Drug Target Review

DECEMBER 21, 2023

As we navigate the current landscape of pharmaceutical exploration, we discern a future in which healthcare is characterised by personalised medicines and precision-targeted treatments. To provide comprehensive insights into ongoing developments, we are pleased to present the latest edition of Drug Target Review.

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Drugs DNA Engineering Disease 98

Codon

FEBRUARY 13, 2024

3 Another considerable obstacle to pharmaceutical companies’ interest (and investment) is the fact that for a product to be patentable — and therefore profitable — it has to be considered new and inventive. This process would begin by taking a sample of bacteria from the patient and sequencing its DNA.

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Therapies Virus DNA Clinical Trials 131

Drug Hunter

MAY 18, 2023

Dian eventually made her way to Shanghai, where she encountered a much bigger world while earning degrees in pharmaceutical engineering and medicinal chemistry. researching DNA photoproducts related to skin cancer. She seized the opportunity to pursue a higher degree in the U.S.,

Small Molecule 131

Small Molecule DNA Pharmacokinetics Engineering 131

Drug Target Review

JULY 31, 2023

For my PhD project, I chose an advisor who worked on DNA and I started working with her on the physical properties of DNA. I worked with Jackie Barton in the early days of what’s now called DNA-mediated electron transfer. And that was a very controversial idea.

DNA 98

DNA Small Molecule Science Cell Biology 98

The Pharma Data

JANUARY 21, 2021

–( BUSINESS WIRE )– Spectrum Pharmaceuticals (NasdaqGS: SPPI), a biopharmaceutical company focused on novel and targeted oncology therapies, today announced an oral presentation on updated efficacy, safety, and dosing management of poziotinib from Cohorts 1 and 2 of the ZENITH20 clinical trial. About Spectrum Pharmaceuticals, Inc.

Pharmaceuticals 52

Pharmaceuticals Clinical Trials Licensing Licensing 52

Codon

NOVEMBER 3, 2024

Based on these results, Waksman asked the pharmaceutical company Merck to mass-produce streptomycin for further tests that could provide clearer evidence of its efficacy and safety. Some fluoroquinolones — a class of antibiotics that inhibits DNA replication — may even cause psychosis.

Vaccine 102

Vaccine Trials Therapies Treatment 102

The Pharma Data

DECEMBER 23, 2020

” Dr. Stanley Plotkin , Professor Emeritus at The Wistar Institute, said, “INOVIO’s DNA vaccine appeared to be quite safe with few significant reactions but yet induced both antibody and T cell responses to SARS-CoV-2.” About INOVIO’s DNA Medicines Platform. mg and 2.0

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DNA Vaccine Clinical Trials Immune Response 40

Drug Target Review

SEPTEMBER 4, 2023

5 Cytology-based profiling can facilitate antibiotic discovery efforts and, these assays assess cell cycle progression, nuclear and mitochondrial DNA content, mitochondrial DNA replication, nuclear DNA damage, mitochondrial membrane potential, and lysosome structure and function. References: Antunes Luisa (2023). Sebastian, B.,

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Drugs RNA DNA Disease 111

Broad Institute

MAY 14, 2024

His T7 expression technology can be used to make large quantities of nearly any RNA or protein and has been for decades, and continues to be, a mainstay of biomedical research and pharmaceutical production. coli machinery was relatively slow, and scientists often ran into problems with the bacteria turning off their DNA-reading programs.

RNA 84

RNA Production Molecular Biology Laboratories 84

The Pharma Data

OCTOBER 19, 2020

20, 2020 /PRNewswire/ — CNS PHARMACEUTICALS AG , Inc. manufacturer, Pharmaceutics International, Inc. (“Pii”), has completed the manufacturing process for Berubicin Drug Product, its lead drug candidate for the treatment of glioblastoma multiforme (GBM), an aggressive form of brain cancer currently considered incurable.

Clinical Trials 52

Clinical Trials Trials Pharmaceuticals Treatment 52

Codon

SEPTEMBER 29, 2024

mRNA was the intermediate stage between DNA and protein, a dynamic entity that shifted depending on the second-to-second needs of the cell, able to point out if a cell was cancerous or stressed, what kind of cell it was, and so on. Collections of mRNA have been understood as a proxy for cell states for decades.

Engineering 142

Engineering Virus DNA Therapies 142

The Pharma Data

DECEMBER 16, 2020

17, 2020 /PRNewswire/ — CNS Pharmaceuticals, Inc. We will now rapidly move to initiate our Phase 2 trial of Berubicin for adults with GBM and expect to begin enrolling patients in the first quarter of next year,” commented John Climaco , CEO of CNS Pharmaceuticals. About CNS Pharmaceuticals, Inc.

FDA Approval 52

FDA Approval FDA Pharmaceuticals Clinical Trials 52

Codon

DECEMBER 12, 2024

DNA and RNA molecules are also built from exclusively right-handed nucleic acids. A drug called thalidomide, initially made by a West German pharmaceutical company called Chemie Grünenthal, was manufactured and given to patients as a mixture containing both enantiomers.

DNA 104

DNA RNA Vaccine Virus 104

DrugBank

OCTOBER 17, 2024

By harnessing the vast amounts of data generated throughout the development pipeline, pharmaceutical companies can accelerate the discovery of novel therapies, optimize clinical trial design, enhance drug safety monitoring, and deliver personalized medicine, ultimately improving patient outcomes and transforming the future of healthcare.

Drug Development 98

Drug Development Metabolic Stability Clinical Trials Drugs 98

Drug Target Review

JULY 18, 2023

If we look at the pharmaceutical industry’s discovery and development success rate over the last 20 to 30 years, it has not improved, staying stubbornly at around 10 percent. With support from pharmaceutical companies, ultimately, the answer to this question should be yes. This means that we are not doing something right.

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Drug Development Drugs Clinical Development Pharmaceutical Companies 98

Drug Target Review

OCTOBER 26, 2023

Genome engineering and gene therapies that manipulate DNA sequences in cells have driven a biotechnological revolution over the past decade. 1 Adeno-associated virus (AAV) vectors are the leading platform for in vivo gene delivery for the treatment of various human diseases.

Engineering 105

Engineering Virus Therapies Immune Response 105

PLOS: DNA Science

JUNE 20, 2024

Instead, the genomes of plant cells cultured in a lab receive the DNA sequences – genes – that enable them to manufacture specific enzymes required for the biochemical pathways to produce certain molecules of value to us. appeared first on DNA Science. Transgenic plants have diverse applications.

Engineering 52

Engineering DNA Vaccine Production 52

The Premier Consulting Blog

JULY 9, 2023

These evaluations include the active pharmaceutical ingredient (API), also known as the drug substance, and the drug product (formulated product). Assessment and control of DNA reactive impurities Another important guidance document related to impurities and degradants in new small molecule drugs is ICH M7(R1).

Small Molecule 52

Small Molecule DNA Drugs Clinical Development 52

DrugBaron

OCTOBER 17, 2022

Over the next few years, the practice of asset-centric investing was honed through various iterations all designed to counter the inherent progression bias that damages returns in pharmaceutical R&D. Doing that allowed the creation of new tools that are appropriate to deploy much later in the pharmaceutical R&D process.

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Pharma Companies Pharmaceuticals Drug Development Production 100

Drug Target Review

DECEMBER 6, 2023

This report invites you to explore the latest breakthroughs in RNA-centric fields, from innovative proteolipid platforms with transformative potential in DNA-based vaccines, as presented by Dr John Lewis, to the remarkable journey of Sam Hasson in drug discovery, emphasising the challenges and opportunities in RNA-centric drug development.

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RNA DNA Vaccine Drug Development 52

Drug Target Review

JANUARY 5, 2024

In this work alone we made more than 22,000 biophysical measurements, a similar number as the total ever made for all proteins before we started harnessing the remarkable strides in DNA sequencing and synthesis methodologies.” The findings showed that KRAS has many more strong allosteric sites than expected.

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Regulations Pharmaceutical Companies DNA Drug Development 98

The Pharma Data

NOVEMBER 23, 2021

The study compared the two groups’ plasma CMV DNA concentration levels at the end of the study’s eighth week, with efficacy defined as having a level below what is measurable. The FDA granted the approval of Livtencity to Takeda Pharmaceuticals Company Limited. Cleveland Clinic Cytomegalovirus (CMV) CMV is short for cytomegalovirus.

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FDA Approval Treatment FDA DNA 52

The Pharma Data

NOVEMBER 22, 2020

Back in September, Vertex Pharmaceuticals and CRISPR Therapeutics – the company behind the CRISPR Cas-9 platform – announced that the European Medicines Agency (EMA) had granted Priority Medicines (PRIME) designation to CTX001, an investigational ex vivo CRISPR Cas-9 gene-edited therapy for the treatment of severe sickle cell disease.

DNA 52

DNA Medical Schools Treatment Science 52

FDA Law Blog: Biosimilars

APRIL 4, 2023

Innovative medical devices; Innovative and essential pharmaceuticals; Digital health care; Advanced regenerative medicine and advanced bio-pharmaceuticals; DNA tests; Brain-machine interface; Infrastructure” We are excited to hear that South Korea is investing in the growth of the biohealth industry and promoting digital healthcare.

Production 52

Production DNA Pharmaceuticals Government 52

PLOS: DNA Science

JANUARY 4, 2024

” CRISPRs are short DNA sequences, peppered with repeats, that latch onto DNA-cutting enzymes, commandeering and directing them to snip certain parts of a chromosome. Unlike gene therapy as originally-envisioned since the 1950s, which adds a functioning copy of a gene, CRISPR can add, remove, or replace a DNA sequence.

FDA Approval 52

FDA Approval DNA Therapies Clinical Trials 52

DrugBank

MAY 15, 2024

In the early 20th century, the discovery process was largely random , focused on cytotoxic agents that kill cells by disrupting key cellular functions like DNA replication. A Historical Perspective on Drug Development The history of drug discovery gives us great insights into the evolution from hit-or-miss strategies to precise interventions.

Small Molecule 98

Small Molecule Molecular Biology Drugs Disease 98

The Pharma Data

OCTOBER 14, 2020

15, 2020 (GLOBE NEWSWIRE) — Tonix Pharmaceuticals Holding Corp. Assistant Professor of Medical Sciences at Columbia University Vagelos College of Physicians and Surgeons, is designed to generate DNA aptamer-based anti-idiotypes to selected monoclonal antibodies identified in Dr. Ilya Trakht’s study. CHATHAM, N.J.,

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Vaccine Pharmaceuticals Small Molecule Virus 40

The Pharma Data

DECEMBER 2, 2020

Twist intends to use the net proceeds to be received by it in the offering, along with its existing cash, cash equivalents and short-term investments to increase its operational capacity, tooling, and scaling an additional manufacturing location to support its growth in NGS, synbio, DNA prep, its pharmaceutical biologics antibody platform and IgG products; (..)

DNA 52

DNA Licensing Licensing Pharmaceuticals 52

New Drug Approvals

SEPTEMBER 29, 2024

gingivalis DNA was detected in postmortem cortices from people with AD and healthy controls, and in CSF of AD patients ( Jan 2019 news on Dominy et al., gingivalis infection led to the appearance of bacterial DNA in the brain, increased brain Aβ42 production, neuroinflammation, and hippocampal degeneration. and Europe.

Small Molecule 62

Small Molecule DNA Disease Trials 62

New Drug Approvals

SEPTEMBER 6, 2024

TLR7-9 are among the set that are endosomally located and respond to single-stranded RNA (TLR7and TLR8) or unmethylated single-stranded DNA containing cytosine-phosphate-guanine (CpG) motifs (TLR9). A total of 13 TLR family members have been identified, 10 in human, that span either the cell surface or the endosomal compartment.

RNA 62

RNA Clinical Trials Disease DNA 62

Drug Target Review

OCTOBER 4, 2023

2 In response, DNA-damaging agents that could target the entire cell cycle received renewed attention as ADC payloads. DNA damaging agent-based antibody-drug conjugates for cancer therapy. While highly effective against proliferating tumour cells, ADCs with antimitotic payloads typically struggled against slower-growing cancer types.

Small Molecule 126

Small Molecule Drugs Immune Response Targeted Protein Degradation 126

The Pharma Data

MAY 18, 2021

MMR is a molecular mechanism that functions to correct certain errors that can spontaneously occur during DNA replication. This companion diagnostic (CDx) provides clinicians with a standardised testing option that uses a comprehensive panel of DNA mismatch repair (MMR) biomarkers tested by immunohistochemistry (IHC).

FDA Approval 40

FDA Approval FDA DNA Therapies 40

The Pharma Data

AUGUST 27, 2020

Cancer is a disease of the genome, driven by genetic mutations within a tumour’s DNA. FoundationOne Liquid CDx analyses circulating cell-free DNA from a patient’s blood sample and uses massively parallel sequencing to detect the four main classes of genomic alterations. Roche is the majority shareholder in Chugai Pharmaceutical, Japan.

FDA Approval 52

FDA Approval FDA DNA Therapies 52

LifeSciVC

AUGUST 5, 2024

In 2001, I was at Millennium Pharmaceuticals, one of the major players in the nascent field of genomics drug discovery, and that time has strong parallels to the changing state of drug development today. But that initial quote isn’t from 2024, it is from an interview in 2021 with Mark Levin, CEO at Millennium (MIT Technology Review).

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Molecular Biology Production Drug Development Small Molecule 90

The Pharma Data

OCTOBER 26, 2021

About the AVENIO Tumor Tissue CGP Kit The AVENIO Tumor Tissue CGP Kit is a Research Use Only next-generation sequencing test that provides an end-to-end workflow from DNA extraction and library preparation to generation of variant results by the FoundationOne Analysis Platform via AVENIO Connect. Source link: [link].

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Research Clinical Trials Laboratories DNA 52

Drug Target Review

JUNE 19, 2024

Also, many companies never reached the point where they received validation from big pharmaceutical companies. Mr Culley served on the Board of Orphagen Pharmaceuticals, Inc. Lineage is different because our approach is more like a cell transplant , akin to making tiny pieces of organs or tissues. from May 2017 until December 2022.

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Therapies Small Molecule Pharmaceutical Companies Molecular Biology 84

Drug Target Review

DECEMBER 5, 2024

2 Structure and function of AAV capsids in gene therapy Wild-type AAV is composed of a protein shell (capsid) that contains a single-stranded DNA genome encoding proteins involved in viral replication, structure and assembly. Therefore, vectors based on these serotypes may enable targeted gene delivery and optimal transduction efficiency.

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Therapies Virus DNA Compliance 52