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Several viral vectors are being used currently, in addition to non-viral vectors, such as oligonucleotides, naked DNA, and lipoplexes and polyplexes. They work by binding to specific sequences of nucleotides present within the mRNA structure and can induce mechanisms that either decrease, restore, or modify proteinexpression.
Genetic factors Mutations or alterations in tumour DNA (eg, EGFR mutations in lung cancer or HER2 amplification in breast cancer) are key targets of precision medicine. Molecular factors Molecular markers, such as proteinexpression and signalling pathway activation, also guide therapy choices.
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