103

Codon

FEBRUARY 23, 2025

In 2024, the pharmaceutical company Gilead announced that a single injection of lenacapavir protected 96 to 100 percent of recipients from HIV for up to six months. Researcher Jerome Horwitz at the Michigan Cancer Foundation developed it as a potential cancer treatment by chemically-modifying thymine, a DNA building block.

Clinical Trials 71

Clinical Trials Virus Vaccine DNA 71