Chemical Biology and Drug Design

APRIL 24, 2023

Raltegravir, an integrase inhibitor approved for the treatment of HIV infection, led to an increase in DNA damage and apoptosis in multiple myeloma that remains as an incurable malignancy. In addition, the mRNA levels of V(D)J recombination and DNA repair genes were analyzed using qPCR. 01 for U66 and p  ˂ .0001

DNA 100

DNA Treatment Research 100

Chemical Biology and Drug Design

APRIL 15, 2023

The chemosensitive effects of miR-34 is mediated through increasing DNA damage and apoptosis in a p53 depended manner. The present study aimed to evaluate the effects of miR-34 restoration in OECM-1 oral cancer resistant to paclitaxel (OECM-1/PTX) and its underlying mechanisms through p53-mediated DNA damage and apoptosis.

DNA 100

DNA Protein Expression Research 100

Covalent Modifiers

DECEMBER 22, 2023

Mutations in the TRF2TRFH domain physically impair t-loop formation and prevent the recruitment of several factors that promote efficient telomere replication, causing telomeric DNA damage. We identify APOD53 as our most promising compound, as it consistently induces a telomeric DNA damage response in cancer cell lines.

DNA 162

DNA Regulations Treatment 162

Broad Institute

JANUARY 18, 2024

McAlpine January 18, 2024 Credit: Susanna Hamilton, Broad Communications One of the new "priming agents" works by preventing immune cells from engulfing tumor DNA circulating in the bloodstream. Liquid biopsies promise to transform how cancers are diagnosed, monitored, and treated by detecting DNA that tumors shed into the blood.

DNA 133

DNA Engineering Science Disease 133

PLOS: DNA Science

MAY 18, 2023

Perhaps more telling, I recently discovered a previously unknown branch of my own family tree that includes a dozen half-siblings that I know of, from a DNA test that I didn’t even remember taking. So his memories connect past to present, fleshing out the archival documents. Which one was our biodad?

DNA 92

DNA Doctors Research Science 92

Broad Institute

JUNE 28, 2023

By Leah Eisenstadt June 28, 2023 Credit: Courtesy of the Zhang lab Cryo-EM map of a Fanzor protein in complex with ωRNA and its target DNA. They showed that Fanzor proteins use RNA as a guide to target DNA precisely, and that Fanzors can be reprogrammed to edit the genome of human cells.

RNA 139

RNA DNA Research Engineering 139

Covalent Modifiers

MAY 29, 2023

Here we present a global map of a human sulfenome that is susceptible to covalent modification by members of a nucleophilic fragment library. We further show that members of our nucleophilic fragment library can impair functional protein–protein interactions involved in nuclear oncoprotein transport and DNA damage repair.

Small Molecule 130

Small Molecule DNA 130

PLOS: DNA Science

JANUARY 25, 2024

We can learn about life, past and present, anywhere we find DNA and determine its sequence. DNA Science has described intriguing sources of environmental DNA, aka eDNA: DNA in Strange Places: Hippo Poop, Zoo Air, and Cave Dirt and A Glimpse of the Ocean’s Twilight Zone Through Environmental DNA.

Disease 98

Disease DNA Science Virus 98

DrugBaron

JULY 19, 2022

The first is the growing popularity of DNA-encoded libraries (DELs). Here, libraries are constructed on DNA tags in a variety of different ways, but in essence in a broadly similar way to the creation of a virtual chemical space. Two solutions, one physical and one computational have emerged.

Small Molecule 100

Small Molecule Drugs DNA Pharma Companies 100

PLOS: DNA Science

APRIL 20, 2023

DNA is a sleek double helix, with “rungs” consisting of a purine base paired with a smaller pyrimidine base: adenine (A) with thymine (T) and guanine (G) with cytosine (C). . ” DNA encodes amino acid sequences comprising proteins, which impart traits. Watson and F.

DNA 52

DNA Virus Science RNA 52

Drug Target Review

JULY 3, 2023

In considering the present and future of potential therapeutics for genetic diseases, gene editing emerges as a critical player. The ability to edit DNA holds hope for patients currently experiencing incurable genetic diseases and has spurred ongoing efforts in academia and industry to develop and improve gene editing technologies.

Disease 98

Disease Therapies DNA Treatment 98

Broad Institute

MARCH 26, 2024

The team analyzed ancient DNA and traced the variant all the way back to the first people to enter the Americas about 13,000 years ago. "We The researchers then analyzed ancient DNA samples to understand when the risk variant arose in human history. Further investigation revealed that the variant was promoted by natural selection.

DNA 59

DNA Research Disease Treatment 59

ASPET

AUGUST 21, 2024

The present study was based on the hypothesis that pharmacological inhibition of FAAH activity could mitigate cisplatin-induced AKI, exploring potential renoprotective mechanism. Significance Statement Oral administration of FAAH inhibitor, can reduce cisplatin-induced DNA damage response, tubular damages, and kidney dysfunction.

DNA 100

DNA Treatment 100

Drug Target Review

JULY 5, 2023

In the study presented at ASGCT, what were the specific findings regarding the synergistic killing of SKOV3 ovarian tumour cells by the iPSC-derived lymphoid and myeloid cells? What are the key advancements in nucleic-acid delivery and targeted gene insertion that Eterna and Factor Bioscience presented at the ASGCT?

Therapies 103

Therapies DNA Engineering Virus 103

PLOS: DNA Science

SEPTEMBER 19, 2024

And discovering the DNA sequence of a novel genome intrigues me in much the same way as those ancient worm borings did, but it’s even more telling, because genetic information reveals clues to the past and connects the ancient species to their modern descendants.

DNA 90

DNA Science Research 90

Drug Target Review

SEPTEMBER 28, 2023

After some time in that role and launching several products, I received a call from Bill Banyai and Bill Peck, or ‘The Bills’ as we call them, who were building a company around technology that creates DNA by ‘writing’ it on a silicon chip. We’ve miniaturised the chemical process to making DNA and synthesize or ‘write’ DNA on a silicon chip.

DNA 116

DNA Organic Chemistry Science Virus 116

NIH Director's Blog: Drug Discovery

MARCH 8, 2016

Instead of the black, printed stripes of the Universal Product Codes (UPCs) that we see on everything from package deliveries to clothing tags, they used short, unique snippets of DNA to label cells. DNA barcoding has already empowered single-cell analysis, including for nerve cells in the brain.

DNA 52

DNA Drugs Small Molecule FDA Approval 52

Drug Target Review

DECEMBER 28, 2023

During the process of transformation from a normal cell into a cancer cell, a cell acquires a series of changes, or mutations, in its DNA. But DNA mutations can also result in changes to the proteins that are displayed on the surface of the cancer cell. These mutations are called clonal mutations or clonal neoantigens.

Bioinformatics 105

Bioinformatics Immune Response DNA Vaccine 105

Drug Target Review

JANUARY 15, 2024

An important limitation of antibodies against tumour antigens is that these agents direct responses to molecular targets present on the surface of the cell. Figure 1: HLA Class I presentation of peptides derived from intracellular antigens. As described below, it also presents challenges and opportunities for TCR-based therapeutics.

Engineering 110

Engineering DNA Virus Immune Response 110

Conversations in Drug Development Trends

NOVEMBER 12, 2024

For example, once considered incurable and terminal, patients with sickle cell disease may reach new summits in their lives with gene editing technologies such as CRISPR to repair affected DNA and, in some cases, functionally cure the condition.

Therapies 72

Therapies Clinical Supply Clinical Trials Trials 72

PLOS: DNA Science

MARCH 28, 2024

A Scant Protein with Outsize Importance Slowing the muscle decline of DMD presents two huge challenges: the ubiquity of muscle and a giant gene. million DNA bases. The gene presents a complex landscape. The gene presents a complex landscape. It delivers a shortened dystrophin gene, just 4,558 DNA bases.

FDA Approval 97

FDA Approval Treatment FDA DNA 97

PLOS: DNA Science

AUGUST 24, 2023

“Pangenomics” is a newish term, referring to ways that a species’ genome can vary, DNA base by DNA base. I wrote The Age of the Pangenome Dawns here at DNA Science last year, about the Human Pangenome Reference Consortium. A genome of 3,054,832 billion DNA base pairs can vary in many ways. colocynthis.

DNA 97

DNA Disease Science Research 97

The Pharma Data

NOVEMBER 26, 2020

26, 2020 /PRNewswire/ — BASE10 Genetics and DNA Link today announced their collaboration on a research project to evaluate the usability of DNA Link ‘ s AccuFind COVID-19 IgG antibody test in a healthcare setting. At present, most antibody tests on the market require samples to be sent to a lab for analysis.

DNA 52

DNA Nurses Research Laboratories 52

Codon

AUGUST 27, 2024

Allison Berke makes the case for real-time DNA sequencing and AI tools to detect pathogens before they spread widely. Reading DNA The first step in detecting a novel pathogen is recognizing it as an anomaly amidst a noisy background of other material. After copying the DNA to form a big pool, each piece is sequenced.

DNA 97

DNA Laboratories Hospitals Virus 97

Broad Institute

OCTOBER 4, 2023

Related links Merkin Prize Inaugural Merkin Prize in Biomedical Technology awarded to Dr. Marvin Caruthers for developing technology that efficiently synthesizes DNA The inaugural Richard N. Caruthers was announced as the winner in June for his development, in 1981, of an efficient, automated technology for synthesizing DNA.

DNA 52

DNA RNA Science Protein Expression 52

Drug Target Review

JANUARY 26, 2024

To find a DNA fragment that contained the intact ACE2 gene, complete with its embedded regulatory information, they searched libraries of cloned DNA fragments generated as part of the Human Genome Project. Several of the mouse cell clones produced about 50 times more ACE2 than is normally present on mouse cells.

Production 114

Production DNA Virus Protein Expression 114

Broad Institute

OCTOBER 3, 2024

Since URVs are so rare, and because the scientists wanted to understand many different types of epilepsy, the researchers analyzed DNA from people across the world with a range of different genetic ancestries to find meaningful signals. The study’s 54,000 participants included about 21,000 patients with epilepsy and 33,000 controls.

DNA 133

DNA Doctors Treatment Disease 133

DrugBaron

JANUARY 8, 2021

The underlying assumption of most gene therapy procedures, irrespective of the disease being targeted, is that restoration of a wild-type DNA sequence will alone be sufficient to normalise the phenotype of the individual. Surely, then, a correct set of DNA plans will ensure a correctly functioning cell?

DNA 100

DNA Therapies Disease Production 100

Conversations in Drug Development Trends

JUNE 13, 2024

At Worldwide, our recent study delved into the intricacies of PGx, comparing two common methods of DNA sample collection: buccal swabs and blood samples. These results are largely due to the higher cell density in blood, which includes DNA-rich white blood cells. for buccal swabs and 93.2% for blood samples.

DNA 72

DNA Compliance Clinical Trials Trials 72

The Pharma Data

SEPTEMBER 6, 2021

First data to be presented from the phase II coopERA Breast Cancer study evaluating neoadjuvant giredestrant treatment for oestrogen receptor (ER)-positive, HER2-negative breast cancer. Breast Cancer Highlights. Lung Cancer Highlights.

Treatment 52

Treatment Therapies DNA Trials 52

Drug Target Review

DECEMBER 21, 2023

To provide comprehensive insights into ongoing developments, we are pleased to present the latest edition of Drug Target Review. Dr Susanne Rafelski, from the Allen Institute for Cell Science, presents a framework for comprehending cell organisation and variation.

Drugs 98

Drugs DNA Engineering Disease 98

PLOS: DNA Science

MAY 23, 2024

Researchers roughly date events that led to today’s crops by considering changes in DNA sequences and mutation rates. Archeological evidence, such as preserved seeds, complements DNA sequence studies. Genomes Reveal Clues from the Past appeared first on DNA Science. canephora (Robusta) and C. eugenioides. .

DNA 90

DNA Research Science Disease 90

The Pharma Data

NOVEMBER 15, 2020

Triplet’s chief executive officer, president, and founder, will present at the Stifel Virtual Healthcare Conference taking place November 16-18, 2020. Dr. Bermingham will discuss Triplet’s recent activities, including: Dr. Bermingham’s presentation details are as follows: Date: Wednesday, November 18 Time: 9:20 a.m.

DNA 40

DNA Engineering Disease Treatment 40

Broad Institute

OCTOBER 23, 2023

Some participants will receive a kit in the mail that they can use to send a saliva sample for DNA analysis. Now, 1 in 4 individuals across the world are of South Asian ancestry and an increased cardiometabolic disease risk is present across the diaspora.

Disease 145

Disease Research Hospitals DNA 145

The Pharma Data

JANUARY 21, 2021

.–( BUSINESS WIRE )– Spectrum Pharmaceuticals (NasdaqGS: SPPI), a biopharmaceutical company focused on novel and targeted oncology therapies, today announced an oral presentation on updated efficacy, safety, and dosing management of poziotinib from Cohorts 1 and 2 of the ZENITH20 clinical trial.

Pharmaceuticals 52

Pharmaceuticals Clinical Trials Licensing Licensing 52

Drug Target Review

NOVEMBER 13, 2023

The instructions to form a cell are encoded in DNA strands, wrapped in proteins and RNA, and wound together into a 3D structure called chromatin. When the researchers compared the architecture of regulatory and effector T cells, they found there were many unique Foxp3 binding regions only present in regulatory T cells.

Government 104

Government DNA RNA Regulations 104

Chemical Biology and Drug Design

SEPTEMBER 12, 2023

Preliminary therapeutics becoming ineffective that might lead to noteworthy mortality presents a crucial challenge for the scientific community. In the drug development process, linker hybrids acquire the top position due to their excellent π-stacking and Van der Waals interaction with the DNA active sites of pathogens.

DNA 100

DNA Drug Development Drugs 100